公开(公告)号：WO2023089010A1

公开(公告)日：2023-05-25

申请号：PCT/EP2022/082233

申请日：2022-11-17

Applicant: BIOTRONIK AG

Inventor： RZANY, Alexander ,  ANDREE, Verena ,  HENSEL, Bernhard

IPC: A61L27/20 ,  A61L27/34 ,  A61L29/08 ,  A61L31/04 ,  A61L31/10

Abstract: The invention relates to a bacterial nanocellulose and shaped elements made of bacterial nanocellulose and a method for producing the same.

公开(公告)号：WO2023081341A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/048939

申请日：2022-11-04

Applicant: NUTRITION & BIOSCIENCES USA 4, INC.

Inventor： LI, Ziang ,  RAJAN, Jana ,  FRATTARELLI, David L.

IPC: D06M16/00 ,  D06M15/03 ,  A01N33/12 ,  A01N43/16 ,  A01P1/00 ,  A61L15/46 ,  A61L31/16 ,  C11D3/22 ,  C11D11/00 ,  C11D3/48 ,  A61L15/28 ,  A61L15/38 ,  A61L2300/23 ,  A61L2300/232 ,  A61L2300/254 ,  A61L2300/404 ,  A61L2300/45 ,  A61L27/34 ,  A61L27/54 ,  A61L28/0038 ,  A61L28/0069 ,  A61L31/10 ,  C11D11/0017 ,  C11D3/222 ,  C11D3/227 ,  D06M16/003

Abstract: Compositions are disclosed herein comprising at least (a) a derivative of an alpha-glucan, wherein (i) at least about 40% of the glycosidic linkages of the alpha-glucan are alpha-1,6 linkages, and (ii) the alpha-glucan has a degree of substitution (DoS) of about 0.001 to about 3.0 with at least one positively charged organic group (optionally in ether linkage); and (b) an insoluble alpha-glucan, wherein at least about 50% of the glycosidic linkages of the insoluble alpha-glucan are alpha-1,3 glycosidic linkages, and the weight-average degree of polymerization (DPw) of the insoluble alpha-glucan is at least 10. The insoluble alpha-glucan can enhance the degree to which the alpha-glucan derivative deposits onto a fiber-containing material/article such as fabric, for example. Methods are further disclosed for preparing compositions comprising an alpha-glucan ether derivative, as well as various applications of using these compositions, such as for controlling microbes on fabric surfaces.

公开(公告)号：WO2023039551A2

公开(公告)日：2023-03-16

申请号：PCT/US2022/076241

申请日：2022-09-09

Applicant: WAYNE STATE UNIVERSITY

Inventor： HARRIS, Carolyn ,  ZARANEK, Mira ,  KHODADADEI, Fatemeh

IPC: A61L31/10 ,  A61L31/16 ,  A61K39/395 ,  C07K16/28 ,  A61B5/00 ,  A61F2/24 ,  A61K47/34 ,  A61M25/007 ,  A61M27/006 ,  A61M39/22 ,  A61M5/00 ,  A61M5/142 ,  F16K31/025 ,  F16K7/045

Abstract: This disclosure provides compositions, devices, systems, and methods that reduce the likelihood, amount, or level of cellular deposition (and associated blockage and/or failure) of implantable medical devices, such as central nervous system implants. Embodiments involve use of inhibitor(s) of one or more of TLR-4, TNF-α, IL-1β, or IL-6, for instance, to prevent, reduce, or reverse activation of astrocyte and/or glia cells, and/or to prevent, reduce, or reverse attachment of such cells to the surface of a medical device in contact with a biological fluid, such as cerebrospinal fluid.

公开(公告)号：WO2023279664A1

公开(公告)日：2023-01-12

申请号：PCT/CN2021/138086

申请日：2021-12-14

Applicant: 深圳先进技术研究院

Inventor： 杜学敏 ,  刘美金 ,  王芳

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/08 ,  A61L31/16

Abstract: 本发明公开了一种医疗器械表面用的润滑涂层及其制备方法，其包括直接在医疗器械表面设置的润滑层、医疗器械表面设置的基层及在基层表面设置的润滑层；所述基层选自铁电材料基层、油凝胶基层、水凝胶基层、硅胶基层或太阳能电池基层；所述润滑层为在医疗器械表面或基层表面进行润滑液灌注所形成的润滑层。所述润滑涂层在医疗器械表面的应用。本发明利用润滑液或润滑液灌注铁电材料、油凝胶、水凝胶、硅胶和太阳能电池的润滑层降低医疗器械表面和血管壁之间的摩擦，提高其生物相容性并降低细菌在医疗器械表面的黏附。本发明的可用于表面超滑、抗菌医疗器械的涂层材料具有制备工艺简单、润滑效果持久以及抗菌效果稳定等优点。

公开(公告)号：WO2023278731A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/035772

申请日：2022-06-30

Applicant: THE CHARLES STARK DRAPER LABORATORY, INC.

Inventor： KING, Daniel Frederick ,  CARTER, David J. ,  WILLIAMS, Corin ,  GOLMON, Stephanie Lynne

IPC: A61L31/02 ,  A61F2/24 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61F2/2415 ,  A61F2/2418 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2430/20 ,  A61L27/50 ,  A61L27/54 ,  A61L31/022 ,  A61L31/148

Abstract: A biocompatible adhesive is disclosed. The biocompatible adhesive includes a substrate and a plurality of micro-scale elements extending from a surface of the substrate having a length selected to puncture a layer of a target tissue or target material. At least some of the micro-scale elements include at least one protrusion dimensioned to anchor the biocompatible adhesive to the target tissue or target material. A medical device assembly is also disclosed. The medical device assembly includes the biocompatible adhesive coupled to a surface of a component of the medical device assembly and positioned to attach the medical device assembly to the target tissue or target material. A method of facilitating attachment of a medical device assembly to a target tissue is also disclosed. A method of facilitating treatment of a wound is also disclosed.

公开(公告)号：WO2022251963A1

公开(公告)日：2022-12-08

申请号：PCT/CA2022/050883

申请日：2022-06-02

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： KIZHAKKEDATHU, Jayachandran ,  LANGE, Dirk ,  YU, Kai ,  HANCOCK, Robert

IPC: C09D165/00 ,  A61L31/10 ,  A61L31/16 ,  C07K7/08 ,  C09D5/16 ,  C09D133/26 ,  A01N25/10 ,  A01N63/50 ,  A01P1/00

Abstract: Provided herein are compositions including polymeric binder, for example polydopamine (PDA); a poly(N,N-dimethylacrylamide) (PDMA) polymer or a PDMA co- N-(3-Aminopropyl) Methacrylamide (APMA) polymer; and an antimicrobial peptide (AMP), methods for using the compositions to coat a substrate, and methods for making the compositions. Alternatively, the composition may include a polymeric binder or a salt thereof, high molecular weight polymer and a pharmaceutically active agent. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.

公开(公告)号：WO2022238849A1

公开(公告)日：2022-11-17

申请号：PCT/IB2022/054222

申请日：2022-05-06

Applicant: CILAG GMBH INTERNATIONAL

Inventor： SHELTON, IV, Frederick E. ,  HARRIS, Jason L. ,  ECKERT, Chad E.

IPC: A61B17/064 ,  A61B17/072 ,  A61B17/00 ,  A61N5/10 ,  A61B17/0644 ,  A61B17/0686 ,  A61B17/07207 ,  A61B17/07292 ,  A61B17/105 ,  A61B2017/00004 ,  A61B2017/00017 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/00115 ,  A61B2017/00119 ,  A61B2017/00221 ,  A61B2017/00398 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/0053 ,  A61B2017/00845 ,  A61B2017/00849 ,  A61B2017/00853 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00938 ,  A61B2017/0688 ,  A61B2017/07228 ,  A61B2017/07235 ,  A61B2017/07257 ,  A61B2017/07264 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2017/07285 ,  A61B2050/0065 ,  A61B2050/3004 ,  A61B2050/314 ,  A61B2090/038 ,  A61B2090/0807 ,  A61B2090/0809 ,  A61B50/20 ,  A61B50/3001 ,  A61B50/33 ,  A61B90/92 ,  A61B90/94 ,  A61B90/98 ,  A61L2/02 ,  A61L2/16 ,  A61L2/232 ,  A61L2202/23 ,  A61L2202/24 ,  A61L2300/252 ,  A61L2400/10 ,  A61L2420/04 ,  A61L31/022 ,  A61L31/028 ,  A61L31/042 ,  A61L31/048 ,  A61L31/08 ,  A61L31/082 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61N2005/1087 ,  A61N2005/1098 ,  A61N5/1027

Abstract: A staple cartridge assembly includes a cartridge body with a deck, a longitudinal slot defined in the deck, and staple cavities defined in the deck. The staple cartridge assembly includes staples removably stored in the staple cavities, wherein the staples are deployable from the staple cavities into tissue of a patient, and wherein the staples comprise substrates comprised of metal that degrades when exposed to a degradation source in the patient. The staple cartridge assembly includes an implantable adjunct, wherein the staples are configured to hold the implantable adjunct to the tissue, and wherein the implantable adjunct is configured to delay an initiation of the degradation of regions of the metal in contact with the implantable adjunct in the patient, and wherein the implantable adjunct is configured to modify a local environment surrounding the staples to control a degradation rate of the staples after the initial delay.

公开(公告)号：WO2022238848A1

公开(公告)日：2022-11-17

申请号：PCT/IB2022/054220

申请日：2022-05-06

Applicant: CILAG GMBH INTERNATIONAL

Inventor： SHELTON, IV, Frederick E. ,  RECTOR, Jason M. ,  JONES, Shannon L. ,  MCGHEE, Ryan W. ,  ECKERT, Chad E.

IPC: A61B17/064 ,  A61B17/072 ,  A61B17/00 ,  A61B17/0644 ,  A61B17/0686 ,  A61B17/07207 ,  A61B17/07292 ,  A61B17/105 ,  A61B2017/00004 ,  A61B2017/00017 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/00115 ,  A61B2017/00119 ,  A61B2017/00221 ,  A61B2017/00398 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/0053 ,  A61B2017/00845 ,  A61B2017/00849 ,  A61B2017/00853 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00938 ,  A61B2017/0688 ,  A61B2017/07228 ,  A61B2017/07235 ,  A61B2017/07257 ,  A61B2017/07264 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2017/07285 ,  A61B2050/0065 ,  A61B2050/3004 ,  A61B2050/314 ,  A61B2090/038 ,  A61B2090/0807 ,  A61B2090/0809 ,  A61B50/20 ,  A61B50/3001 ,  A61B50/33 ,  A61B90/92 ,  A61B90/94 ,  A61B90/98 ,  A61L2/02 ,  A61L2/16 ,  A61L2/232 ,  A61L2202/23 ,  A61L2202/24 ,  A61L2300/252 ,  A61L2400/10 ,  A61L2420/04 ,  A61L31/022 ,  A61L31/028 ,  A61L31/042 ,  A61L31/048 ,  A61L31/08 ,  A61L31/082 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61N2005/1087 ,  A61N2005/1098 ,  A61N5/1027

Abstract: A staple cartridge comprising staples that are lubricated before they are loaded into the staple cartridge and after they have been loaded into the staple cartridge is disclosed.

公开(公告)号：WO2022238840A1

公开(公告)日：2022-11-17

申请号：PCT/IB2022/054211

申请日：2022-05-06

Applicant: CILAG GMBH INTERNATIONAL

Inventor： HARRIS, Jason L. ,  ECKERT, Chad E. ,  RANSICK, Mark H. ,  CRONE, William J. K. ,  LOVELOCK, Stephen R. ,  KOBAYASHI, Haruka ,  BOWN, Richard T. ,  ANDREWS, Richard J. ,  TROTT, Sophie K. ,  BRADBURY, Ailsa G. ,  GOLDREIN, Howell T. ,  PATHAK, Shashi S. ,  RECTOR, Jason M. ,  VENDELY, Michael J. ,  JONES, Shannon L. ,  MCGHEE, Ryan W. ,  SHELTON, IV, Frederick E.

IPC: A61B17/064 ,  A61B17/072 ,  A61B17/068 ,  A61B90/92 ,  A61L15/00 ,  A61B90/94 ,  A61B90/98 ,  A61B90/00 ,  A61B50/33 ,  A61B17/00 ,  A61B50/30 ,  A61B17/0644 ,  A61B17/07207 ,  A61B17/07292 ,  A61B2017/00004 ,  A61B2017/00017 ,  A61B2017/00115 ,  A61B2017/00398 ,  A61B2017/00526 ,  A61B2017/0053 ,  A61B2017/00849 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00938 ,  A61B2017/0688 ,  A61B2017/07228 ,  A61B2017/07235 ,  A61B2017/07257 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2050/0065 ,  A61B2050/3004 ,  A61B2050/314 ,  A61B2090/038 ,  A61B2090/0807 ,  A61L31/022 ,  A61L31/086 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148

Abstract: Staple cartridges including bioabsorbable staples are disclosed. The staples are configured such that they are bioabsorbable within a desired time frame.

公开(公告)号：WO2022191271A1

公开(公告)日：2022-09-15

申请号：PCT/JP2022/010494

申请日：2022-03-10

Applicant: テルモ株式会社

Inventor： 小濱　弘昌

IPC: A61L29/08 ,  A61L29/02 ,  A61L29/04 ,  A61L29/14 ,  A61L31/02 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

Abstract: 本発明は、優れた潤滑性および耐久性（潤滑維持性）を発揮する表面潤滑層を形成できる親水性共重合体を提供することを目的とする。本発明は、基材層と、前記基材層の少なくとも一部に形成された親水性共重合体を含む潤滑層と、を備える医療用具であって、前記親水性共重合体が、スルホン酸イオンの対イオンがアルカリ金属カチオンであるスルホベタイン構造を有する重合性単量体（Ａ）由来の構成単位、および光反応性基を有する重合性単量体（Ｂ）由来の構成単位を含み、前記重合性単量体（Ａ）由来の構成単位の含有量が全単量体由来の構成単位の合計に対して、８０モル％を超え１００モル％未満である、医療用具に関する。