公开(公告)号：WO2012154009A3

公开(公告)日：2013-03-21

申请号：PCT/KR2012003722

申请日：2012-05-11

申请人： KOREA RES INST CHEM TECH ,  JEON MOON KOOK ,  AHN JIN HEE ,  KANG SEUNG KYU ,  LEE KYU MYUNG ,  RHEE SANG DAL ,  KIM HI YOUN ,  JUNG WON HOON ,  KIM KWANG ROK ,  BAE MYUNG-AE ,  SONG JIN SOOK ,  SUH JEE HEE ,  KANG MYOUNG KU ,  KIM MIN HYE

发明人： JEON MOON KOOK ,  AHN JIN HEE ,  KANG SEUNG KYU ,  LEE KYU MYUNG ,  RHEE SANG DAL ,  KIM HI YOUN ,  JUNG WON HOON ,  KIM KWANG ROK ,  BAE MYUNG-AE ,  SONG JIN SOOK ,  SUH JEE HEE ,  KANG MYOUNG KU ,  KIM MIN HYE

IPC分类号： C07D495/04 ,  A61K31/519 ,  A61P3/10 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07D495/04

摘要： The present invention relates to novel thienopyrimidine derivatives, and to a pharmaceutical composition containing thienopyrimidine derivatives as active ingredients for preventing or treating diabetes or various diabetes-related diseases. The thienopyrimidine derivatives of the present invention efficiently accelerate the activity of G protein-coupled receptor 119 (GPR119), which has the effects of increasing glucose-dependent insulin secretion and inhibiting increases in appetite and body weight, thus enhancing glucose metabolism and lipid metabolism. Therefore, the thienopyrimidine derivatives of the present invention may be valuably used in a composition for efficiently preventing and treating not only diabetes but also various complications of diabetes such as obesity, hyperlipidemia, and diabetic vascular diseases.

摘要翻译： 本发明涉及新颖的噻吩并嘧啶衍生物，以及含有噻吩并嘧啶衍生物作为预防或治疗糖尿病或各种糖尿病相关疾病的有效成分的药物组合物。 本发明的噻吩并嘧啶衍生物有效加速G蛋白偶联受体119（GPR119）的活性，其具有增加葡萄糖依赖性胰岛素分泌和抑制食欲和体重增加的作用，从而增强葡萄糖代谢和脂质代谢。 因此，本发明的噻吩并嘧啶衍生物可以有价值地用于不仅有效预防和治疗糖尿病的组合物，还包括肥胖症，高脂血症和糖尿病性血管疾病等糖尿病的各种并发症。

公开(公告)号：WO2012134233A3

公开(公告)日：2013-01-10

申请号：PCT/KR2012002407

申请日：2012-03-30

申请人： KOREA RES INST CHEM TECH ,  SK BIOPHARMACEUTICALS CO LTD ,  KIM KI YOUNG ,  AHN JIN HEE ,  KANG SEUNG KYU ,  RHEE SANG DAL ,  BAE MYUNG AE ,  AHN SUNG HOON ,  KIM HEE YOUN ,  JUNG WON HOON ,  KANG NAM SOOK

发明人： KIM KI YOUNG ,  AHN JIN HEE ,  KANG SEUNG KYU ,  BAE MYUNG AE ,  AHN SUNG HOON ,  KIM HEE YOUN ,  JUNG WON HOON ,  KANG NAM SOOK

IPC分类号： C07C307/06 ,  A61K31/18 ,  A61P3/10

CPC分类号： C07D417/04 ,  A61K31/18 ,  C07C307/10 ,  C07C2603/74 ,  C07D285/10 ,  C07D285/14 ,  C07D285/15 ,  C07D285/16 ,  C07D285/36 ,  C07D417/10 ,  C07D417/12

摘要： Provided is a sulphamide derivative having an adamantyl group, represented by the accompanying chemical formula 1, or a pharmaceutically acceptable salt thereof. The sulphamide derivative suppresses the activity of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1), and is useful in the treatment of various diseases that are mediated by 11ß-HSD1.

摘要翻译： 提供具有金刚烷基的磺酰胺衍生物，由所附化学式1表示，或其药学上可接受的盐。 磺酰胺衍生物抑制11β-羟基类固醇脱氢酶1型（11β-HSD1）的活性，可用于治疗由11β-HSD1介导的各种疾病。

公开(公告)号：WO2008087560A3

公开(公告)日：2008-09-12

申请号：PCT/IB2008000773

申请日：2008-01-16

申请人： KAINOS MEDICINE INC ,  KOREAN RES INST OF CHEMICAL TE ,  YUNGJIN PHARM CO LTD ,  KIM SUNG SOO ,  AHN JIN HEE ,  CHEON HYAE GYEONG ,  RHEE SANG DAL ,  KANG NAM SOOK ,  KIM KI YOUNG ,  KANG SEUNG KYU ,  JUNG WON HOON ,  KIM SUNG GYU ,  KIM SUN YOUNG ,  KWEON JAE HONG ,  SOHN SANG KWON ,  SHIN MIN KI ,  HA NI NA

发明人： KIM SUNG SOO ,  AHN JIN HEE ,  CHEON HYAE GYEONG ,  RHEE SANG DAL ,  KANG NAM SOOK ,  KIM KI YOUNG ,  KANG SEUNG KYU ,  JUNG WON HOON ,  KIM SUNG GYU ,  KIM SUN YOUNG ,  KWEON JAE HONG ,  SOHN SANG KWON ,  SHIN MIN KI ,  HA NI NA

IPC分类号： C07D277/06 ,  A61K31/427 ,  A61P3/10 ,  C07D417/12

CPC分类号： C07D277/06 ,  C07D417/12 ,  Y02P20/55

摘要： The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a ß-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.

摘要翻译： 本发明涉及在游离的前体药物形式或其药学上可接受的盐，包括它们的对映异构体，非对映异构体和外消旋体的酰基链上具有β-氨基的新的2-羰基-3-酰基-1,3-噻唑烷， 有效的抗DPP-IV抑制剂。 本发明进一步涉及包含所公开的化合物的药物组合物。 本发明还涉及制备所公开的化合物和用于治疗DPP-IV介导的疾病的方法。

公开(公告)号：WO2005100297A1

公开(公告)日：2005-10-27

申请号：PCT/KR2005/001051

申请日：2005-04-12

申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  JEIL PHARM. CO., LTD. ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  CJ CORP. ,  CHEON, Hyae Gyeong ,  YOO, Sung-Eun ,  KIM, Sung Soo ,  YANG, Sung-Don ,  KIM, Kwang-Rok ,  RHEE, Sang Dal ,  AHN, Jin Hee ,  KANG, Seung Kyu ,  JUNG, Won Hoon ,  PARK, Sung Dae ,  KIM, Nam Gee ,  KIM, Sun Mee ,  MO, Kil Woong ,  LEE, Jae Mok ,  KANG, Hye Jung ,  LEE, Koun Ho ,  KIM, Jong Hoon ,  LEE, Jeong-Hyung ,  KIM, Seung Jun

发明人： CHEON, Hyae Gyeong ,  YOO, Sung-Eun ,  KIM, Sung Soo ,  YANG, Sung-Don ,  KIM, Kwang-Rok ,  RHEE, Sang Dal ,  AHN, Jin Hee ,  KANG, Seung Kyu ,  JUNG, Won Hoon ,  PARK, Sung Dae ,  KIM, Nam Gee ,  KIM, Sun Mee ,  MO, Kil Woong ,  LEE, Jae Mok ,  KANG, Hye Jung ,  LEE, Koun Ho ,  KIM, Jong Hoon ,  LEE, Jeong-Hyung ,  KIM, Seung Jun

IPC分类号： C07C69/753

CPC分类号： C07D295/088 ,  C07C65/26 ,  C07C69/757 ,  C07C229/50 ,  C07C233/52 ,  C07C255/47 ,  C07C2601/14 ,  C07C2602/08 ,  C07D295/155

摘要： The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.

摘要翻译： 式（I）的本发明的茚衍生物能够选择性调节过氧化物酶体增殖物激活受体（PPAR）的活性，不引起副作用，因此它们可用于治疗和预防由PPARs调节的病症， 糖尿病，肥胖，动脉硬化，高脂血症，高胰岛素血症和高血压等代谢综合征，骨质疏松症，肝硬化和哮喘等炎性疾病和癌症。

公开(公告)号：WO2012081893A3

公开(公告)日：2012-08-16

申请号：PCT/KR2011009597

申请日：2011-12-13

申请人： KOREA RES INST CHEM TECH ,  AHN JIN-HEE ,  BAE MYUNG-AE ,  CHOI EUN-BOK

发明人： AHN JIN-HEE ,  BAE MYUNG-AE ,  CHOI EUN-BOK

IPC分类号： C07D209/36 ,  A61K31/4015 ,  A61K31/404 ,  A61K49/00

CPC分类号： A61K31/4015 ,  A61K31/404 ,  A61K49/006 ,  C07D209/42

摘要： The present invention relates to a novel 3-indolinon derivative and a composition having same, which enable selective fluorescent dyeing of fat in particular, and thus, can be useful as a bio-diagnostic reagent.

摘要翻译： 本发明涉及新的3-吲哚满酮衍生物和具有该衍生物的组合物，其特别是能够对脂肪进行选择性荧光染色，因此可用作生物诊断试剂。

公开(公告)号：WO2008087560A9

公开(公告)日：2008-07-24

申请号：PCT/IB2008/000773

申请日：2008-01-16

申请人： KAINOS MEDICINE, INC., ,  KOREAN RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  YUNGJIN PHARM. Co Ltd., ,  KIM, Sung Soo ,  AHN, Jin Hee ,  CHEON, Hyae Gyeong ,  RHEE, Sang Dal ,  KANG, Nam Sook ,  KIM, Ki Young ,  KANG, Seung Kyu ,  JUNG, Won Hoon ,  KIM, Sung Gyu ,  KIM, Sun Young ,  KWEON, Jae Hong ,  SOHN, Sang Kwon ,  SHIN, Min Ki ,  HA, Ni Na

发明人： KIM, Sung Soo ,  AHN, Jin Hee ,  CHEON, Hyae Gyeong ,  RHEE, Sang Dal ,  KANG, Nam Sook ,  KIM, Ki Young ,  KANG, Seung Kyu ,  JUNG, Won Hoon ,  KIM, Sung Gyu ,  KIM, Sun Young ,  KWEON, Jae Hong ,  SOHN, Sang Kwon ,  SHIN, Min Ki ,  HA, Ni Na

IPC分类号： C07D277/22 ,  C07D277/24 ,  C07D277/04 ,  A61P3/04 ,  A61P3/10 ,  A61P19/10

摘要： The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a β-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.

公开(公告)号：WO2007081091A8

公开(公告)日：2007-11-22

申请号：PCT/KR2006005343

申请日：2006-12-08

申请人： KOREA RES INST OF BIOSCIENCE ,  KOREA RES INST CHEM TECH ,  RYU SEONG EON ,  KIM SEUNG JUN ,  JEONG DAE GWIN ,  LEE SANG HYEUP ,  JUNG SUK KYEONG ,  KIM HWAN MOOK ,  PARK SONG KYU ,  LEE KI HO ,  LEE CHANG WOO ,  CHOI JOONG-KWON ,  AHN JIN HEE

发明人： RYU SEONG EON ,  KIM SEUNG JUN ,  JEONG DAE GWIN ,  LEE SANG HYEUP ,  JUNG SUK KYEONG ,  KIM HWAN MOOK ,  PARK SONG KYU ,  LEE KI HO ,  LEE CHANG WOO ,  CHOI JOONG-KWON ,  AHN JIN HEE

IPC分类号： C07D277/06 ,  A61K31/426 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00

CPC分类号： C07D277/20 ,  C07D417/12

摘要： Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTPlB, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PPl and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity fliereof is modulated.

摘要翻译： 本文公开了绕丹宁衍生物，其制备方法和含有它们的药物组合物。 罗丹明衍生物对PTPlB，Prl-3，LAR，CD45，Cdc25A，Cdc25B，Cdc25C，Yop，PP1和VHR等蛋白磷酸酶（PPase）具有抑制活性，可用于预防和治疗PPase引起的疾病 包括自身免疫疾病，糖尿病，葡萄糖不耐受受损，胰岛素抵抗，肥胖，癌症等。

公开(公告)号：WO2005100303A1

公开(公告)日：2005-10-27

申请号：PCT/KR2005/001066

申请日：2005-04-13

申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  JEIL PHARM. CO., LTD. ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  CJ CORP. ,  CHEON, Hyae Gyeong ,  YOO, Sung-Eun ,  KIM, Sung Soo ,  YANG, Sung-Don ,  KIM, Kwang-Rok ,  RHEE, Sang Dal ,  AHN, Jin Hee ,  KANG, Seung Kyu ,  JUNG, Won Hoon ,  PARK, Sung Dae ,  KIM, Nam Gee ,  LEE, Jang Hyuk ,  HUH, Sun Chul ,  LEE, Jae Mok ,  SONG, Seog Beom ,  KWON, Soon Ji ,  KIM, Jong Hoon ,  LEE, Jeong-Hyung ,  KIM, Seung Jun

发明人： CHEON, Hyae Gyeong ,  YOO, Sung-Eun ,  KIM, Sung Soo ,  YANG, Sung-Don ,  KIM, Kwang-Rok ,  RHEE, Sang Dal ,  AHN, Jin Hee ,  KANG, Seung Kyu ,  JUNG, Won Hoon ,  PARK, Sung Dae ,  KIM, Nam Gee ,  LEE, Jang Hyuk ,  HUH, Sun Chul ,  LEE, Jae Mok ,  SONG, Seog Beom ,  KWON, Soon Ji ,  KIM, Jong Hoon ,  LEE, Jeong-Hyung ,  KIM, Seung Jun

IPC分类号： C07C251/44

CPC分类号： C07D213/30 ,  C07C291/02 ,  C07C309/66 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2603/74 ,  C07D213/53 ,  C07D233/64 ,  C07D277/24 ,  C07D295/088 ,  C07D295/185 ,  C07D307/54 ,  C07D317/60 ,  C07D317/70 ,  C07D333/24 ,  C07D333/28 ,  C07D417/12

摘要： The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.

摘要翻译： 本发明式（I）的茚衍生物能够选择性地调节过氧化物酶体增殖物激活受体（PPAR）的活性，引起无副作用，因此它们可用于治疗和预防 由PPARs调节的疾病，即代谢综合征如糖尿病，肥胖症，动脉硬化，高脂血症，高胰岛素血症和高血压，炎性疾病如骨质疏松症，肝硬化和哮喘以及癌症。

公开(公告)号：WO2007081091A1

公开(公告)日：2007-07-19

申请号：PCT/KR2006/005343

申请日：2006-12-08

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  RYU, Seong Eon ,  KIM, Seung Jun ,  JEONG, Dae Gwin ,  LEE, Sang Hyeup ,  JUNG, Suk Kyeong ,  KIM, Hwan Mook ,  PARK, Song Kyu ,  LEE, Ki Ho ,  LEE, Chang Woo ,  CHOI, Joong-Kwon ,  AHN, Jin Hee

发明人： RYU, Seong Eon ,  KIM, Seung Jun ,  JEONG, Dae Gwin ,  LEE, Sang Hyeup ,  JUNG, Suk Kyeong ,  KIM, Hwan Mook ,  PARK, Song Kyu ,  LEE, Ki Ho ,  LEE, Chang Woo ,  CHOI, Joong-Kwon ,  AHN, Jin Hee

IPC分类号： C07D277/06 ,  A61K31/426 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00

CPC分类号： C07D277/20 ,  C07D417/12

摘要： Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTPlB, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PPl and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity fliereof is modulated.

摘要翻译： 本文公开了罗丹宁衍生物，其制备方法以及包含其的药物组合物。 绕丹宁衍生物对PTP1B，Prl-3，LAR，CD45，Cdc25A，Cdc25B，Cdc25C，Yop，PP1和VHR等蛋白质磷酸酶（PPase）具有抑制活性，可用于预防和治疗由PPase引起的疾病 ，包括自身免疫性疾病，糖尿病，葡萄糖耐受不良，胰岛素抵抗，肥胖症，癌症等，当抑制活性受到调节时。

公开(公告)号：WO2012002642A3

公开(公告)日：2012-02-23

申请号：PCT/KR2011003358

申请日：2011-05-04

申请人： YOOHO DEV & CONSTRUCTION CO LTD ,  UNIV YONSEI IACF ,  KIM SANG HYO ,  AHN JIN HEE ,  YOO JUNG HO ,  HAN SEUNG SOO ,  CHO CHANG KEON ,  CHOI KYU TAE

发明人： KIM SANG HYO ,  AHN JIN HEE ,  YOO JUNG HO ,  HAN SEUNG SOO ,  CHO CHANG KEON ,  CHOI KYU TAE

IPC分类号： E01D2/00 ,  E04C3/04

CPC分类号： E04C5/162 ,  E01D2/00 ,  E01D2/02 ,  E01D2101/32 ,  E04C3/04 ,  E04C5/08 ,  E04C2003/0417 ,  E04C2003/0434 ,  E04C2003/0452

摘要： The present invention relates to a steel structure including a pre-stressing bracket for improving load-carrying capacity and serviceability, and more particularly, to a steel structure including: a steel girder; a plurality of connecting brackets connected to the bottom surface of the steel girder, and spaced apart from one another; and a cover plate connected to the bottom surfaces of the connecting brackets. Accordingly, since the cover plate is installed regardless of the connecting portion of the steel girder, pre-stressing sections can be consecutively formed to improve the pre-stress effect. In addition, since the connecting brackets space the steel girder a constant distance from the cover plate, the second moment of area is increased to maximize area efficiency, thereby increasing the span of a bridge.

摘要翻译： 本发明涉及一种钢结构，其包括用于提高承载能力和可使用性的预应力支架，更具体地，涉及一种钢结构，包括：钢梁; 多个连接支架连接到钢梁的底表面并且彼此间隔开; 以及连接到连接支架的底表面的盖板。 因此，由于不管钢梁的连接部分如何安装盖板，因此能够连续地形成预应力部，以提高预应力的效果。 此外，由于连接支架将盖板与盖板间隔一定距离，所以增加了第二时刻的面积以使面积效率最大化，从而增加了桥的跨度。