专利检索 ipc:C07D211/72 第 1 页

1.

发明公开
CONJUGATED DIYNES AND THEIR USE AS FLAVOR MODIFIERS 审中-公开

公开(公告)号：US20230345986A1

公开(公告)日：2023-11-02

申请号：US18014789

申请日：2021-10-26

申请人： Firmenich SA

发明人： Wen-Juan XIANG , Dan-Ting YIN

IPC分类号： A23L27/00 , C07C225/16 , C07D317/50 , C07D207/04 , C07D207/325 , C07D207/18 , C07D211/36 , C07D211/72

CPC分类号： A23L27/88 , C07C225/16 , C07D317/50 , C07D207/04 , C07D207/325 , C07D207/18 , C07D211/36 , C07D211/72

摘要： The present disclosure generally provides conjugates diynes, particularly 6,8-diyne amides, and the use of such compounds and related compounds as flavor modifiers. In some aspects, the disclosure provides compositions that include such conjugated diynes, such as compositions that include such conjugated diynes and one or more additional compounds, such as a sweetener, salt, a glutamate, an arginate, and the like. In some other aspects, the disclosure provides methods of reducing or eliminating the amount of sweetener, salt, glutamate, or arginate in a food or beverage product.

2.

发明授权
Method for preparing 4-(piperidin-4-yl)morpholine 有权

公开(公告)号：US10526288B2

公开(公告)日：2020-01-07

申请号：US16308312

申请日：2017-06-09

申请人： YUKI GOSEI KOGYO CO., LTD.

发明人： Hiromi Ishikawa , Kiyono Nakagawa , Yukiko Takeda

IPC分类号： C07D211/72 , C07D265/30 , C07D413/04 , C07D211/58 , C07B61/00

摘要： The object of the present invention is to provide a method for preparing 4-(piperidin-4-yl)morpholine, which is easy to operate. The object can be solved by a method for preparing 4-(1-benzylpiperidin-4-yl)morpholine, characterized in that 5-fold molar or more of morpholine is added to 1-benzyl-4-piperidone, and the mixture is reacted with hydrogen under 1 MPa or less in the presence of platinum catalyst or palladium catalyst.

3.

发明授权
UV absorbing compounds, compositions comprising same and uses thereof 有权

公开(公告)号：US10519111B2

公开(公告)日：2019-12-31

申请号：US15888631

申请日：2018-02-05

申请人： CORAL SUNSCREEN PTY LTD

发明人： Mark York , John Henry Ryan , Gregory Paul Savage , Adam Gerhard Meyer , Karen Jarvis

IPC分类号： C07D211/70 , C07D211/72 , C07D211/78 , C07D401/06 , C07D401/04 , C07D223/04 , C07D207/20 , A61Q17/04 , A61K8/49 , C07F7/21 , A61K8/58 , C09D5/32 , C09D7/63 , C07D405/06 , C08K5/544 , C08K5/3432 , C08K5/41 , C08K5/3445 , C08K5/36 , C08K5/435

摘要： There is provided a range of novel compounds which have been demonstrated to have useful electromagnetic radiation absorbing properties. These compounds will find use in a range of applications such as active components in sunscreen formulations, paints, plastics, fabrics, glass and UV protective coatings.

4.

发明授权
Mixed disulfide conjugates of thienopyridine compounds and uses thereof 有权

公开(公告)号：US10173980B2

公开(公告)日：2019-01-08

申请号：US15570115

申请日：2016-04-29

申请人： The Regents of the University of Michigan

发明人： Haoming Zhang

IPC分类号： C07D211/72 , A61K45/06 , A61K47/52 , A61P9/00 , A61K9/00 , A61K31/445 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/53 , A61K31/5395 , A61K31/541 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D419/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D419/12

摘要： This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardiovascular diseases.

5.

发明授权
2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treating alzheimer's disease 有权

公开(公告)号：US10059669B2

公开(公告)日：2018-08-28

申请号：US15524479

申请日：2015-11-09

申请人： H. Lundbeck A/S

发明人： Karsten Juhl , Lena Tagmose , Mauro Marigo

IPC分类号： C07D211/72 , C07D401/12 , C07D413/12 , A61K31/4427 , C07D417/12 , C07B59/00

CPC分类号： C07D211/72 , C07B59/002 , C07B2200/05 , C07D401/12 , C07D413/12 , C07D417/12

摘要： The present invention is directed to compounds according to Formula (I) which compounds are inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for 5 which the reduction of Aβ deposits is beneficial such as Alzheimer's disease.

6.

发明授权
2-amino-3-fluoro-3-(fluoromethyl)-6-methyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors 有权

公开(公告)号：US10011596B2

公开(公告)日：2018-07-03

申请号：US15233463

申请日：2016-08-10

申请人： H. Lundbeck A/S

发明人： Karsten Juhl , Lena Tagmose , Mauro Marigo

IPC分类号： C07D417/12 , C07B59/00 , C07D211/72 , C07D401/12 , C07D413/12 , C07D211/76

CPC分类号： C07D401/12 , C07B59/002 , C07B2200/05 , C07D211/72 , C07D211/76 , C07D413/12 , C07D417/12

摘要： The present invention provides compounds of Formula I for the treatment of neurodegenerative or cognitive diseases. The method further provides for piperidine-2-one and piperidine-2-thione intermediates to compounds of formula I.

7.

发明申请
MIXED DISULFIDE CONJUGATES OF THIENOPYRIDINE COMPOUNDS AND USES THEREOF 审中-公开

公开(公告)号：US20170334853A1

公开(公告)日：2017-11-23

申请号：US15631822

申请日：2017-06-23

申请人： The Regents of the University of Michigan

发明人： Haoming Zhang , Paul Hollenberg

IPC分类号： C07D211/72 , C07D405/12 , C07D401/12 , A61K45/06 , A61K31/4545 , A61K31/501 , A61K47/54 , A61K31/4525 , A61K31/445 , A61K47/64 , C07K5/093 , A61K38/06

CPC分类号： C07D211/72 , A61K31/445 , A61K31/4525 , A61K31/4545 , A61K31/501 , A61K38/06 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/545 , A61K47/64 , A61P9/00 , C07D401/12 , C07D405/12 , C07K5/0819 , A61K2300/00

摘要： This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardiovascular diseases.

8.

发明授权
N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors 有权

公开(公告)号：US09790210B2

公开(公告)日：2017-10-17

申请号：US14442604

申请日：2013-11-12

申请人： Array BioPharma Inc.

发明人： Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Timothy Kercher , Shannon L. Winski

IPC分类号： C07D231/00 , C07D403/00 , C07D401/00 , C07D211/72 , C07D413/00 , C07D405/12 , C07D403/12 , C07D401/14 , C07D231/40 , C07D231/44 , C07D401/04 , C07D413/12 , C07D231/52 , C07D401/12 , C07D405/04 , A61K31/4155

CPC分类号： C07D405/12 , A61K31/4155 , C07D231/40 , C07D231/44 , C07D231/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D413/12

摘要： Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.