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    APPARATUS FOR TEETH CLEANING AND ORAL DELIVERY OF AN AGENT AND METHOD OF USING THE SAME
    31.
    发明申请
    APPARATUS FOR TEETH CLEANING AND ORAL DELIVERY OF AN AGENT AND METHOD OF USING THE SAME 审中-公开
    用于牙齿清洁和口服递送的装置及其使用方法

    公开(公告)号：WO2004019808A1

    公开(公告)日：2004-03-11

    申请号：PCT/US2003/027142

    申请日：2003-08-27

    Applicant: CHEN & CHEN LLC.

    Inventor： CHEN, Shuqi ,  CHEN, Lingjun

    IPC: A61C17/02

    CPC classification number: A61C17/0211 ,  A61C15/00 ,  A61C17/0208 ,  A61C19/063

    Abstract: A mouthpad for cleaning teeth and oral transmucosal drug delivery has a U-shaped plate sized to cover substantially only the biting surfaces of upper and lower teeth of a human jaw. The plate is positioned between the upper teeth and lower teeth such that when the teeth are rinsed with a liquid, the liquid flows primarily through the crevices between individual teeth and physically detaches the adhering residue within. Alternatively, using fluids containing drugs for rinsing while biting on the plate can deliver drugs through the oral mucosa. A method of cleaning teeth and delivering drugs through oral mucosa using a plate positioned between the upper and lower teeth is also disclosed.

    Abstract translation: 用于清洁牙齿和口腔经粘膜药物递送的口垫具有U形板，其大小仅基本上仅覆盖人颚的上齿和下牙的咬合表面。 板被定位在上齿和下齿之间，使得当牙齿用液体漂洗时，液体主要流过各个齿之间的缝隙并物理地分离粘附的残留物。 或者，使用含有用于冲洗的药物的流体在咬在板上时可以通过口腔粘膜递送药物。 还公开了一种通过使用位于上下牙之间的板来清洁牙齿并通过口腔粘膜输送药物的方法。

    LUNG CANCER THERAPEUTICS AND DIAGNOSTICS
    32.
    发明申请
    LUNG CANCER THERAPEUTICS AND DIAGNOSTICS 审中-公开
    肺癌治疗与诊断

    公开(公告)号：WO2003040317A2

    公开(公告)日：2003-05-15

    申请号：PCT/US2002/035149

    申请日：2002-11-02

    Applicant: PFIZER PRODUCTS INC. ,  TRUSTEES OF DARTMOUTH COLLEGE ,  BEEBE, Jean, S. ,  COLEMAN, Kevin, G. ,  DMITROVSKY, Ethan ,  TURI, Thomas, G.

    Inventor： BEEBE, Jean, S. ,  COLEMAN, Kevin, G. ,  DMITROVSKY, Ethan ,  TURI, Thomas, G.

    IPC: C12N

    CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  Y02A90/26

    Abstract: The present invention provides genes that are differentially expressed during neoplasia. These genes and gene products comprise panels for use in screening candidate agents for therapeutic intervention in lung cancers, and for use in therapeutic, prognostic and diagnostic methods and compositions. Therapeutic agents are also provided by the invention. Diagnostic compositions include compositions comprising detection agents for detecting one or more genes that have been shown to be up- or down-regulated in pathogenesis of lung cancer. Exemplary detection agents include nucleic acid probes, which can be in solution or attached to a solid surface, e.g., in the form of a microarray. The invention also provides computer-readable media comprising values of levels of expression of one more genes that are modulated in lung cancer.

    Abstract translation: 本发明提供在瘤形成期间差异表达的基因。 这些基因和基因产物包含用于筛选用于肺癌治疗性干预的候选药物的片剂，并且用于治疗，预后和诊断方法和组合物。 治疗剂也由本发明提供。 诊断组合物包括含有检测试剂的组合物，所述检测剂用于检测在肺癌的发病机理中已被证明是上调或下调的一种或多种基因。 示例性的检测剂包括核酸探针，其可以在溶液中或连接到固体表面，例如以微阵列的形式。 本发明还提供了包括在肺癌中调节的另外一个基因的表达水平的值的计算机可读介质。

    MULTI-MODAL DEPTH-RESOLVED TISSUE STATUS MONITOR
    36.
    发明申请
    MULTI-MODAL DEPTH-RESOLVED TISSUE STATUS MONITOR 审中-公开
    多模式深度解决组织状态监视器

    公开(公告)号：WO2014165049A1

    公开(公告)日：2014-10-09

    申请号：PCT/US2014/024242

    申请日：2014-03-12

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： GRUNDFEST, Warren, S. ,  KOSTIC, Marko, N.

    IPC: A61B5/1455 ,  A61B5/026

    CPC classification number: A61B5/7278 ,  A61B5/0062 ,  A61B5/0064 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0261 ,  A61B5/0285 ,  A61B5/03 ,  A61B5/1079 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  A61B5/6832 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0214 ,  A61B2560/0223 ,  A61B2562/164

    Abstract: The properties inside a human tissue as well as how those properties vary over time can include information of great importance to a healthcare provider. For example, the concentration of hemoglobin, oxygenated or nonoxygenated, blood flow velocity, body temperature, and even change in size of the tissue, can all be relevant to a doctor's understanding of how a wound is healing. In some cases, the tissue of interest may not be easily accessible, as a tissue that is under a cast or beneath a bandage, or may be beneath a layer of skin that makes it difficult to evaluate the tissue visually or in a non-invasive manner. Improved systems and methods for evaluating and monitoring tissues are needed. A system for monitoring tissue at a plurality of depths can include a sensor strip, a data acquisition module and analysis software. The sensor strip can have a first side including a first photodetector element and a plurality of light-emitting elements, wherein the plurality of light-emitting elements are disposed in a predetermined configuration relative to the photodetector element. The data acquisition module can be capable of being coupled to the sensor strip, wherein the data acquisition module is configured to control the sensor strip and store signals received from the light-emitting elements. The analysis software can analyze and/or display the received signals. The system can be adapted to be placed on the surface of a patient's skin, e.g., under a cast, splint, or dressing. The sensor strip can be adapted to be placed over an area of a patient's body, e.g., that has suffered trauma.

    Abstract translation: 人体组织内的特性以及这些性质随时间的变化可能包括对医疗保健提供者非常重要的信息。 例如，血红蛋白的浓度，氧合或非氧化，血流速度，体温，甚至组织尺寸的变化，都可以与医生对伤口愈合的理解有关。 在一些情况下，感兴趣的组织可能不容易接近，作为在铸件下面或在绷带下方的组织，或者可能在一层皮肤之下，使得难以在视觉上或非侵入性地评估组织 方式。 需要改进用于评估和监测组织的系统和方法。 用于在多个深度监测组织的系统可以包括传感器条，数据采集模块和分析软件。 传感器条可以具有包括第一光电检测器元件和多个发光元件的第一侧，其中多个发光元件相对于光电检测器元件设置成预定的配置。 数据采集​​模块能够耦合到传感器条，其中数据采集模块被配置为控制传感器条并存储从发光元件接收的信号。 分析软件可以分析和/或显示接收到的信号。 该系统可以适于放置在患者皮肤的表面上，例如在铸件，夹板或敷料之下。 传感器条可以适于放置在患者身体的区域上，例如已经遭受创伤的区域。

    SENSITIVE AND SPECIFIC ASSAY FOR BABESIA SPP.
    37.
    发明申请
    SENSITIVE AND SPECIFIC ASSAY FOR BABESIA SPP. 审中-公开
    BABESIA SPP的敏感和特异性测定。

    公开(公告)号：WO2013059795A1

    公开(公告)日：2013-04-25

    申请号：PCT/US2012/061333

    申请日：2012-10-22

    Applicant: IMMUNETICS, INC.

    Inventor： ERWIN, James, L. ,  KRUEGER, Neil, X. ,  LEVIN, Andrew, E.

    IPC: G01N33/569 ,  G01N33/532 ,  G01N33/543 ,  G01N33/68

    CPC classification number: G01N33/6893 ,  G01N33/56905 ,  G01N2333/44

    Abstract: The invention is directed to methods of using novel Babesia antigen peptides in detecting Babesia spp. in a sample. The methods may be adapted to assays suitable for high blood volume screening, use for clinical diagnosis of patients with babesiosis, or assaying blood contaminated with Babesia spp. , such as B. microti .

    Abstract translation: 本发明涉及使用新型巴贝虫抗原肽检测巴贝虫属（Babesia spp）的方法。 在一个样本。 所述方法可适用于适合于高血容量筛选，用于临床诊断患有巴西病的患者或测定受巴贝虫感染的血液（如微生物）的测定。

    INTRAVASCULAR CATHETER WITH POSITIONING MARKERS AND METHOD OF PLACEMENT
    39.
    发明申请
    INTRAVASCULAR CATHETER WITH POSITIONING MARKERS AND METHOD OF PLACEMENT 审中-公开
    具有定位标记的血管内导管和放置方法

    公开(公告)号：WO2011081859A2

    公开(公告)日：2011-07-07

    申请号：PCT/US2010/059998

    申请日：2010-12-13

    Applicant: TAL, Michael, G.

    Inventor： TAL, Michael, G.

    IPC: A61M25/098 ,  A61M25/095 ,  A61B17/34 ,  A61M1/14 ,  A61B6/00

    CPC classification number: A61M25/0108 ,  A61M25/0029 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/0071 ,  A61M2025/0008 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0037

    Abstract: An intravascular catheter may include a distal end for insertion and a proximal end. The distal end for insertion may terminate with a tip. It may define at least two openings, of which one is proximal-most in the distal end. The distal tip may include a first radiopaque marker that is discretely positioned at the proximal-most opening and radiographically distinguishes the proximal-most opening from the rest of the distal end. The distal tip may also include a second radiopaque marker that marks the tip.

    Abstract translation: 血管内导管可以包括用于插入的远端和近端。 用于插入的远端可以以尖端终止。 它可以限定至少两个开口，其中一个开口在远端最近侧。 远侧尖端可以包括不连续地定位在最近侧开口处并且射线照相区分最远侧开口与远侧端部的其余部分的第一不透射线标记。 远端尖端还可以包括标记尖端的第二不透射线标记。

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