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    DELIVERY OF HIGHLY LIPOPHILIC AGENTS VIA MEDICAL DEVICES
    74.
    发明申请
    DELIVERY OF HIGHLY LIPOPHILIC AGENTS VIA MEDICAL DEVICES 审中-公开
    通过医疗设备提供高度亲脂性药物

    公开(公告)号：WO2006102359A3

    公开(公告)日：2007-05-10

    申请号：PCT/US2006010307

    申请日：2006-03-22

    Applicant: ABBOTT LAB ,  CROMACK KEITH R ,  TONER JOHN L ,  BURKE SANDRA E ,  KRASULA RICHARD W ,  SCHWARTZ LEWIS B

    Inventor： CROMACK KEITH R ,  TONER JOHN L ,  BURKE SANDRA E ,  KRASULA RICHARD W ,  SCHWARTZ LEWIS B

    IPC: A61L27/54

    CPC classification number: A61L31/10 ,  A61F2/04 ,  A61F2/82 ,  A61F2002/044 ,  A61F2002/047 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/606

    Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

    Abstract translation: 一种用于递送与医疗装置相关联的亲脂性试剂的设备和系统，所述设备和系统包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的传递系数的量在统计学上显着为 其中所述第一亲脂试剂与所述医疗装置相关联，其中所述第一亲脂试剂/医疗装置放置在所述体腔附近，并且其中将治疗有效量的所述第一亲脂试剂递送至所述医疗装置内的期望区域 课程。 此外，本发明涉及一种用于改善受试者中的开放的方法，该方法涉及将医疗装置放置在体腔中以用于治疗和/或预防相邻疾病或维持体腔的开放。

    MULTIPLE LUMEN CATHETER AND METHOD OF MAKING SAME
    76.
    发明申请
    MULTIPLE LUMEN CATHETER AND METHOD OF MAKING SAME 审中-公开
    多个灯管及其制造方法

    公开(公告)号：WO2006127931A3

    公开(公告)日：2007-03-22

    申请号：PCT/US2006020302

    申请日：2006-05-23

    Applicant: ABBOTT LAB ,  GRANDT AXEL ,  VON OEPEN RANDOLF ,  GRATHWOHL HARTMUT ,  JEFFREY ANDY ,  QUINT BODO ,  NIELSEN STEVAN

    Inventor： GRANDT AXEL ,  VON OEPEN RANDOLF ,  GRATHWOHL HARTMUT ,  JEFFREY ANDY ,  QUINT BODO ,  NIELSEN STEVAN

    IPC: A61M25/00 ,  B29C65/68

    CPC classification number: A61M25/0043 ,  A61M25/0009 ,  B23K26/009 ,  B23K26/18 ,  B23K26/24 ,  B23K2201/06

    Abstract: The invention provides a catheter and method of making the same including an outer tubular member having a length, an outer surface, an inner surface and a lumen therein. The catheter also includes an inner tubular member having an outer surface, an inner surface and a lumen therein, at least a length of the inner lumen is disposed in the lumen of the outer tubular member. The catheter also includes a support member biasing a portion of the outer surface of the inner tubular member against a portion of the inner surface of the outer tubular member. The method of the invention includes providing a first tubular member and a second tubular member, arranging the first tubular member in contact with the second tubular member to define a contact area therebetween and joining the first and second tubular members at the contact area by irradiating them to define a fusion area having an intensity gradient.

    Abstract translation: 本发明提供一种导管及其制造方法，其包括具有长度，外表面，内表面和内腔的外管状构件。 导管还包括内管状构件，其具有外表面，内表面和内腔，内管腔的至少一段长度设置在外管状构件的内腔中。 导管还包括支撑构件，该支撑构件偏压内管状构件的外表面的一部分抵靠外管状构件的内表面的一部分。 本发明的方法包括提供第一管状构件和第二管状构件，将第一管状构件与第二管状构件接触以限定其间的接触区域，并且通过照射接触区域将第一和第二管状构件接合在接触区域 以限定具有强度梯度的融合区域。

    APPARATUS AND METHOD FOR DELIVERING A CLOSURE ELEMENT
    77.
    发明申请
    APPARATUS AND METHOD FOR DELIVERING A CLOSURE ELEMENT 审中-公开
    用于传送封闭元件的装置和方法

    公开(公告)号：WO2007002307A3

    公开(公告)日：2007-03-08

    申请号：PCT/US2006024334

    申请日：2006-06-21

    Applicant: ABBOTT LAB ,  CARLY MICHAEL T

    Inventor： CARLY MICHAEL T

    IPC: A61B17/00 ,  A61B17/08

    CPC classification number: A61B17/0057 ,  A61B17/0644 ,  A61B17/083 ,  A61B2017/00336 ,  A61B2017/00672 ,  A61B2017/00867

    Abstract: An apparatus for delivering and deploying a closure element to an opening formed in a body lumen, including a delivery assembly positionable through the tissue and into the opening. The delivery assembly includes a distal locator portion and a carrier portion oriented proximal to the distal locator portion. The distal locator portion is configured to selectably engage the body lumen adjacent to the opening, and the carrier portion is configured to carry and support the closure element in a substantially tubular configuration. The carrier portion is further configured to urge the closure element toward an expanded cross-sectional dimension for deployment thereof, such that the closure element is oriented to engage the tissue when deployed and, when released, to return to the natural, substantially planar configuration and the natural cross-section dimension wherein the engaged tissue is drawn substantially closed.

    Abstract translation: 一种用于将闭合元件递送并展开到形成在体腔中的开口的装置，包括可通过组织定位并进入开口的输送组件。 输送组件包括远端定位器部分和靠近远侧定位器部分定向的支架部分。 远侧定位器部分构造成可选择地接合与开口相邻的体腔，并且承载部分构造成承载和支撑基本上管状的封闭元件。 承载部分进一步构造成推动封闭元件朝向扩展的横截面尺寸以进行展开，使得封闭元件定向成在展开时与组织接合并且当被释放时被重新定位成自然的基本上平面的构造，并且 自然横截面尺寸，其中所接合的组织被拉伸基本上封闭。

    STABILIZATION OF CARDIAC TROPONIN
    78.
    发明申请
    STABILIZATION OF CARDIAC TROPONIN 审中-公开
    CARDIAC TROPONIN的稳定性

    公开(公告)号：WO2006116005A3

    公开(公告)日：2007-02-15

    申请号：PCT/US2006014958

    申请日：2006-04-20

    Applicant: ABBOTT LAB ,  LAIRD DON M ,  YOUNG CHARLES E

    Inventor： LAIRD DON M ,  YOUNG CHARLES E

    IPC: C07K14/47 ,  G01N33/50

    CPC classification number: G01N33/6887 ,  C07K14/4716 ,  G01N2800/324

    Abstract: The present invention relates to a troponin protein or complex of two troponin proteins stabilized in a matrix containing at least one anionic surfactant. The stabilized troponin or complex of troponin proteins is used as a control or calibration standard in assays for the determination of blood levels of troponin in patient samples that are expect to exhibit elevated levels of cardiac proteins. The troponin protein or complex of troponin proteins remains stabilized at room temperatures for at least six (6) months.

    Abstract translation: 本发明涉及稳定在含有至少一种阴离子表面活性剂的基质中的肌钙蛋白或两种肌钙蛋白的复合物。 稳定的肌钙蛋白或肌钙蛋白复合物用作测定用于测定患者样品中肌钙蛋白的血液水平的对照或校准标准，其预期显示升高的心脏蛋白水平。 肌钙蛋白或肌钙蛋白复合物在室温下保持稳定至少六（6）个月。

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