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    PREVENTION OF OPPORTUNISTIC INFECTIONS IN IMMUNE-COMPROMISED SUBJECTS
    3.
    发明申请
    PREVENTION OF OPPORTUNISTIC INFECTIONS IN IMMUNE-COMPROMISED SUBJECTS 审中-公开
    防止免疫缺陷性受体中的机能性感染

    公开(公告)号：WO2009077352A1

    公开(公告)日：2009-06-25

    申请号：PCT/EP2008/066850

    申请日：2008-12-05

    Applicant: NESTEC S.A. ,  SPRENGER, Norbert

    Inventor： SPRENGER, Norbert

    IPC: A61K35/74 ,  A61K31/702 ,  A61P37/04 ,  A61P31/00

    CPC classification number: C12N1/20 ,  A61K31/702 ,  A61K35/74 ,  A61K35/745 ,  A61K2300/00

    Abstract: This invention relates to a composition suitable for use in the prevention of opportunistic infections in immune-compromised individuals comprising a probiotic Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium breve or Bifidobacterium longum and a fucosylated oligosaccharide selected from the group comprising 2'-fucosyllactose, 3 'fucosyllactose, difucosyllactose, lacto-N- fucopentaose, lacto-N-fucohexaose, fucosyllacto-N-hexaose and fucosyllacto-N- neohexaose. The invention further extends to the use of such a composition in the prevention of opportunistic infections in immune-compromised individuals.

    Abstract translation: 本发明涉及一种适用于预防免疫受损个体的机会性感染的组合物，其包含益生菌双歧杆菌，婴儿双歧杆菌，短双歧杆菌或双歧杆菌，以及选自包含2'-岩藻糖基乳糖，3' 岩藻糖基乳糖，二核糖基乳糖，乳糖-N-岩藻糖五糖，乳-N-硝酸核糖，岩藻糖基乳糖-N-己糖和岩藻糖基乳糖-N-新六糖。 本发明进一步延伸到这种组合物在免疫受损个体中预防机会性感染的用途。

    USE OF OLIGOSACCHARIDES CONTAINING N-ACETYLLACTOSAMINE FOR MATURATION OF IMMUNE RESPONSES IN NEONATES
    4.
    发明申请
    USE OF OLIGOSACCHARIDES CONTAINING N-ACETYLLACTOSAMINE FOR MATURATION OF IMMUNE RESPONSES IN NEONATES 审中-公开
    含有N-乙酰氨基脂肪酸的低聚糖用于成熟免疫反应的应用

    公开(公告)号：WO2009060073A1

    公开(公告)日：2009-05-14

    申请号：PCT/EP2008/065143

    申请日：2008-11-07

    Applicant: NESTEC S.A. ,  FICHOT, Marie-Claire ,  SPRENGER, Norbert

    Inventor： FICHOT, Marie-Claire ,  SPRENGER, Norbert

    IPC: A61K31/7028 ,  A23L1/29 ,  A23L1/30 ,  A23L1/308 ,  A61P37/04 ,  A61P37/08 ,  A61K45/06

    CPC classification number: A61K31/7028 ,  A23L29/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K35/741 ,  A61K2300/00 ,  A23V2250/28 ,  A23V2200/324 ,  A23V2200/3202

    Abstract: This invention relates to the use of an oligosaccharide selected from the group consisting of lactc -N-tetraose, lacio-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso- lacto-N-octaose, para- lacto-N-octaose and lacto-N-decaosein the manufacture of a medicament for infants or a therapeutic nutritional composition for infants for modulating immune responses in a neonatal infant. The invention extends to the use of such an oligosaccharide for modulating the immune system of a neonatal infant to promote the development in the first few weeks of the life of the infant of a beneficial intestinal microbiota comparable with that found in breast fed infants and for reducing the risk of subsequent development of allergy in the infant.

    Abstract translation: 本发明涉及选自哺乳-N-四糖，乳糖-N-新四糖，乳-N-十糖，乳-N-新六糖，对 - 乳-N-己糖，对 - 乳糖的寡糖的用途 N-新六氯糖，乳-N-辛糖，乳-N-新糖，异乳-N-辛糖，对 - 乳-N-辛糖和乳-N-去甲糖，制备用于婴儿或治疗营养组合物的药物 为婴儿调节新生儿婴儿的免疫反应。 本发明延伸到使用这种寡糖来调节新生婴儿的免疫系统，以促进有益肠道微生物群的婴幼儿生命的最初几周的发育，与在母乳喂养的婴儿中发现的相当，并减少 婴儿过敏风险随后发展。

    OLIGOSACCHARIDE MIXTURE
    8.
    发明申请
    OLIGOSACCHARIDE MIXTURE 审中-公开
    低聚物混合物

    公开(公告)号：WO2007090894A1

    公开(公告)日：2007-08-16

    申请号：PCT/EP2007/051288

    申请日：2007-02-09

    Applicant: NESTEC S.A. ,  SPRENGER, Norbert ,  MORGAN, François ,  BERROCAL, Rafael ,  BRAUN, Marcel

    Inventor： SPRENGER, Norbert ,  MORGAN, François ,  BERROCAL, Rafael ,  BRAUN, Marcel

    IPC: A23L1/09 ,  A23L1/29 ,  A61K31/702

    CPC classification number: A23L33/10 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/702 ,  A23V2250/28 ,  A23V2250/704 ,  A23V2250/70 ,  A23V2250/156

    Abstract: An oligosaccharide mixture comprising 5-70 wt% of at least one N-acetylated oligosaccharide selected from the group comprising GalNAcαl,3Galβl,4Glc and Galβl,6GalNAcαl,3Galβl,4Glc, 20-90 wt% of at least one neutral oligosaccharide selected from the group comprising Galβl,6Gal, Galβl,6Galβl,4Glc Galβl,6Galβl,6Glc, Galβl,3Galβl,3Glc, Galβl,3Galβl,4Glc, Galβl,6Galβl,6Galβl,4Glc, Galβl,6Galβl,3Galβl,4Glc Galβl,3Galβl,6Galβl,4Glc and Galβl,3Galβl,3Galβl,4Glc and 5-50 wt% of at least one sialylated oligosaccharide selected from the group comprising NeuAcα2,3Galβl,4Glc and NeuAcα2,6Galβl,4Glc; food products comprising said oligosaccharide mixture.

    Abstract translation: 一种寡糖混合物，其包含5-70重量％的至少一种N-乙酰化寡糖，其选自GalNAcal，3Galβ1,4G1c和Galβ1,6GalNAcal，3Galβ1，4Glc，20-90wt％的至少一种中性寡糖，其选自 包含Galβ1,6Gal，Galβ1,6Galβ1,4G1cGalβ1,6Galβ1,6Glc，Galβ1,3Galβ1,3G1c，Galβ1,3Galβ1,4G1c，Galβ1,6Galβ1,6Galβ1,4G1c，Galβ1,6Galβ1,3Galβ1,4G1cGalβ1,3Galβ1,6Galβ1， 4Glc和Galβ1,3Galβ1,3Galβ1,4G1c和5-50wt％的至少一种唾液酸化的寡糖，其选自NeuAca2,3Galβ1,4G1c和NeuAca2,6Galβ1，4Glc; 包含所述寡糖混合物的食品。

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