公开(公告)号：WO03028125A3

公开(公告)日：2003-07-03

申请号：PCT/US0230704

申请日：2002-09-27

Applicant: 3M INNOVATIVE PROPERTIES CO

Inventor： SMITH TERRANCE P ,  VOGEL DENNIS E ,  VOGEL KIM M

IPC: C07C13/62 ,  C07C15/20 ,  C07C25/22 ,  C07C29/145 ,  C07C35/44 ,  C07C43/20 ,  C07C45/46 ,  C07C49/665 ,  C07C49/753 ,  C07C51/083 ,  C07C51/347 ,  C07C321/28 ,  H01L29/786 ,  H01L51/00 ,  H01L51/05 ,  H01L51/30

CPC classification number: C07C321/28 ,  C07C13/62 ,  C07C15/20 ,  C07C25/22 ,  C07C29/145 ,  C07C35/44 ,  C07C43/20 ,  C07C45/46 ,  C07C49/665 ,  C07C49/753 ,  C07C51/083 ,  C07C51/347 ,  C07C2603/52 ,  H01L51/0055 ,  H01L51/0508 ,  C07C49/76 ,  C07C65/34 ,  C07C65/24

Abstract: Substituted pentacene compounds comprise at least one substituent selected from the group consisting of electron-donating substituents, halogen substituents, and combinations thereof; the substituent(s) each being bonded to a carbon atom of a terminal ring of pentacene, and being the only substituent(s); with the proviso that when the compound has only two substituents, both of which are methyl or alkoxy, and one substituent is bonded to the number 2 carbon atom, the other substituent, if methyl, is bonded to the number 1, 3, 4, 8, or 11 carbon atom and, if alkoxy, is bonded to the number 1, 3, 4, 8, 9, or 11 carbon atom; and with the further proviso that when the compound has only four substituents, all of which are alkoxy, the substituents are bonded to the numbers 2, 3, 9, and 10 carbon atoms.

Abstract translation: 取代的并五苯化合物包含至少一个选自给电子取代基，卤素取代基及其组合的取代基; 各取代基各自与并五苯的末端环的碳原子键合，并且是唯一的取代基; 条件是当化合物只有两个取代基（两者都是甲基或烷氧基）和一个取代基与2个碳原子键合时，另一个取代基（如甲基）键合到数字1,3,4， 8或11个碳原子，并且如果烷氧基与数目1,2,3,4,8,9或11个碳原子键合; 并且进一步的条件是当化合物只有四个取代基，它们全部是烷氧基时，取代基与数字2,3,9和10个碳原子键合。

公开(公告)号：WO2003035008A3

公开(公告)日：2003-05-01

申请号：PCT/US2002/034497

申请日：2002-10-28

Applicant: OXIGENE, INC. ,  CHAPLIN, David, J. ,  GARNER, Charles, Manly, III ,  KANE, Robert, Ronald ,  PINNEY, Kevin, G. ,  PREZIOSO, Joseph, Anthony ,  EDVARDSEN, Klaus

Inventor： CHAPLIN, David, J. ,  GARNER, Charles, Manly, III ,  KANE, Robert, Ronald ,  PINNEY, Kevin, G. ,  PREZIOSO, Joseph, Anthony ,  EDVARDSEN, Klaus

IPC: C07C43/20

Abstract: Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and combretastatin A-4. The prodrug forms serve as potent vascular targeting agents (VTAs) useful for the treatment of solid tumor cancers and diseases associated with retinal neovascularization.

公开(公告)号：WO03006158A3

公开(公告)日：2003-04-03

申请号：PCT/US0223302

申请日：2002-07-13

Applicant: UNIV MICHIGAN STATE

Inventor： SMITH MILTON R III

IPC: B01J31/12 ,  B01J31/14 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  B01J31/28 ,  C07C1/32 ,  C07C17/269 ,  C07F15/00 ,  C07F17/02 ,  C08G61/10 ,  B01J31/00 ,  C07C41/00 ,  C07C43/02 ,  C07C43/20 ,  C07C211/00 ,  C07D231/00 ,  C07D233/00 ,  C07D235/00 ,  C07D249/00 ,  C07D261/00 ,  C07D263/00 ,  C07D271/00 ,  C07D273/00 ,  C07D275/00 ,  C07D283/00 ,  C07D291/00 ,  C07D293/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  C07D421/00 ,  C07D498/00 ,  C07D513/00 ,  C07D515/00 ,  C07D517/00 ,  C07F5/02 ,  C07F9/02

CPC classification number: C08G61/10 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/22 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/2409 ,  B01J2231/4211 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  C07C1/321 ,  C07C17/269 ,  C07C2531/22 ,  C07F15/0033 ,  C07F15/004 ,  C07F15/0073 ,  C07F15/008 ,  C07F17/02 ,  C07C15/00 ,  C07C22/08 ,  C07C25/18

Abstract: A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydrogen, bonded to the iridium or rhodium and a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium, to form the ring-substituted arene borane. Also provided are catalytic compounds for catalyzing the process comprising an iridium or rhodium complex with three or substituents, excluding hydrogen, bonded to the iridium or rhodium and optionally, a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium.

Abstract translation: 一种制备环取代的芳烃硼烷的方法，其包括使环取代的芳烃与HB有机化合物在催化有效量的铱或铑络合物的存在下反应，所述铱或铑络合物与三个或更多个除了与铱结合的氢之外的取代基 或至少部分地与铱或铑结合的铑和磷有机配体，以形成环取代的芳烃硼烷。 还提供了用于催化该方法的催化化合物，该方法包括与铱或铑键合的三个或不包括氢的取代基的铱或铑络合物和任选的至少部分与铱或铑结合的磷有机配体。

公开(公告)号：WO02055026A3

公开(公告)日：2002-11-14

申请号：PCT/US0200839

申请日：2002-01-11

Applicant: AFFYMAX INC ,  HOLMES CHRISTOPHER ,  PAN YIJUN

Inventor： HOLMES CHRISTOPHER ,  PAN YIJUN

IPC: G01N33/543 ,  B01J19/00 ,  B01J20/289 ,  B01J20/32 ,  B01J31/10 ,  B01J31/22 ,  B01J31/24 ,  C07B61/00 ,  C07C15/24 ,  C07C43/20 ,  C07C49/76 ,  C07C49/782 ,  C07C49/786 ,  C07C49/807 ,  C07C49/84 ,  C07C233/07 ,  C07C255/54 ,  C07C309/24 ,  C07C309/82 ,  C07C309/83 ,  C07C309/84 ,  C07F7/08 ,  C40B50/14 ,  C40B60/14

CPC classification number: C40B50/14 ,  B01J19/0046 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3257 ,  B01J31/10 ,  B01J31/1658 ,  B01J31/2208 ,  B01J31/2409 ,  B01J2219/00283 ,  B01J2219/00454 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/0072 ,  B01J2219/00738 ,  B01J2231/4211 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2531/824 ,  C07B2200/11 ,  C07C309/10 ,  C07C309/24 ,  C07C309/82 ,  C07C309/84 ,  C07F7/0834 ,  C40B60/14 ,  C40B80/00 ,  C40B99/00

Abstract: Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic synthesis are also provided.

Abstract translation: 提供活化载体，支持活化剂，强酸性载体和甲硅烷基化载体; 具有式（I）的活化载体，其中L是连接基团组分; X是F，CL，OH和三取代的甲硅烷氧基; 阴影圆表示固体或半固体支持物。 还提供了在固相有机合成中使用活化载体的方法。

公开(公告)号：WO01078714A1

公开(公告)日：2001-10-25

申请号：PCT/US2001/012045

申请日：2001-04-13

IPC: C07D263/58 ,  C07D265/36 ,  A61K31/13 ,  A61K31/05 ,  A61K31/075 ,  A61K31/42 ,  A61K31/535 ,  A61P15/10 ,  A61P25/24 ,  A61P25/30 ,  C07C39/10 ,  C07C43/02 ,  C07C43/20 ,  C07C215/00

CPC classification number: C07D263/58 ,  C07D265/36

Abstract: Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen- or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, animals that eat such plants, or chemical synthesis, have been found to act as an antidepressant or otherwise a treatment for bettering mood, a therapy for improving sexual desire or performance, an adjunctive therapy for achieving weight loss, and an adjunctive therapy for substance abuse and addiction. These compounds, at concentrations suitable for human therapeutic use, may be obtained from plants such as corn in their early growth stages and form parts of animals such as the velvet antler tips of deer and elk.

Abstract translation: 具有共价连接含氧基团，含氮基团或另一个含氧基团的酚类分子和可从单子叶植物获得的C1-C4烷氧基，吃这种植物的动物或化学合成的酚类化合物具有 被发现作为抗抑郁药或以其他方式治疗改善情绪，改善性欲或表现的疗法，实现减肥的辅助疗法，以及药物滥用和成瘾的辅助治疗。 在适合于人类治疗用途的浓度下，这些化合物可以从其早期生长阶段的玉米等植物中获得并形成动物的一部分，例如鹿和麋鹿的天鹅绒鹿角。

公开(公告)号：WO01042391A2

公开(公告)日：2001-06-14

申请号：PCT/GB2000/004691

申请日：2000-12-08

IPC: G02F1/13 ,  C07C1/32 ,  C07C15/62 ,  C07C41/30 ,  C07C43/20 ,  C07C69/157 ,  C07C69/24 ,  C07C69/773 ,  C07C205/57 ,  C07C255/57 ,  C07D487/14 ,  C07D487/22 ,  C08F8/00 ,  C08G65/00 ,  C09K19/32 ,  C09K19/34 ,  C09K19/38 ,  C09K19/42

CPC classification number: C07D487/22 ,  C09K19/32 ,  C09K19/3441 ,  C09K19/3452 ,  C09K19/3804 ,  C09K19/3833 ,  C09K2019/328 ,  Y10T428/10

Abstract: A mixture comprising a molecule of formula (I); in which A1, A2, A3, A4, A5 and A6, which may be the same or different, are each N or -CH; Y1, Y2, Y3, Y4, Y5 and Y6, which may be the same or different, are each hydrogen or C1 to C12 alkoxy; X1, X2, X3, X4, X5 and X6, which may be the same or different, are each hydrogen, C1 to C12 alkoxy or alkyl C1 to C12; and R7, R8, R9, R10, R11 and R12 are each hydrogen, or each of R7 and R8, R9 and R10 and R11 and R12 may form a bond; and a molecule of formula (II); in which R1, R2, R3, R4, R5 and R6, which may be the same or different, are each alkyl or substituted (and/or chiral) alkyl C1 to C16, acyl C1 to C16, polyethyleneoxy, a flexible connection to a polymer backbone or part of a polymer backbone in homopolymers, copolymers or block copolymers; and B1, B2, B3, B4, B5 and B6a, which may be the same or different, are each, hydrogen, alkyl C1 to C16, alkoxy C1 to C16, nitro, halogeno, cyano, amido, diazo or ester, e.g. alkyl C1 to C16 ester.

Abstract translation: 包含式（I）分子的混合物; 其中可以相同或不同的A1，A2，A3，A4，A5和A6各自为N或-CH; Y1，Y2，Y3，Y4，Y5和Y6可以相同或不同，分别为氢或C1〜C12烷氧基; 可以相同或不同的X 1，X 2，X 3，X 4，X 5和X 6各自为氢，C 1至C 12烷氧基或C 1至C 12烷基; 和R 7，R 8，R 9，R 10，R 11和R 12各自为氢，或者R 7和R 8，R 9和R 10和R 11和R 12各自可以形成键; 和式（II）的分子; 其中可以相同或不同的R 1，R 2，R 3，R 4，R 5和R 6各自为烷基或取代的（和/或手性）C 1至C 16烷基，C 1至C 16的酰基，聚乙烯氧基，与 聚合物主链或部分聚合物主链在均聚物，共聚物或嵌段共聚物中; 和B1，B2，B3，B4，B5和B6a可以相同或不同，分别为氢，C1至C16烷基，烷氧基C1至C16，硝基，卤代，氰基，酰氨基，重氮或酯。 烷基C1至C16酯。

公开(公告)号：WO01027060A1

公开(公告)日：2001-04-19

申请号：PCT/EP2000/009699

申请日：2000-10-04

IPC: C07B61/00 ,  C07C41/09 ,  C07C43/20 ,  C07C43/205

CPC classification number: C07C41/09 ,  C07C43/202 ,  C07C43/205

Abstract: A method for production of aryl alkyl ethers comprises reacting a hydroxyaromatic compound with an alcohol in the presence of a catalyst, whereby the homogeneous mixture of hydroxyaromatic compound, alcohol and catalyst is introduced into the reactor at normal pressure, reacted at a temperature of 250 to about 370 DEG C and the product concentration in the reaction mixture adjusted such that the catalyst does not precipitate out.

Abstract translation: 一种用于芳基烷基醚的制备，其中羟基芳族化合物是在催化剂的存在下与醇反应过程中，在约250的温度发起正常的压力均匀的羟基，在反应器中的醇及含催化剂的混合物至约370℃ 并在反应混合物中的产物浓度反应进行调整，使得该催化剂不沉淀。

公开(公告)号：WO99050317A1

公开(公告)日：1999-10-07

申请号：PCT/DK1999/000179

申请日：1999-03-26

IPC: C07B61/00 ,  C07C41/09 ,  C07C43/20 ,  C07C391/00 ,  C08F8/42 ,  C08G85/00

CPC classification number: C08F8/42 ,  C07B2200/11 ,  C07C391/00 ,  C40B40/00

Abstract: This invention relates to novel solid support based on selenium and a method for the preparation thereof. The solid support is useful in solid phase synthesis of organic compounds including combinatorial libraries of compounds.

Abstract translation: 本发明涉及基于硒的新型固体支持物及其制备方法。 固体支持物可用于固相合成有机化合物，包括化合物的组合文库。

公开(公告)号：WO99047474A1

公开(公告)日：1999-09-23

申请号：PCT/EP1999/001474

申请日：1999-03-08

IPC: B01J31/22 ,  C07B37/04 ,  C07B61/00 ,  C07C17/26 ,  C07C23/26 ,  C07C25/18 ,  C07C41/30 ,  C07C43/20 ,  C07C43/205 ,  C07C43/215 ,  C07C43/225 ,  C07C43/23 ,  C07C45/68 ,  C07C49/784 ,  C07C49/796 ,  C07C49/813 ,  C07C49/84 ,  C07C67/343 ,  C07C69/73 ,  C07C69/734 ,  C07C201/12 ,  C07C205/06 ,  C07C221/00 ,  C07C225/16 ,  C07C319/20 ,  C07C323/22 ,  C07D251/24 ,  C07F15/00

CPC classification number: C07F15/006 ,  C07B37/04 ,  C07C17/263 ,  C07C41/30 ,  C07C45/68 ,  C07C67/343 ,  C07C201/12 ,  C07C221/00 ,  C07C225/16 ,  C07C319/20 ,  C07D251/24 ,  C07C25/18 ,  C07C323/22 ,  C07C205/06 ,  C07C43/215 ,  C07C43/205 ,  C07C43/2055 ,  C07C43/225

Abstract: This invention relates to a novel, inventive process for the preparation of biphenyls or aromatic olefins by coupling reactions of the Suzuki coupling and Heck coupling type, using allylpalladium catalysts of the mu -halo(triisopropylphosphine)( eta -allyl)palladium(II) type.

Abstract translation: 本发明涉及一种用于通过偶联Suzuki偶联和Heck偶联型的偶联反应制备联苯或芳族烯烃的新颖的本发明方法，该方法是使用多卤（三异丙基膦）（乙烯基） II）类型。

公开(公告)号：WO98030305A1

公开(公告)日：1998-07-16

申请号：PCT/US1998/000022

申请日：1998-01-12

IPC: B01D19/04 ,  B01F17/42 ,  C08G65/24 ,  C08G65/26 ,  C08G65/337 ,  C11D1/66 ,  C11D1/72 ,  C11D1/722 ,  C11D1/825 ,  C11D3/00 ,  C07C43/11 ,  C07C43/18 ,  C07C43/20

CPC classification number: B01D19/0404 ,  B01D19/0427 ,  B01D19/0431 ,  C08G65/24 ,  C08G65/2609 ,  C08G65/337 ,  C11D1/662 ,  C11D1/72 ,  C11D1/722 ,  C11D1/8255 ,  C11D3/0026

Abstract: Defoamers are the products of the reaction of epichlorohydrin and compounds having the formula (II) R3(EO)n(PO)mOH, wherein R3 is an alkyl, alkenyl or arenyl group having from 4 to 22 carbon atoms; a substituted alkyl or alkenyl group having from 4 to 22 carbon atoms wherein; n is a number from 0 to 50 and m is a number from 0 to 10; wherein the mole ratio of epichlorohydrin to (II) is from about 0.60/1 to about 2/1 are extremely efficient defoamers for aqueous surfactant systems. The defoamers are added to a surfactant in an amount sufficient to reduce or eliminate foam and have the advantage of being totally dispersible in water, are readily biodegradable, contain no organic solvents and do not affect the detergency of surfactants with which they are used because they are nonionic surfactants in themselves.

Abstract translation: 消泡剂是表氯醇与具有式（II）R 3（EO）n（PO）mOH的化合物反应的产物，其中R 3是具有4至22个碳原子的烷基，烯基或异戊基; 具有4至22个碳原子的取代的烷基或烯基，其中： n为0〜50的数，m为0〜10的数。 其中表氯醇与（II）的摩尔比为约0.60 / 1至约2/1是用于水性表面活性剂体系的非常有效的消泡剂。 消泡剂以足以减少或消除泡沫的量加入到表面活性剂中，并且具有完全分散在水中的优点，易于生物降解，不含有机溶剂，并且不影响使用它们的表面活性剂的去污力，因为它们 本身是非离子表面活性剂。