公开(公告)号：US12097113B2

公开(公告)日：2024-09-24

申请号：US17115812

申请日：2020-12-09

申请人： Sichuan University

发明人： Yunbing Wang ,  Gaoyang Guo ,  Li Yang

IPC分类号： A61F2/24 ,  A61L27/36 ,  A61L27/54 ,  A61L31/00 ,  A61L33/00 ,  A61L33/04

CPC分类号： A61F2/2415 ,  A61F2/2418 ,  A61L27/3625 ,  A61L27/3687 ,  A61L27/54 ,  A61L31/005 ,  A61L33/0023 ,  A61L33/0041 ,  A61L33/04 ,  A61L2300/208 ,  A61L2430/20

摘要： A bioprosthetic valve and a preparation method thereof are provided. The bioprosthetic valve includes a stent and a functional biological tissue material attached to the stent. The functional biological tissue material is a biologicaltissue covalently bonded with an active group and a functional molecule or group. The method improves the anti-thrombosis and anti-calcification functions by covalently modifying the surface of a biological valve using an active group and a functional molecule or group with a substantial degree of grafting. The new bioprosthetic valve does not include aldehyde residues, exhibits excellent biocompatibility, optimal mechanical properties, high stability, and can meet the performance requirements of a biological valve delivered through a catheter.

公开(公告)号：US11819599B2

公开(公告)日：2023-11-21

申请号：US17117736

申请日：2020-12-10

申请人： Infomed SA

发明人： Olivier Favre

IPC分类号： A61M1/36 ,  A61L33/04 ,  A61L33/12

CPC分类号： A61M1/3672 ,  A61L33/04 ,  A61L33/128 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/502 ,  A61M2205/52

摘要： Disclosed is an extracorporeal blood circulation device including a blood circulation circuit including a blood extraction line and a return line, a blood circulator in the circulation circuit and a control unit including a calculator arranged determining at least one parameter, recording it in a memory, and then comparing the standard value of the parameter with the recorded value. The device also includes a source of solution for liquefying blood clots, a device injecting and conveying the liquefaction solution in the circulation circuit, the control unit including a driver for the injector of the liquefaction solution. The control unit is arranged to actuate the driver when the value is exceeded, meaning that at least one clot has formed, the driver being arranged so that the liquefaction solution is present in the circulation circuit in an amount and for a time determined to be sufficient for liquefying the clot formed.

公开(公告)号：US11484630B2

公开(公告)日：2022-11-01

申请号：US15954943

申请日：2018-04-17

申请人： Colorado State University Research Foundation

发明人： Arun Kumar Kota ,  Ketul Popat ,  Sanli Movafaghi ,  Victoria Leszczak Murphy ,  Wei Wang

IPC分类号： A61L33/00 ,  C01G23/08 ,  A61L33/04 ,  A61L27/50 ,  A61L33/02 ,  A61L27/06 ,  C01G23/053

摘要： In this work, we investigated the blood platelet adhesion and activation of truly superhemophobic surfaces and compared them with that of hemophobic surfaces and hemophilic surfaces. Our analysis indicates that only those superhemophobic surfaces with a robust Cassie-Baxter state display significantly lower platelet adhesion and activation. The understanding gained through this work will lead to the fabrication of improved hemocompatible, superhemophobic medical implants.

公开(公告)号：US20210253550A1

公开(公告)日：2021-08-19

申请号：US17245691

申请日：2021-04-30

申请人： eXIthera Pharmaceuticals, Inc.

发明人： Neil J. Hayward ,  Bertrand L. Chenard ,  Yuelian Xu ,  Roberta L. Dorow ,  Michael E. Matison ,  Alexander Kolchinski ,  Richard Fornicola

IPC分类号： C07D401/06 ,  A61P7/02 ,  A61L33/04 ,  A61L33/00

摘要： Provided herein are compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and compositions.

公开(公告)号：US10786606B2

公开(公告)日：2020-09-29

申请号：US15753266

申请日：2016-08-19

申请人： Anteo Technologies Pty Ltd

发明人： Nobuyoshi Joe Maeji ,  Chang-Yi Huang

IPC分类号： A61L33/00 ,  A61K47/69 ,  A61K47/54 ,  A61K31/727 ,  A61L33/04 ,  A61L33/06 ,  B82Y30/00

摘要： The present invention relates to the coating of a range of functional heparins onto the surface of a substrate for which hemocompatibility is a key functional characteristic, such that the functionality of the functional heparin is maintained. The approach employs a metal coordination complex to bind to the substrate with the functional heparin binding to the metal coordination complex to thereby impart hemocompatibility.

公开(公告)号：US10350334B2

公开(公告)日：2019-07-16

申请号：US15659960

申请日：2017-07-26

申请人： Becton, Dickinson and Company

发明人： John J. Kelley, III ,  Thelma I. Valdes

IPC分类号： A61L33/00 ,  A61K31/167 ,  A61K31/245 ,  A61K31/47 ,  A61K9/00 ,  A61K31/445 ,  A61L29/14 ,  A61L29/16 ,  A61L29/06 ,  A61L33/04 ,  A61L33/06 ,  A61K47/36 ,  A61M25/00

摘要： The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.

公开(公告)号：US09895468B2

公开(公告)日：2018-02-20

申请号：US15449752

申请日：2017-03-03

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61L29/16 ,  A61L29/08 ,  A61L33/06 ,  A61L33/04 ,  A61L33/00 ,  A61L29/06

CPC分类号： A61L33/0017 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：US20110034995A1

公开(公告)日：2011-02-10

申请号：US12906892

申请日：2010-10-18

申请人： Andrew L. Lewis ,  Simon W. Leppard

发明人： Andrew L. Lewis ,  Simon W. Leppard

IPC分类号： A61F2/82 ,  A61L33/04

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/606

摘要： It is provided that a vascular stent having an amphiphilic polymer coating is loaded with a restenosis inhibiting agent which is sparingly soluble in water, whereby delayed release of the agent takes place after implantation of the stent.

摘要翻译： 提供具有两亲性聚合物涂层的血管支架装载有微溶于水的再狭窄抑制剂，由此在植入支架后发生药剂的延迟释放。

公开(公告)号：US20100112033A1

公开(公告)日：2010-05-06

申请号：US11997087

申请日：2006-04-19

申请人： Marcelo Ganzarolli de Oliveira ,  Alexander Marra Moreira ,  Amedea Barozzi Seabra ,  Maíra Martins de Souza Godoy Simões ,  Spero Penha Morato

发明人： Marcelo Ganzarolli de Oliveira ,  Alexander Marra Moreira ,  Amedea Barozzi Seabra ,  Maíra Martins de Souza Godoy Simões ,  Spero Penha Morato

IPC分类号： A61K33/00 ,  A61F2/00 ,  A61P9/00 ,  A61L33/04 ,  A61F2/82

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/114 ,  A61L2300/416 ,  C08L29/04

摘要： This invention relates to stents coated with hydrophilic polymers containing S-nitrosothiols, which are able to provide local delivery of both nitric oxide and S-nitrosothiols by diffusion. This device is intended for coronary angioplasty applications with the purpose of inhibiting acute and chronic restenosis and refers to processes of stent coating with hydrophilic polymers containing incorporated S-nitrosothiols. This invention refers to an intracoronary implant device used in medical procedures, and introduces new S nitrosothiol-eluting stents coated with hydrophilic polymer multilayers. The hydrophilic polymers used for coating are polyvinyl alcohol, polyvinylpirrolidone and polyvinyl alcohol/polyvinylpirrolidone, polyvinyl alcohol/polyethylene glycol, polyvinylpirrolidone/polyethylene glycol and polyvinyl alcohol/polyvinylpirrolidone/polyethylene glycol blends. The S-nitrosothiols incorporated to the polymer coatings are mainly primary S-nitrosothiols, characterized by the fact of the nitric oxide (NO) molecule being covalently bound to a sulfur (S) atom which, in turn, is linked to a primary carbon in the molecule's structure, thus constituting the S—NO chemical group. The coating processes include immersion of the stents in polymer solutions containing S-nitrosothiols and nebulization processes of the polymer solutions containing S-nitrosothiols onto the stent surface.

摘要翻译： 本发明涉及涂覆有含有S-亚硝基硫醇的亲水性聚合物的支架，其能够通过扩散提供一氧化氮和S-亚硝基硫醇的局部递送。 该装置旨在用于冠状动脉血管成形术应用，其目的是抑制急性和慢性再狭窄，并且是指含有含有S-亚硝基硫醇的亲水性聚合物的支架涂覆方法。 本发明涉及在医疗过程中使用的冠状动脉内植入装置，并且引入涂覆有亲水性聚合物多层的新的亚硝基硫醇洗脱支架。 用于涂布的亲水性聚合物是聚乙烯醇，聚乙烯吡咯烷酮和聚乙烯醇/聚乙烯吡咯烷酮，聚乙烯醇/聚乙二醇，聚乙烯吡咯烷酮/聚乙二醇和聚乙烯醇/聚乙烯吡咯烷酮/聚乙二醇共混物。 结合到聚合物涂层中的S-亚硝基硫醇主要是初级S-亚硝基硫醇，其特征在于一氧化氮（NO）分子与硫（S）原子共价结合的事实，其又与主要碳连接 分子的结构，从而构成S-NO化学基团。 涂覆方法包括将支架浸入含有S-亚硝基硫醇的聚合物溶液中，并将含有S-亚硝基硫醇的聚合物溶液的雾化过程浸入支架表面。

公开(公告)号：US07575781B2

公开(公告)日：2009-08-18

申请号：US10911228

申请日：2004-08-03

申请人： Ralph A. Chappa

发明人： Ralph A. Chappa

IPC分类号： C23C16/00 ,  A61L33/04

CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  B05D1/60 ,  B05D3/0218 ,  B05D2202/15 ,  C08L65/04

摘要： The present application relates to a method for vapor depositing a polymeric coating onto a substrate. In an embodiment, the invention is a method for applying a polymer coating to a substrate comprising performing a bake-out cycle with a chemical vapor deposition system and performing a deposition cycle with the chemical vapor deposition system.

摘要翻译： 本申请涉及将聚合物涂层气相沉积到基底上的方法。 在一个实施方案中，本发明是一种将聚合物涂层施加到基底上的方法，包括用化学气相沉积系统执行烘烤循环并且与化学气相沉积系统一起进行沉积循环。