-
公开(公告)号：WO2012168350A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/060785
申请日：2012-06-07
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , GRETHER, Uwe , HEBEISEN, Paul , KIMBARA, Atsushi , LIU, Qingping , NETTEKOVEN, Matthias , PRUNOTTO, Marco , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja , ULLMER, Christoph , WANG, Zhiwei , YANG, Wulun
Inventor： BISSANTZ, Caterina , GRETHER, Uwe , HEBEISEN, Paul , KIMBARA, Atsushi , LIU, Qingping , NETTEKOVEN, Matthias , PRUNOTTO, Marco , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja , ULLMER, Christoph , WANG, Zhiwei , YANG, Wulun
IPC: C07D213/81 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107 , A61K31/44 , A61P29/00
CPC classification number: C07D213/81 , C07D213/79 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107
Abstract: The invention relates to a compound of formula (I) wherein R 1 to R 4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Abstract translation: 本发明涉及式（I）化合物，其中R 1至R 4如说明书和权利要求中所定义。 式（I）化合物可以用作药物。
-
2.发明申请4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS 审中-公开4-苯氧基-N-或4-苯氧基 - 吡咯烷-5-羧酰胺化合物
公开(公告)号：WO2011089099A1
公开(公告)日：2011-07-28
申请号：PCT/EP2011/050558
申请日：2011-01-18
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
Inventor： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
IPC: C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12 , A61K31/44 , A61K31/4427 , A61K31/506 , A61P3/00
CPC classification number: C07D417/14 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D417/12
Abstract: This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula (I), wherein A 1 , A 2 , B 1 , B 2 and R 1 to R 11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
Abstract translation: 本发明涉及式（I）的新型苯基酰胺或吡啶基酰胺衍生物，其中A1，A2，B1，B2和R1至R11如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，可用作治疗II型糖尿病等疾病的药物。
-
3.发明申请[1, 2, 3]TRIAZOLO [4, 5 -D] PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 AGONISTS 审中-公开[1,2,3]三唑并[4,5-D]吡啶衍生物作为CANNABINOID受体2激动剂的激素
公开(公告)号：WO2013076182A1
公开(公告)日：2013-05-30
申请号：PCT/EP2012/073315
申请日：2012-11-22
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
Inventor： BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC: C07D487/04 , A61K31/519
CPC classification number: C07D487/04 , A61K9/0019 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K47/10 , A61K47/12
Abstract: The invention relates to a compound of formula (I) wherein A and R to R 3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Abstract translation: 本发明涉及式（I）化合物，其中A和R至R 3如说明书和权利要求中所定义。 式（I）化合物可以用作药物。
-
公开(公告)号：WO2008080844A1
公开(公告)日：2008-07-10
申请号：PCT/EP2007/064183
申请日：2007-12-19
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
Inventor： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC: C07D491/20 , A61K31/438 , A61P9/12 , A61P25/24
CPC classification number: C07D491/20
Abstract: The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of the general formula (I) wherein R 1 to R 6 , U, V, W, X, Y and Z are as defined in the specification.
Abstract translation: 本发明涉及新的吲哚-3-基 - 羰基 - 氮杂螺哌啶衍生物作为V1a受体拮抗剂，它们的制备，含有它们的药物组合物及其作为药物的用途。 本发明的活性化合物可用于预防和/或治疗焦虑抑郁症和其它疾病。 特别地，本发明涉及通式（I）的化合物，其中R 1至R 6，U，V，W，X，Y和Z分别为 如说明书中所定义。
-
公开(公告)号：WO2008080842A1
公开(公告)日：2008-07-10
申请号：PCT/EP2007/064176
申请日：2007-12-19
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
Inventor： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC: C07D401/14 , A61K31/404 , A61P25/00 , A61P9/00
CPC classification number: C07D401/14
Abstract: The present invention is concerned with novel indol-3-yl-carbonyl-piperidine-benzopyrrolone, -benzoxazolone and -benzotriazole derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of the general formula (I) wherein X, Y and R 1 to R 10 are as described in the specification.
Abstract translation: 本发明涉及作为V1a受体拮抗剂的新的吲哚-3-基 - 羰基 - 哌啶 - 苯并吡咯啉酮 - 苯并恶唑酮和 - 苯并三唑衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。 本发明的活性化合物可用于预防和/或治疗焦虑和抑郁症等疾病。 特别地，本发明涉及通式（I）的化合物，其中X，Y和R 1至R 10如说明书所述。
-
Patent Agency Ranking
公开(公告)号：WO2008077811A1
公开(公告)日：2008-07-03
申请号：PCT/EP2007/063882
申请日：2007-12-13
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
Inventor： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC: C07D211/16 , C07D471/10 , C07D491/10 , C07D519/00 , A61K31/438 , A61K31/5377 , A61P25/00
CPC classification number: C07D211/16 , C07D471/10 , C07D491/10 , C07D519/00
Abstract: The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of the general formula (I), wherein R 1 to R 5 , R 5' , X, Y and A are as defined in the specification.
Abstract translation: 本发明涉及作为V1a受体拮抗剂的新型螺 - 哌啶衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。 本发明的活性化合物可用于预防和/或治疗焦虑和抑郁症等疾病。 特别地，本发明涉及通式（I）的化合物，其中R 1至R 5，R 5'， X，Y和A如说明书中所定义。
-
公开(公告)号：WO2008068159A1
公开(公告)日：2008-06-12
申请号：PCT/EP2007/062857
申请日：2007-11-27
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
Inventor： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC: C07D471/10 , C07D498/10 , A61K31/438 , A61P9/02
CPC classification number: C07D471/10 , C07D498/10
Abstract: Present invention is concerned with novel indol-2-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. The compounds of present invention have the general Formula (I) wherein R 1 to R 11 and X are as defined in the description.
Abstract translation: 本发明涉及作为V1a受体拮抗剂的新的吲哚-2-基 - 羰基 - 螺 - 哌啶衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。 本发明的活性化合物可用于预防和/或治疗焦虑和抑郁症等疾病。 本发明的化合物具有通式（I），其中R 1至R 11和X如说明书中所定义。
-
8.发明申请INDOL-3-YL-CARBONYL-AZASPIRO DERIVATIVES AS VASOPRESSIN RECEPTOR ANTAGONISTS 审中-公开吲哚-3-甲基亚苄基衍生物作为血管紧张素受体拮抗剂
公开(公告)号：WO2007039438A1
公开(公告)日：2007-04-12
申请号：PCT/EP2006/066441
申请日：2006-09-18
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
Inventor： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC: C07D491/10 , C07D471/10 , A61K31/4355 , A61K31/437 , A61P9/00 , A61P25/00
CPC classification number: C07D471/10 , C07D491/10
Abstract: This invention relates to indol-3-yl-carbonyl-azaspiro derivatives which act as Via receptor antagonists and which are represented by Formula (I) wherein the azaspiro-head group A and the residues R 1 , R 2 and R 3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders, and methods of preparation thereof.
Abstract translation: 本发明涉及作为Via受体拮抗剂并由式（I）表示的吲哚-3-基 - 羰基 - 氮杂螺环衍生物，其中阿扎头罗头基A和残基R 1，R ＆lt; SUP＆gt; 2＆gt;和＆lt; 3＆gt;如本文所定义。 本发明还涉及含有这些化合物的药物组合物，其用于抗痛经，高血压，慢性心力衰竭，不适当的血管加压素分泌，肝硬化，肾病综合征，强迫症，焦虑和抑郁障碍的药物中的用途及其制备方法。
-
公开(公告)号：WO2007014851A2
公开(公告)日：2007-02-08
申请号：PCT/EP2006/064395
申请日：2006-07-19
Applicant: F. HOFFMANN-LA ROCHE AG , BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
Inventor： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC: C07D401/06 , C07D405/14 , C07D209/22 , C07D209/42
CPC classification number: C07D209/42 , C07D209/22 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D495/04
Abstract: The present invention relates to indol-3-yl-carbonyl-piperidin and piperazin derivatives which act as V1a receptor antagonists and which are represented by Formula (I) wherein the residues R 1 to R 3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders, and methods of preparation thereof.
Abstract translation: 本发明涉及作为V1a受体拮抗剂并由式（I）表示的吲哚-3-基 - 羰基 - 哌啶和哌嗪衍生物，其中残基R 1至R 3 如本文所定义。 本发明还涉及含有这些化合物的药物组合物，它们在抗痛经药物，高血压，慢性心力衰竭，不适当的血管加压素分泌，肝硬化，肾病综合征，强迫症，焦虑和抑郁障碍中的用途及其制备方法。
-
10.发明申请[1, 2, 3] TRIAZOLO [4, 5 -D] PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 审中-公开[1,2,3]三唑并[4,5-D]吡啶衍生物作为CANNABINOID受体2的激动剂
公开(公告)号：WO2013068306A1
公开(公告)日：2013-05-16
申请号：PCT/EP2012/071788
申请日：2012-11-05
Applicant: F. HOFFMANN-LA ROCHE AG , ADAM, Jean-Michel , BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
Inventor： ADAM, Jean-Michel , BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC: C07D487/04 , A61K31/519 , A61P3/10 , A61P9/10 , A61P27/06
CPC classification number: C07D487/04 , A61K9/0019 , A61K9/2054 , A61K9/4866 , A61K31/519 , A61K47/10 , C07D491/107
Abstract: The invention relates to a compound of formula (I), wherein A, R 1 and R 2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament as agonists of the cannabinoid receptor 2.
Abstract translation: 本发明涉及式（I）化合物，其中A，R 1和R 2如描述和权利要求中所定义。 式（I）化合物可以用作大麻素受体2的激动剂的药物。
-
-
-
-
-
-
-
-
-
Search Results
33
records
(took 0.02 seconds)
