公开(公告)号：WO2006093832A3

公开(公告)日：2007-03-22

申请号：PCT/US2006006615

申请日：2006-02-24

Applicant: RENOVIS INC ,  KELLY MICHAEL ,  KINCAID JOHN ,  DUNCTON MATTHEW ,  SAHASRABUDHE KIRAN ,  JANAGANI SATYNARAHANA ,  UPASANI RAVINDRA ,  WU GUOXIAN ,  FANG YUNFENG ,  WEI ZHI-LIANG

Inventor： KELLY MICHAEL ,  KINCAID JOHN ,  DUNCTON MATTHEW ,  SAHASRABUDHE KIRAN ,  JANAGANI SATYNARAHANA ,  UPASANI RAVINDRA ,  WU GUOXIAN ,  FANG YUNFENG ,  WEI ZHI-LIANG

IPC: A61K31/538 ,  A61K31/4709 ,  C07D405/14 ,  C07D413/02

CPC classification number: C07D209/08 ,  C07D209/48 ,  C07D209/50 ,  C07D215/06 ,  C07D215/38 ,  C07D217/02 ,  C07D217/22 ,  C07D231/56 ,  C07D235/06 ,  C07D235/08 ,  C07D237/28 ,  C07D241/42 ,  C07D263/58 ,  C07D265/16 ,  C07D265/36 ,  C07D267/14 ,  C07D277/46 ,  C07D277/64 ,  C07D295/088 ,  C07D295/13 ,  C07D317/52 ,  C07D317/58 ,  C07D319/18 ,  C07D333/54 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/052 ,  C07D498/04

Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛 ，炎症，创伤性损伤等。

公开(公告)号：WO2005046683A1

公开(公告)日：2005-05-26

申请号：PCT/US2004/033163

申请日：2004-10-07

Applicant: RENOVIS, INC. ,  UPASANI, Ravindra, B. ,  KELLY, Michael, G. ,  JANAGANI, Satyanarayana

Inventor： UPASANI, Ravindra, B. ,  KELLY, Michael, G. ,  JANAGANI, Satyanarayana

IPC: A61K31/44

CPC classification number: C07D319/18 ,  C04B35/632 ,  C07C233/65 ,  C07C233/66 ,  C07C233/69 ,  C07C233/73 ,  C07C233/75 ,  C07C255/60 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/337 ,  C07D209/08 ,  C07D209/14 ,  C07D209/16 ,  C07D209/18 ,  C07D209/88 ,  C07D211/34 ,  C07D211/58 ,  C07D213/40 ,  C07D213/53 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D213/82 ,  C07D215/12 ,  C07D215/38 ,  C07D217/02 ,  C07D221/10 ,  C07D221/12 ,  C07D221/14 ,  C07D231/40 ,  C07D233/54 ,  C07D233/61 ,  C07D233/64 ,  C07D239/42 ,  C07D277/46 ,  C07D295/13 ,  C07D295/135 ,  C07D307/14 ,  C07D307/52 ,  C07D307/54 ,  C07D317/50 ,  C07D317/58 ,  C07D319/12 ,  C07D333/20 ,  C07D333/24 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06

Abstract: Compounds are disclosed that have a formula represented by the following: Formula (I) The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有由下式表示的式的化合物：式（I）化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症， 疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2004034999A2

公开(公告)日：2004-04-29

申请号：PCT/US2003/032883

申请日：2003-10-15

Applicant: RENOVIS, INC. ,  KHAN, M., Amin ,  UPASANI, Ravindra, B. ,  WOOD, Paul, L.

Inventor： KHAN, M., Amin ,  UPASANI, Ravindra, B. ,  WOOD, Paul, L.

IPC: A61K

CPC classification number: C07C309/46 ,  C07C291/02 ,  C07C309/73 ,  C07C311/21 ,  C07C311/51 ,  C07C2601/14 ,  C07D309/12

Abstract: Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therapeutics for inflammation-related conditions and analgesia in mammals, such as arthritis, and for neuropathic pain and traumatic injuries such as traumatic brain injury and acute spinal cord injury. The invention accordingly extends to the use of the compounds and compositions for the stated treatments, and as appropriate, to the use of the compounds for the preparation of pharmaceutical compositions for such treatments.

Abstract translation: 公开了硝酮化合物和含有这些化合物的药物组合物。 硝酮化合物在硝酮官能团和硝酮芳环之间具有一个至六个额外的碳桥连。 所公开的组合物可用作哺乳动物炎症相关病症和镇痛的治疗剂，例如关节炎，以及神经性疼痛和创伤性损伤如创伤性脑损伤和急性脊髓损伤。 因此，本发明延伸到用于所述治疗的化合物和组合物的用途，并且视情况而定，涉及所述化合物用于制备用于这种治疗的药物组合物的用途。

公开(公告)号：WO2005016272A2

公开(公告)日：2005-02-24

申请号：PCT/US2004/025193

申请日：2004-08-04

Applicant: RENOVIS, INC. ,  KELLY, Michael, G. ,  JANAGANI, Satyanarayana ,  UPASANI, Ravindra, B.

Inventor： KELLY, Michael, G. ,  JANAGANI, Satyanarayana ,  UPASANI, Ravindra, B.

IPC: A61K

CPC classification number: C07C291/02 ,  C07C309/46 ,  C07C309/61 ,  C07C309/76 ,  C07C311/16 ,  C07C323/47 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/42 ,  C07D213/65 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D215/36 ,  C07D231/12 ,  C07D233/06 ,  C07D295/135 ,  C07D333/38 ,  C07F9/3856 ,  C07F9/4021

Abstract: Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune and inflammatory diseases or conditions in mammals.

Abstract translation: 公开了芳基，杂芳族和双环芳基硝酮化合物和含有这些衍生物的药物组合物。 所公开的组合物可用于预防和/或治疗哺乳动物中的疼痛，神经退行性，自身免疫性和炎性疾病或病症。

公开(公告)号：WO0057877A8

公开(公告)日：2001-04-05

申请号：PCT/US0007944

申请日：2000-03-24

Applicant: COCENSYS INC ,  HOGENKAMP DERK J ,  UPASANI RAVINDRA ,  NGUYEN PHONG

Inventor： HOGENKAMP DERK J ,  UPASANI RAVINDRA ,  NGUYEN PHONG

IPC: C07D233/64 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/426 ,  A61K31/497 ,  A61K31/506 ,  A61P9/06 ,  A61P9/10 ,  A61P21/02 ,  A61P23/02 ,  A61P25/06 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P27/06 ,  A61P27/16 ,  A61P29/00 ,  A61P43/00 ,  C07D207/40 ,  C07D207/416 ,  C07D231/12 ,  C07D233/54 ,  C07D235/18 ,  C07D263/34 ,  C07D277/20 ,  C07D277/32 ,  C07D277/56 ,  C07D403/04 ,  A61K31/496 ,  A61K31/5377 ,  C07D207/30 ,  C07D231/10 ,  C07D403/00 ,  C07D413/00

CPC classification number: C07D207/416 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/18 ,  C07D263/34 ,  C07D277/56 ,  C07D403/04

Abstract: This invention relates to compounds having Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Abstract translation: 本发明涉及具有式（I）的化合物或其药学上可接受的盐，前药或溶剂化物，其中Het和R5-R13在本说明书中设定。 本发明还涉及式（I）化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及用于治疗，预防 或改善急性或慢性疼痛，作为抗惊厥剂，抗惊厥药，抗抑郁药，作为局部麻醉剂，作为抗心律失常药，以及用于治疗或预防糖尿病性神经病变。

公开(公告)号：WO2022133064A1

公开(公告)日：2022-06-23

申请号：PCT/US2021/063761

申请日：2021-12-16

Applicant: BIOMEA FUSION, INC. ,  BUTLER, Thomas ,  PALMER, James T. ,  KIRSCHBERG, Thorsten ,  LIN, Nan-Horng ,  HUI, Hon ,  UPASANI, Ravindra ,  UNGASHE, Solomon B. ,  SPERANDIO, David

Inventor： BUTLER, Thomas ,  PALMER, James T. ,  KIRSCHBERG, Thorsten ,  LIN, Nan-Horng ,  HUI, Hon ,  UPASANI, Ravindra ,  UNGASHE, Solomon B. ,  SPERANDIO, David

IPC: C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  A61P35/00 ,  A61K31/519

Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

公开(公告)号：WO2013036835A1

公开(公告)日：2013-03-14

申请号：PCT/US2012/054261

申请日：2012-09-07

Applicant: SAGE THERAPEUTICS, INC. ,  UPASANI, Ravindra, B. ,  HARRISON, Boyd, L. ,  ASKEW, Benny, C. Jr. ,  DODART, Jean-Cosme ,  SALITURO, Francesco, G. ,  ROBICHAUD, Albert, J.

Inventor： UPASANI, Ravindra, B. ,  HARRISON, Boyd, L. ,  ASKEW, Benny, C. Jr. ,  DODART, Jean-Cosme ,  SALITURO, Francesco, G. ,  ROBICHAUD, Albert, J.

IPC: C07J41/00 ,  C07J31/00 ,  C07J9/00 ,  A61K31/57 ,  A61K31/575 ,  A61P25/18 ,  A61P25/28

CPC classification number: C07J41/00 ,  C07J1/00 ,  C07J1/0029 ,  C07J3/00 ,  C07J7/007 ,  C07J9/00 ,  C07J9/005 ,  C07J31/003 ,  C07J31/006 ,  C07J41/0005 ,  C07J41/0011 ,  C07J41/0055 ,  C07J43/003

Abstract: Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, wherein Z is a group of the formula (i), (ii), (iii), (iv), or (v), and wherein L 1 , L 2 , L 3 , X 1 , X 2 , Y, R z4 , R z5 , R z6 , n, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b , R 6a , R 6b , R 7a , R 7b , R 11a , R 11b , R 14 , R 17 , R 19 , R 20 , R 23a , R 23b , and R 24 are as defined herein, and pharmaceutical compositions thereof. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions in mammals.

Abstract translation: 根据式（I）和其药学上可接受的盐提供化合物，其中Z是式（i），（ii），（iii），（iv）或（v）的基团，其中L 1， L3，X1，X2，Y，Rz4，Rz5，Rz6，n，R1，R2，R3a，R3b，R4a，R4b，R6a，R6b，R7a，R7b，R11a，R11b，R14，R17，R19，R20， R23b和R24如本文所定义，及其药物组合物。 本发明的化合物可用于预防和治疗哺乳动物中各种CNS相关病症。

公开(公告)号：WO2007100758A2

公开(公告)日：2007-09-07

申请号：PCT/US2007/004912

申请日：2007-02-22

Applicant: RENOVIS, INC. ,  KELLY, Michael, G. ,  KAUB, Carl, J. ,  KINCAID, John ,  JANAGANI, Satyanarayana ,  WU, Guoxian ,  WEI, Zhi-Liang ,  SAHASRABUDHE, Kiran ,  DUNCTON, Matthew ,  UPASANI, Ravindra, B. ,  FANG, Yunfeng ,  COX, Matthew

Inventor： KELLY, Michael, G. ,  KAUB, Carl, J. ,  KINCAID, John ,  JANAGANI, Satyanarayana ,  WU, Guoxian ,  WEI, Zhi-Liang ,  SAHASRABUDHE, Kiran ,  DUNCTON, Matthew ,  UPASANI, Ravindra, B. ,  FANG, Yunfeng ,  COX, Matthew

CPC classification number: C07D209/08 ,  C07D209/48 ,  C07D209/50 ,  C07D215/06 ,  C07D215/38 ,  C07D217/02 ,  C07D217/22 ,  C07D231/56 ,  C07D235/06 ,  C07D235/08 ,  C07D237/28 ,  C07D241/42 ,  C07D263/58 ,  C07D265/16 ,  C07D265/36 ,  C07D267/14 ,  C07D277/46 ,  C07D277/64 ,  C07D295/088 ,  C07D295/13 ,  C07D317/52 ,  C07D317/58 ,  C07D319/18 ,  C07D333/54 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/052 ,  C07D498/04

Abstract: Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有由下式表示的式的化合物：式（I）。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2005037208A3

公开(公告)日：2005-04-28

申请号：PCT/US2004/033746

申请日：2004-10-14

Applicant: RENOVIS, INC. ,  KELLY, Michael, G. ,  UPASANI, Ravindra, B. ,  JANAGANI, Satyanarayana

Inventor： KELLY, Michael, G. ,  UPASANI, Ravindra, B. ,  JANAGANI, Satyanarayana

IPC: A01N43/58

Abstract: Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune and inflammatory diseases or conditions in mammals.

公开(公告)号：WO2006093832A2

公开(公告)日：2006-09-08

申请号：PCT/US2006/006615

申请日：2006-02-24

Applicant: RENOVIS, INC. ,  KELLY, Michael ,  KINCAID, John ,  DUNCTON, Matthew ,  SAHASRABUDHE, Kiran ,  JANAGANI, Satynarahana ,  UPASANI, Ravindra ,  WU, Guoxian ,  FANG, Yunfeng ,  WEI, Zhi-liang

Inventor： KELLY, Michael ,  KINCAID, John ,  DUNCTON, Matthew ,  SAHASRABUDHE, Kiran ,  JANAGANI, Satynarahana ,  UPASANI, Ravindra ,  WU, Guoxian ,  FANG, Yunfeng ,  WEI, Zhi-liang

CPC classification number: C07D209/08 ,  C07D209/48 ,  C07D209/50 ,  C07D215/06 ,  C07D215/38 ,  C07D217/02 ,  C07D217/22 ,  C07D231/56 ,  C07D235/06 ,  C07D235/08 ,  C07D237/28 ,  C07D241/42 ,  C07D263/58 ,  C07D265/16 ,  C07D265/36 ,  C07D267/14 ,  C07D277/46 ,  C07D277/64 ,  C07D295/088 ,  C07D295/13 ,  C07D317/52 ,  C07D317/58 ,  C07D319/18 ,  C07D333/54 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/052 ,  C07D498/04

Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.