公开(公告)号：WO2016205428A1

公开(公告)日：2016-12-22

申请号：PCT/US2016/037711

申请日：2016-06-15

Applicant: INTEGENX INC.

Inventor： WUNDERLE, Philip, Justus ,  PARK, Chungsoo, Charles ,  KING, David ,  LEHTO, Dennis

IPC: G01N27/447 ,  B01L3/00 ,  F16K7/00 ,  F16K7/16 ,  F16K99/00 ,  G01N27/26

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01F13/02 ,  B01L3/502738 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0655 ,  C12Q1/686 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface.

Abstract translation: 本公开尤其提供了一种盒，其包括：（a）包括可延展材料的盒体，并且具有设置在主体表面上的至少一个阀体，其包括阀入口和阀出口，每个阀体流体连接 到流体通道; 和（b）包含结合到所述盒体表面的可变形材料并且在附接点处密封所述至少一个阀体从而形成至少一个阀的层; 其中所述至少一个阀体相对于所述连接点在所述盒体中被压下，并且其中覆盖所述至少一个阀体的所述可变形材料在变形之后保持足够的弹性，使得在基础状态下所述阀是打开的。 还公开了一种包括如本文所述的盒接口和盒与盒接口接合的仪器。

公开(公告)号：WO2015179098A1

公开(公告)日：2015-11-26

申请号：PCT/US2015/028510

申请日：2015-04-30

Applicant: INTEGENX INC.

Inventor： EBERHART, David ,  NIELSEN, William, D. ,  FRANKLIN, Helen ,  JOVANOVICH, Stevan, B. ,  LEHTO, Dennis ,  CHEAR, Kaiwan ,  KING, David ,  KLEVENBERG, James ,  PARK, Chungsoo, Charles ,  SMITH, Corey ,  WUNDERLE, Philip, Justus

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0478 ,  C12Q1/686 ,  G01N27/44743 ,  G01N27/44791 ,  C12Q1/6846 ,  C12Q2565/629

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

Abstract translation: 本文提供了一种流体盒，其具有包括可延展材料的主体和包含结合到主体表面的可变形材料的层，所述可变形材料密封与形成在主体表面中的一个或多个阀体连通的一个或多个流体通道。 可以通过向可变形材料施加足够的压力来关闭阀门，以压缩和关闭体内的流体通道。 还提供了构造成接合盒的盒接口。 还提供了包括盒式接口和使用盒和系统的方法的系统。