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公开(公告)号：US20230022783A1
公开(公告)日：2023-01-26
申请号：US17855823
申请日：2022-07-01
发明人： MINGWEI ZHANG , YUNAYUAN DENG , GUANG LIU , YAN ZHANG , ZHENCHENG WEI , PENGFEI ZHOU , PING LI , ZHIHAO ZHAO , XUCHAO JIA , XIAOJUN TANG
IPC分类号： C07D407/12 , A61K36/42
摘要： The present invention relates to the technical field of natural medicines, and in particular to a triterpenoid compound with an effect of improving glucose and lipid metabolism disorders, and preparation and application thereof. A novel triterpenoid compound was obtained by separation from Momordica charantia L. for the first time in the present invention. Studies on a mouse primary hepatocyte model and a 3T3-L1 preadipocyte model show that the novel triterpenoid compound in the present invention has activity of regulating glucose and lipid metabolism, and after combination with known triterpenoid compound Momordicoside G, the activity of regulating glucose and lipid metabolism is significantly higher than that of a single compound at the same dose, indicating that the novel triterpenoid compound and a complex thereof in the present invention can be used to improve glucose and lipid metabolism disorders and provide a new way for diabetes treatment.
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公开(公告)号：US20220395548A1
公开(公告)日：2022-12-15
申请号：US17660967
申请日：2022-04-27
摘要： The present application relates to a compositions and methods comprising or expressing a hevamine A-related MoMo30 protein from Momordica balsamina. The MoMo30 protein is about 30 kDa in size, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to HIV gp120, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by HIV-1 or alleviating symptoms in an HIV-1 infected patients, and comprises an amino acid sequence of SEQ ID NO: 4. The MoMo30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating microbial infections by HIV, SARS-CoV-2 and other enveloped viruses, as well as other microorganisms comprising cell surface proteins containing glycan residues, such as mannose.
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3.发明申请公开(公告)号：US20220362287A1
公开(公告)日：2022-11-17
申请号：US17870026
申请日：2022-07-21
申请人： Vector Vitale IP LLC
发明人： Peter Y. NOVAK , Maxim V. TEMNIKOV
IPC分类号： A61K33/30 , A23L13/40 , A61K36/81 , A61K35/12 , A23K50/75 , A23L13/50 , A23L33/16 , A23L17/00 , A01G31/00 , A61K31/315 , A61K33/26 , A61K35/60 , C05D9/02 , A23L33/175 , A01C21/00 , A23L15/00 , C05G5/23 , A61K33/00 , A61K35/57 , A23K50/30 , A61K36/42 , A61K36/73 , A61K33/06 , A23K20/142 , A23K20/20 , A23K50/80 , A23L33/00
摘要： Engineered food to promote health and maintain homeostasis in a subject and methods of producing the food.
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公开(公告)号：US20220218775A1
公开(公告)日：2022-07-14
申请号：US17574041
申请日：2022-01-12
申请人： Shonneka Wells
发明人： Shonneka Wells
IPC分类号： A61K36/42 , A23L33/105
摘要： The present invention relates to herbal teas and drinks and methods of using same for purging toxins in the bloodstream and urine of a subject. Such toxins include tetrahydrocannabinol (THC) and its metabolites.
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公开(公告)号：US11241406B2
公开(公告)日：2022-02-08
申请号：US15756548
申请日：2016-08-28
IPC分类号： A61K36/42 , A61K31/198 , A61K36/87 , A61K36/82 , A61K36/63 , A61K36/185 , A61K31/51 , A61K31/555 , A61K36/534 , A61K36/61
摘要： Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting myeloperoxidase activity.
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公开(公告)号：US11166999B1
公开(公告)日：2021-11-09
申请号：US16996153
申请日：2020-08-18
摘要： The present application relates to a compositions and methods comprising or expressing a MOMO30 protein derived from Momordica balsamina. The MOMO30 protein is about 30 kDa in size, binds coronavirus S protein, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to coronavirus spike (S) protein, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by a coronavirus or alleviating symptoms in coronavirus infected patients and comprises the amino acid sequence of SEQ ID NO: 1. The MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating viral infections by coronaviruses and others.
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公开(公告)号：US20210154130A1
公开(公告)日：2021-05-27
申请号：US17076612
申请日：2020-10-21
申请人： Mary Kay Inc.
发明人： Tiffany Florence , Michelle Hines , David Gan
IPC分类号： A61K8/9711 , A61K36/28 , A61K36/287 , A61K36/42 , A61Q19/00 , A61K8/9789 , A61Q19/08
摘要： A method for treating the skin of a subject in need thereof is disclosed. The method includes topically applying to the skin of the subject a cosmetic composition that includes an effective amount of an aqueous, alcoholic, or aqueous-alcoholic extract of Silybum marianum and an aqueous, alcoholic, or aqueous-alcoholic extract of Momordica grosvenori fruit.
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公开(公告)号：US10967027B2
公开(公告)日：2021-04-06
申请号：US16291787
申请日：2019-03-04
摘要： The invention provides a method for extracting active therapeutic components from plant materials of the cyclanthera pedata plant which comprises immersing said plant material containing active components and selected from the group consisting of fruits, flowers, leaves, stems, twigs, bark, wood, buds, seeds, roots, and pods in a solvent for a period of time of about 30 minutes to about 10 hours to achieve transfer of active components from the plant material to the solvent, separating the solvent containing active components from the plant material, and evaporating or distilling the solvent to produce a concentrated fraction containing active components. The invention further includes compositions and therapeutic formulations of such extracts to treat hypercholesterolemia and other high lipid related diseases.
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公开(公告)号：US20210093687A1
公开(公告)日：2021-04-01
申请号：US17039426
申请日：2020-09-30
申请人： Savant Science Inc.
发明人： Jennifer P Cooper
IPC分类号： A61K36/8965 , A61K36/75 , A61K31/366 , A61K36/185 , A61K36/81 , A61K36/9066 , A61K36/53 , A61K31/198 , A61K31/197 , A61K36/575 , A61K36/756 , A61K31/405 , A61K36/48 , A61K36/42 , A61K31/675 , A61K33/06 , A61K31/4045 , A61K36/24 , A61K36/65 , A61K31/216 , A61K36/537 , A61K31/4172
摘要： A composition of matter in the form of a base formula that is specifically formulated to be effective to overcome sleep issues. Optional additions to the base formula are disclosed to be effective in the improvement of specific sleep issues.
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公开(公告)号：US20200376060A1
公开(公告)日：2020-12-03
申请号：US16726234
申请日：2019-12-23
申请人： KING SAUD UNIVERSITY
摘要： The watermelon seed nanoparticles may be synthesized by dissolving powdered watermelon seeds in a solvent to produce a first mixture, adding the first mixture dropwise to boiling water under ultrasonic conditions to produce a second mixture, sonicating the second mixture and drying the second mixture to produce watermelon seed nanoparticles. In an embodiment, the watermelon seeds may be Citrullus lanatus seeds. In an embodiment, the watermelon seed nanoparticles may be included in a pharmaceutical composition, such as an antimicrobial or anti-cancer composition.
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