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公开(公告)号：US20220243165A1
公开(公告)日：2022-08-04
申请号：US17726987
申请日：2022-04-22
发明人： Nephi Jones , Steven Kjar , Brycen Mills , Mark Smith , Derik West
IPC分类号： C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36
摘要： A bioproduction mixing system includes a flexible compartment having a first end, a second end, and a sidewall extending therebetween, a center axis passing through the flexible compartment between the first end and the second end. A helical assembly is disposed within the flexible compartment and is suspended between the first end and the second end, the helical assembly being offset from the center axis of the flexible compartment.
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公开(公告)号：US20230093549A1
公开(公告)日：2023-03-23
申请号：US18060728
申请日：2022-12-01
IPC分类号： B01F27/21 , C12M1/00 , C12M1/06 , B01F27/07 , B01F27/88 , B01F27/191 , B01F27/054 , B01F27/072 , B01F27/906 , B01F27/1125 , B01F27/2111 , B01F35/41 , B01F35/513
摘要： A method of mixing a fluid includes at least partially unfolding a collapsible bag bounding a compartment, the collapsible bag containing in the compartment at least a portion of an elongated drive line or drive shaft and an impeller secured to the drive line or drive shaft, the impeller including a plurality of impeller blades that are pivotable relative to the drive line or drive shaft, at least one of the plurality of impeller blades being in a collapsed position. A fluid is delivered into the compartment of the collapsible bag. The drive line or drive shaft is then rotated so as to rotate the impeller within the compartment and mix the fluid therein, the at least one of the plurality of impeller blades pivoting from the collapsed position to an expanded position as the impeller is rotated within the compartment.
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公开(公告)号：US20220145231A1
公开(公告)日：2022-05-12
申请号：US17582257
申请日：2022-01-24
发明人： Nephi Jones , Steven Kjar , Daniel Price , Mark Smith , Paul Thacker , Tony Hsiao
IPC分类号： C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36
摘要： A method of installing a flexible bioprocess container in a bioprocessing system having a rigid housing with an interior compartment and extending between a top and an opposing base. The method includes coupling a first surface of the flexible bioprocess container to a moveable platform positioned within the interior compartment of the rigid housing; coupling a second surface of the flexible bioprocess container to the base of the rigid housing; and moving the movable platform relative to the rigid housing and toward the top of the rigid housing so as to at least partially expand the flexible bioprocess container within the interior compartment of the rigid housing.
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公开(公告)号：US20230407226A1
公开(公告)日：2023-12-21
申请号：US18458867
申请日：2023-08-30
发明人： Stephan Kaiser
IPC分类号： C12M1/06 , C12M1/00 , B01F27/054 , B01F27/072 , B01F27/2124 , B01F27/1125 , B01F35/513
CPC分类号： C12M27/02 , C12M23/26 , B01F27/054 , B01F27/0727 , B01F27/2124 , B01F27/11251 , B01F35/513 , B01F2101/44
摘要： The present set of embodiments relate to a system, method, and apparatus for culturing cells within a cell culture vessel having a mixing element. The cell culture system includes a flexible portion and a mixing element disposed therein. The mixing element includes a suspended foldable portion. The system is configured to reduce shear stress on cells without compromising mixing efficiency. This reduction is accomplished by using a mixing element having a large surface area allowing for reduced rotational speeds. The system is collapsible for ease of transport and disposal. The flexible portion collapses and the foldable portion folds to minimize the volume of the system while not in operation.
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公开(公告)号：US11364475B2
公开(公告)日：2022-06-21
申请号：US16296006
申请日：2019-03-07
申请人： SANI-TECH WEST, INC.
发明人： Richard J. Shor , Chris A. Ballew
IPC分类号： B01F33/453 , B01F27/053 , B01F27/054 , B01F33/00
摘要： A mixing system typically for use in a container for mixing its contents, the mixing system including a cap unit, an extension unit and a magnetic mixing unit that is attached to the cap unit by the extension unit. The magnetic mixing unit can be folded to permit insertion and/or removal of the system via a mouth of the container. The extension unit and magnetic mixing unit connect via a hinge formed by upper and lower hinge portions that meet at a pivot point. The hinge portions extend from the pivot point along a first axis. The magnetic mixing unit includes a first magnetic elongate member that extends from the lower hinge portion along a second axis that is substantially perpendicular to the first axis, and a second magnetic elongate member that extends from the lower hinge portion along the second axis in the opposite direction relative to the first elongate member. The magnetic member(s) may be provided by a plastic coated magnetic stir bar.
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公开(公告)号：US20220119751A1
公开(公告)日：2022-04-21
申请号：US17425208
申请日：2020-04-29
发明人： RYAN BARRETT , JONATHAN KENNEY
IPC分类号： C12M1/06 , C12M1/00 , B01F27/054 , B01F27/808 , B01F33/453 , B01F35/21 , B01F35/513
摘要： An impeller assembly for a bioprocessing system includes a hub and at least one blade pivotally to the hub, the at least one blade including a first leg portion and a second leg portion extending at an angle from the first leg portion. The at least one blade is rotatable between a first position where the first leg portion extends generally outwardly from the hub and a second position where the second leg portion extends generally outwardly from the hub.
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公开(公告)号：US20230256400A1
公开(公告)日：2023-08-17
申请号：US18015528
申请日：2021-01-21
发明人： Su Hyoun KIM
IPC分类号： B01F27/054 , B01F27/072 , B01F27/113 , B01F27/91
CPC分类号： B01F27/0541 , B01F27/072 , B01F27/91 , B01F27/113 , B01F2101/305
摘要： Disclosed is a foldable agitator. The foldable agitator according to one aspect of the present invention comprises: a coupling body; impeller arms rotatably coupled to the coupling body; and a piston, inserted in the coupling body so as to be movable vertically, for rotating the impeller arms in the process of moving to induce same to fold and unfold.
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公开(公告)号：US20230091993A1
公开(公告)日：2023-03-23
申请号：US18051126
申请日：2022-10-31
发明人： Christopher Brau , Nephi Jones , Mark Smith
IPC分类号： C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36
摘要： The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.
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公开(公告)号：US11584910B2
公开(公告)日：2023-02-21
申请号：US16238591
申请日：2019-01-03
发明人： Christopher Brau , Nephi Jones , Mark Smith
IPC分类号： B01F23/00 , B01F27/00 , C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36 , B01F27/90 , B01F35/30 , B01F101/44
摘要： The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.
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公开(公告)号：US12128371B2
公开(公告)日：2024-10-29
申请号：US16358263
申请日：2019-03-19
IPC分类号： B01F27/054 , B01F27/07 , B01F27/072 , B01F27/1125 , B01F27/191 , B01F27/21 , B01F27/2111 , B01F27/88 , B01F27/906 , B01F35/41 , B01F35/513 , C12M1/00 , C12M1/06
CPC分类号： B01F27/212 , B01F27/0541 , B01F27/071 , B01F27/0726 , B01F27/1125 , B01F27/11253 , B01F27/191 , B01F27/2111 , B01F27/88 , B01F27/906 , B01F35/41 , B01F35/4111 , B01F35/4121 , B01F35/513 , C12M23/14 , C12M23/52 , C12M27/02
摘要： A fluid mixing system includes a container, such as a flexible bag, bounding a compartment. A flexible drive line is disposed within the compartment, the drive line having a first end rotatably connected to a first end of the container and an opposing second end rotatably connected to a second end of the container. At least one mixing element, such as an impeller, can be coupled with the flexible drive line. Rotation of the drive line facilitates rotation of the impeller within the container.
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