公开(公告)号：WO2011044533A3

公开(公告)日：2011-10-06

申请号：PCT/US2010052104

申请日：2010-10-08

Applicant: TO JOHN THAO ,  BLAHA CHARLES M ,  SPECIALIZED VASCULAR TECHNOLOGIES INC

Inventor： TO JOHN THAO ,  BLAHA CHARLES M

IPC: A61K47/30 ,  A61K9/22 ,  A61P35/00

CPC classification number: A61L31/10 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61K31/16 ,  A61K31/192 ,  A61K31/337 ,  A61K31/436 ,  A61K31/565 ,  A61K31/60 ,  A61K31/727 ,  A61K38/1825 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/08 ,  C08L67/04

Abstract: The teachings are directed to a medical device having a drug-retaining coating that at least substantially delays the initial elution of a drug for a time effective at forming a functional endothelium over a surface of the medical device.

Abstract translation: 该教导涉及具有药物保持涂层的医疗装置，该药物保持涂层至少基本延迟药物的初始洗脱持续有效时间以在医疗装置的表面上形成功能性内皮。

公开(公告)号：WO2011119573A1

公开(公告)日：2011-09-29

申请号：PCT/US2011/029377

申请日：2011-03-22

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SCHEUERMANN, Torsten ,  WEBER, Jan ,  DENG, Charles ,  STINSON, Jonathan S. ,  LARSEN, Steven R. ,  BOISMIER, Dennis A. ,  EDICK, Jacob D.

Inventor： SCHEUERMANN, Torsten ,  WEBER, Jan ,  DENG, Charles ,  STINSON, Jonathan S. ,  LARSEN, Steven R. ,  BOISMIER, Dennis A. ,  EDICK, Jacob D.

IPC: A61L31/02 ,  A61L31/14 ,  A61F2/82

CPC classification number: A61L31/148 ,  A61F2/91 ,  A61F2210/0004 ,  A61L31/022 ,  A61L31/088

Abstract: An endoprosthesis includes an expandable tubular body defined by a plurality of struts. In some embodiments, the expandable tubular body includes a bioerodible metal that has at least a first surface region and a second surface region. The first and second surface regions can have different surface oxide compositions. In some embodiments, the first portion has a thermally altered microstructure and the second portion has a wrought microstructure. The thermally altered microstructure can be a cast microstructure comprising dendritic grains. The first portion forms at least a portion of an outer surface of the expandable tubular body. In some embodiments, the expandable tubular body includes iron or a bioerodible iron alloy and at least one surface of the expandable tubular body includes a substantially uniform coating of iron(III) oxide.

Abstract translation: 内假体包括由多个支柱限定的可扩张管状体。 在一些实施例中，可膨胀管状体包括至少具有第一表面区域和第二表面区域的生物浸渍金属。 第一和第二表面区域可以具有不同的表面氧化物组成。 在一些实施例中，第一部分具有热改变的微结构，第二部分具有锻造微结构。 热改变的微结构可以是包含树枝状晶粒的铸造微结构。 第一部分形成可扩张管状体的外表面的至少一部分。 在一些实施例中，可膨胀管状体包括铁或生物腐蚀性铁合金，并且可膨胀管状体的至少一个表面包括基本均匀的氧化铁（III）涂层。

公开(公告)号：WO2011094634A1

公开(公告)日：2011-08-04

申请号：PCT/US2011/023054

申请日：2011-01-28

Applicant: MICRO THERAPEUTICS, INC.

Inventor： LEVY, Elad, Israel ,  SCHUMAN, Victoria ,  SHRIVASTAVA, Sanjay ,  SLEE, Earl

IPC: A61F2/06

CPC classification number: A61B17/12109 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/12172 ,  A61B2017/00004 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/12063 ,  A61F2/07 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148 ,  A61L2430/36 ,  C08L67/04

Abstract: A generally spherical vascular remodeling device is permanently positionable at a junction of afferent and efferent vessels of a bifurcation having an aneurysm. After positioning the device at the junction to substantially conform the device to the shape of the junction, the device acts as a scaffolding to inhibit herniation of objects out of the aneurysm and permits perfusion to the efferent vessels. Positioning the device may include deployment and mechanical or electrolytic release from a catheter. Embolic material may be inserted in the aneurysm before or after positioning the device. The device may have a first end, a second end substantially opposite to the first end, and a plurality of polymer filaments extending between and coupled at the first end and the second end. Such devices may be football shaped, pumpkin shaped, or twisted. The device may include a plurality of polymer loops forming a generally spherical shape.

Abstract translation: 通常为球形的血管重建装置可永久定位在具有动脉瘤的分叉的传入和传出血管的交界处。 在将装置定位在接合处以将装置基本上符合接合部的形状之后，该装置用作支架以抑制物体从动脉瘤中的突出并允许灌注到输出血管。 定位装置可以包括从导管部署和机械或电解释放。 栓塞材料可以在设备定位之前或之后插入动脉瘤。 该装置可以具有第一端，与第一端基本相对的第二端，以及在第一端和第二端处延伸并在其之间耦合的多个聚合物细丝。 这种装置可以是足球形，南瓜形或扭曲的。 该装置可以包括形成大致球形的多个聚合物环。

公开(公告)号：WO2011051731A3

公开(公告)日：2011-06-30

申请号：PCT/GB2010051828

申请日：2010-11-01

Applicant: ISIS INNOVATION ,  BUCKNALL DAVID ,  CZERNUSZK JAN ,  LEE JINHYUN ,  RADZI ZAMRI ,  SWAN MARC

Inventor： BUCKNALL DAVID ,  CZERNUSZK JAN ,  LEE JINHYUN ,  RADZI ZAMRI ,  SWAN MARC

IPC: A61L31/04 ,  A61L27/14 ,  A61L27/50 ,  A61L27/58 ,  A61L31/14

CPC classification number: A61L27/26 ,  A61B90/02 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/04 ,  A61L31/14 ,  A61L31/148

Abstract: This invention relates to a tissue expander for use in medical, veterinary and dental applications. The tissue expander comprises a self-inflating polymer network and a biodegradable polymer having a non-degraded state and a degraded state which in the non- degraded state constrains the inflation of the self-inflating polymer network and in the degraded state allows inflation of the self-inflating polymer network. In a preferred embodiment, the self-inflating polymer network and the biodegradable polymer form an interpenetrating polymer network or a semi-interpenetrating polymer network. Alternatively or in addition, the self-inflating polymer network forms a core and the biodegradable polymer forms coating which partially or fully surrounds the core.

Abstract translation: 本发明涉及用于医疗，兽医和牙科应用的组织扩张器。 组织扩张器包括自充气聚合物网络和具有未降解状态和降解状态的生物可降解聚合物，其在非降解状态下限制自充气聚合物网络的膨胀并且处于降解状态允许 自充气聚合物网络。 在一个优选的实施方案中，自膨胀聚合物网络和生物可降解聚合物形成互穿聚合物网络或半互穿聚合物网络。 或者或另外，自充气聚合物网络形成核心，生物可降解聚合物形成部分或完全包围核心的涂层。

公开(公告)号：WO2010129510A3

公开(公告)日：2011-05-12

申请号：PCT/US2010033488

申请日：2010-05-04

Applicant: INCEPT LLC ,  CAMPBELL PATRICK ,  SAWHNEY AMARPREET S

Inventor： CAMPBELL PATRICK ,  SAWHNEY AMARPREET S

IPC: A61M5/14 ,  A61M37/00

CPC classification number: A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00557 ,  A61B2017/0065 ,  A61B2017/00654 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148

Abstract: Embodiments include coatings for adherence of biomaterials to a tissue. Systems and methods for adapting such coated materials to vascular access closure are further proved.

Abstract translation: 实施方案包括用于将生物材料粘附到组织上的涂层。 进一步证明了将这种涂覆材料适应于血管通路闭合的系统和方法。

公开(公告)号：WO2011049833A1

公开(公告)日：2011-04-28

申请号：PCT/US2010/052899

申请日：2010-10-15

Applicant: ATRIUM MEDICAL CORPORATION ,  SWANICK, Thomas, M. ,  BIENKIEWICZ, Joe ,  FERRARO, Joseph ,  MARTAKOS, Paul ,  FAUCHER, Keith, M. ,  DALE, Alicia

Inventor： SWANICK, Thomas, M. ,  BIENKIEWICZ, Joe ,  FERRARO, Joseph ,  MARTAKOS, Paul ,  FAUCHER, Keith, M. ,  DALE, Alicia

IPC: A61F2/00

CPC classification number: A61L31/148 ,  A61F2/06 ,  A61F2250/0067 ,  A61L31/00 ,  A61L31/10 ,  A61L31/145 ,  A61L2420/02

Abstract: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post- surgical adhesions.

Abstract translation: 本发明的示例性实施方案提供了具有抗粘连和组织固定性质的粘合屏障。 粘合屏障由脂肪酸基膜形成。 脂肪酸基膜可以由脂肪酸衍生的生物材料形成。 膜可以涂覆或可以包括组织固定材料以产生粘合屏障。 粘附屏障能很好地被身体耐受，具有抗炎特性，固定到组织上，并具有足以防止手术后粘连的停留时间。

公开(公告)号：WO2010101780A3

公开(公告)日：2011-01-27

申请号：PCT/US2010025558

申请日：2010-02-26

Applicant: PEYTANT SOLUTIONS INC ,  SCHORGL JOHN ,  THOMPSON PAUL ,  HEALY STEVEN J ,  THATCHER ROBERT

Inventor： SCHORGL JOHN ,  THOMPSON PAUL ,  HEALY STEVEN J ,  THATCHER ROBERT

IPC: A61F2/82 ,  A61L27/04 ,  A61L27/14 ,  A61L27/28 ,  A61L27/38 ,  A61L27/58 ,  A61M29/04

CPC classification number: A61L31/005 ,  A61F2/062 ,  A61F2/07 ,  A61F2/82 ,  A61F2/86 ,  A61F2002/065 ,  A61F2210/0076 ,  A61F2220/0025 ,  A61F2220/0066 ,  A61F2310/00982 ,  A61L27/3604 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/507 ,  A61L31/08 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/30 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2400/18

Abstract: A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

Abstract translation: 结合羊膜组织的支架支架提供具有改善的生物相容性和血液相容性的生物相容性支架。 羊膜组织可以是羊膜组织的各种修饰或未修饰形式，例如非低温羊膜组织，溶解的羊膜组织，羊膜组织织物，化学修饰的羊膜组织，用辐射处理的羊膜组织，用热处理的羊膜组织或其组合 。 诸如聚合物，胎盘组织，心包组织，小肠粘膜下层的材料可以与羊膜组织结合使用。 羊膜组织可以连接到内部，外部，内部和外部，或完全包封支架支架。 在一些实施例中，覆盖物或衬里的至少一部分包括多层羊膜织物。 还讨论了制备生物相容性支架及其递送和部署的方法。

公开(公告)号：WO2011008883A1

公开(公告)日：2011-01-20

申请号：PCT/US2010/042013

申请日：2010-07-14

Applicant: TELESIS RESEARCH, LLC ,  SHOKOOHI, Mehrdad, M. ,  GRANADA, Juan, F.

Inventor： SHOKOOHI, Mehrdad, M. ,  GRANADA, Juan, F.

IPC: A61F2/06

CPC classification number: A61F2/966 ,  A61F2/856 ,  A61F2/90 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2250/0039 ,  A61F2250/0098 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606

Abstract: Disclosed herein is a biodegradable prosthesis (10) that includes a first end, a second end, and an elongate tubular body with a lumen therethrough. The prosthesis (10) can have a first layer (201) comprising a set of flexible interbraided bioabsorbable filaments (14), and optionally a set of flexible interbraided metallic filaments (15). Also, the prosthesis (10) can have a second layer (200) comprising a porous thermoplastic material that can be either an outer layer or an inner layer relative to the first layer (201). The prosthesis (10) can include other features including branch apertures, folded portions, and attachment mechanisms for the first (201) and second (200) layers.

Abstract translation: 本文公开了一种可生物降解的假体（10），其包括第一端，第二端和具有通过其的腔的细长管状体。 假体（10）可以具有第一层（201），该第一层（201）包括一组柔性插入式生物可吸收细丝（14），以及任选的一组柔性插入式金属丝（15）。 此外，假体（10）可以具有包括相对于第一层（201）可以是外层或内层的多孔热塑性材料的第二层（200）。 假体（10）可以包括其他特征，包括分支孔，折叠部分和用于第一（201）和第二（200）层的附接机构。

公开(公告)号：WO2010091881A3

公开(公告)日：2011-01-13

申请号：PCT/EP2010000893

申请日：2010-02-12

Applicant: UNIV KING SAUD ,  TERRAMARK MARKENCREATION GMBH ,  AL-SAIDI MOHAMMAD DUGHAILEEB

Inventor： AL-SAIDI MOHAMMAD DUGHAILEEB

IPC: A61L31/00 ,  A61L31/14

CPC classification number: A61L31/005 ,  A61L31/148

Abstract: The present invention relates to a implant for implantation into a body of an animal, wherein the implant comprises material of inner core of drupes and/or palm tree fruits.

Abstract translation: 本发明涉及一种用于植入动物体内的植入物，其中所述植入物包括核心和/或棕榈树果实的材料。

公开(公告)号：WO2010101901A3

公开(公告)日：2011-01-06

申请号：PCT/US2010025896

申请日：2010-03-02

Applicant: BOSTON SCIENT SCIMED INC ,  ATANASOSKA LILIANA ,  SHIPPY JAMES LEE III ,  HOLMAN TOM ,  ARNEY MICHAEL S ,  SCHOENLE VICTOR ,  GENOVESE FRANK ,  FENG JAMES Q ,  FLANAGAN AIDEN ,  WEBER JAN

Inventor： ATANASOSKA LILIANA ,  SHIPPY JAMES LEE III ,  HOLMAN TOM ,  ARNEY MICHAEL S ,  SCHOENLE VICTOR ,  GENOVESE FRANK ,  FENG JAMES Q ,  FLANAGAN AIDEN ,  WEBER JAN

IPC: A61L27/04 ,  A61L27/18 ,  A61L27/42 ,  A61L27/54 ,  A61L31/02 ,  A61L31/06 ,  A61L31/12 ,  A61L31/16

CPC classification number: A61L31/148 ,  A61L27/34 ,  A61L27/446 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/128 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2400/12 ,  A61L2420/04 ,  C08L67/04

Abstract: A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.

Abstract translation: 医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。