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    Brush-poly (glycoamidoamine)-lipids and uses thereof
    1.
    发明授权
    Brush-poly (glycoamidoamine)-lipids and uses thereof 有权

    公开(公告)号：US10736966B2

    公开(公告)日：2020-08-11

    申请号：US14825127

    申请日：2015-08-12

    申请人： Massachusetts Institute of Technology

    发明人： Yizhou Dong ,  Joseph R. Dorkin ,  Robert S. Langer ,  Daniel Griffith Anderson

    IPC分类号： A61K38/18 ,  A61K9/127 ,  C08G69/48 ,  C08G69/50 ,  A61K47/48 ,  C08G73/00 ,  C08L79/00 ,  A61K47/60 ,  A61K47/69 ,  A61K47/54 ,  A61K47/59 ,  A61K48/00 ,  C12N15/113

    摘要： The present disclosure provides brush-poly(glycoamidoamine)-lipids (PGALs) (e.g., polymers of any one of Formulae (I)-(IV)) and methods of preparing the PGALs. A described PGAL may include poly(glycoamidoamine)-derived moieties (e.g., such as which may assist the PGAL and/or a complex of the PGAL and an agent to pass through cell membranes or be taken up by cells. Also provided are compositions including a described PGAL and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that include or involve the PGALs or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing in a subject a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, genitourinary diseases, and metabolic disorders

    BRUSH-POLY (GLYCOAMIDOAMINE)-LIPIDS AND USES THEREOF
    2.
    发明申请
    BRUSH-POLY (GLYCOAMIDOAMINE)-LIPIDS AND USES THEREOF 审中-公开
    BRUSH-POLY（GLYCOAMIDOAMINE） - 脂类及其用途

    公开(公告)号：US20160067346A1

    公开(公告)日：2016-03-10

    申请号：US14825127

    申请日：2015-08-12

    申请人： Massachusetts Institute of Technology

    发明人： Yizhou Dong ,  Joseph R. Dorkin ,  Robert S. Langer ,  Daniel Griffith Anderson

    IPC分类号： A61K47/48 ,  A61K38/18 ,  C12N15/113 ,  A61K9/127 ,  C08G69/48 ,  C08G69/50

    CPC分类号： A61K47/48207 ,  A61K9/1273 ,  A61K38/1816 ,  A61K47/544 ,  A61K47/554 ,  A61K47/595 ,  A61K47/60 ,  A61K47/6915 ,  A61K47/6935 ,  A61K48/00 ,  A61K48/0041 ,  C08G69/48 ,  C08G69/50 ,  C08G73/00 ,  C08L79/00 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/32

    摘要： The present disclosure provides brush-poly(glycoamidoamine)-lipids (PGALs) (e.g., polymers of any one of Formulae (I)-(IV)) and methods of preparing the PGALs. A described PGAL may include poly(glycoamidoamine)-derived moieties (e.g., such as which may assist the PGAL and/or a complex of the PGAL and an agent to pass through cell membranes or be taken up by cells. Also provided are compositions including a described PGAL and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that include or involve the PGALs or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing in a subject a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, genitourinary diseases, and metabolic disorders.

    摘要翻译： 本公开内容提供了刷 - 聚（糖醇胺）脂质（PGAL）（例如式（I） - （IV）中任一项的聚合物））和制备PGAL的方法。 所描述的PGAL可以包括衍生自聚（糖糖胺基胺）的部分（例如，可以帮助PGAL和/或PGAL和试剂的复合物通过细胞膜或被细胞摄取），还提供包括 所描述的PGAL和药剂（例如，多核苷酸，小分子，肽或蛋白质），本公开还提供了包括或涉及用于将药剂递送至受试者，组织或组织的PGAL或组合物的方法，试剂盒和用途 细胞和/或用于在受试者中治疗和/或预防一系列疾病，例如遗传疾病，增殖性疾病，血液病，神经疾病，免疫疾病，胃肠道疾病，呼吸系统疾病，疼痛病症，精神病学，肌肉骨骼疾病， 泌尿生殖系疾病和代谢紊乱。

    Process for the preparation of crosslinked poly .beta.-alanine in the form of microspheres
    3.
    发明授权
    Process for the preparation of crosslinked poly .beta.-alanine in the form of microspheres 失效
    以微球形式制备交联聚β-丙氨酸的方法

    公开(公告)号：US4927883A

    公开(公告)日：1990-05-22

    申请号：US283960

    申请日：1988-12-13

    申请人： Claudine Lapoiriere ,  Claude Mahieu ,  Christos Papantoniou

    发明人： Claudine Lapoiriere ,  Claude Mahieu ,  Christos Papantoniou

    IPC分类号： C08G69/08 ,  C08F8/28 ,  C08F20/56 ,  C08G69/00 ,  C08G69/50

    CPC分类号： C08G69/50 ,  C08F8/28 ,  C08F8/48 ,  C08F2810/20

    摘要： A process for preparing crosslinked poly .beta.-alanine in the form of microspheres comprises (a) polymerizing acrylamide in a tert. butanol/toluene solvent mixture in the presence of a polymerization initiator and an octadecene-maleic anhydride copolymer as a suspension agent; (b) submitting the resulting suspension of poly .beta.-alanine to a crosslinking reaction using a dialdehyde as the crosslinking agent; and (c) isolating the crosslinked poly .beta.-alanine microspheres. These microspheres exhibit a low size dispersity.

    摘要翻译： 制备微球形式的交联聚β-丙氨酸的方法包括（a）在叔丁醇中聚合丙烯酰胺。 丁醇/甲苯溶剂混合物在聚合引发剂和十八碳烯 - 马来酸酐共聚物存在下作为悬浮剂; （b）使用二醛作为交联剂将所得的聚β-丙氨酸悬浮液进行交联反应; 和（c）分离交联的聚β-丙氨酸微球。 这些微球表现出较小的分散性。

    Blends of polyolefins and poly amides
    6.
    再颁专利
    Blends of polyolefins and poly amides 失效

    公开(公告)号：USRE28167E

    公开(公告)日：1974-09-17

    申请号：US28167D

    申请日：1972-11-13

    IPC分类号： C08G69/00 ,  C08G69/26 ,  C08G69/50 ,  C08L23/02

    CPC分类号： C08G69/50 ,  C08G69/00 ,  C08G69/26 ,  C08L23/02 ,  C08L2666/20

    摘要： A NEW CLASS OF BASIC POLYAMIDES HAVING A MOLECULAR WEIGHT BETWEEN ABOUT 2,000 AND 200,000. THE POLYAMIDES ARE PREPARED BY FIRST REACTING AN ACRYLIC OR METHACRYLIC ESTER WITH A MONOAMINE AND THEN FURTHER REACTING THE PRODUCT OBTAINABLE WITH A POLYAMIDE. THE POLYAMIDES ARE SUITABLE FOR USE AS TINCTORIAL MODIFIERS FOR POLYMERIC MATERIALS AND PARTICULARLY FOR CRYSTALLINE POLYOLEFINS CONSISTING ESSENTIALLY OF ISOTACTIC MACROMOLECULES.

    Method of producing polyamide membranes and rigid foamed products
    7.
    发明授权
    Method of producing polyamide membranes and rigid foamed products 失效
    生产聚酰胺薄膜和刚性发泡产品的方法

    公开(公告)号：US3711583A

    公开(公告)日：1973-01-16

    申请号：US3711583D

    申请日：1969-12-31

    申请人： SKLAR L

    发明人： SKLAR L

    IPC分类号： A61L15/42 ,  C08G69/50 ,  B29D7/20 ,  B29D7/24 ,  B29D27/00 ,  C08G20/40

    CPC分类号： C08G69/50 ,  A61L15/425

    摘要： Polyamide membranes of desired thickness are prepared by dissolving polyamide in HCl, admixing paraformaldehyde and then zinc chloride to produce a viscous paste, forming expanded gelatinous material by treatment with formaldehyde, curing this material and applying tensile stress thereto. Rigid, water insoluble, polyamide foam material is prepared by treating polyamide with concentrated solution of zinc chloride in HCl to make a gum-like solid and supernatant liquid, admixing 1,3,5trioxane and the gum-like solid to make a homogeneous, light, and flowable paste which is then cured in a suitable mold at atmospheric conditions, preferably in the presence of weakly acidic water. The membranes are useful, e.g., for bandages and the nylon foam is useful, e.g., as a construction material, for trays, containers, etc.

    摘要翻译： 通过将聚酰胺溶解在HCl中，混合多聚甲醛然后氯化锌以制备粘性糊剂，通过用甲醛处理形成膨胀的凝胶状材料，固化该材料并向其施加拉伸应力来制备所需厚度的聚酰胺膜。 通过用氯化锌在HCl中的浓缩溶液处理聚酰胺以制备胶状固体和上清液，混合1,3,5-三恶烷和胶状固体以制备均匀的水溶性聚酰胺泡沫材料来制备刚性，水不溶性聚酰胺泡沫材料 ，轻质和可流动的糊剂，然后在大气条件下，优选在弱酸性水存在下，在合适的模具中固化。 膜是有用的，例如用于绷带，并且尼龙泡沫是有用的，例如用作托盘，容器等的构造材料。