公开(公告)号：US11608353B2

公开(公告)日：2023-03-21

申请号：US16675535

申请日：2019-11-06

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Stephen G. Withers ,  Gary D. Brayer ,  Leslie Karen Williams ,  Xiaohua Zhang

IPC分类号： A61K31/7034 ,  A61K31/7048 ,  A61K31/7032 ,  C07H15/26 ,  C07C33/26 ,  C07D311/30 ,  C07H15/203 ,  A23G4/12 ,  A23L33/105 ,  C07H1/06

摘要： There are provided compounds of Formula I: various compositions thereof and methods for their use in the inhibition of α-amylase.

公开(公告)号：US20230071924A1

公开(公告)日：2023-03-09

申请号：US17818591

申请日：2022-08-09

申请人： GINA SLOAN

发明人： GINA SLOAN

IPC分类号： A61K35/745 ,  A61K35/747 ,  A61K38/47 ,  A61K38/46 ,  A61K31/717 ,  A61K31/719 ,  A61K31/7016 ,  A61K31/715 ,  A61K31/7032 ,  A61K47/14 ,  A61K47/12 ,  A61K47/18 ,  A61K47/24 ,  A61P1/14 ,  A61K9/00 ,  A61P31/04 ,  A23K10/18 ,  A23K20/189 ,  A23K50/75

摘要： A probiotic composition comprised of a probiotic, a prebiotic, a complex-starch reducing enzyme, an enzymatic co-factor, and a pH modifier. The probiotic composition facilitates the creation of a biofilm within the GI tract of poultry that outcompetes and excludes pathogens. The probiotic composition can be incorporated into an eggwash and sprayed onto an egg, the sprayed egg developing a stable probiotic population within the GI tract of the pre-hatched chick. The probiotic composition can also be incorporated into poultry feed by applying the probiotic composition as a mash prior to pelleting. The probiotic composition can also be applied post-pelleting as a wet or dry spray, directly onto the pellets. In some instances, the probiotic composition can be added a drinking water source used by poultry as a water additive. Poultry that consume feed or water that contain the probiotic composition develop a stable probiotic population within their GI tracts.

公开(公告)号：US20220395520A1

公开(公告)日：2022-12-15

申请号：US17821282

申请日：2022-08-22

申请人： GLYCOM A/S

发明人： Nikolay KHANZHIN ,  Markus JONDELIUS HEDEROS ,  Louise Kristine VIGSNÆS ,  Bruce MCCONNELL

IPC分类号： A61K31/702 ,  C12P19/04 ,  C12P1/04 ,  C12N9/10 ,  A61K31/716 ,  A61P31/04 ,  A61K31/7016 ,  A61K31/7032 ,  C07H1/00

摘要： A mixture of human milk oligosaccharides that comprises or consists essentially of a) LNTri II, LNT, pLNH II and optionally lactose, or b) LNTri II, LNnT, pLNnH and optionally lactose, and is useful for preventing or treating viral or bacterial, intestinal and respiratory infections and for modulating the human gastrointestinal microbiota to increase Bifidobacterium abundance. A process for preparing the mixture and methods of crystallizing LNnT and LNT is also described.

公开(公告)号：US11382924B2

公开(公告)日：2022-07-12

申请号：US17377829

申请日：2021-07-16

申请人： SyneuRx International (Taiwan) Corp.

发明人： Guochuan Emil Tsai ,  Yi-Wen Mao ,  Lu-Ping Lu ,  Wei-Hua Chang ,  Han-Yi Hsieh ,  Jhe Wei Hu ,  Tsai-Miao Shih ,  ChanHui Huang

IPC分类号： A61K31/7032 ,  A61K9/00 ,  A61P31/14 ,  A61K45/06

摘要： A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220184108A1

公开(公告)日：2022-06-16

申请号：US17119734

申请日：2020-12-11

申请人： East West Products Corp.

发明人： Steve S. Lee ,  Francis YM Wong ,  Thee Sheng Tan ,  Siew Seng NG

IPC分类号： A61K31/7076 ,  A61K31/455 ,  A61K31/706 ,  A61K31/7004 ,  A61K31/015 ,  A61K31/198 ,  A61K31/52 ,  A61K36/02 ,  A61K31/7032 ,  A61K36/31 ,  A61K9/00 ,  A61K36/87 ,  A61K36/70 ,  A61K36/05 ,  A61K35/748

摘要： There is a composition for maximizing NAD enzyme's health benefits. The composition includes a nucleoside; the nucleoside is adenosine. The nucleoside is a phosphate derivative; wherein the composition includes 1 to 5 percent weight of adenosine. The composition includes a vitamin B3; wherein the vitamin B3 is in the form of niacin, niacinamide, nicotinic acid or nicotinamide. The composition includes 0.1 to 10 percent weight of the Vitamin B3. The composition includes a nicotinamide mononucleotide. The composition includes a stilbene derivative; wherein the composition includes 0.1 to 5 percent weight stilbene derivative.

公开(公告)号：US20220184107A1

公开(公告)日：2022-06-16

申请号：US17593755

申请日：2020-03-27

申请人： Glycomine, Inc.

发明人： Agnes RAFALKO ,  Teppei SHIRAKURA ,  Samuel Eric GREENBERG

IPC分类号： A61K31/7032 ,  A61K9/127 ,  A61K47/10 ,  A61P3/00

摘要： The disclosure provides phosphorylated carbohydrate replacement therapies (CRT) that include compositions of phosphorylated carbohydrates and phospholipids, as well as methods for preparing such compositions. Such compositions are suitable for pharmaceutical delivery of phosphorylated carbohydrates to cell interior, endoplasmic reticulum, and Golgi, and can be used for treating CDG type I and CDG type II diseases as well as other metabolic disorders.

公开(公告)号：US11331102B2

公开(公告)日：2022-05-17

申请号：US17158897

申请日：2021-01-26

申请人： Nectero Medical, Inc.

发明人： Eric Wells ,  Kelvin Ning

IPC分类号： C07H13/08 ,  C07H1/06 ,  A61B17/12 ,  A61L29/16 ,  A61M25/10 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/20

摘要： Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

公开(公告)号：US11324698B2

公开(公告)日：2022-05-10

申请号：US16856349

申请日：2020-04-23

申请人： VGSK Technologies, Inc.

发明人： Kameswari S. Konduri ,  Sandhya N. Nandedkar ,  Nejat Duzgunes ,  Pattisapu Ram Jogi Gangadharam

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K31/7032 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7028 ,  A61K38/17 ,  A61K38/48

摘要： The application disclosure provides a sterically stabilized liposome carrier encapsulating a selected drug for the aerosol delivery of the drug effectual in the treatment of a mammal, a composition containing the sterically stabilized liposome carrier and the selected drug effective for the treatment of airway hypersensitivity and inflammation such as of the lungs of a mammal as an aerosol, and a method of treatment using the composition. The composition disclosed herein provides effective treatment for the longer of a period of time at least twice as long as the selected drug alone or up to at least one week.

公开(公告)号：US20220054516A1

公开(公告)日：2022-02-24

申请号：US17377829

申请日：2021-07-16

申请人： SyneuRx International (Taiwan) Corp.

发明人： Guochuan Emil Tsai ,  Yi-Wen Mao ,  Lu-Ping Lu ,  Wei-Hua Chang ,  Han-Yi Hsieh ,  Jhe Wei Hu ,  Tsai-Miao Shih ,  ChanHui Huang

IPC分类号： A61K31/7032 ,  A61K45/06 ,  A61P31/14 ,  A61K9/00

摘要： A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11197854B1

公开(公告)日：2021-12-14

申请号：US16684445

申请日：2019-11-14

申请人： National Technology & Engineering Solutions of Sandia, LLC

发明人： Michael S. Kent ,  Susan Rempe ,  Juan M. Vanegas

IPC分类号： A61K31/69 ,  A61K31/435 ,  A61K31/335 ,  A61K31/35 ,  A61P31/14 ,  A61K31/4745 ,  G01N33/68 ,  A61K45/06 ,  A61K31/351 ,  A61K31/366 ,  A61K31/7032 ,  A61K31/12 ,  A61K31/121 ,  A61K31/122 ,  A61K31/201

摘要： The present invention relates to methods for identifying candidate therapeutics for a disease caused by a viral envelope protein. In particular, the method can include contacting a test envelope protein with the candidate and determining its activity.