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公开(公告)号：EP1250340A1
公开(公告)日：2002-10-23
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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2.发明授权PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER 有权吡唑并吡啶衍生物作为TGF BETA抑制剂用于治疗癌症的
公开(公告)号：EP1543001B1
公开(公告)日：2007-08-15
申请号：EP03749105.7
申请日：2003-09-16
发明人： BEIGHT, Douglas, Wade , BONJOUKLIAN, Rosanne , LIAO, Junkai , MCMILLEN, William, Thomas , PARKHURST, Brandon, Lee , SAWYER, Jason, Scott , YINGLING, Jonathan, Michael , YORK, Jeremy, Schulenburg
IPC分类号： C07D471/04 , A61K31/41 , A61P35/00 , A61P17/00
CPC分类号： C07D471/04
摘要： Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
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公开(公告)号：EP1250340B1
公开(公告)日：2004-11-17
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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公开(公告)号：EP1543001A1
公开(公告)日：2005-06-22
申请号：EP03749105.7
申请日：2003-09-16
发明人： BEIGHT, Douglas, Wade , BONJOUKLIAN, Rosanne , LIAO, Junkai , MCMILLEN, William, Thomas , PARKHURST, Brandon, Lee , SAWYER, Jason, Scott , YINGLING, Jonathan, Michael , YORK, Jeremy, Schulenburg
IPC分类号： C07D471/04 , A61K31/41 , A61P35/00 , A61P17/00
CPC分类号： C07D471/04
摘要： Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
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