摘要:
The invention provides novel compositions based on a structure designated as "Honaucin A", including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
摘要:
The invention provides novel compositions based on a structure designated as "Honaucin A", including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
摘要:
An alpha-pentafluoroethylacrylic acid derivative represented by the general formula [I]: wherein R represents hydrogen, an (un)substituted aromatic ring, or C1-20 linear or branched alkyl optionally having a cyclic moiety which may have one or more substituents (selected among halogeno, hydroxy, C1-10 linear or branched alkoxy optionally having a cyclic moiety, and an (un)substituted aromatic ring).
摘要:
The invention relates to the partially known 3,3-dichloro-2-fluoro-acrylic acid derivatives of formula (I), wherein A has the meanings mentioned in the description. Said substances are suitable for protecting plants against the attack of undesired microorganisms and for controlling animal pests. The substances of formula (I) are also suitable for enhancing the effectiveness of azole fungicides. The invention further relates to novel 3,3-dichloro-2-fluoro-acrylic acid derivatives of formula (Ia), wherein A has the meanings mentioned in the description, and to a method for producing said novel substances.
摘要:
The invention relates to the partially known 3,3-dichloro-2-fluoro-acrylic acid derivatives of formula (I), wherein A has the meanings mentioned in the description. Said substances are suitable for protecting plants against the attack of undesired microorganisms and for controlling animal pests. The substances of formula (I) are also suitable for enhancing the effectiveness of azole fungicides. The invention further relates to novel 3,3-dichloro-2-fluoro-acrylic acid derivatives of formula (Ia), wherein A has the meanings mentioned in the description, and to a method for producing said novel substances.
摘要:
Synthesis of compounds having varying degrees of conformational rigidity is obtained via a low cost, high yield and efficient synthetic reactions. The library of compounds is structurally diverse, having at least one or more chiral centers and providing large numbers of compounds having building block diversity and substantial scaffold diversity. The compounds further provide a novel method for obtaining candidate therapeutic agents for prevention, treatment or diagnosis of diseases.
摘要:
The invention relates to a method of preparing alpha , beta -difluoroacrylic acid and alpha , beta -alkyl difluoroacrylates. The inventive method consists in: preparing 2,3-difluoro-2,3-dichloropropanol (I) by radical telomerisation of CFCl=CFCl with CH3OH; oxidising (I) in order to obtain 2,3-difluoro-2,3-dichloropropanoic acid (II); and treating (II) with Zn in order to dechlorinate and, optionally, esterify the acid function before or after the dechlorination step.