公开(公告)号：WO0064521A9

公开(公告)日：2002-02-14

申请号：PCT/US0011763

申请日：2000-04-27

Applicant: UNIV LOMA LINDA MED

Inventor： KIRSCH WOLFF M ,  FARNSWORTH ALBERT W ,  ZHU YONG HUA

IPC: A61M16/06 ,  A61M16/20 ,  A61M25/02

CPC classification number: A61M16/0683 ,  A61M16/0666 ,  A61M16/0677 ,  A61M16/0833 ,  A61M16/20 ,  A61M16/202 ,  A61M16/209 ,  A61M25/02 ,  A61M2025/0226

Abstract: A nasal cannula is provided having a first and second nasal plug connected to a gas supply such as oxygen. A holder frictionally engages each nasal plug and a connector connects the two holders. The plugs are movable along the length of the connector to allow adjustment of the spacing between nasal plugs to accommodate a person's nostrils but with sufficient friction to retain the selected position. The plugs are rotatable around the longitudinal axis of the connector to adjust the orientation of the plug within a nostril relative to a patient's face, but with sufficient friction to retain the selected position. One of the connector or holder is removably fastened to the patient's face. A regulator is interposed in the gas supply to vary the flow rate and pressure to meet predetermined patterns.

Abstract translation: 提供鼻插管，其具有连接到气体供应例如氧的第一和第二鼻塞。 保持器摩擦地接合每个鼻塞，并且连接器连接两个支架。 塞子可以沿着连接器的长度移动，以允许调节鼻塞之间的间距以容纳人的鼻孔，但是具有足够的摩擦力以保持所选择的位置。 塞子可绕着连接器的纵向轴线旋转，以相对于患者的面部调整插头在鼻孔内的取向，但具有足够的摩擦力以保持所选择的位置。 连接器或保持器中的一个可拆卸地紧固到患者的脸部。 在气体供给装置中插入调节器以改变流量和压力以满足预定的模式。

公开(公告)号：WO2015195570A3

公开(公告)日：2016-03-10

申请号：PCT/US2015035866

申请日：2015-06-15

Applicant: UNIV LOMA LINDA

Inventor： SCHULTE REINHARD W ,  BASHKIROV VLADIMIR A

IPC: A61B6/03 ,  G01N23/04

CPC classification number: G01N23/046 ,  A61B6/032 ,  A61B6/14 ,  A61B6/4258 ,  A61B6/501 ,  A61B6/502 ,  A61B6/503 ,  A61B6/5205 ,  G01N2223/102 ,  G06T7/0012 ,  G06T11/003 ,  G06T11/006 ,  G06T2207/10028 ,  G06T2207/10081 ,  G06T2207/30016 ,  G06T2207/30036 ,  G06T2207/30048 ,  G06T2207/30061 ,  G06T2207/30068 ,  G06T2207/30084

Abstract: An imaging system can use high-energy electrons at a low dose level to generate 3D computed tomography images and/or 2D radiographic images of living tissue and other objects. In some embodiments, a nozzle directs a source of high-energy electrons to the imaging target, and a detector system detects physical quantities of electrons that interact with the imaging target. In some embodiments, a computer system can calculate estimated paths taken by individual electrons within the imaging target, determine interactions between voxels of a digitized image of the imaging target and individual electrons, and reconstruct a digitized image of the imaging target based at least in part on the determined interactions between individual electrons and voxels. The imaging target can include but is not limited to living tissue, humans, pediatric patients, small animals, and other objects, such as those used in industrial applications.

Abstract translation: 成像系统可以使用低剂量水平的高能电子来生成活体组织和其他物体的3D计算机断层摄影图像和/或2D放射照相图像。 在一些实施例中，喷嘴将高能电子源引导到成像靶，并且检测器系统检测与成像靶相互作用的电子的物理量。 在一些实施例中，计算机系统可以计算成像目标内的各个电子所采取的估计路径，确定成像目标的数字化图像的体素与各个电子之间的相互作用，以及至少部分地重构成像目标的数字化图像 关于个体电子和体素之间确定的相互作用。 成像目标可以包括但不限于生物体组织，人类，儿科患者，小动物和其他物体，例如在工业应用中使用的那些。

公开(公告)号：WO2013090204A3

公开(公告)日：2013-11-14

申请号：PCT/US2012068806

申请日：2012-12-10

Applicant: UNIV LOMA LINDA ,  JARAMILLO DAVID E

Inventor： JARAMILLO DAVID E

IPC: A61C5/00

CPC classification number: A61K6/0035 ,  A61K6/0038 ,  A61K6/0067 ,  C08K5/05 ,  C08K5/092 ,  C09D5/1625

Abstract: A composition for reducing bacterial biofilm formation after endodontic therapy comprising water, ethanol, benzalkonium chloride, citric acid, and Triton X-100. A method of making a composition for reducing bacterial biofilm. A method for reducing bacterial biofilm formation after a dental procedure.

Abstract translation: 用于减少牙髓治疗后细菌生物膜形成的组合物，包含水，乙醇，苯扎氯铵，柠檬酸和Triton X-100。 制备用于减少细菌生物膜的组合物的方法。 一种减少牙科手术后细菌生物膜形成的方法。

公开(公告)号：WO2008070579A3

公开(公告)日：2009-03-19

申请号：PCT/US2007086177

申请日：2007-11-30

Applicant: UNIV LOMA LINDA MED ,  UNIV GEORGE MASON ,  STONY BROOK UNIVERSITY ,  UNIV CALIFORNIA ,  KIRSCH WOLFF ,  LIOTTA LANCE A ,  VAN NOSTRAND WILLIAM E ,  VINTERS HARRY V ,  ESPINA VIRGINIA

Inventor： KIRSCH WOLFF ,  LIOTTA LANCE A ,  VAN NOSTRAND WILLIAM E ,  VINTERS HARRY V ,  ESPINA VIRGINIA

IPC: A61K31/409 ,  A61K31/713 ,  A61P25/28 ,  A61P27/00 ,  C12N15/113

CPC classification number: C12N15/1137 ,  A61K31/409 ,  C12N2310/14 ,  C12N2320/32 ,  C12Y114/99003

Abstract: A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase- 1 (HO-I) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrin in a manner that permits access to brain sites and/or the macula of the patient.

Abstract translation: 治疗或抑制哺乳动物痴呆和/或黄斑变性进程的方法包括给含有血红素加氧酶-1（HO-1）或血红素加氧酶-2（HO-2），基质金属蛋白酶（MMP）抑制剂 ，胱天蛋白酶抑制剂或金属卟啉以允许接近患者的脑部位和/或黄斑的方式。

公开(公告)号：WO2008031067A2

公开(公告)日：2008-03-13

申请号：PCT/US2007077931

申请日：2007-09-07

Applicant: UNIV LOMA LINDA MED ,  GRANGE JEFF T ,  MCPHERSON BRETT G ,  BENDER JEFFREY L ,  CORBETT STEPHEN W

Inventor： GRANGE JEFF T ,  MCPHERSON BRETT G ,  BENDER JEFFREY L ,  CORBETT STEPHEN W

IPC: B64D11/06

CPC classification number: A61G3/001 ,  A61B6/4405

Abstract: A mobile telemedicine device for use in disasters and emergency response comprising four or more wheels connected to a drive train and a main compartment. The main compartment comprises an interior portion and an exterior portion and a supplemental compartment connected to the main compartment. Communications ports are connected to the exterior, and the supplemental compartment. Patient care tables are located in the main compartment. A method for using an all terrain mobile telemedicine vehicle, first driving the mobile telemedicine device to a disaster or emergency location and lowering and deploying a vehicle from the storage compartment to search for patients in need of medical services.

Abstract translation: 一种用于灾害和应急响应的移动远程医疗装置，包括连接到传动系和主舱的四个或更多个轮。 主隔室包括内部部分和连接到主隔间的外部部分和补充室。 通信端口连接到外部和辅助隔间。 病房护理台位于主隔间。 一种使用全地形移动远程医疗车辆的方法，首先将移动远程医疗设备驱动到灾难或紧急位置，并从存储隔间中降低和部署车辆以搜索需要医疗服务的患者。

公开(公告)号：WO2005018735A3

公开(公告)日：2006-12-28

申请号：PCT/US2004026113

申请日：2004-08-12

Applicant: UNIV LOMA LINDA MED

Inventor： RIGNEY NICK ,  ANDERSON DAN ,  LESYNA DAVID ,  MILLER DAN ,  MOYERS MICHAEL ,  CHENG CHIEH ,  BAUMANN MIKE ,  MCALLASTER STEVEN ,  SLATER JERRY

IPC: A61N5/10 ,  A61B34/20 ,  A61N20060101 ,  G01K1/08 ,  G21F5/02 ,  G21G4/00 ,  G21K5/08

CPC classification number: A61N5/107 ,  A61B6/0442 ,  A61B6/4092 ,  A61B6/547 ,  A61B2090/3937 ,  A61N5/1037 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/1078 ,  A61N2005/105 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1087 ,  A61N2005/1097 ,  B25J9/1666 ,  G05B15/02 ,  G05B2219/45117

Abstract: A radiation treatment system (100) for accurately delivering radiation to a targeted site within a cancer patient (108) that includes a modular patient support system and a patient positioner (114). The modular patient support system includes a modularly expandable patient pod (200) and at least one immobilization device, such as, for example, a rigid moldable foam cradle. The patient pod (200) includes a generally hemi-cylindrical support shell (212) that extends longitudinally between proximal edge (214) and distal edge (216), and transversely between two lateral edges. In one embodiment, the lateral edges are tapered to minimize edge effects that result when radiation beams traverse the lateral edges.

Abstract translation: 1.一种辐射治疗系统（100），用于将辐射准确地传送到癌症患者（108）内的目标部位，其包括模块化患者支撑系统和患者定位器（114）。 模块化患者支撑系统包括模块化可扩张的患者支架（200）和至少一个固定装置，例如刚性可模制泡沫支架。 患者荚（200）包括在近侧边缘（214）和远端边缘（216）之间纵向延伸并且横向于两个侧边缘之间延伸的大致半圆柱形的支撑壳体（212）。 在一个实施例中，横向边缘是锥形的，以最小化当辐射束横过侧边缘时产生的边缘效应。

公开(公告)号：WO2004034966A3

公开(公告)日：2004-07-08

申请号：PCT/US0324625

申请日：2003-08-06

Applicant: UNIV LOMA LINDA ,  ESCHER ALAN P ,  LI FENGCHUN

Inventor： ESCHER ALAN P ,  LI FENGCHUN

IPC: A61K38/17 ,  A61K39/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/075 ,  C07K14/47 ,  C12N5/00 ,  C12N15/00 ,  C12N15/87

CPC classification number: C07K14/4713 ,  A61K38/1709 ,  A61K39/0008 ,  A61K48/005 ,  A61K2039/53 ,  A61K2039/55516 ,  C07K14/005 ,  C07K14/4747 ,  C12N2710/10322 ,  C12N2840/203

Abstract: A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoimmune disease or who has the autoimmune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding DeltaBCL-2.

Abstract translation: 一种用于预防，延迟一种或多于一种自身免疫性疾病发作或治疗一种或多种自身免疫性疾病的物质，所述物质包含多核苷酸构建体，所述多核苷酸构建体包含编码促凋亡蛋白BAX并编码自身免疫性疾病的一种或多种自身抗原的多核苷酸序列。 一种预防，延迟或治疗患者自身免疫疾病的方法，包括选择易患发展自身免疫性疾病的患者，正在发展自身免疫性疾病或患有自身免疫性疾病的患者，并给患者施用一种或多种 所述多核苷酸构建体包含编码促凋亡蛋白BAX并编码一种或多于一种自身免疫疾病的自身抗原或包含编码腺病毒蛋白E3-GP19k的多核苷酸序列或包含编码多核苷酸序列的多核苷酸序列的多核苷酸构建体 DeltaBCL-2。

公开(公告)号：WO0245793A3

公开(公告)日：2002-10-24

申请号：PCT/US0147634

申请日：2001-12-10

Applicant: UNIV LOMA LINDA MED ,  BAUMANN MICHAEL A ,  BELOUSSOV ALEXANDRE V ,  BAKIR JULIDE ,  ARMON DEGANIT ,  OLSEN HOWARD B ,  SALEM DANA

Inventor： BAUMANN MICHAEL A ,  BELOUSSOV ALEXANDRE V ,  BAKIR JULIDE ,  ARMON DEGANIT ,  OLSEN HOWARD B ,  SALEM DANA

IPC: A61N5/10 ,  G06F9/46 ,  G06F15/00 ,  G06F19/00 ,  H04L29/08 ,  G21F5/04 ,  G06F13/38

CPC classification number: A61N5/1079 ,  A61N5/10 ,  A61N2005/1074 ,  A61N2005/1087 ,  G16H40/63 ,  H04L67/12 ,  H04L67/32 ,  H04L69/329

Abstract: A tiered communications architecture for managing network traffic in a distributed system (100). Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system (115) to provide flexible security policies which improve patient safety and facilitate system maintenance and development.

Abstract translation: 用于管理分布式系统（100）中的网络流量的分层通信架构。 客户端或控制计算机与多个硬件设备之间的通信由其协调活动的代理和监视设备来管理以减少开放的通道或插座的数量。 通信架构还通过减少网络映射依赖性来提高分布式系统的透明度和可扩展性。 该结构理想地在质子束治疗系统（115）中实现，以提供灵活的安全策略，其改善患者的安全性并促进系统维护和开发。

公开(公告)号：WO0162159A3

公开(公告)日：2002-04-18

申请号：PCT/US0106149

申请日：2001-02-26

Applicant: UNIV LOMA LINDA MED

Inventor： ZHU YONG HUA ,  KIRSCH WOLFF M

IPC: A61B17/00 ,  A61M37/00

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/00637 ,  A61B2017/00659

Abstract: A patch applicator has an elongate body with an inner lumen and an outer lumen arranged concentrically. First and second connectors are provided and correspond to the inner and outer lumens, respectively. A patch is also provided. In operation, a source of vacuum is connected to the first connector and draws a vacuum through the inner lumen. The inner lumen is then applied to a patch to releasably hold the patch. The patch is advanced within the patient until it is placed on top of and over a wound in tissue. The source of vacuum is then transferred to the second connector and pulls a vacuum through the outer lumen to clear bodily fluid from a field around the wound. After the field is cleared, the source of vacuum is removed and replaced by a source of flowable adhesive. Adhesive is injected through the outer lumen onto the patch and tissue surrounding the patch. The patch applicator holds the patch in place, allowing the adhesive to set. A release rod is advanced through the first connector and through the inner lumen into contact with the patch. The applicator is then removed from the patch, followed by the release rod. Thus, an adhesive patch is attached to close an opening in tissue.

Abstract translation: 贴片施加器具有细长体，其具有内腔和同心排列的外腔。 提供第一和第二连接器并分别对应于内腔和外腔。 还提供了一个补丁。 在操作中，真空源连接到第一连接器并且通过内腔抽真空。 然后将内腔施加到贴片以可释放地保持贴片。 贴片在患者体内前进，直至放置在组织中的伤口顶部和上面。 然后将真空源转移到第二连接器，并通过外腔抽真空以从伤口周围的场清除体液。 在场清除之后，真空源被去除并由可流动的粘合剂源代替。 胶粘剂通过外腔注射到补片周围的贴片和组织上。 贴片器将贴片保持在适当位置，使粘合剂固定。 释放杆通过第一连接器前进并穿过内腔与贴片接触。 然后从贴片上取下涂敷器，然后将其放在释放杆上。 因此，粘附贴片以封闭组织中的开口。

公开(公告)号：WO9962405A9

公开(公告)日：2000-04-27

申请号：PCT/US9912507

申请日：1999-06-04

Applicant: UNIV LOMA LINDA MED

Inventor： ZHU YONG HUA ,  KIRSCH WOLFF M

IPC: A61B17/00 ,  A61B17/02 ,  A61B17/068 ,  A61B17/128 ,  A61B17/30 ,  A61B17/34

CPC classification number: A61B17/0206 ,  A61B17/0057 ,  A61B17/02 ,  A61B17/0682 ,  A61B17/128 ,  A61B17/3439 ,  A61B2017/306 ,  B29K2067/003

Abstract: An apparatus for facilitating the locating, everting, and closing of an opening in a blood vessel. The apparatus can include a closure instrument having an elongated member defining a longitudinal axis and proximal and distal ends. The elongated member has a vacuum lumen extending at least a portion of the length thereof for conveying a vacuum and terminating in a vacuum port adjacent the distal end of the elongated member. The distal end of the elongated member is dimensioned to be positioned proximal a vessel opening in a blood vessel whereby vessel edge portions defining the vessel opening are at least partially drawn toward the vacuum port in response to a vacuum conveyed through the vacuum lumen. At least one surgical clip is mounted adjacent the distal end of the elongated member and is adapted to be formed to an at least partially formed condition thereof. The one clip is positioned with respect to the vacuum port so as to engage the vessel edge portions drawn toward the vacuum port when the clip is moved to the formed condition, thus at least partially closing the vessel opening. A method for locating, everting, and closing an opening in a blood vessel is also disclosed.

Abstract translation: 一种用于促进血管中的开口的定位，旋转和关闭的装置。 该装置可以包括具有限定纵向轴线和近端和远端的细长构件的封闭器械。 细长构件具有延伸其长度的至少一部分的真空腔，用于输送真空并终止在与细长构件的远端相邻的真空口中。 细长构件的远端的尺寸被设计成位于血管中的容器开口的近侧，由此响应于通过真空腔输送的真空，限定容器开口的容器边缘部分至少部分地被抽吸到真空端口。 至少一个手术夹子被安装在细长构件的远端附近，并适于形成至少部分形成的状态。 一个夹子相对于真空端口定位，以便当夹子移动到形成状态时接合朝向真空端口拉出的容器边缘部分，从而至少部分地关闭容器开口。 还公开了一种用于在血管中定位，旋转和关闭开口的方法。