公开(公告)号：WO0167129A2

公开(公告)日：2001-09-13

申请号：PCT/US0140199

申请日：2001-02-27

Applicant: SURMODICS INC

Inventor： SWAN DALE G ,  SWANSON MELVIN J

IPC: G01N33/53 ,  C07B61/00 ,  C07C45/63 ,  C07C235/84 ,  C07C323/42 ,  C07H21/00 ,  C08L63/00 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  C40B80/00 ,  G01N33/566 ,  G01N37/00 ,  G01S5/30

CPC classification number: C40B80/00 ,  B01J2219/00317 ,  B01J2219/00531 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00722 ,  B82Y30/00 ,  C07B2200/11 ,  C07C45/63 ,  C07C235/84 ,  C07C323/42 ,  C07H21/00 ,  C08L63/00 ,  C09D4/00 ,  C12Q1/6834 ,  C40B40/06 ,  C40B60/14 ,  C07C49/813

Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.

Abstract translation: 用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。 试剂组合物包括能够与靶分子共价结合的环氧基。 任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。 试剂组合物可用于提供用于制备核酸微阵列的活性载玻片。

公开(公告)号：WO9947176A2

公开(公告)日：1999-09-23

申请号：PCT/US9905245

申请日：1999-03-11

Applicant: SURMODICS INC

Inventor： GUIRE PATRICK E ,  ANDERSON ARON B ,  AMOS RICHARD A ,  EVERSON TERRENCE P

IPC: A61L27/00 ,  A61K47/48 ,  A61L31/04 ,  A61L33/00

CPC classification number: A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

Abstract translation: 用于钝化生物材料表面的试剂和相关方法，所述试剂包括潜在反应性基团和双官能脂肪酸（例如脂肪酸），以及以潜在反应性基团与脂肪酸以一种方式连接的间隔基团 这保留了每个组的所需功能。 一旦结合到表面，通过潜在的反应性基团，试剂以足以保持和取向白蛋白的方式（例如浓缩和取向）在体内将脂肪酸提供给生理环境。

公开(公告)号：WO2018112196A1

公开(公告)日：2018-06-21

申请号：PCT/US2017/066410

申请日：2017-12-14

Applicant: SURMODICS, INC.

Inventor： SLAGER, Joram ,  MURPHY, Rick

IPC: A61L29/08 ,  A61L29/16 ,  C08L39/06 ,  C08L67/04

Abstract: Drug delivery coatings and devices including the same are described herein. The drug delivery coating has a first coated layer with non-ionic polymer and photogroups, a second coated layer with acid polymer in contact and hydrogen bonded with the first layer, particles with hydrophobic therapeutic agent, and cationic agent. The coating can be provided on a balloon catheter, and the particles and cationic agent can be transferred to tissue during a medical procedure, such as an angioplasty procedure, for a therapeutic effect.

公开(公告)号：WO2018112031A1

公开(公告)日：2018-06-21

申请号：PCT/US2017/066091

申请日：2017-12-13

Applicant: SURMODICS, INC.

Inventor： OLSON, Charles

IPC: A61M39/06

Abstract: Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.

公开(公告)号：WO2018064617A1

公开(公告)日：2018-04-05

申请号：PCT/US2017/054581

申请日：2017-09-29

Applicant: SURMODICS, INC.

Inventor： FOX, Noel ,  SLAGER, Joram ,  LOCKWOOD, Nathan Allyn

IPC: A61B17/22 ,  A61F2/844 ,  A61M25/10 ,  A61M29/00

Abstract: A balloon system includes a balloon catheter extending from a proximal end portion to a distal end portion. The balloon catheter includes an inflation lumen therein. A balloon assembly is coupled with the distal end portion of the balloon catheter. The balloon assembly includes a balloon having distal and proximal balloon ends, has inflated and folded deflated configurations. One or more deflation guides are coupled with the balloon. The one or more deflation guides are configured to bias the balloon toward the folded deflated configuration.

Abstract translation: 气囊系统包括从近端部分延伸到远端部分的气囊导管。 球囊导管中包括膨胀腔。 球囊组件与球囊导管的远端部分联接。 气囊组件包括具有远端和近端气囊末端的气囊，具有膨胀和折叠的放气构造。 一个或多个放气导管与球囊连接。 一个或多个放气导向器被构造成朝向折叠的放气构型偏压气囊。

公开(公告)号：WO2017173114A1

公开(公告)日：2017-10-05

申请号：PCT/US2017/025079

申请日：2017-03-30

Applicant: SURMODICS, INC.

Inventor： MILITELLO, Mike

IPC: A61L29/08 ,  A61L29/14

Abstract: Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body.

Abstract translation: 本公开的实施例包括润滑涂层。 在一个实施方案中，本公开包括用于包括丙烯酸聚合物，包含至少一个光反应性基团的丙烯酰胺共聚物和包含至少两个光反应性基团的交联剂的医疗装置的润滑涂层。 涂层可用于导管表面，以促进其在体内的运动。

公开(公告)号：WO2017172609A1

公开(公告)日：2017-10-05

申请号：PCT/US2017/024289

申请日：2017-03-27

Applicant: SURMODICS, INC.

Inventor： JELLE, Bruce M. ,  SLAGER, Joram ,  MCGONIGLE, Joseph Schmidt ,  LOCKWOOD, Nathan A.

IPC: A61M25/06 ,  A61M25/00

CPC classification number: A61M25/0662 ,  A61M25/0023 ,  A61M25/0045 ,  A61M25/0097 ,  A61M25/0668 ,  A61M39/06 ,  A61M2025/0024 ,  A61M2025/0046 ,  A61M2025/0047 ,  A61M2025/006 ,  A61M2025/0681 ,  A61M2025/0687 ,  A61M2039/064 ,  A61M2039/0666 ,  A61M2207/00

Abstract: An insertion tool 100 for inserting a medical device into another medical device, such as a hemostasis sealing valve. The insertion tool includes a guide sheath 101 and a protection tube 105. The guide sheath includes a flared proximal end. The guide sheath can further include a central lumen. The guide sheath further includes a locking notch 104 disposed on the inner surface between the proximal end and the distal end. The protection tube includes a flared proximal end 108. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube is sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

Abstract translation: 用于将医疗装置插入另一医疗装置（例如止血密封阀）中的插入工具100。 插入工具包括引导护套101和保护管105.引导护套包括扩大的近端。 引导护套可以进一步包括中央内腔。 引导护套还包括设置在近端和远端之间的内表面上的锁定凹口104。 保护管包括张开的近端108.保护管的一部分可以位于引导护套的中心腔内。 保护管的张开的近端的尺寸设置成配合在锁定凹口内并且可以具有比紧邻锁定凹口的内表面的部分更大的外径。 其他实施例也包括在本文中。

公开(公告)号：WO2017116707A2

公开(公告)日：2017-07-06

申请号：PCT/US2016/066559

申请日：2016-12-14

Applicant: SURMODICS, INC.

Inventor： BABCOCK, David E. ,  SLAGER, Joram ,  HERGENROTHER, Robert W.

CPC classification number: A61L29/085 ,  A61L29/14 ,  A61L2400/10 ,  A61L2420/02 ,  B05D1/18 ,  B05D3/007 ,  B05D3/067 ,  B05D5/08 ,  B05D7/02 ,  B05D7/54 ,  C08L5/08 ,  C08L29/04 ,  C08L33/08

Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.

Abstract translation: 这里的实施方案包括涂布的医疗装置和具有盐基团的涂层。 在一个实施例中，包括涂覆的医疗装置，涂覆的医疗装置包括基底和设置在基底上的聚合物层。 聚合物层包含聚合物并具有外表面。 涂覆的医疗装置还包括与聚合物层的聚合物结合并设置在聚合物层的外表面上的多个盐基团。 盐基团可以是反应性基团与酸或碱的反应产物。 在一个实施例中，包括制造医疗装置的方法。 其他实施例也包括在本文中。

公开(公告)号：WO2016123480A1

公开(公告)日：2016-08-04

申请号：PCT/US2016/015644

申请日：2016-01-29

Applicant: SURMODICS, INC.

Inventor： SLAGER, Joram ,  HEYER, Toni M. ,  BABCOCK, David E.

IPC: A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/608

Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括药物递送涂层和包括其的装置。 在一个实施方案中，本发明包括包含聚合物层的药物递送涂层。 聚合物层可包括亲水性外表面。 涂层还可以包括接触亲水性外表面的基体。 基质可以包括颗粒疏水性治疗剂和阳离子剂。 聚合物层还可以包括具有侧基光反应性基团的亲水聚合物和包含两个芳基酮官能团的光交联剂。 本文还包括其它实施例。

公开(公告)号：WO2016022796A1

公开(公告)日：2016-02-11

申请号：PCT/US2015/044002

申请日：2015-08-06

Applicant: SURMODICS, INC.

Inventor： BABCOCK, David E. ,  LUNDQUIST, Sean ,  OPPERMAN, Gary ,  TORGUSON, Adriyn ,  JENTZ, Tim

IPC: A61L27/34 ,  A61L29/06 ,  A61L29/08 ,  A61K31/7024 ,  C08L29/04

CPC classification number: A61L27/34 ,  A61K31/7024 ,  A61L29/06 ,  A61L29/085

Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

Abstract translation: 本公开的实施方案包括包含低聚多酚层的涂层。 低聚多酚层可以用作医疗装置上的中间涂层，氢层与合成或天然聚合物键合，其又可以用作顶涂层，或进一步与另一涂层相连。 多层涂层可以提供诸如血液相容性或润滑性的性质。 在其它实施方案中，低聚多酚层用作医疗装置，作为构造成接触血液并促进凝血的止血层。 低聚多酚层也可用于医疗装置的内表面（例如内径），以防细菌粘附。 低聚多酚层也可用于体外诊断制品或细胞培养装置的表面，以促进生物分子的吸附。