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1406 条记录 (耗时 0.041 秒)

    BACILLUS LICHENIFORMIS HOST CELL FOR PRODUCTION OF A COMPOUND OF INTEREST WITH INCREASED PURITY
    1.
    发明公开
    BACILLUS LICHENIFORMIS HOST CELL FOR PRODUCTION OF A COMPOUND OF INTEREST WITH INCREASED PURITY 审中-公开

    公开(公告)号：US20240318188A1

    公开(公告)日：2024-09-26

    申请号：US18572827

    申请日：2022-06-24

    申请人： BASF SE

    发明人： Max Fabian Felle ,  Mathis Appelbaum ,  Christopher Sauer ,  Stefan Jenewein

    IPC分类号： C12N15/75 ,  C07K14/32 ,  C12N9/48

    CPC分类号： C12N15/75 ,  C07K14/32 ,  C12N9/48

    摘要： The present invention relates to a Bacillus licheniformis host cell for production of biological compounds with increased purity. Specifically, the invention relates to a Bacillus licheniformis host with one or more genetic modifications selected from a) a genetic modification causing compared to an unmodified control cell an increased expression of at least one of the genes selected from the group consisting of degQ, degll, degS, degR, and phrG, b) a genetic modification causing compared to an unmodified control cell an increased autophosphorylation activity of the DegS protein, and c) a genetic modification causing compared to an unmodified control cell a reduced phosphatase activity of the DegS protein. The present invention further relates to a method for production of at least one compound of interest with increased purity based on cultivating the bacterial host cell of the present invention.

    Modified Enzyme and Method of Producing Imidazole Dipeptide Using Same
    5.
    发明公开
    Modified Enzyme and Method of Producing Imidazole Dipeptide Using Same 审中-公开

    公开(公告)号：US20240240167A1

    公开(公告)日：2024-07-18

    申请号：US18618330

    申请日：2024-03-27

    申请人： AJINOMOTO CO., INC.

    发明人： Mizuki Tamori ,  Uno Tagami ,  Hiroyuki Nozaki

    IPC分类号： C12N9/48 ,  C12P21/02

    CPC分类号： C12N9/485 ,  C12P21/02

    摘要： Described herein is an enzyme useful for producing a target peptide, capable of producing the target peptide without requiring ATP. More specifically, provided herein is a modified enzyme includes an amino acid sequence such as a modified amino acid sequence including a mutation of one or more of the following amino acid residues: E81, I127, I136, T139, F140, G142, W143, I147, I181, I201, Q219, T229, M244, A249, P255, E256, I260, S293, N294, Y295, and I299 in an amino acid sequence of SEQ ID NO: 1, and



    having the following property (a) or (b) enhanced relative to an enzyme of the amino acid sequence of SEQ ID NO: 1:
    (a) imidazole dipeptide production activity; or
    (b) thermal stability.

    Antifouling Composition and Process for Production Thereof
    7.
    发明公开
    Antifouling Composition and Process for Production Thereof 审中-公开

    公开(公告)号：US20240209311A1

    公开(公告)日：2024-06-27

    申请号：US18432964

    申请日：2024-02-05

    申请人： Gonçalo Costa ,  Patrick Freire ,  Romana Santos ,  Ana Cristina Silva ,  Inês Guinote

    发明人： Gonçalo Costa ,  Patrick Freire ,  Romana Santos ,  Ana Cristina Silva ,  Inês Guinote

    IPC分类号： C12N1/02 ,  A01N63/27 ,  C12N1/20 ,  C12N9/48 ,  C12N9/52

    CPC分类号： C12N1/02 ,  A01N63/27 ,  C12N1/20 ,  C12N9/485 ,  C12N9/52 ,  C12Y304/00

    摘要： This invention concerns a method for preparing a bacterial supernatant comprising culturing a cell of Pseudomonas environmental strain PF-11; and recovering the supernatant. This invention also concerns a method for reducing the amount of a biofilm on a surface, reducing adhesion of at least one organism to a surface, or reducing microfouling or macrofouling on a surface comprising contacting the surface with a supernatant, supernatant fraction, modified supernatant or modified supernatant fraction of Pseudomonas strain PF-11; or a composition comprising a supernatant, supernatant fraction, modified supernatant or modified supernatant fraction of Pseudomonas strain PF-11, and one or more acceptable carriers. This invention also concerns a method for killing or reducing the growth of a fungus or bacterial cell, or killing or inhibiting the development of an insect or marine copepod, comprising contacting the fungus, bacteria, insect or marine copepod with a supernatant, supernatant fraction, modified supernatant or modified supernatant fraction of a Pseudomonas strain PF-11 culture; or a composition comprising a supernatant, supernatant fraction, modified supernatant or modified supernatant fraction of a Pseudomonas strain PF-11 culture, and one or more acceptable carriers. This invention also concerns a substantially pure culture of Pseudomonas strain PF-11. This invention also concerns a culture that is enriched in Pseudomonas strain PF-11. This invention also provides a method of identifying whether a bacteria is capable of producing one or more extracellular proteases capable of digesting a high molecular weight substrate.