-
11.发明申请COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开使用医疗器械治疗吡虫啉类似物的组合物和方法
公开(公告)号：WO2007047416A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/040027
申请日：2006-10-12
Applicant: ABBOTT LABORATORIES , BURKE, Sandra E. , CROMACK, Keith R. , MACK, Matthew , TONER, John L.
Inventor： BURKE, Sandra E. , CROMACK, Keith R. , MACK, Matthew , TONER, John L.
IPC: A61F2/82 , A61K31/4745 , A61K31/192
CPC classification number: A61L31/16 , A61K31/192 , A61K31/4745 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/256 , A61L2300/416
Abstract: Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
Abstract translation: 公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及递送方法，其中药物具有彼此补充的效果。 包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，该载体或赋形剂可以含有一种或多种治疗剂或物质，其中载体优选在其表面上包括涂层，并且包括治疗物质的包衣 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状动脉支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎药，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其它药物的组合。
-
12.发明申请COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS USING MEDICAL DEVICES FOR LONG-TERM EFFICACY 审中-公开使用医疗器械长期治疗RAPAMYCIN模拟物的组合物和方法
公开(公告)号：WO2007032777A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/010700
申请日：2006-03-22
Applicant: ABBOTT LABORATORIES , TONER, John K. , BURKE, Sandra E. , CROMACK, Keith R.
Inventor： TONER, John K. , BURKE, Sandra E. , CROMACK, Keith R.
CPC classification number: A61L31/16 , A61L2300/416 , A61L2300/602
Abstract: Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
Abstract translation: 公开了包含佐他莫司的系统和组合物，其比雷帕霉素和紫杉醇系统更安全，更有效并且产生较少的炎症。 医疗装置包括能够包含或支持药学上可接受的载体或赋形剂的载体结构的载体或赋形剂，所述载体或赋形剂可以包含一种或多种治疗剂或物质，载体包括其表面上的涂层，以及具有治疗化合物的涂层， 包括例如药物。 用于医疗装置的支撑结构包括冠状动脉支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统的药物递送气囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。
-
公开(公告)号：WO2005089855A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/009310
申请日：2005-03-17
Applicant: ABBOTT LABORATORIES , TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , VON OEPEN, Randolf
Inventor： TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , VON OEPEN, Randolf
IPC: A61M25/10
CPC classification number: A61F2/91 , A61F2/86 , A61F2/915 , A61F2/958 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2002/91591 , A61F2250/0067 , A61F2310/0097 , A61K47/6957 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
Abstract: Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
Abstract translation: 公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。 本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。 本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。 本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。
-
公开(公告)号：WO2003022807A3
公开(公告)日：2003-03-20
申请号：PCT/US2002/028776
申请日：2002-09-10
Applicant: ABBOTT LABORATORIES , MOLLISON, Karl, W. , LECAPTAIN, Angela, M. , BURKE, Sandra, E. , CROMACK, Keith, R. , TARCHA, Peter, J. , CHEN, Yen-Chih, J.
Inventor： MOLLISON, Karl, W. , LECAPTAIN, Angela, M. , BURKE, Sandra, E. , CROMACK, Keith, R. , TARCHA, Peter, J. , CHEN, Yen-Chih, J.
Abstract: A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.
-
公开(公告)号：WO2010093800A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/023910
申请日：2010-02-11
Applicant: ABBOTT LABORATORIES , TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , OEPEN, Randolf, Von
Inventor： TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , OEPEN, Randolf, Von
IPC: A61L29/16
CPC classification number: A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
Abstract: Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
Abstract translation: 公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。 本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。 本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。 本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。
-
Patent Agency Ranking
公开(公告)号：WO2007109372A3
公开(公告)日：2008-10-23
申请号：PCT/US2007007357
申请日：2007-03-22
Applicant: ABBOTT LAB , CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
Inventor： CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
CPC classification number: A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61L2300/22 , A61L2300/416 , A61L2300/45
Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.
-
17.发明申请COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开使用医疗设备管理吡虫啉类似物的组合物和方法
公开(公告)号：WO2008045961A3
公开(公告)日：2008-08-28
申请号：PCT/US2007080987
申请日：2007-10-10
Applicant: ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
Inventor： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
IPC: A61K31/37 , A61K31/436 , A61P9/00
CPC classification number: A61K31/337 , A61K9/0024 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , C07D498/18
Abstract: Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
Abstract translation: 公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。 包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。
-
18.发明申请COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开使用医疗设备用紫杉醇施用雷帕霉素类似物的组合物和方法
公开(公告)号：WO2008045961A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/080987
申请日：2007-10-10
Applicant: ABBOTT LABORATORIES , TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , MACK, Matthew
Inventor： TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , MACK, Matthew
CPC classification number: A61K31/337 , A61K9/0024 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , C07D498/18
Abstract: Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
Abstract translation: 包括紫杉醇和第二药物如雷帕霉素，其类似物，衍生物，盐和酯的系统和组合物以及递送方法，其中药物具有彼此互补的作用。 包含能够包含或承载药学上可接受的载体或赋形剂的载体结构的医疗器械，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层，并且包含治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。 这些组合物和系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂 ，抗血液流变剂，基质金属蛋白酶抑制剂，细胞抑制药物或这些与其他药物的组合。
-
19.发明申请ZOTAROLIMUS-CONTAINING DRUG DELIVERY SYSTEMS FOR IMPLANTATION INTO A BODY LUMEN OF A SUBJECT 审中-公开含ZOTAROLIMUS的药物输送系统，用于植入身体的身体
公开(公告)号：WO2007111925A3
公开(公告)日：2007-11-15
申请号：PCT/US2007007090
申请日：2007-03-21
Applicant: ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R
Inventor： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R
CPC classification number: A61K9/0019 , A61F2/91 , A61K31/192 , A61K31/4745 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602
Abstract: Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
Abstract translation: 公开了包含佐他莫司的系统和组合物，其比雷帕霉素和紫杉醇系统更安全，更有效并且产生较少的炎症。 医疗装置包括能够包含或支持药学上可接受的载体或赋形剂的载体结构的载体或赋形剂，所述载体或赋形剂可以包含一种或多种治疗剂或物质，载体包括其表面上的涂层，以及具有治疗化合物的涂层， 包括例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。
-
公开(公告)号：WO2007112006A2
公开(公告)日：2007-10-04
申请号：PCT/US2007007255
申请日：2007-03-22
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS , CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
Inventor： CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
CPC classification number: A61L31/16 , A61L15/44 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/22 , A61L2300/416 , A61L2300/45
Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.
Abstract translation: 一种用于递送与医疗装置相关联的亲脂剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数为统计学上显着的 至少约5,000，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至 课程。 此外，本发明涉及一种用于提高受试者通畅的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。
-
-
-
-
-
-
-
-
-
Search Results
33
records
(took 0.015 seconds)
