公开(公告)号：WO2005111196A1

公开(公告)日：2005-11-24

申请号：PCT/CA2005/000745

申请日：2005-05-16

Applicant: NATIONAL RESEARCH COUNCIL CANADA ,  COX, Andrew ,  RICHARDS, James, C.

Inventor： COX, Andrew ,  RICHARDS, James, C.

IPC: C12N1/20

CPC classification number: C12N1/36 ,  A61K31/739 ,  A61K39/0208 ,  A61K39/05 ,  A61K39/102 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/522 ,  A61K2039/552 ,  A61K2039/6081 ,  A61K2039/70 ,  C07H3/06 ,  C07H13/04 ,  C07K16/1242 ,  C08B37/0003 ,  C08B37/006 ,  C12P19/04 ,  C12P19/44 ,  C12R1/01

Abstract: A conserved inner-core oligosaccharide epitope expressed on the lipopolysaccharide (LPS) of a range of disease causing pathogenic bacterial isolates, including Actinobacillus pleuropneumoniae (Ap), Mannheimia haemolytica (Mh) and Pasteurella multocida (Pm), is disclosed. Construction of a mutant bacterial strain exclusively expressing the conserved inner core OS epitope as a terminally exposed structure has allowed the identification, production and isolation of an inner core LPS which is common to all three organisms. Further provided are associated vaccines, antibodies raised against the conserved LPS inner core and glycoconjugates comprising the LPS inner core linked to an immunogenic carrier.

Abstract translation: 公开了在致病细菌分离物的一系列疾病的脂多糖（LPS）上表达的保守的内核寡糖表位，包括放线杆菌胸膜肺炎放线芽孢杆菌（Ap），溶血性马氏解毒血症（Mh）和多杀巴斯德氏菌（Pm））。 构建仅表达保守的内核OS表位作为末端暴露结构的突变细菌菌株允许鉴定，产生和分离所有三种生物共同的内核LPS。 还提供了相关疫苗，针对保守的LPS内核产生的抗体和包含与免疫原性载体连接的LPS内核的糖缀合物。

公开(公告)号：WO2014055784A1

公开(公告)日：2014-04-10

申请号：PCT/US2013/063306

申请日：2013-10-03

Applicant: ZYMEWORKS INC. ,  NATIONAL RESEARCH COUNCIL CANADA (NRC) ,  BAARDSNES, Jason ,  O'CONNOR-MCCOURT, Maureen

Inventor： BAARDSNES, Jason ,  O'CONNOR-MCCOURT, Maureen ,  OHRN, Anders ,  CORPER, Adam, Louis ,  NG, Gordon, Yiu Kon ,  SAMIOTAKIS, Antonios ,  CHOU, Yang-Chieh

IPC: C12N5/07 ,  C12N5/16 ,  A61K39/00

CPC classification number: C12N15/1055 ,  A61K39/00 ,  C07K16/468 ,  C07K2317/55 ,  G01N21/6486

Abstract: Provided is a method of quantitatively determining the ability of individual IgG heavy chains to selectively pair with a particular IgG light chain when the heavy chains and two unique light chains are co-expressed. The method provides results with reasonable throughput and is robust and accurate. The co-expressed heavy and light chains do not need to be isolated and purified which enables more efficient screening.

Abstract translation: 提供了当重链和两个独特的轻链共表达时，定量测定个体IgG重链与特定IgG轻链选择性配对的能力的方法。 该方法提供了具有合理吞吐量的结果，并且是鲁棒和准确的。 共表达的重链和轻链不需要被分离和纯化，这使得能够更有效地筛选。

公开(公告)号：WO2013164655A1

公开(公告)日：2013-11-07

申请号：PCT/IB2012/001022

申请日：2012-05-04

Applicant: UNIVERSIDAD DE MÁLAGA ,  UNIVERSITÉ PARIS SUD 11 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  NATIONAL RESEARCH COUNCIL CANADA ,  ALONSO-RAMOS, Carlos Alberto ,  VIVIEN, Laurent ,  CHEBEN, Pavel ,  HALIR, Robert ,  MARRIS-MORINI, Delphine ,  ORTEGA MONUX, Alejandro ,  MOLINA FERNÁNDEZ, Inigo ,  SCHMID, Jens, Holger ,  JANZ, Siegfried ,  XU, Dan-Xia

Inventor： ALONSO-RAMOS, Carlos Alberto ,  VIVIEN, Laurent ,  CHEBEN, Pavel ,  HALIR, Robert ,  MARRIS-MORINI, Delphine ,  ORTEGA MONUX, Alejandro ,  MOLINA FERNÁNDEZ, Inigo ,  SCHMID, Jens, Holger ,  JANZ, Siegfried ,  XU, Dan-Xia

IPC: G02B6/126 ,  G02F1/01

CPC classification number: G02B6/126 ,  G02F1/0136 ,  G02F1/0353

Abstract: The present invention relates to an integrated optical polarization rotator component, comprising three passive unitary polarization rotator cascaded and alternated with two phase shifters, which are adjusted to accurately and robustly provide a given polarization rotation, in order to compensate for manufacturing deviations from a nominal geometry and/or tuning the central wavelength of component to a given value. Thus, increased functionality is provided together with improved fabrication tolerances, possibly through implementing only known and well tested waveguide cross-section geometries and manufacturing processes

Abstract translation: 本发明涉及一种集成光偏振旋转器部件，其包括与两个移相器级联和交替的三个被动单位偏振旋转器，其被调整为准确地并且稳健地提供给定的偏振旋转，以便补偿与标称几何形状的制造偏差 和/或将组件的中心波长调谐到给定值。 因此，增加的功能性与改进的制造公差一起提供，可能通过仅实现已知和良好测试的波导横截面几何形状和制造过程

公开(公告)号：WO2008101348A1

公开(公告)日：2008-08-28

申请号：PCT/CA2008/000342

申请日：2008-02-21

Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY ,  INDUSTRIAL MATERIALS INSTITUTE, NATIONAL RESEARCH COUNCIL CANADA ,  MALIC, Lidija ,  TABRIZIAN, Maryam ,  VERES, Teodor ,  CUI, Bo ,  NORMANDIN, François

Inventor： MALIC, Lidija ,  TABRIZIAN, Maryam ,  VERES, Teodor ,  CUI, Bo ,  NORMANDIN, François

IPC: G01N21/75 ,  C40B20/00 ,  C40B30/00 ,  C40B50/00 ,  C40B60/00 ,  G01N21/01 ,  G01N21/78 ,  C12Q1/68

CPC classification number: G01N21/554 ,  B01J2219/00619 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01L3/502792 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2300/0896 ,  B01L2300/161 ,  B01L2400/0427 ,  B01L2400/086 ,  B82Y30/00 ,  C40B20/08 ,  C40B30/04 ,  C40B40/08 ,  C40B60/02 ,  Y10T436/2575

Abstract: A system and method for molecule detection uses a surface plasmon resonance (SPR) system with detection spots having fixed nanostructures. An SPR assembly may be combined with a digital microfluidic control system such as an electrowetting-on-dielectric (EWOD) chip. The microfluidic system individually directs sample droplets to different detection spots of the SPR assembly, thus allowing the SPR examination of different samples or sample reactions on the same surface. The nanostructures at the detection spots enhance the sensitivity of the SPR signals.

Abstract translation: 用于分子检测的系统和方法使用具有固定纳米结构的检测点的表面等离子体共振（SPR）系统。 SPR组件可以与诸如电润湿介电（EWOD）芯片的数字微流控制系统组合。 微流体系统将样品液滴单独引导到SPR组件的不同检测点，从而允许SPR在同一表面上检查不同的样品或样品反应。 检测点的纳米结构提高了SPR信号的灵敏度。

公开(公告)号：WO2001069647A3

公开(公告)日：2001-09-20

申请号：PCT/CA2001/000314

申请日：2001-03-14

Applicant: NATIONAL RESEARCH COUNCIL CANADA ,  GUEVREMONT, Roger

Inventor： GUEVREMONT, Roger

IPC: H01J49/00

Abstract: A tandem mass spectrometer is disclosed. A first mass analyzer within a low-pressure region is provided for passing ions therethrough. A collision cell is at an ion outlet of the mass analyzer to provide a location for ions to collide therein with a collision gas to form resultant ions. The resultant ions are then provided to a FAIMS analyzer for separation thereof and the separate resultant ions are provided to a mass analyzer for analysis.

公开(公告)号：WO2017027980A1

公开(公告)日：2017-02-23

申请号：PCT/CA2016/050977

申请日：2016-08-19

Applicant: NATIONAL RESEARCH COUNCIL CANADA

Inventor： SCHOENHOFEN, Ian C.

IPC: A61K31/7068 ,  A61K31/7012 ,  A61K9/00 ,  A61P31/04 ,  C07H19/01 ,  C07H7/02

CPC classification number: A61K31/7012 ,  A61K9/0034 ,  A61K31/7068 ,  A61K45/06 ,  A61K2300/00

Abstract: There is provided a method for treating or preventing a Neisseria gonorrhoeae infection in a subject, comprising administering to the subject an effective amount of a compound of general formula I below or a pharmaceutical composition comprising said compound, or a derivative thereof, or a pharmaceutically acceptable salt thereof, or a solvate or hydrate thereof, or a stereoisomer thereof.

Abstract translation: 提供了治疗或预防受试者淋病奈瑟氏球菌感染的方法，其包括向受试者施用有效量的下列通式I化合物或包含所述化合物或其衍生物或药学上可接受的药物组合物的药物组合物 其盐或其溶剂合物或水合物，或其立体异构体。

公开(公告)号：WO2011020183A1

公开(公告)日：2011-02-24

申请号：PCT/CA2010/001267

申请日：2010-08-18

Applicant: NATIONAL RESEARCH COUNCIL CANADA ,  ZHANG, Jianbing ,  HIRAMA, Tomoko

Inventor： ZHANG, Jianbing

IPC: C12N15/62 ,  C07K19/00 ,  C40B30/00 ,  G01N33/68

CPC classification number: G01N33/557 ,  C07K14/765 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/74 ,  C12N15/62 ,  G01N33/6803

Abstract: Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides s method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously. PCs are fused to a protein anchor, which is captured by the target/antigen. The captured PCs are evaluated for their expression levels, biophysical properties and affinities using conventional methods.

Abstract translation: 成功应用工程蛋白作为治疗剂或其他行业将需要蛋白质具有良好的表达水平，良好的生物物理性质，并且通常对其靶标具有期望的亲合力。 本发明提供了在所有三个方面同时筛选大量蛋白质候选物（PC）的方法。 PC融合到被靶/抗原捕获的蛋白质锚。 使用常规方法评估所捕获的PC的表达水平，生物物理性质和亲和力。

公开(公告)号：WO2006092063A1

公开(公告)日：2006-09-08

申请号：PCT/CA2006/000322

申请日：2006-03-03

Applicant: NATIONAL RESEARCH COUNCIL CANADA ,  LECLERC, Mario ,  HO, Hoang-Anh

Inventor： LECLERC, Mario ,  HO, Hoang-Anh

IPC: C12Q1/68 ,  C12Q1/00

CPC classification number: C12Q1/6816 ,  C12Q1/682 ,  Y10T436/143333 ,  C12Q2565/113 ,  C12Q2565/107 ,  C12Q2563/107

Abstract: The present invention relates to a novel integrated PCR-free signal amplification polynucleotide detection system which combines a specific receptor, an optical transducer, and an amplification mechanism. This novel detection system is based on different electrostatic interactions and conformations between a cationic polythiophene (i.e. polymer 1) and single-stranded or double-stranded polynucleotides (such as ss-DNA or ds-DNA), and the efficient energy transfer between the triplex (complexation between the cationic polythiophene and ds-DNA) and neighboring fluorophores attached to ss-DNA or ds-DNA probes. It is to be understood that in the case of ss-DNA, triplex formation occurs via the hybridization of complementary ss-DNA strands, combined with complexation with the cationic polythiophene. The present detection system allows for the detection of single nucleotide polymorphisms (SNPs) from samples in only a few minutes, without the need for nucleic acid amplification.

Abstract translation: 本发明涉及一种结合特异性受体，光学换能器和放大机制的新型无PCR信号整合多聚核苷酸检测系统。 这种新型检测系统是基于阳离子聚噻吩（即聚合物1）和单链或双链多核苷酸（如ss-DNA或ds-DNA）之间的不同静电相互作用和构象，以及三链体之间的有效能量转移 （阳离子聚噻吩和ds-DNA之间的络合）和与ss-DNA或ds-DNA探针相连的相邻荧光团。 应当理解，在ss-DNA的情况下，通过互补的ss-DNA链的杂交与阳离子聚噻吩的络合结合发生三链体形成。 本检测系统允许仅在几分钟内从样品中检测单核苷酸多态性（SNPs），而不需要核酸扩增。

公开(公告)号：WO2003044502A1

公开(公告)日：2003-05-30

申请号：PCT/CA2002/001747

申请日：2002-11-15

Applicant: NATIONAL RESEARCH COUNCIL CANADA ,  DETALLE, Vincent ,  DUFOUR, Marc ,  MONCHALIN, Jean-Pierre ,  SABSABI, Mohamad ,  ST-ONGE, Louis

Inventor： DETALLE, Vincent ,  DUFOUR, Marc ,  MONCHALIN, Jean-Pierre ,  SABSABI, Mohamad ,  ST-ONGE, Louis

IPC: G01N21/71

CPC classification number: G01B9/02029 ,  G01B9/02019 ,  G01B9/0209 ,  G01N21/718

Abstract: Laser ablation combined with spectrometric analysis is a good tool for determining the composition of heterogeneous materials. By measuring the depth of an ablation crater at a target of a heterogeneous material, it is possible to generate a compositional profile as a function of the depth. It is also possible to generate a 3 dimensional profile by depth profiling of a plurality of craters. The depth measurement is conducted in situ and in real time so that the evolution of composition as a fucntion of the depth can be measured. An interferometric technique with a short coherence length light is one of the preferred embodiments for measuring the depth in situ and in real time.

Abstract translation: 激光消融结合光谱分析是确定异质材料组成的好工具。 通过测量异质材料的目标处的消融凹坑的深度，可以产生作为深度的函数的组成分布。 也可以通过多个凹坑的深度剖析来生成三维轮廓。 深度测量在现场和实时进行，以便可以测量作为深度的影响的组成的演变。 具有短相干长度光的干涉技术是用于在现场和实时测量深度的优选实施例之一。

公开(公告)号：WO1992013679A1

公开(公告)日：1992-08-20

申请号：PCT/CA1992000047

申请日：1992-02-05

Applicant: NATIONAL RESEARCH COUNCIL CANADA

Inventor： NATIONAL RESEARCH COUNCIL CANADA ,  VIJAY, Mohan

IPC: B24C01/00

CPC classification number: B24C5/005 ,  B05B1/08 ,  B05B17/0623 ,  B24C1/00 ,  E21B7/18 ,  E21B7/24

Abstract: There is described an improved ultrasonic nozzle (30) including a nozzle body (31) having a fluid flow channel (32) formed axially therethrough with an inlet (2) at an upstream end of the channel (32) for receiving a pressurized fluid and an orifice (36) at the downstream end of the body for discharging the pressurized fluid towards a surface to be eroded (37), a transformer (38) axially aligned within the flow channel (32) to form, in cooperation with the flow channel (32), an annulus (28) between the two for the flow of the pressurized fluid, a vibrator (29) for ultrasonically oscillating the transformer (38) to pulse the pressurized fluid prior to its discharge through the orifice (36). The flow channel (32) and transformer (38) taper conformably axially inwardly in the direction of flow of the pressurized fluid at a uniform rate so that the transverse width of the annulus (28) remains constant along the length of the transformer (38).