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    NEURAL INTERFACE SYSTEM WITH AN EDGE ARRAY
    1.
    发明申请
    NEURAL INTERFACE SYSTEM WITH AN EDGE ARRAY 审中-公开
    具有边缘阵列的神经接口系统

    公开(公告)号：WO2012122502A1

    公开(公告)日：2012-09-13

    申请号：PCT/US2012/028552

    申请日：2012-03-09

    Applicant: NEURONEXUS TECHNOLOGIES ,  SEYMOUR, John ,  HETKE, Jamille ,  VETTER, Rio ,  KIPKE, Daryl ,  PELLINEN, David ,  KONG, K.C.

    Inventor： SEYMOUR, John ,  HETKE, Jamille ,  VETTER, Rio ,  KIPKE, Daryl ,  PELLINEN, David ,  KONG, K.C.

    IPC: A61N1/00

    CPC classification number: A61N1/0534 ,  A61B1/07 ,  A61M25/0009 ,  A61M25/0023 ,  A61N1/0553 ,  A61N5/0601 ,  A61N2005/0632 ,  H05K1/028 ,  H05K1/118 ,  H05K3/10 ,  H05K2201/051 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155

    Abstract: The neural interface system of one embodiment includes a cylindrical shaft, a lateral extension longitudinally coupled to at least a portion of the shaft and having a thickness less than a diameter of the shaft, and an electrode array arranged on the lateral extension and radially offset from the shaft, including electrode sites that electrically interface with their surroundings. The method of one embodiment for making the neural interface system includes forming a planar polymer substrate with at least one metallization layer, patterning on at least one metallization layer an electrode array on a first end of the substrate, patterning conductive traces on at least one metallization layer, rolling a portion of the substrate toward the first end of the substrate, and securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft.

    Abstract translation: 一个实施例的神经接口系统包括圆柱形轴，纵向耦合到轴的至少一部分并且具有小于轴的直径的厚度的横向延伸部和布置在横向延伸部上的径向偏移的电极阵列 轴，包括与其周围环境电接触的电极位置。 用于制造神经接口系统的一个实施例的方法包括：形成具有至少一个金属化层的平面聚合物衬底，在至少一个金属化层上图案化在衬底的第一端上的电极阵列，在至少一个金属化层 将基板的一部分朝向基板的第一端滚动，并且将轧制的基板固定到轴中，该轴具有从轴横向延伸的基板的第一端并且电极阵列从轴径向偏移。

    NEURAL INTERFACE SYSTEM
    3.
    发明申请
    NEURAL INTERFACE SYSTEM 审中-公开
    神经接口系统

    公开(公告)号：WO2008109298A3

    公开(公告)日：2008-12-24

    申请号：PCT/US2008055025

    申请日：2008-02-26

    Applicant: NEURONEXUS TECHNOLOGIES INC ,  VETTER RIO ,  KIPKE DARYL ,  PELLINEN DAVID ,  ANDERSON DAVID ,  HETKE JAMILLE FARRAYE

    Inventor： VETTER RIO ,  KIPKE DARYL ,  PELLINEN DAVID ,  ANDERSON DAVID ,  HETKE JAMILLE FARRAYE

    IPC: A61N1/00

    CPC classification number: A61N1/0534 ,  A61B5/04001 ,  A61N1/0539 ,  A61N1/36082

    Abstract: The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.

    Abstract translation: 优选实施例的神经接口系统包括具有多个电极位置的电极阵列和支撑电极阵列的载体。 电极阵列耦合到载体，使得电极位置沿着载体周向布置并且沿着载体轴向布置。 可以同时激活一组电极部位以产生激活模式。 优选实施例的系统优选地设计用于深部脑刺激，更具体地，针对具有精细电极位置定位，选择性，可调性和精确激活图案化的深部脑刺激。 然而，优选实施例的系统可以替代地在任何合适的环境（例如脊髓，周围神经，肌肉或任何其他合适的解剖学位置）中使用，并且由于任何合适的原因。

    SYSTEMS AND METHODS FOR INDUCING INTELLIGIBLE HEARING
    4.
    发明申请
    SYSTEMS AND METHODS FOR INDUCING INTELLIGIBLE HEARING 审中-公开
    用于诱导智能听觉的系统和方法

    公开(公告)号：WO2005089470A2

    公开(公告)日：2005-09-29

    申请号：PCT/US2005/009046

    申请日：2005-03-17

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  LIM, Hubert, H. ,  ANDERSON, David, J. ,  WILER, James, A. ,  HETKE, Jamille, F.

    Inventor： LIM, Hubert, H. ,  ANDERSON, David, J. ,  WILER, James, A. ,  HETKE, Jamille, F.

    IPC: H04R25/00

    CPC classification number: A61N1/36036

    Abstract: The present invention comprises systems and methods for inducing auditory sensations in patients by stimulating the inferior colliculus of the mammalian midbrain. In some embodiments, the invention comprises an auditory prosthesis system comprising a microphone, a sound processor, a current stimulator, and one or more stimulating electrodes disposed in the inferior colliculus of a mammal. At least one of the stimulating electrodes may be comprised of one or more shanks, each shank comprised of one or more stimulation sites. In some embodiments, without limitation, the invention comprises methods of inducing auditory sensation in a mammal, comprising the steps of providing a microphone, a sound processor, and a current stimulator; providing one or more stimulating electrodes each comprised of two or more shanks, each shank comprised of one or more stimulation sites; disposing at least one stimulating electrode in the inferior colliculus of a mammal; and stimulating at least one isofrequency lamina of the inferior colliculus by applying an electrical signal through at least one of the stimulation sites.

    Abstract translation: 本发明包括通过刺激哺乳动物中脑的下丘来诱导患者的听觉的系统和方法。 在一些实施例中，本发明包括听觉假体系统，其包括麦克风，声音处理器，电流刺激器以及设置在哺乳动物的下丘中的一个或多个刺激电极。 刺激电极中的至少一个可以由一个或多个柄构成，每个柄由一个或多个刺激部位组成。 在一些实施例中，但不限于，本发明包括在哺乳动物中诱发听觉的方法，包括提供麦克风，声音处理器和电流刺激器的步骤; 提供一个或多个刺激电极，每个刺激电极由两个或多个柄组成，每个柄由一个或多个刺激部位组成; 在哺乳动物的下丘中设置至少一个刺激电极; 以及通过施加通过至少一个所述刺激部位的电信号来刺激所述下丘的至少一个异频层。

    NEURAL INTERFACE SYSTEM
    7.
    发明申请
    NEURAL INTERFACE SYSTEM 审中-公开
    神经接口系统

    公开(公告)号：WO2008109298A2

    公开(公告)日：2008-09-12

    申请号：PCT/US2008/055025

    申请日：2008-02-26

    Applicant: NEURONEXUS TECHNOLOGIES, INC. ,  VETTER, Rio ,  KIPKE, Daryl ,  PELLINEN, David ,  ANDERSON, David ,  HETKE, Jamille, Farraye

    Inventor： VETTER, Rio ,  KIPKE, Daryl ,  PELLINEN, David ,  ANDERSON, David ,  HETKE, Jamille, Farraye

    IPC: A61N1/05

    CPC classification number: A61N1/0534 ,  A61B5/04001 ,  A61N1/0539 ,  A61N1/36082

    Abstract: The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.

    Abstract translation: 本优选实施例的神经界面系统包括具有多个电极部位的电极阵列和支撑电极阵列的载体。 电极阵列耦合到载体，使得电极位置围绕载体周向布置并且沿着载体轴向布置。 一组电极位点可以被同时激活以创建激活模式。 优选实施例的系统优选设计用于深度脑刺激，并且更具体地用于具有精细电极位置定位，选择性，可调谐性和精确激活图案化的深度脑刺激。 然而，优选实施例的系统可以可选地用于任何合适的环境（诸如脊髓，周围神经，肌肉或任何其它合适的解剖位置）并且用于任何合适的原因。

    NEURAL INTERFACE SYSTEM
    9.
    发明申请
    NEURAL INTERFACE SYSTEM 审中-公开
    神经接口系统

    公开(公告)号：WO2011046665A1

    公开(公告)日：2011-04-21

    申请号：PCT/US2010/044167

    申请日：2010-08-02

    Applicant: NEURONEXUS TECHNOLOGIES ,  ANDERSON, David ,  VETTER, Rio, J. ,  HETKE, Jamille, F. ,  KIPKE, Daryl, R.

    Inventor： ANDERSON, David ,  VETTER, Rio, J. ,  HETKE, Jamille, F. ,  KIPKE, Daryl, R.

    IPC: A61B5/04

    CPC classification number: A61B5/04001 ,  A61N1/0534 ,  A61N1/0539 ,  Y10T29/49204

    Abstract: A neural interface system including an electrode array and a carrier that supports the electrode array, in which the electrode array includes a substrate rolled into a three- dimensional shape, a plurality of conductive traces patterned on the substrate and adapted to transmit electrical signals, and a plurality of elliptically shaped, externally facing electrode sites coupled to the plurality of conductive traces that electrically communicate with their surroundings. The plurality of electrodes are arranged in a triangular lattice circumferentially around and axially along the carrier, and the substrate includes an edge that extends axially along the carrier and is constrained between a first axial row portion of the plurality of electrode sites and a second axial row portion of the plurality of electrode sites adjacent to the first axial row portion.

    Abstract translation: 一种包括支撑电极阵列的电极阵列和载体的神经接口系统，其中电极阵列包括滚动成三维形状的基底，在基底上图案化并适于传输电信号的多个导电迹线，以及 耦合到与其周围环境电连通的多个导电迹线的多个椭圆形的外部对置的电极位置。 多个电极沿着载体围绕并且沿轴向布置成三角形格栅，并且基板包括沿着载体轴向延伸并且限制在多个电极位置的第一轴向行部分和第二轴向行 所述多个电极位置的与所述第一轴向行部分相邻的部分。

    THREE-DIMENSIONAL SYSTEM OF ELECTRODE LEADS
    10.
    发明申请
    THREE-DIMENSIONAL SYSTEM OF ELECTRODE LEADS 审中-公开
    电极引线三维系统

    公开(公告)号：WO2009052423A1

    公开(公告)日：2009-04-23

    申请号：PCT/US2008/080364

    申请日：2008-10-17

    Applicant: NEURONEXUS TECHNOLOGIES ,  VETTER, Rio, J. ,  KIPKE, Daryl, R. ,  HETKE, Jamille, F.

    Inventor： VETTER, Rio, J. ,  KIPKE, Daryl, R. ,  HETKE, Jamille, F.

    IPC: A61B5/04

    CPC classification number: A61B5/0478 ,  A61B5/04001 ,  A61N1/0534 ,  A61N1/0551

    Abstract: The electrode lead system of a preferred embodiment includes a series of first electrical subsystems; a guiding element that positions the series of first electrical subsystems in a three dimensional arrangement within body tissue; a second electrical subsystem; and at least one connector that couples the first electrical subsystems to the second electrical subsystem. The electrode lead system of another preferred embodiment includes a series of electrode arrays; a guide tube that facilitates implantation of electrode arrays within body tissue and temporarily contains the series of electrode arrays; and a guiding element that provides a bias on the series of electrode arrays such that (a) when contained by the guide tube, the first electrical subsystems maintain a substantially singular path within body tissue, and (b) when not contained by the guide tube, the first electrical subsystems diverge along more than one path into a three dimensional arrangement within body tissue.

    Abstract translation: 优选实施例的电极引线系统包括一系列第一电子子系统; 引导元件，其将所述一系列第一电子系统定位在身体组织内的三维排列中; 第二电子系统; 以及将第一电子系统耦合到第二电子系统的至少一个连接器。 另一个优选实施例的电极引线系统包括一系列电极阵列; 引导管，其有助于将电极阵列植入体内组织并暂时包含一系列电极阵列; 以及引导元件，其在所述一系列电极阵列上提供偏置，使得（a）当由所述引导管容纳时，所述第一电子系统在所述主体组织内保持基本上奇异的路径，以及（b）当所述引导管未被所述导管 ，第一电子子系统沿着多于一条的路径发散成体内组织内的三维排列。

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