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    MRI AND CT CONTRAST-ENABLED COMPOSITE IMPLANTS FOR IMAGE-GUIDED TISSUE REGENERATION AND THERAPY
    2.
    发明申请
    MRI AND CT CONTRAST-ENABLED COMPOSITE IMPLANTS FOR IMAGE-GUIDED TISSUE REGENERATION AND THERAPY 审中-公开
    磁共振成像和CT造影剂使成像组织再生和治疗的复合植入物

    公开(公告)号：WO2017152127A1

    公开(公告)日：2017-09-08

    申请号：PCT/US2017/020793

    申请日：2017-03-03

    Applicant: AMRITA VISHWA VIDYAPEETHAM ,  KOYAKUTTY, Manzoor ,  MEETHALEVEEDU, Sajesh ,  ASHOKAN, Anusha ,  SOMASUNDARAM, Vijay Harish ,  NAIR, Shantikumar

    Inventor： KOYAKUTTY, Manzoor ,  MEETHALEVEEDU, Sajesh ,  ASHOKAN, Anusha ,  SOMASUNDARAM, Vijay Harish ,  NAIR, Shantikumar

    IPC: A61K49/04 ,  A61K51/00

    Abstract: A composite implant (100) for providing simultaneous magnetic resonance imaging (MRI) and computed tomographic (CT) imaging contrast is disclosed. The composite implant (100) is formed of a calcium compound (120) in the form of nano or microparticles doped with a first dopant (126) configured to provide MRI contrast and a second dopant (127) configured to provide CT contrast. The calcium compound (120) is loaded onto a polymer gel matrix (110) and lyophilized to form a mass with 3-dimensionally interconnected porosity (102), configured to provide tissue integration and proliferation sites. Methods (200) of forming the composite implant (100) are also disclosed. The implant could be a scaffold (101) or bead (105) structured to enable treatment of human or animal patient for bone/cartilage injury or defect by implantation, with MRI and CT monitoring.

    Abstract translation: 公开了用于提供同时磁共振成像（MRI）和计算机断层扫描（CT）成像对比度的复合植入物（100）。 复合植入物（100）由纳米或微米颗粒形式的钙化合物（120）形成，所述纳米颗粒或微米颗粒掺杂有配置成提供MRI对比度的第一掺杂剂（126）和配置成提供CT对比度的第二掺杂剂（127）。 将钙化合物（120）装载到聚合物凝胶基质（110）上并冻干以形成具有三维互连孔隙的团块（102），该团块构造成提供组织整合和增殖位点。 还公开了形成复合植入物（100）的方法（200）。 植入物可以是支架（101）或珠（105），其被构造成能够通过MRI和CT监测来处理人或动物患者的骨/软骨损伤或植入缺陷。

    RADIO-WAVE RESPONSIVE DOPED NANOPARTICLES FOR IMAGE-GUIDED THERAPEUTICS
    6.
    发明申请
    RADIO-WAVE RESPONSIVE DOPED NANOPARTICLES FOR IMAGE-GUIDED THERAPEUTICS 审中-公开
    用于图像引导治疗的放射性纳米粒子

    公开(公告)号：WO2017096342A1

    公开(公告)日：2017-06-08

    申请号：PCT/US2016/064890

    申请日：2016-12-05

    Applicant: AMRITA VISHWA VIDYAPEETHAM ,  DEPARTMENT OF BIOTECHNOLOGY ,  KOYAKUTTY, Manzoor ,  ASHOKAN, Anusha ,  HARISH, Vijay ,  NAIR, Shantikumar

    Inventor： KOYAKUTTY, Manzoor ,  ASHOKAN, Anusha ,  HARISH, Vijay ,  NAIR, Shantikumar

    IPC: A61B5/055 ,  A61B18/18 ,  A61K47/04 ,  A61K49/08

    CPC classification number: A61K41/0052 ,  A61B18/14 ,  A61K9/0024 ,  A61K49/1818

    Abstract: The invention discloses nanoparticles comprising compounds of calcium with anions such as phosphate, pyrophosphate, sulphate, silicate, carbonate, molybdate, or phosphosilicate that are doped with various ions. The nanoparticles are configured to produce heat (hyperthermia) under radio-wave (1KHz-1000GHz) exposure together with magnetism suitable for contrast imaging in MRI, X-ray absorption for computed tomography, near-infrared optical fluorescence for optical imaging, and/or radio-isotope emission for nuclear imaging or therapy. The nanoparticles can also be incorporated into micro-beads or other 3 dimensional scaffolds for image-guided (MRI, CT, NIR, nuclear) tissue regeneration, vascular or tumor embolization, and/or chemo/radio-embolization.

    Abstract translation: 本发明公开了包含掺杂有各种离子的钙与阴离子例如磷酸盐，焦磷酸盐，硫酸盐，硅酸盐，碳酸盐，钼酸盐或磷硅酸盐的化合物的纳米颗粒。 纳米颗粒被配置为在无线电波（1KHz-1000GHz）暴露下产生热量（热疗）以及适合于MRI中的造影成像，计算机断层摄影的X射线吸收，用于光学成像的近红外光学荧光和/或 用于核成像或治疗的放射性同位素发射。 纳米颗粒也可以纳入微型珠或其他三维支架进行图像引导（MRI，CT，NIR，核）组织再生，血管或肿瘤栓塞和/或化疗/放射性栓塞。

    NON-IODINATED RADIOLABELED RADIOPAQUE MICROBEADS WITH MRI CONTRAST FOR RADIOEMBOLIZATION
    8.
    发明申请
    NON-IODINATED RADIOLABELED RADIOPAQUE MICROBEADS WITH MRI CONTRAST FOR RADIOEMBOLIZATION 审中-公开
    非碘酸盐放射性标记的不透射线微球与磁共振对比剂进行放射性硬化

    公开(公告)号：WO2017201375A1

    公开(公告)日：2017-11-23

    申请号：PCT/US2017/033486

    申请日：2017-05-19

    Applicant: AMRITA VISHWA VIDYAPEETHAM ,  KOYAKUTTY, Manzoor ,  SOMASUNDARAM, Vijay Harish ,  ASHOKAN, Anusha ,  NAIR, Shantikumar

    Inventor： KOYAKUTTY, Manzoor ,  SOMASUNDARAM, Vijay Harish ,  ASHOKAN, Anusha ,  NAIR, Shantikumar

    IPC: A61K51/12

    Abstract: The invention discloses non-iodinated radiopaque microbeads that may be used in image guided embolization in a subject ailing with tumor. The non-iodinated radiopaque microbeads include a ceramic material doped with a CT contrast agent or a MRI contrast agent or both. The doped ceramic is blended with a polymer and the blend is electrosprayed to form the radiopaque microbeads. Further the radiopaque microbeads are radiolabeled with a radioactive isotope. Methods of synthesis of the radiopaque microspheres are also disclosed. The non-iodinated radiopaque microbeads with radiolabeling are capable of rendering an imageable computed tomography (CT) contrast or magnetic resonance imaging (MRI) contrast when administered in a subject. Also the microspheres are biodegradable and hence the treatment could be repeated in case of recurrence of the tumor in the subject.

    Abstract translation: 本发明公开了可用于肿瘤患者的图像引导栓塞中的非碘化不透射线微珠。 非碘化的不透射线微珠包括掺有CT造影剂或MRI造影剂或二者的陶瓷材料。 将掺杂的陶瓷与聚合物混合并将共混物电喷雾以形成不透射线的微珠。 此外，不透射线的微珠用放射性同位素进行放射性标记。 还公开了不透射线微球体的合成方法。 具有放射性标记的非碘化不透射线微珠能够在受试者中施用时呈现可成像计算机断层摄影（CT）对比度或磁共振成像（MRI）对比度。 此外，微球是可生物降解的，因此在受试者中肿瘤复发的情况下可以重复治疗。

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