公开(公告)号：WO2009127822A3

公开(公告)日：2010-03-11

申请号：PCT/GB2009000966

申请日：2009-04-16

Applicant: BIOLIPOX AB ,  NILSSON PETER ,  KATKEVICS MARTINS ,  PELCMAN BENJAMIN

Inventor： NILSSON PETER ,  KATKEVICS MARTINS ,  PELCMAN BENJAMIN

IPC: C07C311/10 ,  A61K31/33

CPC classification number: C07C233/75 ,  C07C229/64 ,  C07C233/81 ,  C07C235/64 ,  C07C237/40 ,  C07C311/21 ,  C07C311/29 ,  C07C311/51 ,  C07C317/14 ,  C07C317/50 ,  C07C323/63 ,  C07C2601/02 ,  C07C2601/08 ,  C07D213/82 ,  C07D307/79

Abstract: There is provided compounds of formula I, wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract translation: 提供了式I化合物，其中环A，D1，D2a，D2b，D3，L1，Y1，L3和Y3在说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗疾病 其中需要和/或需要抑制白细胞三烯C4合酶，特别是在治疗呼吸障碍和/或炎症中。

公开(公告)号：WO2009127822A2

公开(公告)日：2009-10-22

申请号：PCT/GB2009/000966

申请日：2009-04-16

Applicant: BIOLIPOX AB ,  NILSSON, Peter ,  KATKEVICS, Martins ,  PELCMAN, Benjamin

Inventor： NILSSON, Peter ,  KATKEVICS, Martins ,  PELCMAN, Benjamin

IPC: C07C311/10 ,  A61K31/33

CPC classification number: C07C233/75 ,  C07C229/64 ,  C07C233/81 ,  C07C235/64 ,  C07C237/40 ,  C07C311/21 ,  C07C311/29 ,  C07C311/51 ,  C07C317/14 ,  C07C317/50 ,  C07C323/63 ,  C07C2601/02 ,  C07C2601/08 ,  C07D213/82 ,  C07D307/79

Abstract: There is provided compounds of formula I, wherein ring A, D 1 , D 2a , D 2b , D 3 , L 1 , Y 1 , L 3 and Y 3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C 4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract translation: 提供了式I化合物，其中环A，D1，D2a，D2b，D3，L1，Y1，L3和Y3在说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗疾病 其中需要和/或需要抑制白细胞三烯C4合酶，特别是在治疗呼吸障碍和/或炎症中。

公开(公告)号：WO2007042816A1

公开(公告)日：2007-04-19

申请号：PCT/GB2006/003792

申请日：2006-10-12

Applicant: BIOLIPOX AB ,  PELCMAN, Benjamin ,  OLOFSSON, Kristofer ,  SCHAAL, Wesley ,  KALVINS, Ivars ,  KATKEVICS, Martins ,  OZOLA, Vita ,  SUNA, Edgars

Inventor： PELCMAN, Benjamin ,  OLOFSSON, Kristofer ,  SCHAAL, Wesley ,  KALVINS, Ivars ,  KATKEVICS, Martins ,  OZOLA, Vita ,  SUNA, Edgars

IPC: A61K31/423 ,  A61K31/4439 ,  A61K31/497 ,  A61P29/00 ,  A61P11/06 ,  C07D263/56 ,  C07D413/12

CPC classification number: A61K31/423 ,  A61K31/4439 ,  A61K31/497 ,  C07D263/57 ,  C07D413/12

Abstract: There is provided the use of a compound of formula (I),wherein Y, W 1 to W 4 , Z 1 to Z 4 and R have meanings given in the description, and pharmaceutically-acceptable salts thereof, for the manufacture of a medicament for the treatment of a disease in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.

Abstract translation: 提供式（I）化合物的用途，其中Y，W 1至W 4，Z 1至Z 0 > 4和R在本说明书中给出的含义及其药学上可接受的盐用于制备用于治疗其中希望抑制MAPEG家族成员的活性的疾病的药物，以及 /或需要，特别是治疗炎症。

公开(公告)号：WO2005123674A1

公开(公告)日：2005-12-29

申请号：PCT/GB2005/002396

申请日：2005-06-17

Applicant: BIOLIPOX AB ,  OLOFSSON, Kristofer ,  SUNA, Edgars ,  PELCMAN, Benjamin ,  OZOLA, Vita ,  KATKEVICS, Martins ,  KALVINS, Ivars ,  SCHAAL, Wesley

Inventor： OLOFSSON, Kristofer ,  SUNA, Edgars ,  PELCMAN, Benjamin ,  OZOLA, Vita ,  KATKEVICS, Martins ,  KALVINS, Ivars ,  SCHAAL, Wesley

IPC: C07D209/42

CPC classification number: C07D401/12 ,  C07D209/42

Abstract: There is provided a compound of formula: (I) wherein X, R l , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.

Abstract translation: 提供了式（I）化合物，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R <8>在本说明书中给出含义及其药学上可接受的盐，该化合物可用于治疗期望和/或需要抑制微粒体前列腺素E合成酶-1的活性的疾病，特别是在 治疗炎症。

公开(公告)号：WO2010103297A3

公开(公告)日：2010-11-18

申请号：PCT/GB2010000481

申请日：2010-03-15

Applicant: BIOLIPOX AB ,  NILSSON PETER ,  PELCMAN BENJAMIN ,  KATKEVICS MARTINS

Inventor： NILSSON PETER ,  PELCMAN BENJAMIN ,  KATKEVICS MARTINS

IPC: C07D213/74 ,  A61K31/4406 ,  A61P11/00 ,  A61P29/00 ,  C07C317/14

CPC classification number: C07C323/63 ,  C07C317/48 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/74 ,  C07D213/50 ,  C07D213/65 ,  C07D213/74 ,  C07D317/46 ,  C07D335/02 ,  C07D401/10 ,  C07D405/12 ,  C07D409/12

Abstract: There is provided compounds of formula (I), wherein Y, ring A1 D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract translation: 提供式（I）化合物，其中Y，环A1D1，D2a，D2b，D3，L1，Y1，L3和Y3在说明书中给出的含义及其药学上可接受的盐，该化合物可用于 治疗其中期望和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。

公开(公告)号：WO2010029300A1

公开(公告)日：2010-03-18

申请号：PCT/GB2009/002170

申请日：2009-09-10

Applicant: BIOLIPOX AB ,  PELCMAN, Benjamin ,  ALMEIDA, Maria ,  KATKEVICS, Martins ,  NILSSON, Peter ,  SCHAAL, Wesley ,  OLOFSSON, Kristofer

Inventor： PELCMAN, Benjamin ,  ALMEIDA, Maria ,  KATKEVICS, Martins ,  NILSSON, Peter ,  SCHAAL, Wesley ,  OLOFSSON, Kristofer

IPC: C07D401/12 ,  A61P11/06 ,  A61K31/44

CPC classification number: C07D401/12 ,  C07C233/81 ,  C07C235/56 ,  C07C237/42 ,  C07C311/21

Abstract: There is provided compounds of formula (I), wherein ring A, D 1 , D 2a , D 2b , D 3, Y, Y 1 , L 3 and Y 3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C 4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract translation: 提供式（I）化合物，其中环A，D1，D2a，D2b，D3，Y，Y1，L3和Y3在说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗 需要和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。

公开(公告)号：WO2009030887A3

公开(公告)日：2009-06-04

申请号：PCT/GB2008002964

申请日：2008-09-03

Applicant: BIOLIPOX AB ,  PELCMAN BENJAMIN ,  NILSSON PETER ,  KATKEVICS MARTINS

Inventor： PELCMAN BENJAMIN ,  NILSSON PETER ,  KATKEVICS MARTINS

IPC: C07C237/40 ,  A61K31/166 ,  A61K31/194 ,  C07C59/90 ,  C07C65/40 ,  C07C233/75

CPC classification number: C07C229/58 ,  C07C59/90 ,  C07C65/40 ,  C07C205/61 ,  C07C229/52 ,  C07C233/81 ,  C07C235/56 ,  C07C235/64 ,  C07C251/48 ,  C07C271/28 ,  C07C275/42 ,  C07C311/21 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2603/18 ,  C07D213/74 ,  C07D213/82 ,  C07D257/04 ,  C07D317/46 ,  C07D333/54

Abstract: There is provided compounds of formula (I): wherein Y, ring A, D1, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract translation: 提供式（I）的化合物：其中Y，环A，D1，D2，D3，L1，Y1，L2，Y2，L3和Y3具有说明书中给出的含义，及其药学上可接受的盐， 用于治疗需要和/或需要抑制白三烯C4合酶的疾病，特别是用于治疗呼吸障碍和/或炎症。

公开(公告)号：WO2009030887A2

公开(公告)日：2009-03-12

申请号：PCT/GB2008/002964

申请日：2008-09-03

Applicant: BIOLIPOX AB ,  PELCMAN, Benjamin ,  NILSSON, Peter ,  KATKEVICS, Martins

Inventor： PELCMAN, Benjamin ,  NILSSON, Peter ,  KATKEVICS, Martins

CPC classification number: C07C229/58 ,  C07C59/90 ,  C07C65/40 ,  C07C205/61 ,  C07C229/52 ,  C07C233/81 ,  C07C235/56 ,  C07C235/64 ,  C07C251/48 ,  C07C271/28 ,  C07C275/42 ,  C07C311/21 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2603/18 ,  C07D213/74 ,  C07D213/82 ,  C07D257/04 ,  C07D317/46 ,  C07D333/54

Abstract: There is provided compounds of formula (I): wherein Y, ring A, D 1 , D 2 , D 3 , L 1 , Y 1 , L 2 , Y 2 , L 3 and Y 3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C 4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract translation: 提供式（I）化合物：其中Y，环A，D1，D2，D3，L1，Y1，L2，Y2，L3和Y3具有说明书中给出的含义及其药学上可接受的盐， 可用于治疗期望和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。

公开(公告)号：WO2005005415A1

公开(公告)日：2005-01-20

申请号：PCT/GB2004/002996

申请日：2004-07-09

Applicant: BIOLIPOX AB ,  MCNEENEY, Stephen, Phillip ,  OLOFSSON, Kristofer ,  SUNA, Edgars ,  PELCMAN, Benjamin ,  OZOLA, Vita ,  KATKEVICS, Martins ,  KALVINS, Ivars

Inventor： OLOFSSON, Kristofer ,  SUNA, Edgars ,  PELCMAN, Benjamin ,  OZOLA, Vita ,  KATKEVICS, Martins ,  KALVINS, Ivars

IPC: C07D403/04

CPC classification number: C07D401/04 ,  C07D209/42 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04

Abstract: There is provided a compound of formula (I), wherein X, Y, Z, R 1 , R 2 , R 3 , R 4 and R 5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.

Abstract translation: 提供了式（I）化合物，其中X，Y，Z，R 1，R 2，R 3，R 4和R 5具有说明书中给出的含义，和 其化合物可用于治疗期望和/或需要抑制微粒体前列腺素E合成酶-1的活性，特别是治疗炎症的疾病。

公开(公告)号：WO2010103297A2

公开(公告)日：2010-09-16

申请号：PCT/GB2010/000481

申请日：2010-03-15

Applicant: BIOLIPOX AB ,  NILSSON, Peter ,  PELCMAN, Benjamin ,  KATKEVICS, Martins

Inventor： NILSSON, Peter ,  PELCMAN, Benjamin ,  KATKEVICS, Martins

IPC: C07D213/50 ,  C07D213/74 ,  C07D401/10 ,  C07D405/12 ,  C07D409/12 ,  A61K31/4406 ,  A61P11/00 ,  A61P29/00 ,  C07D317/46 ,  C07D335/02 ,  C07C233/87 ,  C07C237/40 ,  C07D213/65

CPC classification number: C07C323/63 ,  C07C317/48 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/74 ,  C07D213/50 ,  C07D213/65 ,  C07D213/74 ,  C07D317/46 ,  C07D335/02 ,  C07D401/10 ,  C07D405/12 ,  C07D409/12

Abstract: There is provided compounds of formula (I), wherein Y, ring A 1 D 1 , D 2a , D 2b , D 3 , L 1 , Y 1 , L 3 and Y 3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C 4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract translation: 提供了式（I）的化合物，其中Y，环A 1，D 1，D 2， ，D 2，D 3，D 3，L 1，Y 1，L 3， Y 3和Y 3具有说明书中给出的含义及其药学上可接受的盐，所述化合物可用于治疗需要抑制白细胞三烯C 4合酶的疾病 和/或需要，特别是在治疗呼吸障碍和/或炎症中。