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    신규한 카나비디올 유도체, 이의 제조방법 및 이를 포함하는 인지기능 개선용 조성물
    11.
    发明申请
    신규한 카나비디올 유도체, 이의 제조방법 및 이를 포함하는 인지기능 개선용 조성물 审中-公开

    公开(公告)号：WO2023043197A1

    公开(公告)日：2023-03-23

    申请号：PCT/KR2022/013736

    申请日：2022-09-14

    Applicant: 강원대학교 산학협력단

    Inventor： 이구연

    IPC: C07C39/23 ,  C07C39/373 ,  C07C323/16 ,  C07C323/18 ,  C07C245/08 ,  C07C255/33 ,  C07C205/16 ,  C07C311/29 ,  C07C329/06 ,  C07C43/23

    Abstract: 본 발명은 카나비디올 유도체, 이의 제조방법 및 이를 포함하는 인지기능 개선용 조성물을 제공한다. 본 발명의 신규한 카나바디올 유도체는 아세틸콜린에스테라제 저해 효능 및 부틸릴콜린에스테라제 저해 효능뿐만 아니라 모노아민 옥시다아제 B에 대한 저해 효능을 나타내는 것으로 확인되어, 치매 환자들에게서 나타나는 뇌조직 내의 아세틸콜린 수준 저하 및 혈중 부티릴콜린 수준 저하를 동시에 달성할 수 있고, 뇌세포 손상을 막음으로써 보다 효과적인 인지기능 개선 치료 효과를 기대할 수 있다. 따라서, 본 발명의 카나비디올 유도체, 이의 제조방법, 및 이를 유효성분으로 포함하는 인지기능 개선용 조성물은 아세틸콜린에스테라제, 부티릴콜린에스테라제 및 모노아민 옥시다아제 B를 동시에 저해하는 물질로 의약 및 건강기능식품 분야에서 인지기능 개선 물질로서 유용하게 사용될 수 있다.

    レジスト材料
    13.
    发明申请
    レジスト材料 审中-公开

    公开(公告)号：WO2019021758A1

    公开(公告)日：2019-01-31

    申请号：PCT/JP2018/025164

    申请日：2018-07-03

    Applicant: DIC株式会社

    Inventor： 今田　知之 ,  山本　辰弥 ,  宮本　正紀

    IPC: G03F7/004 ,  C07C323/16 ,  G03F7/023

    Abstract: 塗膜の平滑性や均質性が高く、解像度等のパターニング性能にも優れるレジスト材料を提供することを目的とし、下記構造式（１）　（式中Ｒ １ はパーフルオロアルキル基又はパーフルオロアルキル基を有する構造部位である。Ｒ ２ は水素原子、極性基、重合性基、極性基又は重合性基を有する構造部位である。Ｒ ３ は水素原子、置換基を有していてもよい脂肪族炭化水素基、置換基を有していてもよいアリール基の何れかである。ｎは２～１０の整数である。＊は芳香環との結合点である。） で表される分子構造を有するカリックスアレーン化合物（Ａ）と樹脂成分（Ｂ）とを含有するレジスト材料を提供する。

    ORGANOSULFUR COMPOUNDS, A METHOD OF MAKING ORGANOSULFUR COMPOUNDS AND THEIR USE FOR INHIBITING THE GROWTH OF TUMOUR CELLS
    15.
    发明申请
    ORGANOSULFUR COMPOUNDS, A METHOD OF MAKING ORGANOSULFUR COMPOUNDS AND THEIR USE FOR INHIBITING THE GROWTH OF TUMOUR CELLS 审中-公开
    组氨酸化合物，制备有机骨架化合物的方法及其用于抑制肿瘤细胞生长的用途

    公开(公告)号：WO2010016011A1

    公开(公告)日：2010-02-11

    申请号：PCT/IB2009/053399

    申请日：2009-08-05

    Applicant: UNIVERSITY OF CAPE TOWN ,  KASCHULA, Catherine, Hart ,  HUNTER, Roger ,  PARKER, Mohamed, Iqbal

    Inventor： KASCHULA, Catherine, Hart ,  HUNTER, Roger ,  PARKER, Mohamed, Iqbal

    IPC: C07C321/18 ,  C07C321/20 ,  C07C323/07 ,  C07C323/16 ,  C07C323/25 ,  C07C209/48 ,  A61K31/105 ,  A61K31/18 ,  A61K31/4035 ,  A61P35/00

    CPC classification number: A61K31/105 ,  A61K31/18 ,  A61K31/4035 ,  C07C323/65 ,  C07D209/48

    Abstract: Organosulfur compounds of the general formula (2) are described, wherein R 1 and R 2 are linear or branched C1- C5 alkyl; linear or branched C1- C5 alkenyl with the proviso that R 1 is not prop-1-enyl (allyl); substituted linear or branched C1- C5 alkenyl or substituted linear or branched C1- C5 alkyl, in which the substituents are selected from OR 3 , NR 4 R 5 , COOR 6 , CONR 7 R 8 , in which R 3 is selected from H, COR 9 , para- methoxybenzyl and trialkylsilyl, in which R 9 is alkyl or substituted alkyl; R 4 and R 5 are alkyl or R 4 and R 5 together form a phthalimido group; R 6 is alkyl or substituted alkyl; and R 7 and R 8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R 1 and R 2 are benzyl, para -methoxybenzyl and/or ortho , para - methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumour cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.

    Abstract translation: 描述了通式（2）的有机硫化合物，其中R 1和R 2是直链或支链C 1 -C 5烷基; 直链或支链C 1 -C 5烯基，条件是R 1不是丙-1-烯基（烯丙基）; 取代的直链或支链C 1 -C 5链烯基或取代的直链或支链C 1 -C 5烷基，其中取代基选自OR 3，NR 4 R 5，COOR 6，CONR 7 R 8，其中R 3选自H，COR 9，对甲氧基苄基和三烷基甲硅烷基， 其中R 9为烷基或取代的烷基; R4和R5是烷基或R4和R5一起形成苯二甲酰亚氨基; R6是烷基或取代的烷基; 并且R 7和R 8是烷基或取代的烷基; 取代或未取代的芳族化合物，其中R 1和R 2是苄基，对甲氧基苄基和/或邻甲氧基苄基和取代或未取代的杂芳族。 该化合物可用于抑制肿瘤细胞的生长和治疗癌症。 还描述了药物组合物和制备该化合物的方法。

    PERFLUOROALKYL SUBSTITUTED PHENOL DERIVATIVES AS SURFACE MODIFIERS
    16.
    发明申请
    PERFLUOROALKYL SUBSTITUTED PHENOL DERIVATIVES AS SURFACE MODIFIERS 审中-公开
    全氟烷基取代的苯酚衍生物作为表面改性剂

    公开(公告)号：WO2008028845A1

    公开(公告)日：2008-03-13

    申请号：PCT/EP2007/058954

    申请日：2007-08-29

    Applicant: CIBA SPECIALTY CHEMICALS HOLDING INC. ,  GERSTER, Michèle ,  MIHALIC, Manuel

    Inventor： GERSTER, Michèle ,  MIHALIC, Manuel

    IPC: C07C43/205 ,  C07C43/225 ,  C07C69/63 ,  C07C69/712 ,  C07C271/44 ,  C07C271/58 ,  C07C323/16

    CPC classification number: C07C69/82 ,  C07C43/225 ,  C07C43/23 ,  C07C43/315 ,  C07C69/63 ,  C07C69/65 ,  C07C69/712 ,  C07C235/20 ,  C07C271/44 ,  C07C271/58 ,  C07C323/16 ,  C08K5/06 ,  C08K5/10 ,  C08K5/136 ,  C08K5/205 ,  C08K5/375

    Abstract: The instant invention relates to a composition comprising a) an organic material which is susceptible to oxidative, thermal or light-induced degra- dation, and b) at least one compound of the formula (I) wherein the general symbols are as defined in claim 1; especially wherein at least one of the radicals R 2 , R 3 or R 4 is is -CH 2 -CH(CH 3 )-S(O) p -R 12 , -CH 2 -CH 2 -CH 2 -S(O) p -R 12 , -CH 2 -CH(R 11 )-CH 2 -R 12 or -CH 2 -CH=CH-R 12 , R 11 is hydrogen or halogen, R 12 is a monovalent perfluorinated alkyl or alkenyl, linear or branched organic radical having four to twenty fully fluorinated carbon atoms; or -CH 2 CH 2 (CF 2 ) m CF 3 , m is 3 to 12, and p is 0, 1 or 2. The compounds of the formula I are useful as reducers of surface energy for organic mat- erials, for example synthetic polymer. Polymers with such a reduced surface energy possess an "easy-to-clean", "self-cleaning" "antisoiling", "soil-release" "antigraffiti", "oil resistance", "solvent resistance", "chemical resistance", "self lubricating", "scratch resistance", "low moi- sture absorption", "dirt pickup resistance", "slip properties" and "hydrophobic surface"; and anti-adhesion properties against proteins and against microorganism such as for example bacteria, fungi and algae.

    Abstract translation: 本发明涉及一种组合物，其包含a）对氧化，热或光诱导的降解敏感的有机材料，以及b）至少一种式（I）化合物，其中通式如权利要求中所定义 1; 特别是其中基团R 2，R 3或R 4中的至少一个为-CH 2 - CH（CH 3 3）-S（O）p -R 12，-CH 2 -CH 2 -CH 2 -S（O）p -R 12，-CH 2 -CH（R 11） - CH 2 -R 12或-CH 2 -CH = CH-R R 12是氢或卤素，R 12是单价全氟化的烷基或烯基，直链或支链的有机基团，其具有四至二十个完全 氟化碳原子; 或-CH 2 CH 2（CF 2）m CF 3，m，m 为3至12，p为0,1或2.式I的化合物可用作有机物的表面能的还原剂，例如合成聚合物。 具有这种表面能降低的聚合物具有“易清洁”，“自清洁”“防污”，“释放”，“防刮涂”，“耐油性”，“耐溶剂性”，“耐化学性” “自润滑”，“耐擦伤性”，“低吸湿性”，“抗污性”，“滑爽性”和“疏水性表面”; 和抗蛋白质和抗微生物（例如细菌，真菌和藻类）的抗粘附性。

    MOLECULES DERIVED FROM MECHANISM BASED DRUG DESIGN
    18.
    发明申请
    MOLECULES DERIVED FROM MECHANISM BASED DRUG DESIGN 审中-公开
    从基于机制的药物设计衍生的分子

    公开(公告)号：WO01045836A3

    公开(公告)日：2002-01-03

    申请号：PCT/US2000/034964

    申请日：2000-12-22

    IPC: A61K45/00 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07C49/84 ,  C07C233/65 ,  C07C323/16 ,  C07C323/24 ,  C07C323/25 ,  C12Q1/37 ,  C12Q1/00

    CPC classification number: C12Q1/37

    Abstract: A method for identifying molecules and designing novel pharmaceuticals is disclosed. The disclosed method of novel pharmaceutical design identifies a novel chemical group that triggers a mechanism of action for an identified reaction, thereby avoiding the various structural complexities associated with the application of the structure-based drug design. Additionally, examples of potential therapeutics identified by the mechanism based drug design method are provided.

    Abstract translation: 公开了一种用于鉴定分子和设计新型药物的方法。 所公开的新型药物设计的方法鉴定了一种新的化学基团，其触发鉴定的反应的作用机制，从而避免与应用基于结构的药物设计相关的各种结构复杂性。 另外，提供了基于机制的药物设计方法鉴定的潜在治疗剂的实例。

    LINKER ARMS FOR NANOCRYSTALS AND COMPOUNDS THEREOF
    19.
    发明申请
    LINKER ARMS FOR NANOCRYSTALS AND COMPOUNDS THEREOF 审中-公开
    关于纳米晶体及其化合物的链接

    公开(公告)号：WO01090717A2

    公开(公告)日：2001-11-29

    申请号：PCT/US2001/016947

    申请日：2001-05-24

    IPC: C07C323/12 ,  C07C323/16 ,  C07D209/16 ,  C07D277/24 ,  C07D277/26 ,  C07D295/135 ,  C07D451/02 ,  C07D451/14 ,  G01N33/58 ,  G01N

    CPC classification number: C07D295/135 ,  B82Y15/00 ,  C07C323/12 ,  C07C323/16 ,  C07D209/16 ,  C07D277/24 ,  C07D277/26 ,  C07D451/02 ,  C07D451/14 ,  G01N33/588

    Abstract: This invention generally relates to nanocrystal compounds, and linker arm for nanocrystal compounds that attach the nanocrystals to the organic compounds. The nanocrystal compound comprises a nanocrystal, linker arm, and organic compound. Preferably, the organic compound is a biologically active compound that can provide a fluorescent sensor. Preferably, the linker arm is a carbon chain with an attachment point for the nanocrystal and an attachment point for the organic compound. Specifically, the nanocrystal is attached to the linker arm through a R3 group and the organic compound is attached to the linker arm through a R2 group. R2 is a bond or selected from the group consisting of carbonyl, O, NH, S, CONH, COO, S, C1-10 alkyl, carbamate, and thiocarbamate. R3 is selected from the group consisting of: SH, O(CH2(n)O)nSH, NH(CH2(n)O)nSH, NH(CH2(n)NH)SH, S(CH2(n)O)nSH, S(CH2(n)S)SH, anda polyether chain. n is 1-10. S is attached to the nanocrystal.

    Abstract translation: 本发明一般涉及将纳米晶体附着到有机化合物上的纳米晶体化合物和用于纳米晶体化合物的连接臂。 纳米晶体化合物包括纳米晶体，连接臂和有机化合物。 优选地，有机化合物是可以提供荧光传感器的生物活性化合物。 优选地，连接臂是具有纳米晶体的附着点和有机化合物的附着点的碳链。 具体地，纳米晶体通过R3基团连接到连接臂上，有机化合物通过R2基团连接到连接臂上。 R2是选自羰基，O，NH，S，CONH，COO，S，C 1-10烷基，氨基甲酸酯和硫代氨基甲酸酯的键。 R 3选自：SH，O（CH 2（n）O）nSH，NH（CH 2（n）O）n SH，NH（CH 2（n）NH）SH，S（CH 2（n）O） ，S（CH 2（n）S）SH和聚醚链。 n为1-10。 S附着在纳米晶体上。

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