利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

16 条记录 (耗时 0.016 秒)

    ELECTROPHORETIC SYSTEM WITH MULTI-NOTCH FILTER AND LASER EXCITATION SOURCE
    2.
    发明申请
    ELECTROPHORETIC SYSTEM WITH MULTI-NOTCH FILTER AND LASER EXCITATION SOURCE 审中-公开
    具有多孔过滤器和激光源的电泳系统

    公开(公告)号：WO2005008235A3

    公开(公告)日：2005-08-18

    申请号：PCT/US2004022202

    申请日：2004-07-08

    申请人： APPLERA CORP ,  OLDHAM MARK F ,  NORDMAN ERIC S ,  REEL RICHARD T ,  SHIGEURA JANICE G LF

    发明人： OLDHAM MARK F ,  NORDMAN ERIC S ,  REEL RICHARD T ,  SHIGEURA JOHN S DI

    IPC分类号： G01N15/14 ,  G01N27/447 ,  G02B5/28

    CPC分类号： G01N15/1475 ,  B01D57/02 ,  G01N27/44721 ,  G01N2015/144 ,  G01N2015/149

    摘要： Apparatus and methods for detecting analytes in a sample are provided. The apparatus includes: one or more channels having a dectection zone (14); one or more irradiation sources (16) disposed for irradiating the detection zone (14) with radiation; a detector (34) capable of collecting at least one chage corresponding to an emission beam (22) emitted from the detection zone (14), the detector (34) having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

    摘要翻译： 提供了用于检测样品中分析物的装置和方法。 该装置包括：一个或多个通道，具有检测区域（14）; 一个或多个辐射源（16）被设置用于用辐射照射检测区域（14）; 检测器（34），其能够收集对应于从所述检测区域（14）发射的发射光束（22）的至少一个机器，所述检测器（34）具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

    SYSTEM WITH ENHANCED EMISSION LIGHT COLLECTION FOR INCREASED FLUORESCENT LIGHT DETECTION EFFICIENCY
    4.
    发明申请
    SYSTEM WITH ENHANCED EMISSION LIGHT COLLECTION FOR INCREASED FLUORESCENT LIGHT DETECTION EFFICIENCY 审中-公开
    增强荧光灯检测效率的增强型发光系统

    公开(公告)号：WO2005093393A3

    公开(公告)日：2005-12-22

    申请号：PCT/US2005009232

    申请日：2005-03-18

    申请人： APPLERA CORP ,  REEL RICHARD T ,  NORDMAN ERIC S

    发明人： REEL RICHARD T ,  NORDMAN ERIC S

    IPC分类号： G01N15/14 ,  G01N21/03 ,  G01N21/64 ,  G01N27/447

    CPC分类号： G01N21/645 ,  G01N21/0303 ,  G01N2021/0346 ,  G01N2021/6417 ,  G01N2021/6478

    摘要： System and method for fluorescent light detection from biological samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light. The numerical aperture is enhanced by changing the material of construction of a numeral aperture (NA) enhancing element, such as a truncated sphere, in the fluorescent light detection system, such that NA enhancing optial element (40) is constructed of a different material than the housing (560) containing the sample. To eliminate the spherical aberration, the housing is positioned in a source plane that is offset from the theoretical aplanatic source plane. Cross-talk is reduced by using a mask (440).

    摘要翻译： 用于生物样品的荧光检测的系统和方法，以增强数值孔径和/或减少荧光灯的串扰。 通过在荧光检测系统中改变数字孔径（NA）增强元件（例如截顶球）的构造的材料来增强数值孔径，使得NA增强光学元件（40）由不同于 所述壳体（560）包含所述样品。 为了消除球面像差，壳体被定位在偏离理论平面源平面的源平面中。 通过使用掩模（440）减少串扰。

    METHOD AND SYSTEM FOR MULTIPLEX GENETIC ANALYSIS
    9.
    发明申请
    METHOD AND SYSTEM FOR MULTIPLEX GENETIC ANALYSIS 审中-公开
    多基因遗传分析方法与系统

    公开(公告)号：WO2006135782A2

    公开(公告)日：2006-12-21

    申请号：PCT/US2006022545

    申请日：2006-06-09

    申请人： APPLERA CORP ,  NORDMAN ERIC S ,  OLDHAM MARK F ,  WOUDENBERG TIMOTHY

    发明人： NORDMAN ERIC S ,  OLDHAM MARK F ,  WOUDENBERG TIMOTHY

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6874 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/6486 ,  G01N2021/6441 ,  C12Q2563/107

    摘要： The present disclosure provides apparatus, systems and method for detecting separately and substantially simultaneously light emissions from a plurality of localized light-emitting analytes. A system according to exemplary embodiments of the present disclosure comprises a sample holder having structures formed thereon for spatially separating and constraining a plurality of light-emitting analytes each having a single nucleic acid molecule or a single nucleic acid polymerizing enzyme, a light source configured to illuminate the sample holder, an optical assembly configured to collect and detect separately and substantially simultaneously light emissions associated with the plurality of light emitting analytes. The system may further include a computer system configured to analyze the light emissions to determine the structures or properties of a target nucleic acid molecule associated with each analyte.

    摘要翻译： 本公开提供了用于单独和基本上同时检测来自多个局部发光分析物的光发射的装置，系统和方法。 根据本公开的示例性实施例的系统包括具有形成在其上的结构的样本保持器，用于空间分离和约束各自具有单个核酸分子或单个核酸聚合酶的多个发光分析物，光源被配置为 照亮样品架，光学组件被配置成分别收集和检测与多个发光分析物相关联的基本上同时的发光。 该系统还可以包括被配置为分析光发射以确定与每个分析物相关联的靶核酸分子的结构或性质的计算机系统。

    SYSTEMS AND METHODS FOR COOLING IN A THERMAL CYCLER
    10.
    发明申请
    SYSTEMS AND METHODS FOR COOLING IN A THERMAL CYCLER 审中-公开
    用于在热循环中冷却的系统和方法

    公开(公告)号：WO2007150043A3

    公开(公告)日：2008-09-12

    申请号：PCT/US2007071930

    申请日：2007-06-22

    申请人： APPLERA CORP ,  OLDHAM MARK F ,  HENDERSON ERIC G ,  MIRCHANDANI VINOD ,  NORDMAN ERIC S ,  HABERSTROH MARC ,  SLUIS JOHANNES PAUL

    发明人： OLDHAM MARK F ,  HENDERSON ERIC G ,  MIRCHANDANI VINOD ,  NORDMAN ERIC S ,  HABERSTROH MARC ,  SLUIS JOHANNES PAUL

    IPC分类号： C12M1/36

    CPC分类号： B01L7/52 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2300/185

    摘要： A device for performing polymerase chain reactions using cooling members not used in conventional thermal cyclers. A device for performing polymerase chain reactions may include a sample holder configured to receive a nucleic acid sample, a heating system configured to raise the temperature of the sample, a cooling system configured to lower the temperature of the sample, and a controller configured to operably control the heating system and the cooling system to cycle the device through a desired time-temperature profile. The cooling system may comprise at least one cooling member selected from a synthetic jet ejector array, a vibration-induced droplet atomization system, a vibrating diaphragm system, a piezo fan, a Cold Gun, a microchannel cooling loop, and a Cool Chip.

    摘要翻译： 使用不用于常规热循环仪的冷却部件进行聚合酶链反应的装置。 用于进行聚合酶链式反应的装置可以包括配置成接收核酸样品的样品架，配置成提高样品温度的加热系统，配置成降低样品温度的冷却系统，以及配置成可操作地 控制加热系统和冷却系统以使设备循环所需的时间 - 温度曲线。 冷却系统可以包括选自合成射流喷射器阵列，振动诱导液滴雾化系统，振动膜系统，压电风扇，冷枪，微通道冷却回路和冷却芯片中的至少一个冷却构件。