公开(公告)号：WO2012088075A1

公开(公告)日：2012-06-28

申请号：PCT/US2011/066096

申请日：2011-12-20

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-Si ,  HELMKE, Charles R. ,  KENSLER, Ann M.

Inventor： LAI, Chron-Si ,  HELMKE, Charles R. ,  KENSLER, Ann M.

IPC: A23L1/30 ,  A23L1/305

CPC classification number: A23L1/305 ,  A23L33/10 ,  A23L33/12 ,  A23L33/17 ,  A23V2002/00 ,  A23V2200/316 ,  A23V2200/332 ,  A23V2250/1866

Abstract: Disclosed are nutritional products comprising calcium beta-hydroxy-beta methylbutyrate, conjugated linoleic acid, and protein. The nutritional product forms include nutritional liquids and nutritional powders. The nutritional products not only provide benefits for individuals concerned with muscle health and functionality, but also exhibit physical stability, sensory and/or aesthetic benefits in each of the selected product forms.

Abstract translation: 公开了包含β-羟基-β-甲基丁酸钙，共轭亚油酸和蛋白质的营养产品。 营养产品形式包括营养液和营养粉。 营养产品不仅为有关肌肉健康和功能的个人提供益处，而且在每种选定的产品形式中也表现出物理稳定性，感官和/或美学效益。

公开(公告)号：WO2012092086A1

公开(公告)日：2012-07-05

申请号：PCT/US2011/066678

申请日：2011-12-21

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-Si ,  GARLEB, Keith A. ,  LASEKAN, John B. ,  DAVIS, Steven R. ,  CORDEL, Christopher T. ,  MERRITT, Dr. Russell J.

Inventor： LAI, Chron-Si ,  GARLEB, Keith A. ,  LASEKAN, John B. ,  DAVIS, Steven R. ,  CORDEL, Christopher T. ,  MERRITT, Dr. Russell J.

IPC: A23L1/30 ,  A23L1/29 ,  A23C9/152 ,  A61P1/00

CPC classification number: A61K31/05 ,  A23K20/158 ,  A23K50/30 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/00 ,  A61K31/20

Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Abstract translation: 公开了营养配方，其包括可以对早产儿，婴儿，幼儿和儿童施用的预消化脂肪，用于改善营养物质的耐受性，消化和吸收以及降低坏死性小肠结肠炎，绞痛和短肠综合征的发生率。 预先消化的脂肪包括含脂肪酸的单甘油酯和/或脂肪酸组分。

公开(公告)号：WO2011146443A1

公开(公告)日：2011-11-24

申请号：PCT/US2011/036760

申请日：2011-05-17

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-si ,  SHEARER, Kati, E ,  HELMKE, Charles, R ,  WALTON, Joseph, E.

Inventor： LAI, Chron-si ,  SHEARER, Kati, E ,  HELMKE, Charles, R ,  WALTON, Joseph, E.

IPC: A23L1/09 ,  A23L1/30 ,  A23L1/305 ,  A23L1/308 ,  A23L1/00

CPC classification number: A23L1/3008 ,  A23L29/35 ,  A23L33/105 ,  A23L33/115 ,  A23L33/12 ,  A23L33/17 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/16 ,  A23V2200/224 ,  A23V2250/1882 ,  A23V2250/5114

Abstract: Disclosed are nutritional emulsions comprising fat, protein, and carbohydrate, including from about 0.01% to about 5% by weight of an oil having hydrophobic off-notes that is process-encapsulated by an emulsifying agent having a melt point above about 25 C, and maltodextrin having a DE of about 10 or less, wherein the weight ratio of the emulsifying agent to the process-encapsulated oil is at least about 1:15 and the weight ratio of the maltodextrin to the process-encapsulated oil is at least about 1:2. The nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils.

Abstract translation: 公开了包含脂肪，蛋白质和碳水化合物的营养乳液，包括约0.01重量％至约5重量％的油，其具有疏水性纸屑，其通过熔点高于约25℃的乳化剂进行工艺包封，以及 DE为约10或更小的麦芽糖糊精，其中乳化剂与工艺包封的油的重量比至少为约1:15，麦芽糖糊精与工艺包封的油的重量比为至少约1： 2。 营养乳液有效地遮蔽通常与某些油相关的纸币，例如多不饱和脂肪酸，大豆油，β-羟基-β-甲基丁酸油。

公开(公告)号：WO2012092087A1

公开(公告)日：2012-07-05

申请号：PCT/US2011/066679

申请日：2011-12-21

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-Si ,  GARLEB, Keith A. ,  LASEKAN, John B. ,  DAVIS, Steven R.

Inventor： LAI, Chron-Si ,  GARLEB, Keith A. ,  LASEKAN, John B. ,  DAVIS, Steven R.

IPC: A23L1/30 ,  A23L1/29 ,  A23C9/152 ,  A61P1/00

CPC classification number: A61K31/05 ,  A23K20/158 ,  A23K50/30 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/00 ,  A61K31/20

Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Abstract translation: 公开了营养配方，其包括可以对早产儿，婴儿，幼儿和儿童施用的预消化脂肪，用于改善营养物质的耐受性，消化和吸收以及降低坏死性小肠结肠炎，绞痛和短肠综合征的发生率。 预先消化的脂肪包括含脂肪酸的单甘油酯和/或脂肪酸组分。

公开(公告)号：WO2006004574A3

公开(公告)日：2006-03-16

申请号：PCT/US2005004940

申请日：2005-02-16

Applicant: ABBOTT LAB ,  WOLF BRYAN ,  CHOW JOMAY ,  LAI CHRON-SI

Inventor： WOLF BRYAN ,  CHOW JOMAY ,  LAI CHRON-SI

IPC: A23L1/308 ,  A23L1/0522 ,  A61K31/724 ,  A61P3/04 ,  A61P3/10

CPC classification number: A61K31/724 ,  A23L2/02 ,  A23L29/35 ,  A23L33/10 ,  A23P10/28 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/0095 ,  A23V2250/5112 ,  A23V2200/332 ,  A23V2200/328 ,  A23V2250/54252 ,  A23V2250/61 ,  A23V2250/628 ,  A23V2250/606 ,  A23V2250/708 ,  A23V2250/1644 ,  A23V2250/5488 ,  A23V2250/6406 ,  A23V2250/702 ,  A23V2250/242 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/6416 ,  A23V2250/54246 ,  A23V2250/28 ,  A23V2250/5432 ,  A23V2250/5054 ,  A23V2250/5062 ,  A23V2250/5114

Abstract: Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.

Abstract translation: 公开的是在个体中产生平坦的餐后血糖反应和/或减少餐后胰岛素分泌的方法，所述方法包括向个体施用包含γ-环糊精的营养物或其它产品。 还公开了类似的其它方法，涉及使用这些产品来提供重量和食欲控制，使葡萄糖耐量降低的个体的血糖水平正常化，以使糖尿病和非糖尿病患者的夜间低血糖最小化，以防止易感性中的反应性低血糖 使非糖尿病患者在妊娠期间使妊娠糖尿病患者或葡萄糖耐量降低的血糖水平正常化，和/或在运动期间提供延长的血糖反应。 这些方法是基于发现γ-环糊精在小肠中快速代谢和吸收，但随后导致出乎意料的平坦的餐后血糖反应和降低的胰岛素分泌。

公开(公告)号：WO2006004574A2

公开(公告)日：2006-01-12

申请号：PCT/US2005/004940

申请日：2005-02-16

Applicant: ABBOTT LABORATORIES ,  WOLF, Bryan ,  CHOW, Jomay ,  LAI, Chron-si

Inventor： WOLF, Bryan ,  CHOW, Jomay ,  LAI, Chron-si

IPC: A23L1/522 ,  A23L1/30 ,  A61K31/724 ,  A61P3/04 ,  A61P3/10

CPC classification number: A61K31/724 ,  A23L2/02 ,  A23L29/35 ,  A23L33/10 ,  A23P10/28 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/0095 ,  A23V2250/5112 ,  A23V2200/332 ,  A23V2200/328 ,  A23V2250/54252 ,  A23V2250/61 ,  A23V2250/628 ,  A23V2250/606 ,  A23V2250/708 ,  A23V2250/1644 ,  A23V2250/5488 ,  A23V2250/6406 ,  A23V2250/702 ,  A23V2250/242 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/6416 ,  A23V2250/54246 ,  A23V2250/28 ,  A23V2250/5432 ,  A23V2250/5054 ,  A23V2250/5062 ,  A23V2250/5114

Abstract: Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.

Abstract translation: 公开了在个体中产生钝化的餐后血糖反应和/或减少餐后胰岛素分泌的方法，所述方法包括向个体施用包含γ-环糊精的营养或其他产品。 还公开了类似的其他方法，涉及使用这些产品来提供体重和食欲控制，使葡萄糖耐量降低的个体的血糖水平正常化，使糖尿病和非糖尿病患者的夜间低血糖最小化，以防止易感的反应性低血糖症 在妊娠期间使妊娠糖尿病或葡萄糖耐量降低的个体的血糖水平正常化，和/或在运动期间提供延长的血糖反应。 该方法基于这样的发现，即γ-环糊精在小肠中被快速代谢和吸收，但随后导致令人吃惊的餐后血糖反应变差和胰岛素分泌减少。

公开(公告)号：WO2012009426A1

公开(公告)日：2012-01-19

申请号：PCT/US2011/043838

申请日：2011-07-13

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-si ,  JOHNS, Paul, W ,  DAVIS, Steven, R ,  LINKE, Hawley, K ,  BORSCHEL, Marlene, W ,  TRAVIS, Benjamin, D ,  PONCE, Richard, T Jr

Inventor： LAI, Chron-si ,  JOHNS, Paul, W ,  DAVIS, Steven, R ,  LINKE, Hawley, K ,  BORSCHEL, Marlene, W ,  TRAVIS, Benjamin, D ,  PONCE, Richard, T Jr

IPC: A23L1/29 ,  A23L1/30 ,  A23L1/305 ,  A23L1/308

CPC classification number: A23L33/21 ,  A23L33/10 ,  A23L33/18 ,  A23L33/40

Abstract: Disclosed are high tolerance infant formulas including hydrolyzed proteins, such as hydrolyzed whey protein and hydrolyzed casein protein. The high tolerance formulas reduce the incidence of loose and discolored stools in infants, and may also reduce gas and spit up. The high tolerance formulas include a hydrolyzed protein, a low glycemic carbohydrate, a substantially digestible fructose-containing carbohydrate, and a substantially indigestible fermentable carbohydrate. Methods of use of the high tolerance infant formula are also disclosed.

Abstract translation: 公开了高耐受性婴幼儿配方，包括水解蛋白质，如水解乳清蛋白和水解酪蛋白。 高公差公式可以减少婴儿松动和变色的粪便的发生，也可能减少气体和吐出。 高耐受性公式包括水解蛋白质，低血糖碳水化合物，基本上可消化的含果糖碳水化合物和基本上难消化的可发酵碳水化合物。 还公开了使用高耐受性婴儿配方奶粉的方法。

公开(公告)号：WO2011146444A1

公开(公告)日：2011-11-24

申请号：PCT/US2011/036761

申请日：2011-05-17

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-si ,  WALTON, Joseph, E. ,  HELMKE, Charles, R ,  SHEARER, Kati, E

Inventor： LAI, Chron-si ,  WALTON, Joseph, E. ,  HELMKE, Charles, R ,  SHEARER, Kati, E

IPC: A23L1/09 ,  A23L1/30 ,  A23L1/305 ,  A23L1/308 ,  A23L1/00

CPC classification number: A23D7/04 ,  A23D7/003 ,  A23D7/0053 ,  A23D7/011 ,  A23L29/10 ,  A23L29/35 ,  A23L33/105 ,  A23L33/115 ,  A23L33/12 ,  A23L33/17 ,  A23L33/21 ,  A23L33/40 ,  A23P10/30 ,  A23V2002/00 ,  A23V2250/1882

Abstract: Disclosed is a method of making nutritional emulsions, comprising: (A) heating and blending together an emulsifying agent having a melt point above about 25 C and oil having hydrophobic off-notes (e.g. non-encapsulated polyunsaturated fatty acid) in a weight ratio of at least about 1:15; (B) adding the heated blend to a fat, protein, and carbohydrate mixture comprising a maltodextrin (DE of about 10 or less), in a weight ratio of the maltodextrin to the oil having hydrophobic off-notes of at least about 1:2; and (C) homogenizing, and then cooling the combination below the melt point of the emulsifying agent to form a nutritional emulsion comprising from about 0.01% to about 5% by weight of process-encapsulated polyunsaturated fatty acid. The resulting nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils.

Abstract translation: 公开了一种制备营养乳液的方法，其包括：（A）将熔点高于约25℃的乳化剂和具有疏水离析物的油（例如非包封的多不饱和脂肪酸）加热并共混在一起，其重量比为 至少约1:15; （B）将加热的共混物加入到包含麦芽糖糊精（DE约10或更低）的脂肪，蛋白质和碳水化合物混合物中，麦芽糖糊精与具有至少约1:2的疏水离析纸的油的重量比 ; 和（C）均化，然后将组合物冷却至低于乳化剂的熔点，以形成包含约0.01重量％至约5重量％的工艺包封的多不饱和脂肪酸的营养乳液。 所得的营养乳液有效地掩盖通常与某些油相关的纸币，例如多不饱和脂肪酸，大豆油，β-羟基-β-甲基丁酸油。

公开(公告)号：WO2007075683A1

公开(公告)日：2007-07-05

申请号：PCT/US2006/048430

申请日：2006-12-19

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-si ,  JOHNS, Paul, W.

Inventor： LAI, Chron-si ,  JOHNS, Paul, W.

IPC: A23L1/05 ,  A23L1/29 ,  A23L1/305

CPC classification number: A23G4/20 ,  A23L29/10 ,  A23L29/20 ,  A23L29/231 ,  A23L29/256 ,  A23L29/27 ,  A23L29/272 ,  A23L33/17 ,  A23L33/40 ,  A61K9/107

Abstract: Disclosed are induced viscosity nutritional emulsions comprising (A) protein having a protein-bound methionine sulfoxide content of 8% or less of the total protein-bound methionine, on a molar basis, (B) fat, and (C) an induced viscosity fiber system that provides the emulsion with a packaged viscosity of less than 300 cps and an induced viscosity following consumption of at least 300 cps, wherein the induced viscosity nutritional emulsion is an oil-in-water emulsion. It has been found that product stability is improved and shelf-life increased by selection of those protein sources having a low methionine sulfoxide content.

Abstract translation: 公开了诱导粘度营养乳液，其包含（A）蛋白质结合的甲硫氨酸亚砜含量为总蛋白质结合的甲硫氨酸的8％以下的蛋白质，（B）脂肪，（C）诱导粘度纤维 系统，其提供具有小于300cps的包装粘度和消耗至少300cps后的诱导粘度的乳液，其中所述诱导粘度营养乳液是水包油乳液。 已经发现，通过选择具有低甲硫氨酸亚砜含量的那些蛋白质源，产物稳定性得到改善并且保质期增加。

公开(公告)号：WO2012092090A1

公开(公告)日：2012-07-05

申请号：PCT/US2011/066682

申请日：2011-12-22

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-Si ,  LASEKAN, John B. ,  KATZ, Gary E. ,  CORDLE, Christopher T.

Inventor： LAI, Chron-Si ,  LASEKAN, John B. ,  KATZ, Gary E. ,  CORDLE, Christopher T.

IPC: A23L1/30 ,  A23L1/29 ,  A23C9/152 ,  A61P1/00

CPC classification number: A61K31/05 ,  A23K20/158 ,  A23K50/30 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/00 ,  A61K31/20

Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Abstract translation: 公开了营养配方，其包括可以对早产儿，婴儿，幼儿和儿童施用的预消化脂肪，用于改善营养物质的耐受性，消化和吸收以及降低坏死性小肠结肠炎，绞痛和短肠综合征的发生率。 预先消化的脂肪包括含脂肪酸的单甘油酯和/或脂肪酸组分。