公开(公告)号：WO2009020787A1

公开(公告)日：2009-02-12

申请号：PCT/US2008/071338

申请日：2008-07-28

Applicant: DSM SOLUTIONS, INC. ,  THUMMALAPALLY, Damodar, R. ,  RAY, Abhijit

Inventor： THUMMALAPALLY, Damodar, R. ,  RAY, Abhijit

IPC: H01L27/098 ,  H01L27/118 ,  H03K19/177

CPC classification number: H01L27/11803 ,  H01L27/098 ,  H01L29/808 ,  H03K19/17736 ,  H03K19/1778

Abstract: A switching circuit (100) comprises a plurality of first signal (106-0) lines of a programmable logic device, a plurality of second signal lines (106-1) of the programmable logic device, and a plurality of switch elements (104-0, 104-1)-. Each switch element couples one first signal line to a second signal line and includes one or more switch junction field effect transistors (JFETs (108, 110) having a first control gate (108-0, 110-0) separated from a second control gate (108-3, 110-3) by a channel region.

Abstract translation: 开关电路（100）包括可编程逻辑器件的多个第一信号（106-0）线，可编程逻辑器件的多个第二信号线（106-1）和多个开关元件（104- 0，104-1） - 。 每个开关元件将一个第一信号线耦合到第二信号线并且包括一个或多个开关结场效应晶体管（JFET（108,110），其具有与第二控制栅极分离的第一控制栅极（108-0,110-0） （108-3,110-3）。

公开(公告)号：WO2012038944A1

公开(公告)日：2012-03-29

申请号：PCT/IB2011/054229

申请日：2011-09-26

Applicant: RANBAXY LABORATORIES LIMITED ,  KHERA, Manoj Kumar ,  PALLE, Venkata P. ,  SATTIGERI, Viswajanani ,  SATTIGERI, Jitendra ,  SONI, Ajay ,  RAUF, Abdul Rehman Abdul ,  SIVAKUMAR, R. ,  REDDY, Ranadheer R. ,  MUSIB, Arpita ,  CLIFFE, Ian A. ,  BHATNAGAR, Pradip Kumar ,  RAY, Abhijit ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

Inventor： KHERA, Manoj Kumar ,  PALLE, Venkata P. ,  SATTIGERI, Viswajanani ,  SATTIGERI, Jitendra ,  SONI, Ajay ,  RAUF, Abdul Rehman Abdul ,  SIVAKUMAR, R. ,  REDDY, Ranadheer R. ,  MUSIB, Arpita ,  CLIFFE, Ian A. ,  BHATNAGAR, Pradip Kumar ,  RAY, Abhijit ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

IPC: C07D209/48 ,  C07D253/04 ,  C07D401/12 ,  C07C271/28 ,  A61K31/27 ,  A61K31/4035 ,  A61K31/53 ,  A61P11/00 ,  A61P19/02 ,  A61P35/00

CPC classification number: C07D253/04 ,  C07C271/28 ,  C07D209/48 ,  C07D401/12

Abstract: The present invention relates to methyl sulfonamides and N-formamides derivatives of formula (I) and to processes for their syntheses. The invention also relates to pharmacological compositions containing these derivatives and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatie arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of an matrix metalloproteinase using the compounds.

Abstract translation: 本发明涉及式（I）的甲基磺酰胺和N-甲酰胺衍生物及其合成方法。 本发明还涉及含有这些衍生物的药物组合物和治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，银屑病关节炎，牛皮癣，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化，牙龈炎，动脉粥样硬化， 干眼症，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他以使用该化合物过度表达和过度活化基质金属蛋白酶为特征的炎症性疾病。

公开(公告)号：WO2008117230A1

公开(公告)日：2008-10-02

申请号：PCT/IB2008/051089

申请日：2008-03-24

Applicant: RANBAXY LABORATORIES LIMITED ,  KATIYAR, Chandra, Kant ,  KANAUJIA, Anil ,  DUGGAR, Rajeev ,  YADAV, Satyapal, Singh ,  SHARMA, Navin ,  RAY, Abhijit ,  SHIRUMALLA, Rajkumar ,  BAJPAI, Malini ,  SHUKLA, Gyanesh ,  LAKSHMI, Baddireddi, Subhadra ,  VINAYKUMAR, Kontham, Sanathkumar

Inventor： KATIYAR, Chandra, Kant ,  KANAUJIA, Anil ,  DUGGAR, Rajeev ,  YADAV, Satyapal, Singh ,  SHARMA, Navin ,  RAY, Abhijit ,  SHIRUMALLA, Rajkumar ,  BAJPAI, Malini ,  SHUKLA, Gyanesh ,  LAKSHMI, Baddireddi, Subhadra ,  VINAYKUMAR, Kontham, Sanathkumar

IPC: A61K36/185 ,  A61P29/00

CPC classification number: A61K36/185

Abstract: The present invention relates to standardized extracts of Boerhaavia diffusa , wherein the extracts have anti inflammatory and analgesic activities. The present invention also includes bioassay guided fractionation of Boerhaavia diffusa leading to the identification of bioactive markers; processes for the isolation of the bioactive markers; processes for the preparation of the extracts enriched with bioactive markers from Boerhaavia diffusa ; pharmaceutical compositions comprising bioactive markers, or standardized extracts of Boerhaavia diffusa and methods of standardization of the extracts.

Abstract translation: 本发明涉及双歧杆菌的标准化提取物，其中提取物具有抗炎和止痛活性。 本发明还包括生物测定引导分离的Boerhaavia diffusa，导致鉴定生物活性标记; 分离生物活性标记物的方法; 用于制备富含Boerhaavia diffusa的生物活性标记物的提取物的方法; 包含生物活性标记物或Boerhaavia diffusa的标准化提取物的药物组合物和提取物的标准化方法。

公开(公告)号：WO2008117229A1

公开(公告)日：2008-10-02

申请号：PCT/IB2008/051088

申请日：2008-03-24

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  KAUR, Kirandeep ,  GARG, Malvika ,  PALLE, Venkata, P. ,  SALMAN, Mohammad ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

Inventor： KUMAR, Naresh ,  KAUR, Kirandeep ,  GARG, Malvika ,  PALLE, Venkata, P. ,  SALMAN, Mohammad ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

IPC: C07D451/00 ,  A61K31/439 ,  A61P11/00 ,  A61P13/00

CPC classification number: C07D451/00

Abstract: The present invention relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Also provided herein are pharmaceutical compositions comprising one or more muscarinic receptor antagonists and at least one or more therapeutic agent selected from histamine antagonists, corticosteroids, beta agonists, leukotriene antagonists, EGFR kinase inhibitors, PAF antagonists, 5-lipoxygenase inhibitors, chemokine inhibitors, PDE-4 inhibitors or p38 MAP Kinase inhibitors.

Abstract translation: 本发明涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。 本文还提供了包含一种或多种毒蕈碱受体拮抗剂和至少一种或多种选自组胺拮抗剂，皮质类固醇，β激动剂，白细胞三烯拮抗剂，EGFR激酶抑制剂，PAF拮抗剂，5-脂肪氧合酶抑制剂，趋化因子抑制剂，PDE -4抑制剂或p38 MAP激酶抑制剂。

公开(公告)号：WO2008029349A2

公开(公告)日：2008-03-13

申请号：PCT/IB2007/053561

申请日：2007-09-04

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  KAUR, Kirandeep ,  SHEJUL, Yogesh, D. ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

Inventor： KUMAR, Naresh ,  KAUR, Kirandeep ,  SHEJUL, Yogesh, D. ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

CPC classification number: C07D221/24 ,  C07D209/12 ,  C07D209/14

Abstract: The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The present invention also relates to processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备本文所述化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：WO2006117653A1

公开(公告)日：2006-11-09

申请号：PCT/IB2006/001133

申请日：2006-05-03

Applicant: RANBAXY LABORATORIES LIMITED ,  PALLE, Venkata ,  BALACHANDRAN, Sarala ,  MUTHUKAMA, Nagarajan ,  RAY, Abhijit ,  DASTIDAR, Sunanda Ghose

Inventor： PALLE, Venkata ,  BALACHANDRAN, Sarala ,  MUTHUKAMA, Nagarajan ,  RAY, Abhijit ,  DASTIDAR, Sunanda Ghose

IPC: C07D413/12 ,  A61K31/4439 ,  A61P11/00 ,  A61P31/00

CPC classification number: C07D413/12

Abstract: The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds of Formula (I), pharmaceutical compositions containing the compounds described herein and their use as PDE type IV selective inhibitors are provided.

Abstract translation: 本发明涉及磷酸二酯酶（PDE）IV型选择性抑制剂。 提供了所公开的式（I）化合物的制备方法，含有本文所述化合物的药物组合物及其作为PDE IV型选择性抑制剂的用途。

公开(公告)号：WO2006085212A2

公开(公告)日：2006-08-17

申请号：PCT/IB2006/000285

申请日：2006-02-13

Applicant: RANBAXY LABORATORIES LIMITED ,  PALLE, Venkata, P. ,  BALACHANDRAN, Sarala ,  GUPTA, Nidhi ,  MUTHUKAMAL, Nagarajan ,  RAMAIAH, Mandadapu, Raghu ,  KHERA, Manoj, Kumar ,  BAREGAMA, Lailt, Kumar ,  KAHIRNAR, Vinayak, Vasantrao ,  RAY, Abhijit ,  DASTIDAR, Sunanda, G.

Inventor： PALLE, Venkata, P. ,  BALACHANDRAN, Sarala ,  GUPTA, Nidhi ,  MUTHUKAMAL, Nagarajan ,  RAMAIAH, Mandadapu, Raghu ,  KHERA, Manoj, Kumar ,  BAREGAMA, Lailt, Kumar ,  KAHIRNAR, Vinayak, Vasantrao ,  RAY, Abhijit ,  DASTIDAR, Sunanda, G.

IPC: C07D498/10 ,  C07D261/20 ,  C07D498/04 ,  A61K31/423 ,  A61K31/424 ,  A61P11/00 ,  A61P31/18

CPC classification number: C07D261/20

Abstract: The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.

Abstract translation: 本发明涉及异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 特别地，本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是在人类中。 本发明还涉及制备所公开的化合物及其药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途的方法。

公开(公告)号：WO2005100373A2

公开(公告)日：2005-10-27

申请号：PCT/IB2005/000974

申请日：2005-04-13

Applicant: RANBAXY LABORATORIES LIMITED ,  SATTIGERI, Viswajanani, Jitendra ,  ARORA, Sudershan, K. ,  SALMAN, Mohammad ,  PALLE, Venkata, P. ,  RAY, Abhijit ,  SHIRUMALLA, Raj, Kumar

Inventor： SATTIGERI, Viswajanani, Jitendra ,  ARORA, Sudershan, K. ,  SALMAN, Mohammad ,  PALLE, Venkata, P. ,  RAY, Abhijit ,  SHIRUMALLA, Raj, Kumar

IPC: C07H

CPC classification number: C07H9/04 ,  C07H3/02 ,  C07H15/00

Abstract: The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

Abstract translation: 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮 ，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。 包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症， 还提供了使用该化合物的瘙痒症或过敏性鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：WO2012038943A1

公开(公告)日：2012-03-29

申请号：PCT/IB2011/054228

申请日：2011-09-26

Applicant: RANBAXY LABORATORIES LIMITED ,  KHERA, Manoj Kumar ,  SATTIGERI, Jitendra ,  YADAV, Neeraj Kumar ,  RAUF, Abdul Rehman Abdul ,  CLIFFE, Ian A. ,  BHATNAGAR, Pradip Kumar ,  RAY, Abhijit ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

Inventor： KHERA, Manoj Kumar ,  SATTIGERI, Jitendra ,  YADAV, Neeraj Kumar ,  RAUF, Abdul Rehman Abdul ,  CLIFFE, Ian A. ,  BHATNAGAR, Pradip Kumar ,  RAY, Abhijit ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

IPC: C07C309/60 ,  C07C321/28 ,  C07C333/08 ,  A61K31/192 ,  A61K31/325 ,  A61P11/00 ,  A61P19/02 ,  A61P35/00

CPC classification number: C07C317/46 ,  C07C323/52 ,  C07C323/60

Abstract: The present invention relates to certain sulfone acetic acid derivatives of formula I as MMP inhibitor and processes for its syntheses. The invention also relates to pharmacological compositions containing the compounds of the present invention and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple scleorisis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of a matrix metalloproteinase using the compounds.

Abstract translation: 本发明涉及作为MMP抑制剂的某些式I的砜乙酸衍生物及其合成方法。 本发明还涉及含有本发明化合物的药物组合物和治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，银屑病关节炎，银屑病，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化症， 牙龈炎，动脉粥样硬化，干眼症，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移以及其他以使用该化合物过度表达和过度激活基质金属蛋白酶为特征的炎症性疾病。

公开(公告)号：WO2012014127A1

公开(公告)日：2012-02-02

申请号：PCT/IB2011/053238

申请日：2011-07-20

Applicant: RANBAXY LABORATORIES LIMITED ,  VERMA, Ashwani Kumar ,  MALHOTRA, Sanjay ,  GHORPADE, Satish Madhav ,  DAWANGE, Mahesh Balasaheb ,  RAY, Abhijit ,  GUPTA, Suman ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

Inventor： VERMA, Ashwani Kumar ,  MALHOTRA, Sanjay ,  GHORPADE, Satish Madhav ,  DAWANGE, Mahesh Balasaheb ,  RAY, Abhijit ,  GUPTA, Suman ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

IPC: C07D233/42 ,  C07C311/08 ,  A61K31/18 ,  A61P29/00

CPC classification number: C07D233/42 ,  A61K45/06 ,  C07C311/08 ,  C07C311/14 ,  C07C311/21 ,  C07C2601/02 ,  C07C2602/08

Abstract: The present invention relates to sulfonamides derivatives as 5-lipoxygenase (5-LO) inhibitors and a process for their synthesis. The present invention also relates to pharmacological compositions containing these sulfonamides derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, Type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders.

Abstract translation: 本发明涉及作为5-脂氧合酶（5-LO）抑制剂的磺酰胺衍生物及其合成方法。 本发明还涉及含有这些磺酰胺衍生物的药物组合物，以及治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮的方法 ，动脉粥样硬化，癌症，瘙痒症，过敏性鼻炎和其它炎性和/或自身免疫性疾病。