公开(公告)号：WO2016205428A1

公开(公告)日：2016-12-22

申请号：PCT/US2016/037711

申请日：2016-06-15

Applicant: INTEGENX INC.

Inventor： WUNDERLE, Philip, Justus ,  PARK, Chungsoo, Charles ,  KING, David ,  LEHTO, Dennis

IPC: G01N27/447 ,  B01L3/00 ,  F16K7/00 ,  F16K7/16 ,  F16K99/00 ,  G01N27/26

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01F13/02 ,  B01L3/502738 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0655 ,  C12Q1/686 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface.

Abstract translation: 本公开尤其提供了一种盒，其包括：（a）包括可延展材料的盒体，并且具有设置在主体表面上的至少一个阀体，其包括阀入口和阀出口，每个阀体流体连接 到流体通道; 和（b）包含结合到所述盒体表面的可变形材料并且在附接点处密封所述至少一个阀体从而形成至少一个阀的层; 其中所述至少一个阀体相对于所述连接点在所述盒体中被压下，并且其中覆盖所述至少一个阀体的所述可变形材料在变形之后保持足够的弹性，使得在基础状态下所述阀是打开的。 还公开了一种包括如本文所述的盒接口和盒与盒接口接合的仪器。

公开(公告)号：WO2015179098A1

公开(公告)日：2015-11-26

申请号：PCT/US2015/028510

申请日：2015-04-30

Applicant: INTEGENX INC.

Inventor： EBERHART, David ,  NIELSEN, William, D. ,  FRANKLIN, Helen ,  JOVANOVICH, Stevan, B. ,  LEHTO, Dennis ,  CHEAR, Kaiwan ,  KING, David ,  KLEVENBERG, James ,  PARK, Chungsoo, Charles ,  SMITH, Corey ,  WUNDERLE, Philip, Justus

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0478 ,  C12Q1/686 ,  G01N27/44743 ,  G01N27/44791 ,  C12Q1/6846 ,  C12Q2565/629

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

Abstract translation: 本文提供了一种流体盒，其具有包括可延展材料的主体和包含结合到主体表面的可变形材料的层，所述可变形材料密封与形成在主体表面中的一个或多个阀体连通的一个或多个流体通道。 可以通过向可变形材料施加足够的压力来关闭阀门，以压缩和关闭体内的流体通道。 还提供了构造成接合盒的盒接口。 还提供了包括盒式接口和使用盒和系统的方法的系统。

公开(公告)号：WO2016065073A1

公开(公告)日：2016-04-28

申请号：PCT/US2015/056764

申请日：2015-10-21

Applicant: INTEGENX INC.

Inventor： KINDWALL, Alexander ,  PARK, Chungsoo, Charles ,  ILKOV, Fedor ,  JOVANOVICH, Stevan ,  KING, David ,  LITTLEHALE, Tristan, Robert ,  NILSON, David, Grant ,  PITTARO, Rick ,  SCHUEREN, Robert, A. ,  VANGBO, Mattias ,  WUNDERLE, Philip, Justus

IPC: B01D59/42 ,  C25B11/02 ,  G01N27/447 ,  G01N27/49

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0421 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44786 ,  G01N27/453

Abstract: The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system. An electrophoresis cartridge adapted to releasably engage with a cartridge interface of a system is provided. The electrophoresis cartridge comprises: an electrophoresis assembly including: (1) an anode sub-assembly comprising an anode, (2) a cathode sub-assembly comprising a cathode; and (3) at least one electrophoresis capillary having a first end and a second end, wherein the cathode and the anode are configured to provide a voltage gradient across the first end and the second end of the at least one electrophoresis capillary.

Abstract translation: 本公开提供了用于样品制备，处理和分析的系统和方法。 本公开还提供了一种完全集成的电泳盒，其具有小的占地面积并且被配置为可移除地与系统接合。 提供了适于与系统的盒接口可释放地接合的电泳盒。 电泳盒包括：电泳组件，包括：（1）包括阳极的阳极子组件，（2）包括阴极的阴极子组件; 和（3）具有第一端和第二端的至少一个电泳毛细管，其中所述阴极和所述阳极被配置为在所述至少一个电泳毛细管的所述第一端和所述第二端提供电压梯度。