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1.发明申请
公开(公告)号：WO2012143404A1
公开(公告)日：2012-10-26
申请号：PCT/EP2012/057094
申请日：2012-04-18
Applicant: NESTEC S.A. , GREENBERG, Norman, Alan , BREUILLE, Denis , ROUGHEAD, Zamzam, Kabiry (Fariba) , BOLSTER, Doug , MAGER, Jennifer
Inventor： GREENBERG, Norman, Alan , BREUILLE, Denis , ROUGHEAD, Zamzam, Kabiry (Fariba) , BOLSTER, Doug , MAGER, Jennifer
CPC classification number: A61K31/7105 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/19 , A61K31/194 , A61K31/198 , A61K31/20 , A61K31/202 , A61K31/205 , A61K31/711 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K36/064 , A61K45/06 , Y02E10/721 , A23V2200/316 , A23V2250/156 , A23V2250/1882 , A23V2250/628 , A23V2250/70
Abstract: Nutritional compositions for maximizing muscle protein synthesis while minimizing the catabolism of muscle proteins and methods of using same are provided. In this manner, the nutritional compositions may provide for retention of lean body mass, which helps to avoid loss of independence and functionality, as well as to improve quality of life especially in the elderly at risk of sarcopenia and frailty. The nutritional compositions include α-hydroxyisocaproic acid eicosapentaenoic acid. It may include other functional ingredients such as, but not limited to whey protein incuding whey protein micelles, prebiotic fibers, citrulline, α-ketoglutarate, L-carnitine, nucleotides, and amino acids. Methods of administering such nutritional products to individuals in need of same are also provided.
Abstract translation: 提供了使肌肉蛋白质合成最大化同时最小化肌肉蛋白质分解代谢的营养组合物及其使用方法。 以这种方式，营养组合物可以提供保持瘦体重，这有助于避免丧失独立性和功能性，以及改善生活质量，特别是在具有肌肉衰弱和虚弱风险的老年人中。 营养组合物包括α-羟基异己酸二十碳五烯酸。 它可以包括其它功能成分，例如但不限于包含乳清蛋白胶束，益生元纤维，瓜氨酸，α-酮戊二酸，L-肉碱，核苷酸和氨基酸的乳清蛋白。 还提供了向需要相同的个体施用这种营养产品的方法。
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公开(公告)号：WO2012045801A1
公开(公告)日：2012-04-12
申请号：PCT/EP2011/067434
申请日：2011-10-06
Applicant: NESTEC S.A. , BOVETTO, Lionel , BREUILLE, Denis , DONATO, Laurence , POUTEAU, Etienne , SCHMITT, Christophe , PANCHAUD, Alexandre
Inventor： BOVETTO, Lionel , BREUILLE, Denis , DONATO, Laurence , POUTEAU, Etienne , SCHMITT, Christophe , PANCHAUD, Alexandre
IPC: A61K9/19 , A61K9/50 , A61K38/16 , A61K9/00 , A61P31/04 , A61P31/12 , A61P3/10 , A61P5/50 , A61P1/14 , A61P3/00 , A61P37/04
CPC classification number: A61K38/40 , A23L33/17 , A23V2002/00 , A61K2300/00 , A23V2200/328 , A23V2200/332 , A23V2250/54244 , A23V2250/54248
Abstract: Lactoferrin-based complex coacervate inducing delayed protein digestion and modified peptide profile for improving metabolic responses, gut inflammatory response, satiety and food intake in humans, in association with an increase in GLP-1 and PYY gut hormones.
Abstract translation: 与GLP-1和PYY肠激素增加相关的，基于乳铁蛋白的复合凝集物诱导延迟蛋白质消化和修饰的肽谱，用于改善人类的代谢反应，肠炎症反应，饱腹感和食物摄取。
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公开(公告)号：WO2004112512A1
公开(公告)日：2004-12-29
申请号：PCT/EP2004/006469
申请日：2004-06-16
Applicant: NESTEC S.A. , FAURE, Magali , ROCHAT, Florence , BREUILLE, Denis , CORTHESY-THEULAZ, Irène
Inventor： FAURE, Magali , ROCHAT, Florence , BREUILLE, Denis , CORTHESY-THEULAZ, Irène
IPC: A23L1/305
CPC classification number: A61K31/198 , A23K20/142 , A23K20/147 , A23K50/40 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K9/0095 , A61K31/195 , A61K31/401 , A23V2250/0642 , A23V2250/064 , A23V2250/0648 , A23V2250/0616 , A23V2250/0612 , A23V2250/16 , A23V2250/1578 , A23V2250/161 , A23V2250/1612 , A23V2250/1592 , A23V2250/1588 , A23V2250/1642 , A23V2250/06 , A23V2250/156 , A23V2250/702 , A23V2250/704 , A23V2250/641 , A23V2250/0644
Abstract: The present invention pertains to a nutritional composition for reconstituting an optimal healthy microbiota ecosystem in humans or animals. In particular, the present invention relates to an ingestible carrier containing specific amino acids designed to favor the growth of bacteria favorable to individuals health or for reducing the risk of developing deleterious events. The invention also pertains to the use of specific amino acids for reconstituting an optimal healthy microbiota ecosystem in humans or animals, in particular in infants, critically ill patients, in the case of chronic diseases or any stresses impacting the gut and in elderly people.
Abstract translation: 本发明涉及用于重建人或动物中最佳健康微生物群落生态系统的营养组合物。 特别地，本发明涉及含有特定氨基酸的可摄入载体，其被设计为有利于有利于个人健康的细菌的生长或用于降低发生有害事件的风险。 本发明还涉及特定氨基酸用于在人或动物，特别是婴儿，危重病患者，慢性疾病或任何影响肠道和老年人的压力的情况下，重建最佳的健康微生物群落生态系统。
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公开(公告)号：WO0119356A3
公开(公告)日：2001-05-17
申请号：PCT/EP0008731
申请日：2000-09-07
Applicant: NESTLE SA , TURINI MARCO , ROESSLE CLAUDIA , BREUILLE DENIS , CROZIER WILLI GAYLE , FINOT PAUL ANDRE , RICHELLE MYRIAM , DUTOT GUY
Inventor： TURINI MARCO , ROESSLE CLAUDIA , BREUILLE DENIS , CROZIER-WILLI GAYLE , FINOT PAUL-ANDRE , RICHELLE MYRIAM , DUTOT GUY
IPC: A23L33/00 , A23L33/12 , A23L33/15 , A23L33/16 , A61K31/00 , A61K31/202 , A61K31/23 , A61K47/00 , A61P3/00 , A61P29/00 , A61P43/00 , A23L1/30
Abstract: A composition for use as a medicament or nutritional product is described which comprises at least one lipid wherein the lipid provides greater than 35 % total energy of the composition. A prefered embodiment comprises a n-6/n-3 fatty acid ratio of about 2/1 to 7/1. In addition, a method of preparing the composition; use of the composition in the manufacture of a medicament or nutritional product; and a method of treatment or prevention of sepsis or inflammatory shock which comprises administering an effective amount of the composition are described.
Abstract translation: 描述了用作药物或营养产品的组合物，其包含至少一种脂质，其中所述脂质提供组合物的总能量的35％以上。 优选的实施方案包括约2/1至7/1的n-6 / n-3脂肪酸比。 另外，制备组合物的方法; 在制备药物或营养产品中使用该组合物; 以及治疗或预防败血症或炎性休克的方法，其包括施用有效量的组合物。
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5.发明申请NUTRITIONAL COMPOSITIONS HAVING ALPHA-HICA AND ALPHA-KETOGLUTARATE 审中-公开有ALPHA-HICA和ALPHA-KETOGLUTARATE的营养组合物
公开(公告)号：WO2012143405A1
公开(公告)日：2012-10-26
申请号：PCT/EP2012/057095
申请日：2012-04-18
Applicant: NESTEC S.A. , GREENBERG, Norman, Alan , BREUILLE, Denis , ROUGHEAD, Zamzam, Kabiry (Fariba) , BOLSTER, Doug , MAGER, Jennifer
Inventor： GREENBERG, Norman, Alan , BREUILLE, Denis , ROUGHEAD, Zamzam, Kabiry (Fariba) , BOLSTER, Doug , MAGER, Jennifer
CPC classification number: A61K31/7105 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/19 , A61K31/194 , A61K31/198 , A61K31/20 , A61K31/202 , A61K31/205 , A61K31/711 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K36/064 , A61K45/06 , Y02E10/721 , A23V2200/316 , A23V2250/156 , A23V2250/1882 , A23V2250/628 , A23V2250/70
Abstract: Nutritional compositions for maximizing muscle protein synthesis while minimizing the catabolism of muscle proteins and methods of using same are provided. In this manner, the nutritional compositions may provide for retention of lean body mass, which helps to avoid loss of independence and functionality, as well as to improve quality of life especially in the elderly at risk of sarcopenia and frailty. The nutritional compositions include α-hydroxyisocaproic acid and α-ketoglutarate. The composition may include other functional ingredients such as, but not limited to whey protein including whey protein micelles, prebiotic fibers, citrulline, eicosapentaenoic acid, L-carnitine, nucleotides, and amino acids. Methods of administering such nutritional products to individuals in need of same are also provided.
Abstract translation: 提供了使肌肉蛋白质合成最大化同时最小化肌肉蛋白质分解代谢的营养组合物及其使用方法。 以这种方式，营养组合物可以提供保持瘦体重，这有助于避免丧失独立性和功能性，以及改善生活质量，特别是在具有肌肉衰弱和虚弱风险的老年人中。 营养组合物包括α-羟基异己酸和α-酮戊二酸。 组合物可以包括其它功能成分，例如但不限于包括乳清蛋白胶束，益生元纤维，瓜氨酸，二十碳五烯酸，L-肉碱，核苷酸和氨基酸的乳清蛋白。 还提供了向需要相同的个体施用这种营养产品的方法。
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Patent Agency Ranking
公开(公告)号：WO2011042501A2
公开(公告)日：2011-04-14
申请号：PCT/EP2010/065021
申请日：2010-10-07
Applicant: NESTEC S.A. , I.N.R.A. , ATTAIX, Didier , CODRAN-RAISON, Audrey , CORTHESY-THEULAZ, Irène , BREUILLE, Denis , COMBARET, Lydie
Inventor： ATTAIX, Didier , CODRAN-RAISON, Audrey , CORTHESY-THEULAZ, Irène , BREUILLE, Denis , COMBARET, Lydie
CPC classification number: A61K38/26 , A23L33/18 , A23V2002/00 , A61K2300/00 , A23V2200/316
Abstract: The present invention generally relates to the field of nutrition and health. In particular, the present invention provides a composition that allows it to treat, limit or prevent muscle atrophy. Embodiments of the present invention are directed at GLP-2 containing compositions and to compositions that stimulate the secretion of GLP-2 in a body to treat or prevent muscle atrophy.
Abstract translation: 本发明一般涉及营养与健康领域。 特别地，本发明提供允许其治疗，限制或预防肌肉萎缩的组合物。 本发明的实施方案涉及含GLP-2的组合物和刺激体内GLP-2分泌以治疗或预防肌肉萎缩的组合物。
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公开(公告)号：WO2003032753A1
公开(公告)日：2003-04-24
申请号：PCT/EP2002/011266
申请日：2002-10-08
Applicant: SOCIETE DES PRODUITS NESTLE S.A. , FINOT, Paul-André , HUYNH-BA, Tuong , VUICHOUD, Jacques , BREUILLE, Denis
Inventor： FINOT, Paul-André , HUYNH-BA, Tuong , VUICHOUD, Jacques , BREUILLE, Denis
IPC: A23L1/305
CPC classification number: A23L33/175 , A23L33/17
Abstract: La présente invention concerne l'utilisation de cystathionine dans une composition nutritionnelle, un supplément alimentaire, une composition prophylactique, ou une formule infantile.
Abstract translation: 本发明涉及胱硫醚在营养组合物，膳食补充剂，预防组合物或婴儿配方中的用途。
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公开(公告)号：WO2012143402A1
公开(公告)日：2012-10-26
申请号：PCT/EP2012/057092
申请日：2012-04-18
Applicant: NESTEC S.A. , GREENBERG, Norman, Alan , BREUILLE, Denis , ROUGHEAD, Zamzam, Kabiry (Fariba) , BOLSTER, Doug , MAGER, Jennifer
Inventor： GREENBERG, Norman, Alan , BREUILLE, Denis , ROUGHEAD, Zamzam, Kabiry (Fariba) , BOLSTER, Doug , MAGER, Jennifer
CPC classification number: A61K31/7105 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/19 , A61K31/194 , A61K31/198 , A61K31/20 , A61K31/202 , A61K31/205 , A61K31/711 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K36/064 , A61K45/06 , Y02E10/721 , A23V2200/316 , A23V2250/156 , A23V2250/1882 , A23V2250/628 , A23V2250/70
Abstract: Nutritional compositions for maximizing muscle protein synthesis while minimizing the catabolism of muscle proteins and methods of using same are provided. In this manner, the nutritional compositions may provide for retention of lean body mass, which helps to avoid loss of independence and functionality, as well as to improve quality of life especially in the elderly at risk of sarcopenia and frailty. The nutritional compositions include α-hydroxyisocaproic acid and may include other functional ingredients such as, but not limited to whey protein incuding whey protein micelles, prebiotic fibers, L-carnitine, nucleotides, and amino acids. Methods of administering such nutritional products to individuals in need of same are also provided.
Abstract translation: 提供了使肌肉蛋白质合成最大化同时最小化肌肉蛋白质分解代谢的营养组合物及其使用方法。 以这种方式，营养组合物可以提供保持瘦体重，这有助于避免丧失独立性和功能性，以及改善生活质量，特别是在具有肌肉衰弱和虚弱风险的老年人中。 营养组合物包括α-羟基异己酸，并且可以包括其它功能成分，例如但不限于包含乳清蛋白胶束，益生元纤维，L-肉毒碱，核苷酸和氨基酸的乳清蛋白。 还提供了向需要相同的个体施用这种营养产品的方法。
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公开(公告)号：WO2012052463A1
公开(公告)日：2012-04-26
申请号：PCT/EP2011/068231
申请日：2011-10-19
Applicant: NESTEC S.A. , INRA , BREUILLE, Denis , PAPET, Isabelle , VIDAL, Karine
Inventor： BREUILLE, Denis , PAPET, Isabelle , VIDAL, Karine
IPC: A61K31/198 , A61P1/14 , A61P3/04
CPC classification number: A61K31/198 , A23L33/175
Abstract: The present invention relates to the field of nutrition; in particular to the prevention and/or treatment of malnutrition. One embodiment of the present invention relates to a nutritional composition enriched in cysteine for use in the treatment and/or prevention of malnutrition and disorders related thereto. Such a composition may in particular, but not exclusively, be useful for the elderly population.
Abstract translation: 本发明涉及营养领域; 特别是预防和/或治疗营养不良。 本发明的一个实施方案涉及富含半胱氨酸的营养组合物，用于治疗和/或预防与其相关的营养不良和紊乱。 这样的组合物可能特别但不排他地对老年人有用。
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公开(公告)号：WO2006134135A2
公开(公告)日：2006-12-21
申请号：PCT/EP2006063229
申请日：2006-06-14
Applicant: NESTEC SA , AGRONOMIQUE INST NAT RECH , BREUILLE DENIS , MERCIER SABINE , PAPET ISABELLE , PATUREAU MIRAND PHILIPPE , OBLED CHRISTIANE
Inventor： BREUILLE DENIS , MERCIER SABINE , PAPET ISABELLE , PATUREAU MIRAND PHILIPPE , OBLED CHRISTIANE
CPC classification number: A61K31/198 , A23L33/175 , A23L33/30
Abstract: A method of improving nutrition and/or treating low grade inflammation in an elderly human subject comprises administering to said subject a cysteine source so as to provide metabolically available cysteine in the diet of said subject in a proportion relative to all available amino acids which is greater that the proportion of cysteine relative to all amino acids which corresponds to the requirements of a healthy young human subject.
Abstract translation: 在老年人受试者中改善营养和/或治疗低度炎症的方法包括向所述受试者施用半胱氨酸源，以便在所述受试者的饮食中以相对于所有受试者的所有可用氨基酸的比例提供代谢可用的半胱氨酸 半胱氨酸相对于所有氨基酸的比例对应于健康年轻人受试者的要求。
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