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    INNATELY MULTIMODAL NANOPARTICLES
    14.
    发明申请
    INNATELY MULTIMODAL NANOPARTICLES 审中-公开
    国际多模式纳米粒子

    公开(公告)号：WO2010111066A3

    公开(公告)日：2011-01-13

    申请号：PCT/US2010027406

    申请日：2010-03-16

    Applicant: GEN HOSPITAL CORP ,  MEDAROVA ZDRAVKA ,  MOORE ANNA ,  YIGIT MEHMET

    Inventor： MEDAROVA ZDRAVKA ,  MOORE ANNA ,  YIGIT MEHMET

    IPC: B82B3/00 ,  B82B1/00

    CPC classification number: A61K49/1833 ,  A61K41/0052 ,  A61K49/0002 ,  A61K49/001 ,  A61K49/0423 ,  A61K49/183 ,  A61K49/1863 ,  B82Y5/00

    Abstract: A gold-coated iron oxide nanoparticle, method of making thereof, and method of using thereof is disclosed. The nanoparticle is substantially toxin free (making it clinically applicable), easily functionalized, and can serve as a contrast agent for a number of imaging techniques, including imaging a subject in at least two distinct imaging modes. Further, the nanoparticle is well-suited for therapeutic uses.

    Abstract translation: 公开了一种镀金氧化铁纳米颗粒，其制备方法及其使用方法。 纳米颗粒基本上不含毒素（使其临床适用），易于功能化，并且可用作许多成像技术的造影剂，包括以至少两种不同成像模式对受试者进行成像。 此外，纳米颗粒非常适合于治疗用途。

    NANOPARTICLES FOR IMAGING ATHEROSCLEROTIC PLAQUE
    16.
    发明申请
    NANOPARTICLES FOR IMAGING ATHEROSCLEROTIC PLAQUE 审中-公开
    纳米颗粒用于成像动脉粥样硬化斑块

    公开(公告)号：WO2006012201A9

    公开(公告)日：2006-04-20

    申请号：PCT/US2005022239

    申请日：2005-06-22

    Applicant: UNIV CALIFORNIA ,  LOUIE ANGELIQUE Y ,  JARRETT BENJAMIN R

    Inventor： LOUIE ANGELIQUE Y ,  JARRETT BENJAMIN R

    IPC: A61B5/055 ,  A61K49/00

    CPC classification number: B82Y5/00 ,  A61K49/183 ,  A61K49/1863

    Abstract: Atherosclerosis is an inflammatory disease of the arterial walls and represents a significant health problem in developed nations. Described is a targeted Magnetic Resonance Imaging (MRI) contrast agent for in vivo imaging of early stage atherosclerosis. Early plaque development is characterized by the influx of macrophages, which express a class of surface receptors known collectively as the scavenger receptors (SR). The macrophage scavenger receptor class A (SRA) is highly expressed during early atherosclerosis. The macrophage SRA therefore presents itself as an ideal target for labeling of lesion formation. By coupling a known ligand for the scavenger receptor, dextran sulfate, to a MRI contrast agent, early plaque formation can be detected in vivo. Targeted MR contrast agents offer a unique opportunity to visualize early plaque development in vivo with high sensitivity and resolution, allowing or early diagnosis and treatment of atherosclerosis.

    Abstract translation: 动脉粥样硬化是动脉壁的炎症性疾病，在发达国家是一个重大的健康问题。 描述了用于早期动脉粥样硬化的体内成像的靶向磁共振成像（MRI）造影剂。 早期斑块发育的特征是巨噬细胞的涌入，巨噬细胞表达一类称为清道夫受体（SR）的表面受体。 A型巨噬细胞清道夫受体（SRA）在早期动脉粥样硬化期间高度表达。 因此巨噬细胞SRA呈现为标记病变形成的理想目标。 通过将已知的清道夫受体配体硫酸葡聚糖与MRI造影剂偶联，可以在体内检测早期斑块形成。 目标MR造影剂提供了一个独特的机会，以高灵敏度和高分辨率观察体内早期斑块发育，从而允许或早期诊断和治疗动脉粥样硬化。

    TREATED APATITE PARTICLES FOR MEDICAL DIAGNOSTIC IMAGING
    17.
    发明申请
    TREATED APATITE PARTICLES FOR MEDICAL DIAGNOSTIC IMAGING 审中-公开
    用于医学诊断成像的治疗APATITE颗粒

    公开(公告)号：WO1993007905A2

    公开(公告)日：1993-04-29

    申请号：PCT/US1992009032

    申请日：1992-10-21

    Applicant: MALLINCKRODT MEDICAL, INC.

    Inventor： MALLINCKRODT MEDICAL, INC. ,  DEUTSCH, Edward, A. ,  DEUTSCH, Karen, F. ,  CACHERIS, William, P. ,  RALSTON, William, P. ,  WHITE, David, H. ,  WOULFE, Steven, R.

    IPC: A61K47/48

    CPC classification number: A61K49/225 ,  A61B90/39 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61K47/6923 ,  A61K49/1818 ,  A61K49/183 ,  A61K49/1842 ,  A61K49/1881 ,  Y10S977/722 ,  Y10S977/775 ,  Y10S977/881 ,  Y10S977/91 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

    Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described apatite particles and then performing the medical diagnostic procedure.

    Abstract translation: 公开了治疗磷灰石颗粒用于增强诸如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像和超声成像的医学诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而导致用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，磷灰石颗粒被治疗为顺磁性，不透射线或回声。 磷灰石颗粒也可以被氟化以形成用于<19> F成像的稳定的氟磷灰石组合物。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述磷灰石颗粒，然后进行医学诊断程序。

    CORE-SATELLITE NANOCOMPOSITES FOR MRI AND PHOTOTHERMAL THERAPY
    18.
    发明申请
    CORE-SATELLITE NANOCOMPOSITES FOR MRI AND PHOTOTHERMAL THERAPY 审中-公开
    用于MRI和光热治疗的核心 - 卫星纳米复合体

    公开(公告)号：WO2015034918A1

    公开(公告)日：2015-03-12

    申请号：PCT/US2014/053892

    申请日：2014-09-03

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： CHEN, Hongwei ,  SUN, Duxin

    IPC: A61B18/18 ,  A61B18/04 ,  A61B5/055 ,  A61K49/06

    CPC classification number: A61K49/1824 ,  A61B5/0035 ,  A61B5/0075 ,  A61B5/055 ,  A61K41/0052 ,  A61K49/183 ,  A61K49/1833 ,  A61K49/1851 ,  A61N5/062 ,  A61N2005/0659 ,  G01R33/4808 ,  G01R33/5601

    Abstract: The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

    Abstract translation: 本发明提供包含可用于光热和/或MRI应用（例如肿瘤治疗和/或成像）的核心 - 卫星纳米复合材料的方法，组合物，系统和试剂盒。 在某些实施方案中，核心 - 卫星纳米复合材料包括：i）核心纳米颗粒复合物，其包含围绕纳米颗粒核心的生物相容性涂层，和ii）附着于或吸收到生物相容性涂层上的至少一个卫星组分。 在一些实施例中，纳米颗粒核心和卫星部件由近红外光热剂材料和/或MRI造影剂材料组成。 在另外的实施例中，卫星组件另外地或替代地由近红外光学染料材料组成。

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