公开(公告)号：WO2006113552A8

公开(公告)日：2007-03-29

申请号：PCT/US2006014286

申请日：2006-04-14

Applicant: SMITHKLINE BEECHAM CORP ,  JONES DAVID G ,  KALDOR ISTVAN ,  LIANG XI ,  TURNBULL PHILIP STEWART ,  HAMMOND MARLYS ,  KALLANDER LARA S ,  THOMPSON SCOTT KEVIN ,  WASHBURN DAVID

Inventor： JONES DAVID G ,  KALDOR ISTVAN ,  LIANG XI ,  TURNBULL PHILIP STEWART ,  HAMMOND MARLYS ,  KALLANDER LARA S ,  THOMPSON SCOTT KEVIN ,  WASHBURN DAVID

IPC: C07C255/58

CPC classification number: C07C255/58 ,  C07D205/04 ,  C07D213/38 ,  C07D277/04 ,  C07D295/185 ,  C07D307/52 ,  C07D333/20

Abstract: The present invention relates to a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or a combination thereof; wherein R°, R 1 , R 1' , R 2 , R 2' , R 3 and n are defined herein. The present invention further relates to a method of treating a patient from endometreosis or uterine fibroids.

Abstract translation: 本发明涉及由下式（I）表示的化合物或其药学上可接受的盐，或其药学上可接受的溶剂合物或其组合; 其中R 1，R 1，R 1，R 2，R 2，R 2， 3和n在本文中定义。 本发明还涉及从子宫内膜异位或子宫肌瘤治疗患者的方法。

公开(公告)号：WO2006133216A2

公开(公告)日：2006-12-14

申请号：PCT/US2006/021966

申请日：2006-06-06

Applicant: SMITHKLINE BEECHAM CORPORATION ,  TURNBULL, Philip Stewart ,  CADILLA, Rodolfo ,  LARKIN, Andrew Lamont ,  STEWART, Eugene Lee ,  STETSON, Katherine

Inventor： TURNBULL, Philip Stewart ,  CADILLA, Rodolfo ,  LARKIN, Andrew Lamont ,  STEWART, Eugene Lee ,  STETSON, Katherine

CPC classification number: C07D307/52 ,  C07C211/52 ,  C07C255/58 ,  C07C317/32 ,  C07C323/32 ,  C07C2601/02 ,  C07C2602/08 ,  C07D233/54 ,  C07D233/64 ,  C07D249/16 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D263/34 ,  C07D271/06 ,  C07D271/10 ,  C07D277/28 ,  C07D277/64 ,  C07D307/54 ,  C07D307/81 ,  C07D333/20 ,  C07D333/62 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及作为雄激素，糖皮质激素，盐皮质激素和黄体酮受体的调节剂的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2005000795A2

公开(公告)日：2005-01-06

申请号：PCT/US2004/018252

申请日：2004-06-09

Applicant: SMITHKLINE BEECHAM CORPORATION ,  BLANC, Jean-Baptiste, E. ,  CADILLA, Rodolfo ,  COWAN, David, John ,  KALDOR, Istvan ,  LARKIN, Andrew, L. ,  STEWART, Eugene, Lee ,  TURNBULL, Philip, Stewart ,  TRUMP, Ryan, Paul

Inventor： BLANC, Jean-Baptiste, E. ,  CADILLA, Rodolfo ,  COWAN, David, John ,  KALDOR, Istvan ,  LARKIN, Andrew, L. ,  STEWART, Eugene, Lee ,  TURNBULL, Philip, Stewart ,  TRUMP, Ryan, Paul

IPC: C07C255/00

CPC classification number: C07C323/25 ,  A61K31/275 ,  C07C211/10 ,  C07C211/11 ,  C07C211/52 ,  C07C211/53 ,  C07C215/76 ,  C07C217/08 ,  C07C217/20 ,  C07C217/28 ,  C07C225/22 ,  C07C247/04 ,  C07C255/58 ,  C07C255/59 ,  C07C311/05 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14

Abstract: This invention relates to non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及被认为是雄激素，糖皮质激素，盐皮质激素和孕酮受体的调节剂的苯胺衍生的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2004110978A3

公开(公告)日：2004-12-23

申请号：PCT/US2004/018456

申请日：2004-06-09

Applicant: SMITHKLINE BEECHAM CORPORATION ,  CADILLA, Rodolfo ,  LARKIN, Andrew, L. ,  STEWART, Eugene, Lee ,  TRUMP, Ryan, Paul ,  TURNBULL, Philip, Stewart

Inventor： CADILLA, Rodolfo ,  LARKIN, Andrew, L. ,  STEWART, Eugene, Lee ,  TRUMP, Ryan, Paul ,  TURNBULL, Philip, Stewart

IPC: C07C211/59

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

公开(公告)号：WO2004110978A2

公开(公告)日：2004-12-23

申请号：PCT/US2004018456

申请日：2004-06-09

Applicant: SMITHKLINE BEECHAM CORP ,  CADILLA RODOLFO ,  LARKIN ANDREW L ,  STEWART EUGENE LEE ,  TRUMP RYAN PAUL ,  TURNBULL PHILIP STEWART

Inventor： CADILLA RODOLFO ,  LARKIN ANDREW L ,  STEWART EUGENE LEE ,  TRUMP RYAN PAUL ,  TURNBULL PHILIP STEWART

IPC: C07C211/59 ,  C07C215/16 ,  C07C255/58 ,  C07D295/13 ,  C07C211/00

CPC classification number: C07D295/13 ,  C07C211/59 ,  C07C215/16 ,  C07C255/58 ,  C07C2601/02 ,  C07C2601/14

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及作为雄激素，糖皮质激素，盐皮质激素和孕酮受体的调节剂的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2006113552A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/014286

申请日：2006-04-14

Applicant: SMITHKLINE BEECHAM CORPORATION ,  JONES, David, G. ,  KALDOR, Istvan ,  LIANG, Xi ,  TURNBULL, Philip, Stewart ,  HAMMOND, Marlys ,  KALLANDER, Lara, S. ,  THOMPSON, Scott, Kevin ,  WASHBURN, David

Inventor： JONES, David, G. ,  KALDOR, Istvan ,  LIANG, Xi ,  TURNBULL, Philip, Stewart ,  HAMMOND, Marlys ,  KALLANDER, Lara, S. ,  THOMPSON, Scott, Kevin ,  WASHBURN, David

IPC: C07C255/58

CPC classification number: C07C255/58 ,  C07D205/04 ,  C07D213/38 ,  C07D277/04 ,  C07D295/185 ,  C07D307/52 ,  C07D333/20

Abstract: The present invention relates to a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or a combination thereof; wherein R°, R 1 , R 1' , R 2 , R 2' , R 3 and n are defined herein. The present invention further relates to a method of treating a patient from endometreosis or uterine fibroids.

Abstract translation: 本发明涉及由下式（I）表示的化合物或其药学上可接受的盐，或其药学上可接受的溶剂合物或其组合; 其中R 1，R 1，R 1，R 2，R 2，R 2， 3和n在本文中定义。 本发明还涉及从子宫内膜异位或子宫肌瘤治疗患者的方法。

公开(公告)号：WO2006002185A1

公开(公告)日：2006-01-05

申请号：PCT/US2005/021963

申请日：2005-06-21

Applicant: SMITHKLINE BEECHAM CORPORATION ,  HEYER, Dennis ,  FANG, Jing ,  NAVAS III, Frank ,  KATAMREDDY, Subba, Reddy ,  PECKHAM, Jennifer, Poole ,  TURNBULL, Philip, Stewart ,  MILLER, Aaron, Bayne ,  AKWABI-AMEYAW, Adwoa

Inventor： HEYER, Dennis ,  FANG, Jing ,  NAVAS III, Frank ,  KATAMREDDY, Subba, Reddy ,  PECKHAM, Jennifer, Poole ,  TURNBULL, Philip, Stewart ,  MILLER, Aaron, Bayne ,  AKWABI-AMEYAW, Adwoa

IPC: C07C65/26

CPC classification number: C07D213/30 ,  C07C43/295 ,  C07C59/68 ,  C07C59/70 ,  C07C59/72 ,  C07C65/24 ,  C07C69/92 ,  C07C233/25 ,  C07C235/34 ,  C07C235/46 ,  C07C255/54 ,  C07C311/08 ,  C07C311/09 ,  C07C311/21 ,  C07C2601/02 ,  C07D211/62 ,  C07D295/108 ,  C07D295/185 ,  C07D307/42 ,  C07D333/16 ,  C07F9/3826 ,  C07F9/4006

Abstract: The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation.

Abstract translation: 本发明涉及具有多种治疗用途的新化合物，更特别地涉及特别适用于选择性雌激素受体调节的新型萘化合物。

公开(公告)号：WO2008121602A1

公开(公告)日：2008-10-09

申请号：PCT/US2008/058091

申请日：2008-03-25

Applicant: SMITHKLINE BEECHAM CORPORATION ,  RAFFERTY, Stephen, William ,  STEWART, Eugene, L. ,  TURNBULL, Philip, Stewart ,  YATES, Christopher M.

Inventor： RAFFERTY, Stephen, William ,  STEWART, Eugene, L. ,  TURNBULL, Philip, Stewart ,  YATES, Christopher M.

IPC: A01N43/00 ,  A61K31/00 ,  A61K31/553

CPC classification number: C07D267/14

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及作为雄激素受体调节剂的非甾体化合物，还涉及制备和使用这些化合物的方法。

公开(公告)号：WO2008042571A2

公开(公告)日：2008-04-10

申请号：PCT/US2007078333

申请日：2007-09-13

Applicant: SMITHKLINE BEECHAM CORP ,  CADILLA RODOLFO ,  LARKIN ANDREW ,  MCDOUGALD DARRYL LYNN ,  RANDHAWA AMARJIT SAB ,  RAY JOHN A ,  STETSON KATHERINE ,  STEWART EUGENE L ,  TURNBULL PHILIP STEWART ,  ZHOU HUIQUIANG

Inventor： CADILLA RODOLFO ,  LARKIN ANDREW ,  MCDOUGALD DARRYL LYNN ,  RANDHAWA AMARJIT SAB ,  RAY JOHN A ,  STETSON KATHERINE ,  STEWART EUGENE L ,  TURNBULL PHILIP STEWART ,  ZHOU HUIQUIANG

IPC: A01N45/00

CPC classification number: C07D413/12 ,  C07D209/10 ,  C07D209/42 ,  C07D235/08 ,  C07D235/10 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/14 ,  C07D417/12

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及作为雄激素受体调节剂的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2006113552A3

公开(公告)日：2007-05-31

申请号：PCT/US2006014286

申请日：2006-04-14

Applicant: SMITHKLINE BEECHAM CORP ,  JONES DAVID G ,  KALDOR ISTVAN ,  LIANG XI ,  TURNBULL PHILIP STEWART ,  HAMMOND MARLYS ,  KALLANDER LARA S ,  THOMPSON SCOTT KEVIN ,  WASHBURN DAVID

Inventor： JONES DAVID G ,  KALDOR ISTVAN ,  LIANG XI ,  TURNBULL PHILIP STEWART ,  HAMMOND MARLYS ,  KALLANDER LARA S ,  THOMPSON SCOTT KEVIN ,  WASHBURN DAVID

IPC: A61K31/535 ,  A61K31/275 ,  A61K31/335 ,  A61K31/38 ,  A61K31/44 ,  A61K31/445 ,  C07C255/50 ,  C07D211/56 ,  C07D211/72 ,  C07D265/30 ,  C07D279/12 ,  C07D307/02 ,  C07D333/22

CPC classification number: C07C255/58 ,  C07D205/04 ,  C07D213/38 ,  C07D277/04 ,  C07D295/185 ,  C07D307/52 ,  C07D333/20

Abstract: The present invention relates to a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or a combination thereof; wherein R°, R 1 , R 1' , R 2 , R 2' , R 3 and n are defined herein. The present invention further relates to a method of treating a patient from endometreosis or uterine fibroids.

Abstract translation: 本发明涉及由下式（I）表示的化合物或其药学上可接受的盐，或其药学上可接受的溶剂化物，或其组合; 其中R 0，R 1，R 1，R 1，R 2，R 2，R 3，R 4， 3和n在此定义。 本发明还涉及治疗子宫内膜异位症或子宫肌瘤患者的方法。