公开(公告)号：WO2013019385A1

公开(公告)日：2013-02-07

申请号：PCT/US2012/046617

申请日：2012-07-13

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  STEWART, Mark T. ,  HONECK, Jordon D.

Inventor： STEWART, Mark T. ,  HONECK, Jordon D.

IPC: A61B18/14 ,  A61N1/32

CPC classification number: A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00613 ,  A61B2018/1435 ,  A61N1/327

Abstract: A medical system, including a medical device having a plurality of deployable arms, and at least one electrode on at least one of the plurality of arms; and an electric signal generator in communication with the medical device, the electric signal generator programmed to deliver pulsed energy to the medical device sufficient to induce irreversible electroporation ablation.

Abstract translation: 一种医疗系统，包括具有多个可展开臂的医疗装置，以及至少一个所述多个臂中的至少一个上的至少一个电极; 以及与该医疗装置通信的电信号发生器，该电信号发生器被编程为将脉冲能量传送到医疗装置，足以引起不可逆电穿孔消融。

公开(公告)号：WO2012121882A1

公开(公告)日：2012-09-13

申请号：PCT/US2012/026042

申请日：2012-02-22

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  WERNETH, Randell L. ,  HOCINI, Meleze ,  STEWART, Mark T. ,  WITTENBERGER, Dan ,  CORVI, Timothy J. ,  LAU, Michael ,  SHARMA, Vinod

Inventor： WERNETH, Randell L. ,  HOCINI, Meleze ,  STEWART, Mark T. ,  WITTENBERGER, Dan ,  CORVI, Timothy J. ,  LAU, Michael ,  SHARMA, Vinod

IPC: A61B5/042 ,  A61N1/05 ,  A61B18/14

CPC classification number: A61B5/0422 ,  A61B18/1492 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2218/002

Abstract: A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.

Abstract translation: 一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。 控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。

公开(公告)号：WO2011089396A3

公开(公告)日：2012-04-26

申请号：PCT/GB2011000079

申请日：2011-01-21

Applicant: ST GEORGE S HOSPITAL MEDICAL SCHOOL ,  UNIV MANCHESTER ,  ROBINSON CLIVE ,  ZHANG JIHUI ,  GARROD DAVID RONALD ,  PERRIOR TREVOR ROBERT ,  NEWTON GARY KARL ,  JENKINS KERRY ,  BEEVERS REBEKAH ELISABETH ,  KIMBERLEY MERIEL RUTH ,  STEWART MARK RICHARD

Inventor： ROBINSON CLIVE ,  ZHANG JIHUI ,  GARROD DAVID RONALD ,  PERRIOR TREVOR ROBERT ,  NEWTON GARY KARL ,  JENKINS KERRY ,  BEEVERS REBEKAH ELISABETH ,  KIMBERLEY MERIEL RUTH ,  STEWART MARK RICHARD

IPC: C07K5/06 ,  A01N43/00 ,  A61K38/06 ,  A61P37/08 ,  C07K5/08

CPC classification number: C07K5/0202 ,  A01N37/46 ,  A01N43/16 ,  A01N43/30 ,  A01N43/36 ,  A01N43/38 ,  A01N43/40 ,  A01N43/42 ,  A01N43/48 ,  A01N43/60 ,  A01N43/72 ,  A01N43/84 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61K45/06 ,  C07K5/06008 ,  C07K5/06034 ,  C07K5/06078 ,  C07K5/06139 ,  C07K5/06191 ,  C07K5/0804 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821 ,  C07K5/0827

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to herein as "PVA compounds"), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.

Abstract translation: 本发明一般涉及治疗化合物领域，更具体地涉及式（X）的某些丙酮酰胺化合物（为了方便起见，统称为“PVA化合物”），其特别是抑制尘螨组 1肽酶变应原（例如，Der p 1，Der f 1，Eur m 1）。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制尘螨组1肽酶变应原和治疗由 尘螨组1肽酶变应原; 通过抑制尘螨组1肽酶变应原而得到改善; 哮喘; 鼻炎; 过敏性结膜炎 特应性皮炎; 由尘螨触发的过敏状况; 由尘螨组1肽酶变应原触发的过敏状况; 和犬特应性

公开(公告)号：WO2012004554A1

公开(公告)日：2012-01-12

申请号：PCT/GB2011/001011

申请日：2011-07-04

Applicant: ST GEORGE'S HOSPITAL MEDICAL SCHOOL ,  THE UNIVERSITY OF MANCHESTER ,  ROBINSON, Clive ,  ZHANG, Jihui ,  GARROD, David Ronald ,  PERRIOR, Trevor Robert ,  NEWTON, Gary Karl ,  JENKINS, Kerry ,  STEWART, Mark Richard ,  KIMBERLEY, Meriel Ruth

Inventor： ROBINSON, Clive ,  ZHANG, Jihui ,  GARROD, David Ronald ,  PERRIOR, Trevor Robert ,  NEWTON, Gary Karl ,  JENKINS, Kerry ,  STEWART, Mark Richard ,  KIMBERLEY, Meriel Ruth

IPC: C07K5/06 ,  A61K38/05 ,  A61P33/14

CPC classification number: C07K5/06191 ,  A61K38/00 ,  C07K5/06034 ,  C07K5/06078

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aldehyde compounds of the following formula (A) (for convenience, collectively referred to herein as "ALD compounds"), which, inter alia , inhibit a dust mite Group 1 peptidase allergen ( e.g. , Der p 1, Der f 1, Eur m 1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.

Abstract translation: 本发明一般涉及治疗化合物领域，更具体地涉及以下式（A）的某些醛化合物（为了方便起见，统称为“ALD化合物”），其特别地抑制尘螨 第1组肽酶变应原（例如，Der p 1，Der f 1，Eur m 1）。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制尘螨组1肽酶变应原和治疗由 尘螨1组肽酶变应原; 通过抑制尘螨组1肽酶变应原而得到改善; 哮喘; 鼻炎; 过敏性结膜炎 特应性皮炎; 由尘螨触发的过敏状况; 由尘螨组1肽酶变应原触发的过敏状况; 和犬特应性

公开(公告)号：WO2010106360A3

公开(公告)日：2011-03-03

申请号：PCT/GB2010050450

申请日：2010-03-16

Applicant: TAILWIND SOLUTIONS LTD ,  STEWART MARK ,  KNOX GARRY

Inventor： STEWART MARK ,  KNOX GARRY

IPC: G06Q30/00

CPC classification number: G07F19/205 ,  G07F7/1033 ,  G07F19/20

Abstract: The invention provides an apparatus (10) for mounting at least one electronic financial transaction (EFT) data input device (34) to a surface. The apparatus (10) comprises a mounting platform (12) which is fixedly attachable to said surface; and at least one adaptor (14) which, in use, receives and secures a first EFT data input device (34) thereto, wherein said at least one adaptor (14) is detachably mountable to said mounting platform (12).

Abstract translation: 本发明提供了一种用于将至少一个电子金融交易（EFT）数据输入装置（34）安装到表面的装置（10）。 所述装置（10）包括可固定地附接到所述表面的安装平台（12） 以及至少一个适配器（14），其在使用中接收并固定到其上的第一EFT数据输入装置（34），其中所述至少一个适配器（14）可拆卸地安装到所述安装平台（12）。

公开(公告)号：WO2010124285A1

公开(公告)日：2010-10-28

申请号：PCT/US2010/032425

申请日：2010-04-26

Applicant: MEDTRONIC INC. ,  SKARDA, Jim ,  STEWART, Mark ,  KEOGH, James ,  FRANCISCHELLI, David ,  GARDESKI, Ken ,  POSS, Tom ,  NEIDERT, Michael

Inventor： SKARDA, Jim ,  STEWART, Mark ,  KEOGH, James ,  FRANCISCHELLI, David ,  GARDESKI, Ken ,  POSS, Tom ,  NEIDERT, Michael

IPC: A61B19/00 ,  A61N1/05 ,  A61B17/00

CPC classification number: A61B1/00154 ,  A61B1/00135 ,  A61B34/20 ,  A61B90/361 ,  A61B2017/00243 ,  A61B2017/00336 ,  A61B2034/2051 ,  A61N1/056

Abstract: The present invention provides devices, instruments, systems, and methods to navigate medical instruments within the thoracic cavity. More specifically, the present invention provides a navigation system comprising medical instruments having electromagnetic tracking functionality and the integration of previously acquired imaging into a user interface of the navigation system.

Abstract translation: 本发明提供了用于在胸腔内导航医疗器械的装置，仪器，系统和方法。 更具体地，本发明提供了一种导航系统，其包括具有电磁跟踪功能的医疗仪器和将先前获取的成像集成到导航系统的用户界面中。

公开(公告)号：WO2008040979A1

公开(公告)日：2008-04-10

申请号：PCT/GB2007/003766

申请日：2007-10-04

Applicant: ARK THERAPEUTICS LTD. ,  JIA, Haiyan ,  ZACHARY, Ian ,  TICKNER, Michelle ,  CHENG, Lili ,  CHAPMAN, Chris ,  ELLARD, Katie ,  HARTZOULAKIS, Basil ,  JARVIS, Ashley ,  LYNCH, Rosemary ,  NALLY, Jamie ,  SELWOOD, David ,  STEWART, Mark

Inventor： JIA, Haiyan ,  ZACHARY, Ian ,  TICKNER, Michelle ,  CHENG, Lili ,  CHAPMAN, Chris ,  ELLARD, Katie ,  HARTZOULAKIS, Basil ,  JARVIS, Ashley ,  LYNCH, Rosemary ,  NALLY, Jamie ,  SELWOOD, David ,  STEWART, Mark

IPC: C07D277/56 ,  C07D307/68 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07K5/06 ,  C07K5/08 ,  A61P3/00 ,  A61P25/00 ,  A61P35/00 ,  C07C279/04

CPC classification number: C07D333/38 ,  C07C279/12 ,  C07D277/56 ,  C07D307/68 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists.

Abstract translation: 本发明是适合作为NP-1拮抗剂的式（I）或式（II）的化合物。

公开(公告)号：WO2007140331A3

公开(公告)日：2008-01-17

申请号：PCT/US2007069789

申请日：2007-05-25

Applicant: MEDTRONIC INC ,  STEWART MARK T ,  FRANCISCHELLI DAVID E ,  KEOGH JAMES R ,  HISSONG JAMES B ,  SKARDA JAMES R ,  LEE HOTAIK ,  SMITH NADINE B

Inventor： STEWART MARK T ,  FRANCISCHELLI DAVID E ,  KEOGH JAMES R ,  HISSONG JAMES B ,  SKARDA JAMES R ,  LEE HOTAIK ,  SMITH NADINE B

IPC: A61N7/02

CPC classification number: A61B17/320068 ,  A61B8/4281 ,  A61B34/20 ,  A61B2017/320076 ,  A61B2017/320078 ,  A61B2018/00291 ,  A61B2034/2051 ,  A61B2090/378 ,  A61B2090/3782 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A device and method for ablating tissue is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding an ablating member within the patient while tracking the position of the ablating member in the patient, positioning the ablating member in a desired position to ablate tissue, emitting ablating energy from the ablating member to form an ablated tissue area and removing the ablating member from the patient.

Abstract translation: 公开了一种用于消融组织的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪患者内的消融部件的位置的同时引导患者内的消融部件，定位消融 成员在消融组织的期望位置，从烧蚀构件发出消融能量以形成消融的组织区域，并从患者身上移除消融部件。

公开(公告)号：WO2007127664A1

公开(公告)日：2007-11-08

申请号：PCT/US2007/066952

申请日：2007-04-19

Applicant: MEDTRONIC, INC. ,  PLOTT, Christopher J. ,  OLSON, Andrew L. ,  CLOUTIER, Patrick J. ,  SMITH, Christopher W. ,  STEWART, Mark T. ,  FRANCISCHELLI, David E. ,  BRISCOE, Roderick E. ,  HAEG, Daniel C. ,  KIM, David J.S. ,  HOBDAY, Michael J. ,  KANAYINKAL, Tessy ,  GUBBIN, Douglas H. ,  ROTHSTEIN, Paul T. ,  CARDINAL, Joseph E. ,  FOLEY, Jessica L. ,  LEUER, Leonard H. ,  DAIGLE, Thomas P.

Inventor： PLOTT, Christopher J. ,  OLSON, Andrew L. ,  CLOUTIER, Patrick J. ,  SMITH, Christopher W. ,  STEWART, Mark T. ,  FRANCISCHELLI, David E. ,  BRISCOE, Roderick E. ,  HAEG, Daniel C. ,  KIM, David J.S. ,  HOBDAY, Michael J. ,  KANAYINKAL, Tessy ,  GUBBIN, Douglas H. ,  ROTHSTEIN, Paul T. ,  CARDINAL, Joseph E. ,  FOLEY, Jessica L. ,  LEUER, Leonard H. ,  DAIGLE, Thomas P.

IPC: A61B17/12 ,  A61B17/128 ,  A61B17/00

CPC classification number: A61B17/12009 ,  A61B17/12013 ,  A61B17/1285 ,  A61B2017/00243 ,  A61B2017/00296 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00632 ,  A61B2017/12018

Abstract: Some embodiments of the invention provide a system for occluding a left atrial appendage of a patient. Some embodiments of the system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. One embodiment discloses a method of accessing endocardial surfaces of the heart through the atrial appendage. Additional embodiments of the invention provide a clip occluder that can be positioned around the left atrial appendage. A clip applicator can position the clip occluder with respect to the left atrial appendage.

Abstract translation: 本发明的一些实施例提供一种用于闭塞患者的左心耳的系统。 该系统的一些实施例可以包括可以围绕左心耳定位的环形阻塞器和环形施放器，以相对于左心耳定位环形闭塞器。 一个实施例公开了通过心房附近获得心脏心内膜表面的方法。 本发明的另外的实施例提供了可围绕左心耳定位的夹子封堵器。 夹子施放器可以相对于左心耳定位夹子封堵器。

公开(公告)号：WO2007089676A1

公开(公告)日：2007-08-09

申请号：PCT/US2007/002333

申请日：2007-01-26

Applicant: MEDTRONIC, INC. ,  THOMPSON, Mark ,  DICKERSON, Darrin ,  BOWMAN, Brett, S. ,  KELLY, Christopher, F. ,  MALECKI, William, W. ,  FRANCISCHELLI, David ,  STEWART, Mark ,  DAIGLE, Thomas ,  GUBBIN, Douglas ,  KIM, David ,  ROTHSTEIN, Paul ,  PODBELSKI, Adam ,  PLOTT, Christopher ,  YAFFE, Benjamin, K.

Inventor： THOMPSON, Mark ,  DICKERSON, Darrin ,  BOWMAN, Brett, S. ,  KELLY, Christopher, F. ,  MALECKI, William, W. ,  FRANCISCHELLI, David ,  STEWART, Mark ,  DAIGLE, Thomas ,  GUBBIN, Douglas ,  KIM, David ,  ROTHSTEIN, Paul ,  PODBELSKI, Adam ,  PLOTT, Christopher ,  YAFFE, Benjamin, K.

IPC: A61B17/00 ,  A61B1/00 ,  A61B17/02 ,  A61B19/00 ,  A61B17/32

CPC classification number: A61B17/00234 ,  A61B1/0055 ,  A61B17/0218 ,  A61B18/1482 ,  A61B90/30 ,  A61B2017/003 ,  A61B2017/00367 ,  A61B2017/320044 ,  A61B2090/0811

Abstract: A device for dissecting tissue and/or guidance of a second device to a desired physiological location, the device comprising: an elongate shaft comprising a proximal portion and a distal portion, wherein the distal portion comprises a plurality of segments that articulate with respect to one another; and a handle attached to the proximal portion of the shaft, wherein the handle comprises controls for articulating the plurality of segments of the distal portion of the shaft with respect to one another. A system for dissecting tissue and or guiding a medical device to a desired physiological location.

Abstract translation: 一种用于将第二装置的组织和/或引导解剖到期望的生理位置的装置，所述装置包括：细长轴，其包括近端部分和远侧部分，其中所述远端部分包括多个相对于一个 另一个; 以及附接到所述轴的近侧部分的手柄，其中所述手柄包括用于相对于彼此铰接所述轴的远侧部分的所述多个段的控制。 一种用于将组织切割和/或将医疗装置引导至所需生理位置的系统。