-
1.发明申请REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开反向酰胺化合物作为蛋白质脱乙酰壳多糖酶抑制剂及其使用方法
公开(公告)号：WO2011091213A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/021982
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS , VAN DUZER, John, H. , MAZITSCHEK, Ralph , OGIER, Walter , BRADNER, James, Elliott , HUANG, Guoxiang , XIE, Dejian , YU, Nan
发明人： VAN DUZER, John, H. , MAZITSCHEK, Ralph , OGIER, Walter , BRADNER, James, Elliott , HUANG, Guoxiang , XIE, Dejian , YU, Nan
IPC分类号： C07D239/42 , C07C233/78 , A61K31/505 , A61P35/00 , A61P25/00
CPC分类号： A61K31/505 , A61K31/164 , A61K31/337 , A61K45/06 , C07C237/36 , C07C259/06 , C07D209/46 , C07D209/48 , C07D213/30 , C07D213/74 , C07D213/81 , C07D235/30 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/24 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/06
摘要： The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
摘要翻译： 本发明涉及包含锌螯合剂基团的新型“逆酰胺”化合物，以及这些化合物在抑制HDAC6中的用途以及治疗与HDAC6相关的各种疾病，病症或病症。
-
2.发明申请
公开(公告)号：WO2005014532A1
公开(公告)日：2005-02-17
申请号：PCT/US2004/025429
申请日：2004-08-06
申请人： TRANSTECH PHARMA, INC. , MJALLI, Adnan, M.M. , HUANG, Guoxiang , ARIMILLI, Murty, N , YOKUM, Scott , ZHU, Jeff
IPC分类号： C07C271/20
CPC分类号： C07D295/155 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07C2601/08
摘要： This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. The compounds of Formula (I) may activate an erythropoietin receptor and thus, may be useful to induce red blood cell production. The compounds of Formula (I) and compositions including compounds of Formula (I) may be useful in a variety of applications including the management, treatment and/or control of diseases caused at least in part by deficient (or inefficient) EPO production relative to hemoglobin level.
摘要翻译： 本发明提供了本文所述的式（I）的芳基和杂芳基化合物及其制备方法。 还提供了用式（I）的化合物制备的药物组合物和制备这些组合物的方法。 式（I）的化合物可以激活促红细胞生成素受体，因此可用于诱导红细胞生成。 式（I）化合物和包含式（I）化合物的组合物可用于各种应用，包括至少部分地由EPO生产缺陷（或低效）引起的疾病的管理，治疗和/或控制，相对于 血红蛋白水平。
-
3.发明申请REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开反式酰胺化合物作为蛋白质脱乙酰酶抑制剂及其使用方法
公开(公告)号：WO2011091213A3
公开(公告)日：2011-12-01
申请号：PCT/US2011021982
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS , VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
发明人： VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
IPC分类号： C07D239/42 , A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78
CPC分类号： A61K31/505 , A61K31/164 , A61K31/337 , A61K45/06 , C07C237/36 , C07C259/06 , C07D209/46 , C07D209/48 , C07D213/30 , C07D213/74 , C07D213/81 , C07D235/30 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/24 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/06
摘要： The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
摘要翻译： 本发明涉及包含锌螯合剂基团的新型“反向酰胺”化合物，以及这些化合物在抑制HDAC6和治疗与HDAC6相关的各种疾病，病症或病症中的用途。
-
4.发明申请
公开(公告)号：WO2005014533A3
公开(公告)日：2005-04-07
申请号：PCT/US2004025463
申请日：2004-08-06
申请人： TRANSTECH PHARMA INC , MJALLI ADNAN M M , ANDREWS ROBERT C , GUO XIAO-CHUAN , CHRISTEN DANIEL PETER , GOHIMMUKKULA DEVI REDDY , HUANG GUOXIANG , ROTHLEIN ROBERT , TYAGI SAMEER , YARAMASU TRIPURA , BEHME CHRISTOPHER
发明人： MJALLI ADNAN M M , ANDREWS ROBERT C , GUO XIAO-CHUAN , CHRISTEN DANIEL PETER , GOHIMMUKKULA DEVI REDDY , HUANG GUOXIANG , ROTHLEIN ROBERT , TYAGI SAMEER , YARAMASU TRIPURA , BEHME CHRISTOPHER
IPC分类号： A61P31/12 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07D295/155 , A61K31/166 , C07C233/29 , C07D207/09 , C07D207/26 , C07D211/66 , C07D213/71 , C07D217/02 , C07D231/14
CPC分类号： C07D295/155 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07C2601/08
摘要： This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway..
摘要翻译： 本发明提供芳基和杂芳基化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物病症中的用途。 本发明的化合物可以是拮抗剂或因子IX和/或因子XI的部分拮抗剂，因此可用于抑制凝血的内在途径。 该化合物可用于各种应用，包括部分由内在凝血途径引起的疾病的管理，治疗和/或控制。
-
公开(公告)号：WO2005014533A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/025463
申请日：2004-08-06
申请人： TRANSTECH PHARMA, INC. , MJALLI, Adnan, M.M. , ANDREWS, Robert, C. , GUO, Xiao-Chuan , CHRISTEN, Daniel, Peter , GOHIMMUKKULA, Devi, Reddy , HUANG, Guoxiang , ROTHLEIN, Robert , TYAGI, Sameer , YARAMASU, Tripura , BEHME, Christopher
发明人： MJALLI, Adnan, M.M. , ANDREWS, Robert, C. , GUO, Xiao-Chuan , CHRISTEN, Daniel, Peter , GOHIMMUKKULA, Devi, Reddy , HUANG, Guoxiang , ROTHLEIN, Robert , TYAGI, Sameer , YARAMASU, Tripura , BEHME, Christopher
IPC分类号： C07C271/20
CPC分类号： C07D295/155 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07C2601/08
摘要： This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway..
摘要翻译： 本发明提供了芳基和杂芳基化合物，它们的制备方法，包含这些化合物的药物组合物，以及它们在治疗人类或动物疾病中的用途。 本发明化合物可以是拮抗剂或因子IX和/或因子XI的部分拮抗剂，因此可用于抑制凝血的固有途径。 这些化合物可用于多种应用，包括部分由固有凝固途径引起的疾病的管理，治疗和/或控制。
-
公开(公告)号：WO2013082756A1
公开(公告)日：2013-06-13
申请号：PCT/CN2011/083529
申请日：2011-12-06
申请人： LEO PHARMA A/S , SOERENSEN, Morten Dahl , LARSEN, Jens Christian Hoejland , NOERREMARK, Bjarne , LIANG, Xifu , HUANG, Guoxiang , CHEN, Jinzhong
发明人： SOERENSEN, Morten Dahl , LARSEN, Jens Christian Hoejland , NOERREMARK, Bjarne , LIANG, Xifu , HUANG, Guoxiang , CHEN, Jinzhong
IPC分类号： C07D213/16 , C07D231/12 , A61K31/415 , A61K31/44 , A61P3/14 , A61P5/18 , A61P5/20 , A61P5/22 , A61P19/10 , A61P9/00 , A61P13/12
CPC分类号： C07D403/12 , A61K45/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： Compounds according to formula (I) are useful in the treatment of phosphate homeostasis.
摘要翻译： 根据式（I）的化合物可用于治疗磷酸盐体内平衡。
-
公开(公告)号：WO2006099379A3
公开(公告)日：2006-09-21
申请号：PCT/US2006/009049
申请日：2006-03-14
申请人： TRANSTECH PHARMA, INC. , MJALLI, Adnan, M.M. , JONES, David , GOHIMMUKKULA, Devi, Reddy , HUANG, Guoxiang , ZHU, Jeff , RAO, Mohan , ANDREWS, Robert, C. , REN, Tan
发明人： MJALLI, Adnan, M.M. , JONES, David , GOHIMMUKKULA, Devi, Reddy , HUANG, Guoxiang , ZHU, Jeff , RAO, Mohan , ANDREWS, Robert, C. , REN, Tan
IPC分类号： C07D235/30 , C07D401/14 , C07D401/04 , A61K31/4184 , A61K31/4709 , A61K31/4725 , A61K31/4439 , A61P25/28 , C07D417/14 , C07D401/12 , C07D409/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D471/04 , C07D473/00
摘要： The present invention is directed to benzazole compounds that inhibit ß-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
-
8.发明申请BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS 审中-公开苯并噻唑衍生物，组合物和作为B-分泌酶抑制剂的方法
公开(公告)号：WO2006099379A2
公开(公告)日：2006-09-21
申请号：PCT/US2006009049
申请日：2006-03-14
申请人： TRANSTECH PHARMA INC , MJALLI ADNAN M M , JONES DAVID , GOHIMMUKKULA DEVI REDDY , HUANG GUOXIANG , ZHU JEFF , RAO MOHAN , ANDREWS ROBERT C , REN TAN
发明人： MJALLI ADNAN M M , JONES DAVID , GOHIMMUKKULA DEVI REDDY , HUANG GUOXIANG , ZHU JEFF , RAO MOHAN , ANDREWS ROBERT C , REN TAN
IPC分类号： C07D235/30 , A61K31/4184 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61P25/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/00 , C07D403/12 , C07D409/14 , C07D417/14 , C07D491/04 , C07D495/04 , C07D513/04
CPC分类号： C07D401/14 , A61K31/4725 , C07D235/30 , C07D401/04 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention is directed to benzazole compounds that inhibit ß-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
摘要翻译： 本发明涉及抑制β-位淀粉样蛋白前体蛋白切割酶（BACE）的苯并唑化合物，其可用于治疗或预防BACE所涉及的疾病如阿尔茨海默氏病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及BACE的疾病中的用途。
-
9.发明申请
公开(公告)号：WO2004014844A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/025045
申请日：2003-08-08
申请人： TRANSTECH PHARMA, INC. , MJALLI, Adnan, M.M. , ANDREWS, Rob , GUO, Xiao-Chuan , CHRISTEN, Daniel, Peter , GOHIMMUKKULA, Devi, Reddy , HUANG, Guoxiang , ROTHLEIN, Robert , TYAGI, Sameer , YARAMASU, Tripura , BEHME, Christopher
发明人： MJALLI, Adnan, M.M. , ANDREWS, Rob , GUO, Xiao-Chuan , CHRISTEN, Daniel, Peter , GOHIMMUKKULA, Devi, Reddy , HUANG, Guoxiang , ROTHLEIN, Robert , TYAGI, Sameer , YARAMASU, Tripura , BEHME, Christopher
IPC分类号： C07C235/00
CPC分类号： C07D207/267 , C07C233/29 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C237/44 , C07C255/60 , C07C257/18 , C07C271/20 , C07C271/44 , C07C311/18 , C07C311/19 , C07C311/44 , C07C317/14 , C07C317/28 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D207/09 , C07D211/26 , C07D213/30 , C07D213/70 , C07D213/71 , C07D213/74 , C07D213/81 , C07D217/02 , C07D217/16 , C07D217/22 , C07D231/12 , C07D231/14 , C07D231/18 , C07D233/84 , C07D239/94 , C07D249/08 , C07D261/10 , C07D263/32 , C07D271/10 , C07D277/46 , C07D285/08 , C07D295/088 , C07D295/155 , C07D307/66 , C07D307/79 , C07D307/85 , C07D317/60 , C07D333/24 , C07D333/38 , C07D333/70 , C07D401/04 , C07D409/04 , C07D409/06 , C07D413/04
摘要： This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds are useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX. Such diseases or disease states include stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures, long periods of confinement, and acquired or inherited pro-coagulant states.
摘要翻译： 本发明提供某些化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物疾病中的用途。 本发明的化合物可用作拮抗剂，或更优选为因子IX的部分拮抗剂，因此可用于抑制血液凝固的内在途径。 该化合物可用于各种应用，包括通过利用因子IX的内在凝血途径部分引起的疾病的管理，治疗和/或控制。 这些疾病或疾病状态包括中风，心肌梗死，动脉瘤手术以及与外科手术相关的深部静脉血栓形成，长时间的约束，以及获得性或遗传的促凝血状态。
-
公开(公告)号：WO2013082751A1
公开(公告)日：2013-06-13
申请号：PCT/CN2011/083521
申请日：2011-12-06
申请人： LEO PHARMA A/S , SOERENSEN, Morten Dahl , LARSEN, Jens Christian Hoejland , NOERREMARK, Bjarne , LIANG, Xifu , HUANG, Guoxiang
发明人： SOERENSEN, Morten Dahl , LARSEN, Jens Christian Hoejland , NOERREMARK, Bjarne , LIANG, Xifu , HUANG, Guoxiang
IPC分类号： C07D231/12 , C07D233/58 , A61K31/415 , A61K31/4164 , A61P3/14 , A61P5/18 , A61P5/20 , A61P5/22 , A61P19/10 , A61P9/00 , A61P13/12
CPC分类号： C07D233/64 , C07D231/12
摘要： Compounds according to formula (I) are useful in the treatment of phosphate homeostasis.
摘要翻译： 根据式（I）的化合物可用于治疗磷酸盐体内平衡。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.025 秒)
