公开(公告)号：US12116372B1

公开(公告)日：2024-10-15

申请号：US18539527

申请日：2023-12-14

申请人： William Allen Boulanger

发明人： William Allen Boulanger

IPC分类号： C07D471/12 ,  C07C69/02 ,  C07D209/16 ,  C07D307/20 ,  C07D317/26 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07C69/02 ,  C07D209/16 ,  C07D307/20 ,  C07D317/26 ,  C07D471/04

摘要： Reactions, reagents and process conditions for the preparation of methyl 3-bromo-2-(2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)propanoate.

公开(公告)号：US11576933B2

公开(公告)日：2023-02-14

申请号：US16616087

申请日：2018-05-24

申请人： EFFECTOR THERAPEUTICS, INC.

发明人： Peggy A. Thompson ,  Kevin R. Webster

IPC分类号： A61K35/17 ,  A61P35/00 ,  A61K31/343 ,  A61K31/4355 ,  A61K45/06 ,  C07D471/12

摘要： The present disclosure provides compositions and methods for improving an antitumor response against non-inflamed solid tumors. Methods of this disclosure include use of an eIF4A inhibitor to promote infiltration of antitumor lymphocytes into a non inflamed solid tumor. Methods of treating cancer associated with a non-inflamed solid tumor are also provided.

公开(公告)号：US20220017519A1

公开(公告)日：2022-01-20

申请号：US17357008

申请日：2021-06-24

申请人： CHIMERIX, INC.

发明人： Joshua E. ALLEN ,  Martin STOGNIEW ,  Richard S. POTTORF ,  Bhaskara Rao NALLAGANCHU ,  Gary OLSON ,  Yanjun SUN

IPC分类号： C07D471/14 ,  A61K31/519 ,  C07D471/12 ,  C07D487/14 ,  A61K45/06 ,  A61K31/337

摘要： This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.

公开(公告)号：US10939682B2

公开(公告)日：2021-03-09

申请号：US14898597

申请日：2014-06-19

申请人： Syngenta Participations AG

发明人： Andrew Edmunds ,  Michel Muehlebach ,  Andre Stoller ,  Olivier Loiseleur ,  Anke Buchholz ,  Ottmar Franz Hueter ,  Roger Graham Hall ,  Daniel Emery ,  Pierre Joseph Marcel Jung ,  Long Lu ,  Yaming Wu ,  Aurelien Bigot ,  Ruifang Chen

IPC分类号： A01N43/90 ,  C07D471/04 ,  C07D471/12 ,  C07D487/04 ,  C07D498/04

摘要： Pesticidally active bi- or tricyclic heterocycles with sulphur-containing substituents, stereoisomers and tautomeric forms thereof that can be used as insecticides and can be prepared in a manner known per se.

公开(公告)号：US10899765B2

公开(公告)日：2021-01-26

申请号：US16246181

申请日：2019-01-11

申请人： ChemoCentryx, Inc.

发明人： Antoni Krasinski ,  Sreenivas Punna ,  Solomon Ungashe ,  Qiang Wang ,  Yibin Zeng

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D471/12 ,  C07D473/00 ,  C07D213/79 ,  C07D213/81 ,  C07D213/84 ,  A61P31/06

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases and as controls in assays for the identification of CCR2 antagonists.

公开(公告)号：US10355225B2

公开(公告)日：2019-07-16

申请号：US15553405

申请日：2016-03-04

申请人： LG CHEM, LTD.

发明人： Miyeon Han ,  Sung Kil Hong ,  Dong Hoon Lee ,  Hyungjin Lee ,  Boonjae Jang ,  Minyoung Kang ,  Dong Uk Heo ,  Wooyung Jung

IPC分类号： H01L51/00 ,  C07F9/6561 ,  C09K11/06 ,  C07D471/04 ,  C07D471/12 ,  H01L51/50

摘要： The present specification provides a hetero-cyclic compound and an organic light emitting device including the same.

公开(公告)号：US10266533B2

公开(公告)日：2019-04-23

申请号：US15817896

申请日：2017-11-20

申请人： ONCOCEUTICS, INC. ,  PROVID PHARMACEUTICALS INC.

发明人： Joshua E. Allen ,  Martin Stogniew ,  Richard S. Pottorf ,  Bhaskara Rao Nallaganchu ,  Gary Olson ,  Yanjun Sun

IPC分类号： C07D471/14 ,  C07D471/12 ,  C07D487/14 ,  A61K31/519 ,  A61K45/06 ,  A61K31/37 ,  A61K31/337

摘要： This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.

公开(公告)号：US20180162859A1

公开(公告)日：2018-06-14

申请号：US15892142

申请日：2018-02-08

申请人： PharmAkea, Inc.

发明人： John Howard Hutchinson ,  David Lonergan ,  Martin Rowbottom ,  Andiliy Gokching Lai

IPC分类号： C07D471/14 ,  A61K9/51 ,  A61K31/437 ,  C07D471/12 ,  A61K45/06 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4985 ,  C07D471/22 ,  A61K9/10 ,  C07D498/22 ,  C07D498/14

CPC分类号： C07D471/14 ,  A61K9/10 ,  A61K9/5153 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/12 ,  C07D471/22 ,  C07D498/14 ,  C07D498/22 ,  A61K2300/00

摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

公开(公告)号：US09862726B2

公开(公告)日：2018-01-09

申请号：US15107023

申请日：2014-12-23

申请人： PURDUE PHARMA L.P.

发明人： Mark Youngman

IPC分类号： A61K31/436 ,  C07D471/12 ,  C07D491/18 ,  C07B59/00 ,  C07D491/08 ,  G01N33/94

CPC分类号： C07D491/18 ,  C07B59/002 ,  C07B2200/05 ,  C07D491/08 ,  G01N33/9486 ,  G01N2500/04

摘要： The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, Y, Z, and G are defined as set forth in the specification. The invention is also directed to use of compounds of Formula (I), and pharmaceutically acceptable salts and solvates thereof, to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.

公开(公告)号：US09688697B2

公开(公告)日：2017-06-27

申请号：US14742907

申请日：2015-06-18

申请人： Tel HaShomer Medical Research Infrastructure and Services Ltd.

发明人： Anat Achiron ,  Roi Mashiach ,  Michael Gurevich

IPC分类号： A61K31/55 ,  C07D471/12 ,  C07D513/14 ,  A61K31/551 ,  C12Q1/68

CPC分类号： A61K31/551 ,  C07D513/14 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y02A50/414

摘要： Provided are novel compounds which are capable of inhibiting an activity of RNA polymerase I, and uses thereof in treating diseases or disorders modulated by RNA polymerase I, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.