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    METHODS OF PRESERVING MUSCLE STRENGTH DURING A PERIOD OF MUSCLE DISUSE BY ADMINISTERING BETA-HYDROXY-BETA-METHYLBUTYRATE AND GREEN TEA EXTRACT
    3.
    发明申请
    METHODS OF PRESERVING MUSCLE STRENGTH DURING A PERIOD OF MUSCLE DISUSE BY ADMINISTERING BETA-HYDROXY-BETA-METHYLBUTYRATE AND GREEN TEA EXTRACT 审中-公开
    通过管理β-羟基 - 甲基丁酸钠和绿茶提取物在肌肉发育期间保存肌肉强度的方法

    公开(公告)号：WO2016044272A1

    公开(公告)日：2016-03-24

    申请号：PCT/US2015/050179

    申请日：2015-09-15

    Applicant: ABBOTT LABORATORIES

    Inventor： PEREIRA, Suzette ,  EDENS, Neile

    IPC: A61K36/82 ,  A61K31/19 ,  A61K31/198 ,  A61K31/353 ,  A61P21/06

    CPC classification number: A61K31/19 ,  A61K31/198 ,  A61K31/353 ,  A61K36/82 ,  A61K2300/00

    Abstract: Methods of preserving muscle strength in a subject during a period of muscle disuse are provided. Methods of preserving muscle strength in a subject during a period of muscle disuse and a subsequent period of muscle recovery are also provided. The methods include administering a composition including β-hydroxy-β-methylbutyrate and green tea extract to the subject during at least a portion of the period of muscle disuse and, optionally, during at least a portion of the period of muscle recovery. The composition may also include leucine or another leucine metabolite, such as α-ketoisocaproic acid or α-hydroxyisocaproic acid.

    Abstract translation: 提供在肌肉消除期间保持受试者肌肉力量的方法。 还提供了在肌肉消除期间和随后的肌肉恢复期间保持受试者肌肉力量的方法。 所述方法包括在至少一段时间的肌肉消除期间和任选地在至少一部分肌肉恢复期间内向受试者施用包含β-羟基-β-甲基丁酸酯和绿茶提取物的组合物。 组合物还可以包括亮氨酸或另一亮氨酸代谢物，例如α-酮异己酸或α-羟基异己酸。

    LIQUID NUTRITIONAL COMPOSITIONS COMPRISING GCG AND EGCG
    4.
    发明申请
    LIQUID NUTRITIONAL COMPOSITIONS COMPRISING GCG AND EGCG 审中-公开
    包含GCG和EGCG的液体营养组合物

    公开(公告)号：WO2015126716A1

    公开(公告)日：2015-08-27

    申请号：PCT/US2015/015566

    申请日：2015-02-12

    Applicant: ABBOTT LABORATORIES

    Inventor： MEADOR, Benjamin ,  PEREIRA, Suzette ,  EDENS, Neile ,  PATEL, Gaurav

    IPC: A23L1/30 ,  A23L1/305 ,  A23L2/52 ,  A23L2/66

    CPC classification number: A23L2/52 ,  A23L2/66 ,  A23L33/10 ,  A23L33/105 ,  A23L33/17

    Abstract: A liquid nutritional composition includes a source of epigallocatechin gallate and at least one of a source of protein, a source of carbohydrate, and a source of fat. The liquid nutritional composition includes gallocatechin gallate and epigallocatechin gallate in a ratio of about 1:20 to about 1:0.60. At least a portion of the gallocatechin gallate is formed by epimerization of the epigallocatechin gallate as a result of application of heat to the liquid nutritional composition. Methods of making the liquid nutritional composition are also provided.

    Abstract translation: 液体营养组合物包括表没食子儿茶素没食子酸酯的来源和蛋白质来源，碳水化合物源和脂肪源中的至少一种。 液体营养组合物包含比例为约1:20至约1:0.60的没食子儿茶素没食子酸酯和表没食子儿茶素没食子酸酯。 通过向液体营养组合物施加热量，表儿茶素没食子酸酯的至少一部分由表没食子儿茶素没食子酸酯的差向异构化形成。 还提供了制备液体营养组合物的方法。

    CONDITIONAL ESSENTIALITY OF HMB
    7.
    发明申请
    CONDITIONAL ESSENTIALITY OF HMB 审中-公开
    HMB的条件性质

    公开(公告)号：WO2015105981A2

    公开(公告)日：2015-07-16

    申请号：PCT/US2015/010631

    申请日：2015-01-08

    Applicant: ABBOTT LABORATORIES

    Inventor： EDENS, Neile ,  GELLING, Richard ,  SATHYAVAGEESWARAN, Shreeram

    IPC: A23L1/29

    CPC classification number: A61K45/06 ,  A23L33/10 ,  A23L33/17 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/155 ,  A61K31/19 ,  A61K31/573 ,  A61K2300/00 ,  A23V2200/316

    Abstract: A method of increasing or maintaining lean body mass in leucine conversion-compromised subjects and subjects undergoing treatment for diabetes is provided. The method includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to a subject with compromised leucine conversion efficiency or a subject undergoing treatment for insulin resistance associated with diabetes. Administration of HMB to a leucine conversion-compromised subject or a subject undergoing treatment for diabetes is effective to increase or maintain the human's lean body mass.

    Abstract translation: 提供了一种增加或维持亮氨酸转化受损受试者和经历糖尿病治疗的受试者的瘦体重的方法。 该方法包括向具有降低的亮氨酸转化效率的受试者或经历与糖尿病相关的胰岛素抵抗治疗的受试者施用有效量的β-羟基-β-甲基丁酸酯（HMB）。 将HMB给予亮氨酸转化受损对象或正在接受糖尿病治疗的受试者有效地增加或维持人的瘦体重。

    METHODS OF MAINTAINING AND IMPROVING MUSCLE FUNCTION
    9.
    发明申请
    METHODS OF MAINTAINING AND IMPROVING MUSCLE FUNCTION 审中-公开
    维持和改善肌肉功能的方法

    公开(公告)号：WO2014144458A1

    公开(公告)日：2014-09-18

    申请号：PCT/US2014/028879

    申请日：2014-03-14

    Applicant: ABBOTT LABORATORIES

    Inventor： GARVEY, Sean ,  PEREIRA, Suzette ,  EDENS, Neile

    IPC: A23L1/30 ,  A23L2/50

    CPC classification number: A61K31/353 ,  A23L2/50 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/316 ,  A61K9/0053 ,  A23V2250/214

    Abstract: Methods of decreasing muscle function decline and improving muscle function in a subject are provided. The methods utilize an effective amount of epigallocatechin-3-gallate (EGCg) to increase the level of muscle vascular endothelial growth factor A (VEGF), to decrease myostatin levels, or both, and thereby decrease muscle function decline or improve muscle function. The EGCg may be provided as part of a nutritional composition.

    Abstract translation: 提供减少肌肉功能下降和改善受试者肌肉功能的方法。 该方法利用有效量的表没食子儿茶素-3-没食子酸酯（EGCg）来增加肌肉血管内皮生长因子A（VEGF）的水平，降低肌生成抑制素水平或两者，从而降低肌肉功能下降或改善肌肉功能。 EGCg可以作为营养组合物的一部分提供。

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