公开(公告)号：WO2009137717A1

公开(公告)日：2009-11-12

申请号：PCT/US2009/043203

申请日：2009-05-07

Applicant: CARDIOXYL PHARMACEUTICALS INC. ,  FROST, Lisa, Marie ,  COURTNEY, Stephen, Martin ,  BROOKFIELD, Frederick, Arthur ,  KALISH, Vincent, J.

Inventor： FROST, Lisa, Marie ,  COURTNEY, Stephen, Martin ,  BROOKFIELD, Frederick, Arthur ,  KALISH, Vincent, J.

IPC: A61K31/535

CPC classification number: C07C207/00 ,  C07C207/04 ,  C07C255/19 ,  C07D211/44 ,  C07D211/58 ,  C07D309/10 ,  C07D309/14 ,  C07D333/42 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D451/10 ,  C07F9/117 ,  C07F9/585 ,  C07F9/595

Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

Abstract translation: 本发明涉及在生理条件下给予硝酰基（HNO）的羟基亚硝基化合物的羧酸和磷酸酯的亚硝基衍生物。 本发明的化合物和组合物可用于治疗和/或预防对硝酰病毒治疗（包括心力衰竭，局部缺血/再灌注损伤和癌症）有反应的疾病或病症的发作和/或发展。

公开(公告)号：WO2007120839A3

公开(公告)日：2008-07-24

申请号：PCT/US2007009160

申请日：2007-04-13

Applicant: UNIV WAKE FOREST HEALTH SCIENCES ,  KING S BRUCE

Inventor： KING S BRUCE

IPC: C07C211/00 ,  A61K31/24

CPC classification number: C07C207/04 ,  C07C2601/14

Abstract: Active compounds of Formula (I) are described: wherein: R 1 and R 2 are each independently C1-C4 alkyl; or R 1 and R 2 together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); along with pharmaceutically acceptable salts and prodrug thereof, and methods of using the same.

Abstract translation: 描述了式（I）的活性化合物：其中：R 1和R 2各自独立地为C 1 -C 4烷基; 或R 1和R 2一起形成C 2 -C 7亚烷基链; Z是非甾体抗炎药（NSAID）; 以及其药学上可接受的盐和前药，及其使用方法。

公开(公告)号：WO2014037307A1

公开(公告)日：2014-03-13

申请号：PCT/EP2013/068094

申请日：2013-09-02

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  BOEHRINGER INGELHEIM INTERNATIONAL TRADING (SHANGHAI) CO., LTD.

Inventor： SHI, Wenjian ,  SONG, Yanli ,  BAO, Yuhui ,  LU, Jun ,  HUANG, Yao ,  WEBER, Dirk

IPC: C07C201/12 ,  C07C205/56 ,  C07D209/34

CPC classification number: C07D209/34 ,  C07C69/78 ,  C07C201/12 ,  C07C205/56 ,  C07C207/04 ,  C07D209/12 ,  C07D209/42 ,  C07C205/12

Abstract: Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.

Abstract translation: 公开了用作合成制备药物活性成分的6-碘-2-羟基吲哚的方法。 还公开了用于合成该化合物的新型中间体。

公开(公告)号：WO1994010128A1

公开(公告)日：1994-05-11

申请号：PCT/US1993010162

申请日：1993-10-22

Applicant: AFFYMAX TECHNOLOGIES N.V. ,  HOLMES, Christopher, P. ,  SOLAS, Dennis, W. ,  KIANGSOONTRA, Benjang

Inventor： AFFYMAX TECHNOLOGIES N.V.

IPC: C07C205/06

CPC classification number: C07H19/04 ,  C07C205/37 ,  C07C205/42 ,  C07C205/44 ,  C07C205/45 ,  C07C207/04 ,  C07D307/80 ,  C07D317/54 ,  C07D317/62 ,  C07D319/18 ,  C07H21/00 ,  Y02P20/55

Abstract: Photoremovable protecting groups for the creation of large scale chemical diversity are disclosed. Orthonitrobenzyl groups containing various phenyl-ring substituents, benzylic carbon substituents, and benzylic carbon extensions protect nucleoside and amino acid functional groups, including hydroxyl, amino, and carboxyl groups. Phenyl-ring substituents include cyclic orthoesters, acetals, ketals, substituted amines, and cyclic ethers.

Abstract translation: 公开了可产生大规模化学多样性的可光致保护基团。 含有各种苯环取代基的亚硫酰基苄基，苄基碳取代基和苄基碳延伸保护核苷和氨基酸官能团，包括羟基，氨基和羧基。 苯环取代基包括环状原酸酯，缩醛，缩酮，取代的胺和环醚。

公开(公告)号：WO2012084629A1

公开(公告)日：2012-06-28

申请号：PCT/EP2011/072707

申请日：2011-12-20

Applicant: DSM IP Assets B.V. ,  DUVAL, Stephane ,  KINDERMANN, Maik

Inventor： DUVAL, Stephane ,  KINDERMANN, Maik

IPC: A23K1/16 ,  A23K1/18

CPC classification number: C07C203/04 ,  A23K20/10 ,  A23K20/105 ,  A23K20/111 ,  A23K20/121 ,  A23K50/10 ,  A61K31/04 ,  A61K31/045 ,  A61K31/08 ,  A61K31/18 ,  A61K31/21 ,  A61K31/216 ,  A61K31/22 ,  A61K31/24 ,  A61K31/275 ,  A61K31/34 ,  A61K31/345 ,  A61K31/4406 ,  A61K45/06 ,  C07C207/02 ,  C07C207/04 ,  C07C255/11 ,  C07C311/03 ,  C07C311/24 ,  C07D213/82 ,  C07D307/72 ,  C07D493/04 ,  Y02P60/56

Abstract: The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant and/or for improving ruminant animal performance by using, as active compound at least one organic molecule substituted at any position with at least one nitrooxy group, or a salt thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these compounds in feed and feed additives such as premix, concentrates and total mixed ration (TMR) or in the form of a bolus.

Abstract translation: 本发明涉及通过使用至少一个有机分子在至少一个硝基氧基取代的有机分子作为活性化合物来减少由反刍动物的消化活性产生的甲烷和/或改善反刍动物性能的方法 ，或其盐，其与饲料一起施用于动物。 本发明还涉及这些化合物在饲料和饲料添加剂如预混物，浓缩物和总混合比例（TMR）中或在丸剂形式中的用途。

公开(公告)号：WO1998002408A1

公开(公告)日：1998-01-22

申请号：PCT/FR1997001292

申请日：1997-07-11

Applicant: RHONE-POULENC CHIMIE ,  METIVIER, Pascal

Inventor： RHONE-POULENC CHIMIE

IPC: C07C205/60

CPC classification number: C07B43/02 ,  C07C201/00 ,  C07C201/06 ,  C07C205/60 ,  C07C207/04

Abstract: The invention concerns a method of nitrosation of a phenolic compound substituted by an electro-attracting group.The invention also concerns a method of nitration of a phenoic compound substituted by an electro-attracting group. The nitrosation method is characterised in that it consists in effecting the nitrosatio n of the said compound in presence of sulphuric acid; the concentration of the sulphuric acid being at least 60 % by weight, then optionally in effecting the separation of the resulting nitrosated compound. The invention also concerns the oxidation of the resulting p-nitrosated phenolic compound for obtaining the corresponding nitrated compound.

Abstract translation: 本发明涉及一种由电吸引基团取代的酚类化合物的亚硝化方法。本发明还涉及一种由电吸引基团取代的苯基化合物的硝化方法。 亚硝化方法的特征在于其在硫酸存在下实现所述化合物的亚硝基化; 硫酸的浓度为至少60重量％，然后任选地实现所得到的亚硝化化合物的分离。 本发明还涉及所得对硝基化酚类化合物的氧化，以获得相应的硝化化合物。

公开(公告)号：WO2007120839A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/009160

申请日：2007-04-13

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES ,  KING, S. Bruce

Inventor： KING, S. Bruce

IPC: A61K31/616

CPC classification number: C07C207/04 ,  C07C2601/14

Abstract: Active compounds of Formula (I) are described: wherein: R 1 and R 2 are each independently C1-C4 alkyl; or R 1 and R 2 together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); along with pharmaceutically acceptable salts and prodrug thereof, and methods of using the same.

Abstract translation: 描述了式（I）的活性化合物：其中：R 1和R 2各自独立地为C 1 -C 4烷基; 或R 1和R 2一起形成C 2 -C 7亚烷基链; Z是非甾体抗炎药（NSAID）; 以及其药学上可接受的盐和前药，及其使用方法。

公开(公告)号：WO2003035008A2

公开(公告)日：2003-05-01

申请号：PCT/US2002/034497

申请日：2002-10-28

Applicant: OXIGENE, INC. ,  CHAPLIN, David, J. ,  GARNER, Charles, Manly, III ,  KANE, Robert, Ronald ,  PINNEY, Kevin, G. ,  PREZIOSO, Joseph, Anthony

Inventor： CHAPLIN, David, J. ,  GARNER, Charles, Manly, III ,  KANE, Robert, Ronald ,  PINNEY, Kevin, G. ,  PREZIOSO, Joseph, Anthony

IPC: A61K

CPC classification number: C07C43/23 ,  C07C45/63 ,  C07C47/575 ,  C07C205/37 ,  C07C207/04 ,  C07C217/84 ,  C07C237/04 ,  C07F9/12

Abstract: Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and combretastatin A-4. The prodrug forms serve as potent vascular targeting agents (VTAs) useful for the treatment of solid tumor cancers and diseases associated with retinal neovascularization.

Abstract translation: 公开了新的芪类化合物及其前体药物形式，其用作治疗实体瘤癌症和与不想要的新生血管形成相关的其它疾病的有效的血管靶向剂。 新型芪类化合物是与科替布他汀A-1和考布他汀A-4结构相关的微管蛋白结合芪类似物。 前药形式可用作治疗实体瘤癌症和与视网膜新生血管形成相关疾病的有效的血管靶向剂（VTA）。

公开(公告)号：WO2003000644A1

公开(公告)日：2003-01-03

申请号：PCT/GB2002/002896

申请日：2002-06-21

Applicant: THE INSTITUTE OF CANCER RESEARCH ,  SERAFINOWSKI, Pawel, Jerzy ,  GARLAND, Peter, Bryan

Inventor： SERAFINOWSKI, Pawel, Jerzy ,  GARLAND, Peter, Bryan

IPC: C07C205/42

CPC classification number: B82Y30/00 ,  B01J2219/00432 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  C07B2200/11 ,  C07C205/19 ,  C07C205/26 ,  C07C205/35 ,  C07C205/37 ,  C07C205/42 ,  C07C205/44 ,  C07C207/00 ,  C07C207/04 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

Abstract: Compounds which are capable of generating acid on photolysis are disclosed, and the uses of these compounds, especially for deprotecting the termini of nucleic acid molecules or peptides during synthesis of arrays. The compounds described herein may be employed in the detritylation of 5'-O-dimethoxytrityl (DMT) protected nucleotides by photolysing the compounds to generate an acid capable of removing the DMT group allowing oligonucleotide arrays to be synthesised using readily available 5'-O-DMT-nucleoside-3'-O-phosphoramidite monomers conventionally used in solid phase nucleic acid synthesis. A method of avoiding the effects of stray light in projection lithography techniques is also disclosed.

Abstract translation: 公开了能够在光解上产生酸的化合物，以及这些化合物的用途，特别是用于在阵列合成期间使核酸分子或肽的末端脱保护。 本文所述的化合物可以通过光解所述化合物以产生能够除去DMT基团的酸来使用5'- O-二甲氧基三苯甲基（DMT）保护的核苷酸的不合成，从而允许使用容易获得的5'-O- 常规用于固相核酸合成的DMT-核苷-3'-O-亚磷酰胺单体。 还公开了一种在投影光刻技术中避免杂散光的影响的方法。

公开(公告)号：WO01087293A1

公开(公告)日：2001-11-22

申请号：PCT/JP2001/004144

申请日：2001-05-18

IPC: A61K31/135 ,  A61K31/14 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/4453 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07C207/04 ,  C07C217/60 ,  C07C235/34 ,  C07D295/096 ,  C07D521/00

CPC classification number: C07D295/096 ,  A61K31/135 ,  A61K31/14 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/4453 ,  C07C207/04 ,  C07C217/60 ,  C07C235/34 ,  C07C2602/10 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: Excellent -secretase inhibitors are provided, which contain compounds of the general formula (I) or salts thereof, wherein Ar is an aromatic group; X is a divalent group selected from among O-, -S-, -CO-, -SO-, -SO>2 -, -CONR -, -SO2NR - and -COO- (wherein R is hydrogen or the like), a divalent C1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups, or a free valency; Y is a divalent group selected from among O-, -S-, -CO-, -SO-, -SO2-, -NR -, -CONR -, -SO2NR -, and COO-, or a divalent C1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups ; R and R are each hydrogen, a hydrocarbon group, or the like; and A is a ring which may be further substituted.

Abstract translation: 提供优异的分泌酶抑制剂，其含有通式（I）的化合物或其盐，其中Ar为芳族基团; X是选自O，-S - ， - CO - ， - SO - ， - SO 2 - ， - NR 8 8 - ， - CONR 8 - ， - SO 2 NR 8 - 和-COO-（其中R 8是氢等），可以含有这些二价基团中的一个或两个的二价C 1-6脂族烃基或自由价; Y是选自O，-S - ， - CO - ， - SO - ， - SO 2 - ， - NR 8 - ， - CONR 8 - ， - SO 2 NR 8 - 和COO - 或可以含有一个或两个这些二价基团的二价C 1-6脂族烃基; R 1和R 2各自为氢，烃基等; A是可进一步取代的环。