公开(公告)号：US11565958B2

公开(公告)日：2023-01-31

申请号：US17301836

申请日：2021-04-15

申请人： ECOLAB USA INC.

发明人： Ashish Dhawan ,  Jeremy Moloney ,  Carter M. Silvernail ,  Boyd A. Laurent

IPC分类号： C02F5/12 ,  C23F11/14 ,  C07F9/54 ,  C11D7/32 ,  C23F11/10 ,  C07C231/12 ,  C07C237/06 ,  C11D1/62 ,  C11D3/386 ,  C02F1/68

摘要： Disclosed herein are the methods of using di-cationic or di-anionic compounds, which are derived from primary amine through an aza-Michael addition with an activated olefin, in a corrosion control composition to mitigate corrosion of a surface in a water system. The disclosed methods or compositions are found to be more effective than those methods or compositions including commonly used single quaternary compounds for mitigating corrosion for a metal surface in water systems.

公开(公告)号：US20220411448A1

公开(公告)日：2022-12-29

申请号：US17761270

申请日：2020-09-21

申请人： FLORATEK PHARMA AG

发明人： Dan Florin STOICESCU

IPC分类号： C07F9/54

摘要： The present invention relates to chromen-4-one derivatives comprising a quaternary group, and to associated multi-salts, solvates, prodrugs and pharmaceutical compositions. The present invention also relates to the use of such compounds and compositions in the treatment and prevention of medical disorders and diseases, most especially by modulation of neurotrophic factors (such as BDNF) pathways and modulation of mitochondrial function Formula (I).

公开(公告)号：US11427606B2

公开(公告)日：2022-08-30

申请号：US16606340

申请日：2018-04-20

申请人： Rising Tide Foundation

发明人： Tim Sparey ,  Andrew Ratcliffe ,  Brett Stevenson ,  Franz Lagasse ,  Edward Cochrane

IPC分类号： C07F9/6568 ,  C07F9/54

摘要： This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

公开(公告)号：US20220251124A1

公开(公告)日：2022-08-11

申请号：US17612123

申请日：2020-06-11

申请人： INSTITUTE OF BIOTECHNOLOGY CAS, V.V.I. ,  SMART BRAIN S.R.O.

发明人： Jaroslav TRUKSA ,  Lukas WERNER ,  Jan STURSA ,  Kristyna BLAZKOVA ,  Cristian Adrian SANDOVAL ACUNA

IPC分类号： C07F9/54 ,  C07D249/08 ,  C07F9/6518 ,  C07F9/6506 ,  A61K49/04 ,  A61K31/675 ,  A61K31/4196 ,  A61P35/00

摘要： Compounds of general formula I are disclosed. The meaning of individual substituents is described in the claims. The compounds are useful in treatment of cancers, due to their multi-modal mechanism of action.

公开(公告)号：US20220054671A1

公开(公告)日：2022-02-24

申请号：US17517846

申请日：2021-11-03

申请人： UNIVERSITÄTSKLINIKUM REGENSBURG ,  UNIVERSITÄT SALZBURG

发明人： Andreas SPÄTH ,  Kristjan PLÄTZER ,  Tim MAISCH ,  Anja EICHNER

IPC分类号： A61L2/08 ,  A01N55/08 ,  A01N35/02 ,  A01N55/02 ,  A01N47/44 ,  A01N57/34 ,  C07F9/54 ,  C07C279/08 ,  C07C217/18 ,  C07C217/20 ,  C07C217/08 ,  A61L2/18 ,  C07C217/22 ,  C07C217/24 ,  C07C225/06 ,  C07F3/06 ,  C07F5/02

摘要： 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof.

公开(公告)号：US11161801B2

公开(公告)日：2021-11-02

申请号：US15751786

申请日：2016-08-03

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Yoram Cohen ,  Micha Fridman ,  Roymon Joseph ,  Alissa Naugolny ,  Mark Feldman ,  Ido M. Herzog ,  Dana Kaizerman

IPC分类号： C02F1/50 ,  C07C217/54 ,  C07D233/60 ,  C07F9/54 ,  C09D5/16 ,  A61K31/138 ,  A61K31/4178 ,  A61K31/66 ,  A61K45/06

摘要： The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.

公开(公告)号：US20210253827A1

公开(公告)日：2021-08-19

申请号：US16791601

申请日：2020-02-14

申请人： Inovia Materials LLC

发明人： Yanjie Xu

IPC分类号： C08K5/50 ,  C07C211/63 ,  C07F9/54 ,  C07D233/58 ,  C08K5/521 ,  C08K5/3445 ,  C08J3/20

摘要： The present disclosure provides a polymeric composition including a thermoplastic polymer and an ionic liquid compound, wherein the ionic liquid compound improves the melt flow rate of the polymeric composition. The present disclosure also provides a method of preparing a polymeric composition with improved melt flow rate by mixing an ionic liquid compound with a thermoplastic polymer to obtain the polymeric composition.

公开(公告)号：US20210253616A1

公开(公告)日：2021-08-19

申请号：US16606340

申请日：2018-04-20

申请人： Rising Tide Foundation

发明人： Tim Sparey ,  Andrew Ratcliffe ,  Brett Stevenson ,  Franz Lagasse ,  Edward Cochrane

IPC分类号： C07F9/6568 ,  C07F9/54

摘要： This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

公开(公告)号：US11058696B2

公开(公告)日：2021-07-13

申请号：US16879824

申请日：2020-05-21

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  T. G. Murali Dhar ,  Hai-Yun Xiao ,  John L. Gilmore ,  Michael G. Yang ,  Zili Xiao ,  David Marcoux

IPC分类号： A61K31/695 ,  C07F7/08 ,  A61K31/135 ,  C07D215/14 ,  C07D241/04 ,  C07C323/29 ,  C07C251/38 ,  C07C251/42 ,  C07C251/44 ,  C07D209/46 ,  C07D213/38 ,  C07C275/26 ,  C07C217/74 ,  C07C323/25 ,  C07C235/46 ,  C07F9/54 ,  C07F9/572 ,  C07F9/09 ,  C07C215/42 ,  C07C217/52 ,  C07C217/58 ,  C07C219/24 ,  C07C233/41 ,  C07C233/65 ,  C07C251/50 ,  C07C251/52 ,  C07C251/54 ,  C07C271/34 ,  C07C317/28 ,  C07C317/32 ,  C07C321/16 ,  C07C321/22 ,  C07C321/28 ,  C07D213/32 ,  C07D213/69 ,  C07D213/70 ,  C07D215/12 ,  C07D217/24 ,  C07D231/12 ,  C07D231/20 ,  C07D239/26 ,  C07D241/12 ,  C07D277/24 ,  C07D305/08 ,  C07D309/06 ,  C07D309/12 ,  C07D311/58 ,  C07D311/76 ,  C07D319/20 ,  C07D333/16 ,  C07F9/117 ,  C07F9/62 ,  C07F9/6503 ,  C07F9/6509 ,  C07F9/655 ,  C07F9/6553 ,  A61K31/137 ,  A61K31/15 ,  A61K31/165 ,  A61K31/166 ,  A61K31/17 ,  A61K31/222 ,  A61K31/24 ,  A61K31/27 ,  A61K31/337 ,  A61K31/351 ,  A61K31/352 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4174 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/661

摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

公开(公告)号：US11021383B2

公开(公告)日：2021-06-01

申请号：US16116413

申请日：2018-08-29

申请人： ECOLAB USA INC.

发明人： Ashish Dhawan ,  Jeremy Moloney ,  Carter M. Silvernail ,  Boyd A. Laurent

IPC分类号： C02F5/12 ,  C23F11/14 ,  C07F9/54 ,  C11D7/32 ,  C23F11/10 ,  C07C231/12 ,  C07C237/06 ,  C11D1/62 ,  C11D3/386 ,  C02F1/68

摘要： Disclosed herein are the methods of using di-cationic or di-anionic compounds, which are derived from primary amine through an aza-Michael addition with an activated olefin, in a corrosion control composition to mitigate corrosion of a surface in a water system. The disclosed methods or compositions are found to be more effective than those methods or compositions including commonly used single quaternary compounds for mitigating corrosion for a metal surface in water systems.