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    COMPOUNDS ACTIVE IN SPINIGOSINE 1-PHOSPHATE SIGNALING
    2.
    发明申请
    COMPOUNDS ACTIVE IN SPINIGOSINE 1-PHOSPHATE SIGNALING 审中-公开
    螺旋体1-磷酸盐信号中的化合物

    公开(公告)号：WO2004010949A3

    公开(公告)日：2004-10-07

    申请号：PCT/US0323768

    申请日：2003-07-30

    申请人： UNIV VIRGINIA ,  LYNCH KEVIN R ,  MACDONALD TIMOTHY L

    发明人： LYNCH KEVIN R ,  MACDONALD TIMOTHY L

    IPC分类号： C07D233/54 ,  C07F9/09 ,  C07F9/6506 ,  A61K31/4164 ,  C07F9/06

    CPC分类号： C07F9/65068 ,  C07F9/091 ,  C07F9/094 ,  C07F9/65062

    摘要： The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure of Formula (I) wherein R11 is C5-C18 alkyl or C5-C18 alkenyl; Q is selected from the group consisting of C3-C6 optionally substituted cycloalkyl, C3-C6 optionally substituted heterocyclic, C3-C6 optionally substituted aryl C3-C6 optionally substituted heteroaryl and -NH(CO)-; R2 is selected from the group consisting of H, C1 -C4 alkyl, (C1 -C4 alkyl)OH and (C1-C4 alkyl)NH2; R23 is H or C1-C4 alkyl, and R15 is selected from the group consisting of hydroxy, phosphonate, and of Formula (II) wherein X and R12 is selected from the group consisting of O and S; or a pharmaceutically acceptable salt or tautomer thereof.

    摘要翻译： 本发明涉及具有作为S1P受体调节剂的活性的S1P类似物以及这些化合物用于治疗与不适当的S1P受体活性相关的疾病的用途。 化合物具有通式（I）的通式，其中R 11为C 5 -C 18烷基或C 5 -C 18烯基; Q选自C 3 -C 6任选取代的环烷基，C 3 -C 6任选取代的杂环，C 3 -C 6任选取代的芳基C 3 -C 6任选取代的杂芳基和-NH（CO） - ; R2选自H，C1-C4烷基，（C1-C4烷基）OH和（C1-C4烷基）NH2; R 23是H或C 1 -C 4烷基，R 15选自羟基，膦酸酯和式（II），其中X和R 12选自O和S; 或其药学上可接受的盐或互变异构体。

    ORALLY AVAILABLE SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS AND ANTAGONISTS
    10.
    发明申请
    ORALLY AVAILABLE SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS AND ANTAGONISTS 审中-公开

    公开(公告)号：WO2005041899A3

    公开(公告)日：2006-11-02

    申请号：PCT/US2004036563

    申请日：2004-11-03

    申请人： UNIV VIRGINIA ,  LYNCH KEVIN R ,  MACDONALD TIMOTHY L

    发明人： LYNCH KEVIN R ,  MACDONALD TIMOTHY L

    IPC分类号： A61K31/4164 ,  A61K20060101 ,  A61K31/4196 ,  A61K31/426 ,  A61K31/433 ,  C07D231/10 ,  C07D233/61 ,  C07D263/48 ,  C07D273/02 ,  C07D277/28 ,  C07D295/18 ,  C07D307/38 ,  C07F9/6506

    CPC分类号： C07F9/65062

    摘要： The present invention relates to S1P analogs that have activity as S1Preceptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I) wherein R 11 is C 5 -C 18 alkyl or C 5 -C 18 alkenyl; Q is selected from the group consisting of C 3 -C 6 optionally substituted cycloalkyl, C 3 -C 6 optionally substituted heterocyclic, C 3 -C 6 optionally substituted aryl C 3 -C 6 optionally substituted heteroaryl and; R 2 is selected from the group consisting of H, C 1 -C 4 alkyl, (C 1 -C 4 alkyl)OH and (C 1 -C 4 alkyl)NH 2 ; R 23 is H or C 1 -C 4 alkyl, and R 15 is a phosphonate ester or a phosphate ester or a pharmaceutically acceptable salt or tautomer thereof.

    摘要翻译： 本发明涉及具有作为S1Preceptor调节剂的活性的S1P类似物以及这些化合物用于治疗与不适当S1P受体活性相关的疾病的用途。 化合物具有通式（I），其中R 11是C 5 -C 18烷基或C 5 -C 15烷基， -C 18链烯基; Q选自C 3 -C 6任选取代的环烷基，C 3 -C 6亚烷基，C 3 -C 6 - 任选取代的杂环基，C 3 -C 6任选取代的芳基C 3 -C 6 -C 6任选取代的杂芳基和; R 2选自H，C 1 -C 4烷基，（C 1〜 C 4烷基）OH和（C 1 -C 4烷基）NH 2; R 23是H或C 1 -C 4烷基，R 15是膦酸酯或磷酸酯 酯或其药学上可接受的盐或互变异构体。