Abstract:
The present invention provides compositions and pharmaceutical formulations of lalp derived from plasma. Also provided are methods for the manufacture of the lalp compositions and formulations, as well as method for the treatment of diseases associated with lalp dysfunction.
Abstract:
An infusion pump uses sensors, movable members and a control unit to determine tubing thickness in a tube-loading section of the pump. The infusion pump utilizes sensors, such as a pressure sensor, to record forces imparted by a tube undergoing no pressure, a single pressure, or a pressure sweep, to determine thickness. Using these values, the tubing wall thickness can be determined. The infusion pump can also compress a tube using a movable member of the pump and records the distance traveled by the movable member to compress fully the tube. Using this distance, the tubing wall thickness can be determined.
Abstract:
A renal failure blood therapy system includes: (i) a renal failure blood therapy machine; (ii) a therapy prescription for a patient treated by the renal failure blood therapy machine to remove a solute from the patient's blood; (iii) a test including multiple blood samples taken at multiple times during a test therapy to determine concentration levels of the solute at each of the multiple times; and (iv) a device programmed to use a kinetic model for the solute in a first instance with at least one of the concentration levels of the solute to estimate at least one estimated patient parameter. The device is further programmed to enable a user to determine at least one of a therapy duration, a therapy frequency, a dialysate flowrate or a blood flowrate for the therapy prescription.
Abstract:
The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.
Abstract:
Aspects of the invention include methods for enhancing blood coagulation in a subject. In practicing methods according to certain embodiments, an amount of a non-anticoagulant sulfated polysaccharide (NASP) is administered to a subject to enhance blood coagulation in the subject. Also provided are methods for preparing a NASP composition having blood coagulation enhancing activity. Compositions and kits for practicing methods of the invention are also described.
Abstract:
An infusion pump uses an improved shuttle mechanism to more reliably pump liquids in low volumes for medical and other purposes. The improved shuttle uses linear translation and wider, symmetric jaws to grasp infusate tubing and pump liquid infusate through the tubing. Adjustment of the linear motion allows a user to also adjust a pumping volume of the infusion pump. Other shuttles with wider jaws may also pump infusate using a rotary motion. In addition, more than one shuttle, such as two or three shuttles, may be used to approximate continuous pumping. A series of several smaller linear shuttles with sequential actuation may be used as a linear peristaltic pump for general peristaltic pump applications.
Abstract:
The present invention relates, generally, to a transgenic non-human animal model of hemophilia A, wherein the transgenic animal is deficient in endogenous Factor VIII and endogenous von Willebrand Factor, and methods to treat hereditary or acquired hemophilia A or von Willebrand Disease (VWD) by administration of exogenous human VWF.
Abstract:
A low noise solenoid valve system (10) includes a solenoid valve (20); and a controller (50) configured to perform a power actuation sequence in which power to the solenoid (20) valve undergoes a plurality of cycles that switch from an actuation level power to a hold level power, wherein the actuation level power is increased at each subsequent cycle, and wherein the actuation power level of one of the plurality of cycles is sufficient to fully actuate the solenoid valve (20).
Abstract:
The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.
Abstract:
Multilayer films comprising a core layer are provided. In an embodiment, the present disclosure provides a film having a core layer comprising a material selected from a rubber-modified polypropylene and a polymer blend. The polymer blend includes an elastomeric propylene-ethylene copolymer and a component selected from the group consisting of polypropylene random copolymers, styrene/ethylene-butylene/styrene block copolymers, and combinations thereof.