公开(公告)号：WO2011008922A2

公开(公告)日：2011-01-20

申请号：PCT/US2010/042080

申请日：2010-07-15

Applicant: HANSEN MEDICAL, INC. ,  ALVAREZ, Jeffery, B. ,  BARBAGLI, Federico ,  CARLSON, Christopher, R. ,  SEWELL, Christopher, M. ,  STAHLER, Gregory, J. ,  TANNER, Neal, A.

Inventor： ALVAREZ, Jeffery, B. ,  BARBAGLI, Federico ,  CARLSON, Christopher, R. ,  SEWELL, Christopher, M. ,  STAHLER, Gregory, J. ,  TANNER, Neal, A.

IPC: A61B19/00 ,  A61B1/00 ,  A61B17/00 ,  A61B17/22 ,  A61B18/24 ,  A61M1/00 ,  A61B17/221 ,  A61M25/00

CPC classification number: A61B1/00133 ,  A61B1/00128 ,  A61B1/00142 ,  A61B1/00147 ,  A61B1/00149 ,  A61B1/0016 ,  A61B1/0052 ,  A61B1/307 ,  A61B17/00234 ,  A61B17/221 ,  A61B18/24 ,  A61B34/30 ,  A61B34/35 ,  A61B34/37 ,  A61B34/70 ,  A61B34/71 ,  A61B90/36 ,  A61B90/50 ,  A61B2017/00685 ,  A61B2017/22069 ,  A61B2034/301 ,  A61B2090/508 ,  A61B2217/005 ,  A61M25/09041 ,  A61M2025/0036 ,  A61M2025/004

Abstract: A robotic catheter system includes an instrument driver in communication with a controller and having an elongate instrument interface including a plurality of instrument drive elements responsive to control signals generated, at least in part, by user input through a master input device operatively coupled to the controller, and an elongate instrument having a guide instrument base operatively coupled to the guide instrument interface. The elongate instrument comprises additional lumens to accommodate instruments such as an optics bundle, a light bundle, a laser fiber, and flush irrigation. The working lumen preferably is configured to accommodate a grasping or capturing tool, such as a collapsible basket or grasper, for use in procedures such as kidney stone interventions.

Abstract translation: 机器人导管系统包括与控制器通信的仪器驱动器，并具有包括多个仪器驱动元件的细长仪器接口，响应于至少部分地通过可操作地耦合到控制器的主输入设备的用户输入而产生的控制信号 以及具有可操作地连接到引导仪器接口的导向仪器基座的细长器械。 细长仪器包括用于容纳诸如光学束，光束，激光光纤和冲洗冲洗的仪器的附加流明。 工作管腔优选地构造成容纳用于诸如肾结石干预的过程中的抓握或捕获工具，例如可折叠篮或抓紧器。

公开(公告)号：WO2010093894A3

公开(公告)日：2011-01-13

申请号：PCT/US2010024063

申请日：2010-02-12

Applicant: NUCOR CORP ,  CARLSON CHRISTOPHER ,  COLE DAVID ,  DREW KEGAN ,  MANNING CHRISTOPHER

Inventor： CARLSON CHRISTOPHER ,  COLE DAVID ,  DREW KEGAN ,  MANNING CHRISTOPHER

IPC: F27D17/00 ,  C21B15/00

CPC classification number: F27D17/003 ,  C21C5/5211 ,  C21C2005/5288 ,  F27B3/28 ,  F27D19/00 ,  F27D21/00 ,  Y02P10/216

Abstract: A furnace damper control system and method thereof including a furnace having at least one opening through which electromagnetic radiation from within the furnace may be sensed, an exhaust duct capable of receiving an exhaust gas stream emerging from the furnace, and a controllable damper capable of adjusting the pressure in the exhaust duct. A sensor is capable of sensing electromagnetic radiation through one or more of the openings of the furnace and generating a sensor signal corresponding to the electromagnetic radiation, and a processor is capable of processing the sensor signal and generating a monitoring signal responsive to a parameter of the electromagnetic radiation indicative of furnace emissions. A controller is capable of controlling the damper responsive to the monitoring signal indicative of the furnace emissions.

Abstract translation: 一种炉阻尼器控制系统及其方法，其包括具有至少一个开口的炉，通过该开口可以感测来自炉内的电磁辐射，能够接收从炉出来的废气流的排气管，以及能够调节 排气管中的压力。 传感器能够感测通过炉子的一个或多个开口的电磁辐射并产生对应于电磁辐射的传感器信号，并且处理器能够处理传感器信号并响应于 指示炉排放的电磁辐射。 控制器能够响应于指示炉排放的监视信号来控制阻尼器。

公开(公告)号：WO2010151416A1

公开(公告)日：2010-12-29

申请号：PCT/US2010/037477

申请日：2010-06-04

Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER ,  ROBINS, Harlan, S. ,  WARREN, Edus, H. ,  CARLSON, Christopher, Scott

Inventor： ROBINS, Harlan, S. ,  WARREN, Edus, H. ,  CARLSON, Christopher, Scott

IPC: C12Q1/68

CPC classification number: C12N15/1065 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/16 ,  G06F19/24

Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.

Abstract translation: 描述了测量免疫能力的方法。 这种方法提供了一种评估损害免疫系统的疾病或病症的影响以及旨在重建其的治疗方法。 该方法基于通过计算来自血细胞的不同T细胞受体（TCR）β链可变区的数量来量化T细胞多样性。

公开(公告)号：WO2010093894A2

公开(公告)日：2010-08-19

申请号：PCT/US2010/024063

申请日：2010-02-12

Applicant: Nucor Corporation ,  CARLSON, Christopher ,  COLE, David ,  DREW, Kegan ,  MANNING, Christopher

Inventor： CARLSON, Christopher ,  COLE, David ,  DREW, Kegan ,  MANNING, Christopher

CPC classification number: F27D17/003 ,  C21C5/5211 ,  C21C2005/5288 ,  F27B3/28 ,  F27D19/00 ,  F27D21/00 ,  Y02P10/216

Abstract: A furnace damper control system and method thereof including a furnace having at least one opening through which electromagnetic radiation from within the furnace may be sensed, an exhaust duct capable of receiving an exhaust gas stream emerging from the furnace, and a controllable damper capable of adjusting the pressure in the exhaust duct. A sensor is capable of sensing electromagnetic radiation through one or more of the openings of the furnace and generating a sensor signal corresponding to the electromagnetic radiation, and a processor is capable of processing the sensor signal and generating a monitoring signal responsive to a parameter of the electromagnetic radiation indicative of furnace emissions. A controller is capable of controlling the damper responsive to the monitoring signal indicative of the furnace emissions.

Abstract translation: 一种炉阻尼器控制系统及其方法，其包括具有至少一个开口的炉，通过该开口可以感测来自炉内的电磁辐射，能够接收从炉出来的废气流的排气管，以及能够调节 排气管中的压力。 传感器能够感测通过炉子的一个或多个开口的电磁辐射并产生对应于电磁辐射的传感器信号，并且处理器能够处理传感器信号并响应于 指示炉排放的电磁辐射。 控制器能够响应于指示炉排放的监视信号来控制阻尼器。

公开(公告)号：WO2008118481A9

公开(公告)日：2008-12-24

申请号：PCT/US2008003997

申请日：2008-03-26

Applicant: HANSEN MEDICAL INC ,  CARLSON CHRISTOPHER R ,  BARBAGLI FEDERICO

Inventor： CARLSON CHRISTOPHER R ,  BARBAGLI FEDERICO

IPC: A61B19/00 ,  A61B17/00 ,  A61M25/01

CPC classification number: A61B19/2203 ,  A61B34/30 ,  A61B34/37 ,  A61B34/71 ,  A61B34/77 ,  A61B2017/003 ,  A61B2017/00477 ,  A61B2034/2061 ,  A61B2034/301 ,  A61B2034/741 ,  A61M25/0113 ,  A61M25/0147 ,  A61M25/0662 ,  A61M2025/0161

Abstract: A robotic instrument system having an elongate sheath instrument and an elongate catheter instrument positioned within a working lumen of the sheath instrument is controlled by selectively operating an instrument driver coupled to the catheter instrument to place a control element extending through the catheter instrument in tension, and thereby articulate at least a distal end portion the catheter instrument, while automatically compensating for a torsional force exerted on the sheath instrument in a first direction due to articulation of the distal end portion of the catheter, by urging the sheath instrument to twist in a second direction opposite of the first direction.

Abstract translation: 通过选择性地操作耦合到导管器械的仪器驱动器来控制定位在护套仪器的工作腔内的细长护套器械和细长导管器械的机器人仪器系统，以将通过导管器械延伸的控制元件放置在张力下，以及 从而至少将导管器械的远端部分连接起来，同时通过促使护套器械在第二方向上扭转，自动补偿由于导管的远端部分的关节而在第一方向施加在护套器械上的扭转力 方向与第一方向相反。

公开(公告)号：WO2008042423A3

公开(公告)日：2008-07-24

申请号：PCT/US2007021278

申请日：2007-10-02

Applicant: HANSEN MEDICAL INC ,  BARBAGLI FEDERICO ,  KOOLWAL ADITYA ,  CARLSON CHRISTOPHER R ,  WALLACE DANIEL T ,  YOUNGE ROBERT G

Inventor： BARBAGLI FEDERICO ,  KOOLWAL ADITYA ,  CARLSON CHRISTOPHER R ,  WALLACE DANIEL T ,  YOUNGE ROBERT G

IPC: A61B8/12 ,  A61B5/06 ,  A61B8/08

CPC classification number: A61B5/06 ,  A61B5/065 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4254 ,  A61B8/445 ,  A61B8/4477 ,  A61B8/4483 ,  A61B8/483 ,  A61B8/543 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00252 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/256 ,  A61B2090/0811 ,  A61B2090/367 ,  A61B2090/378 ,  A61B2090/3784 ,  A61B2090/3929

Abstract: An automated medical system comprises a first instrument assembly including a first ultrasound transducer having a first transducer field of view that transmits and receives ultrasound signals in imaging planes disposed circumferentially about a guide instrument, and a second instrument assembly including a second ultrasound transducer having a second transducer field of view coupled to one of a second flexible guide instrument and a working instrument. A computing system is operatively coupled to the respective first and second transducers and configured to determine a relative spatial orientation of the respective first and second transducers based at least in part on detecting a signal transmitted by one of the first and second transducers and received by the other of the first and second transducers, the received signal having an amplitude indicating the receiving one of the transducers is in the field of view of the transmitting one of the transducers.

Abstract translation: 一种自动化医疗系统包括第一仪器组件，该第一仪器组件包括第一超声换能器和第二仪器组件，该第一超声换能器具有在围绕导向仪器周向布置的成像平面中发送和接收超声信号的第一换能器视场，该第二仪器组件包括具有第二 换能器视场耦合到第二柔性引导仪器和工作仪器中的一个。 计算系统可操作地耦合到相应的第一换能器和第二换能器，并且被配置为至少部分地基于检测由第一换能器和第二换能器中的一个传输的并且由第一换能器和第二换能器中的一个所接收的信号来确定相应的第一换能器和第二换能器的相对空间取向 第一和第二换能器中的另一个，接收信号具有指示接收换能器之一的幅度在发射换能器之一的视场内。

公开(公告)号：WO2008031077A2

公开(公告)日：2008-03-13

申请号：PCT/US2007077944

申请日：2007-09-07

Applicant: HANSEN MEDICAL INC ,  MOLL FREDERIC H ,  BARBAGLI FEDERICO ,  CARLSON CHRISTOPHER R

Inventor： MOLL FREDERIC H ,  BARBAGLI FEDERICO ,  CARLSON CHRISTOPHER R

IPC: A61B19/00

CPC classification number: A61B34/30 ,  A61B17/29 ,  A61B18/24 ,  A61B34/10 ,  A61B34/37 ,  A61B90/361 ,  A61B2017/003 ,  A61B2034/301

Abstract: A robotic surgical system includes an instrument driver and an instrument assembly operatively coupled to the instrument driver such that mechanisms of the instrument driver operate or control movement, operation, or both, of components of the instrument assembly. The instrument assembly components include an elongate flexible guide instrument and an image capture device, wherein the image capture device is configured to capture images of a forward-oriented field of view. The system further comprises a controller operatively coupled to the instrument driver and configured to operate the instrument driver mechanisms in a manner so as to control advancement of the instrument assembly toward a target along a trajectory that maintains the target in the forward-oriented field of view of the image capture device.

Abstract translation: 机器人手术系统包括仪器驱动器和仪器组件，该仪器组件可操作地耦合到仪器驱动器，使得仪器驱动器的机构操作或控制仪器组件的部件的运动，操作或两者。 器械组件部件包括细长柔性引导器械和图像捕获装置，其中图像捕获装置配置为捕获前向视场的图像。 该系统进一步包括控制器，该控制器可操作地连接至器械驱动器并且被配置为以这样的方式操作器械驱动器机构，以便控制器械组件沿着将目标保持在向前取向的视场中的轨迹朝向目标的前进 的图像捕获设备。

公开(公告)号：WO2007070693A3

公开(公告)日：2007-06-21

申请号：PCT/US2006/048058

申请日：2006-12-14

Applicant: HANSEN MEDICAL, INC. ,  MOLL, Frederic, H. ,  CARLSON, Christopher, R. ,  BARBAGLI, Federico ,  WALLACE, Daniel, T. ,  LUNDMARK, David

Inventor： MOLL, Frederic, H. ,  CARLSON, Christopher, R. ,  BARBAGLI, Federico ,  WALLACE, Daniel, T. ,  LUNDMARK, David

IPC: A61B19/00 ,  A61B17/068 ,  A61B17/12

Abstract: A robotically controlled guide instrument system, comprising an elongate flexible guide instrument; a drive assembly coupled to a proximal portion of the guide instrument and configured to maneuver a distal portion of the guide instrument; a master controller including a user interface that may be manipulated to actuate the drive assembly and thereby maneuver the distal portion the guide instrument; and a closure device detachably coupled to a delivery member carried by the guide instrument, the guide instrument maneuverable to position the closure device proximate an opening of a left atrial appendage of a person’s heart such that the prosthesis may be detached from the delivery member and implanted to substantially close off the left atrial appendage.

公开(公告)号：WO2012027503A3

公开(公告)日：2012-05-31

申请号：PCT/US2011049012

申请日：2011-08-24

Applicant: HUTCHINSON FRED CANCER RES ,  LIVINGSTON ROBERT J ,  CARLSON CHRISTOPHER S ,  ROBINS HARLAN S

Inventor： LIVINGSTON ROBERT J ,  CARLSON CHRISTOPHER S ,  ROBINS HARLAN S

IPC: C12Q1/68 ,  C12N15/11

CPC classification number: C12Q1/6874 ,  C07K14/7051 ,  C07K16/00 ,  C07K2317/565 ,  C12Q1/6804 ,  C12Q1/6883 ,  C12Q2600/16 ,  C12Q2531/113 ,  C12Q2537/143 ,  C12Q2545/114

Abstract: Compositions and methods for measuring adaptive immune receptor (T cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. Lymphoid (B- and T-cell) adaptive immune receptor diversity is quantified by calculating the number of uniquely rearranged, CDR3-containing immunoglobulin (Ig) or T-cell receptor (TCR) variable region-encoding genes from sample cells such as blood cells.

Abstract translation: 描述了用于测量适应性免疫受体（T细胞受体和免疫球蛋白）多样性的组合物和方法，并且发现了用于评估免疫活性和其他目的的用途。 提供手段用于评估损害免疫系统的疾病或病症的效果以及旨在重建它的疗法。 淋巴样（B细胞和T细胞）适应性免疫受体多样性通过计算来自样品细胞如血细胞的独特重排的含CDR3的免疫球蛋白（Ig）或T细胞受体（TCR）可变区编码基因的数量 。

公开(公告)号：WO2011163630A1

公开(公告)日：2011-12-29

申请号：PCT/US2011/041893

申请日：2011-06-24

Applicant: HANSEN MEDICAL, INC. ,  ROELLE, Matthew, J. ,  TANNER, Neal, A. ,  YOUNGE, Robert, G. ,  CARLSON, Christopher ,  BARBAGLI, Federico ,  CAMARILLO, David

Inventor： ROELLE, Matthew, J. ,  TANNER, Neal, A. ,  YOUNGE, Robert, G. ,  CARLSON, Christopher ,  BARBAGLI, Federico ,  CAMARILLO, David

IPC: A61B19/00

CPC classification number: A61M25/0133 ,  A61B1/00149 ,  A61B1/00165 ,  A61B1/008 ,  A61B34/30 ,  A61B34/37 ,  A61B34/76 ,  A61B2017/003 ,  A61B2017/00477 ,  A61B2034/102 ,  A61B2034/2053 ,  A61B2034/2059 ,  A61B2034/2061 ,  A61B2034/301 ,  A61B2034/715 ,  A61B2034/742 ,  A61B2034/744

Abstract: Systems are described herein that improve control of a shapeable or steerable instrument using shape data. Additional systems use such shape data for improved mapping or adjusting models of the instrument. Such systems include robotic medical systems for controlling a shapeable instrument within an anatomical region having a controller, one or more actuators, and a localization system for guiding one or more shapeable instruments.

Abstract translation: 本文描述了使用形状数据改进对可成形或可操纵的仪器的控制的系统。 附加系统使用这种形状数据来改进仪器的映射或调整模型。 这样的系统包括用于控制具有控制器，一个或多个致动器和用于引导一个或多个可成形器械的定位系统的解剖区域内的可成形器械的机器人医疗系统。