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公开(公告)号：EP4122935A1
公开(公告)日：2023-01-25
申请号：EP22178867.2
申请日：2013-12-19
发明人： HAOLUN, Jin , LAZERWITH, Scott, E. , MARTIN, Teresa, Alejandra, Trejo , BACON, Elizabeth, M. , COTTELL, Jeromy, J. , CAI, Zhenhong, R. , PYUN, Hyung-Jung , MORGANELLI, Phillip, Anthony , JI, Mingzhe , TAYLOR, James, G. , CHEN, Xiaowu , MISH, Michael, R. , DESAI, Manoj, C.
IPC分类号： C07D498/14 , C07D471/04 , C07D471/14 , C07D471/22 , C07D487/04 , A61K31/529 , A61K31/553 , A61P31/12 , A61P31/18 , C07D498/18 , C07D471/18 , A61P43/00 , A61K45/06 , C07D487/14
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):
including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , X, W, Y 1 , Y 2 , Z 1 , and Z 4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.-
公开(公告)号：EP1628685B1
公开(公告)日：2010-12-08
申请号：EP04750807.2
申请日：2004-04-26
发明人： BOOJAMRA, Constantine, G. , CANNIZZARO, Carina, E. , CHEN, James, M. , CHEN, Xiaowu , CHO, Aesop , CHONG, Lee, S. , FARDIS, Maria , JIN, Haolun , HIRSCHMANN, Ralph, F. , HUANG, Alan, X. , KIM, Choung, U. , KIRSCHBERG, Thorsten, A. , LEE, Christopher, P. , LEE, William, A. , MACKMAN, Richard, L. , MARKEVITCH, David, Y. , PRASAD, Vidya, K. , PYUN, Hyung-Jung , RAY, Adrian, S. , SHERLOCK, Rosemarie , SWAMINATHAN, Sundaramoorthi , WATKINS, Will , ZHANG, Jennifer, R. , OARE, David
CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/60 , C07F9/65037 , C07F9/650941 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP1628685A2
公开(公告)日：2006-03-01
申请号：EP04750807.2
申请日：2004-04-26
发明人： BOOJAMRA, Constantine, G. , CANNIZZARO, Carina, E. , CHEN, James, M. , CHEN, Xiaowu , CHO, Aesop , CHONG, Lee, S. , FARDIS, Maria , JIN, Haolun , HIRSCHMANN, Ralph, F. , HUANG, Alan, X. , KIM, Choung, U. , KIRSCHBERG, Thorsten, A. , LEE, Christopher, P. , LEE, William, A. , MACKMAN, Richard, L. , MARKEVITCH, David, Y. , PRASAD, Vidya, K. , PYUN, Hyung-Jung , RAY, Adrian, S. , SHERLOCK, Rosemarie , SWAMINATHAN, Sundaramoorthi , WATKINS, Will , ZHANG, Jennifer, R. , OARE, David
IPC分类号： A61K47/48 , C07F9/02 , C07F9/6561
CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/60 , C07F9/65037 , C07F9/650941 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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4.发明公开BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION 有权苯并噻唑-6-基 - 乙酸衍生物及其用于HIV感染的治疗
公开(公告)号：EP3070081A1
公开(公告)日：2016-09-21
申请号：EP15202564.9
申请日：2013-04-19
发明人： BABAOGLU, Kerim , BRIZGYS, Gediminas , CHA, Jake , CHEN, Xiaowu , GUO, Hongyan , HALCOMB, Randall, L. , HAN, Xiaochun , HUANG, Richard , LIU, Hongtao , MCFADDEN, Ryan , MITCHELL, Michael, L. , QI, Yingmei , ROETHLE, Paul, A. , XU, Lianhong , YANG, Hong
IPC分类号： C07D277/66 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K31/428 , A61P31/18
CPC分类号： C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
摘要： Compounds disclosed herein including compounds of formula I':
and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.摘要翻译： 化合物光盘包括I“式的化合物游离缺失：及其盐中提供它们。 药物组合物包含化合物在游离缺失盘，用于制备化合物游离缺失光盘中，用于制备在使用中提供了这样的化合物游离缺失盘治疗HIV感染和治疗方法的化合物游离缺失光盘的有用中间体的处理。
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5.发明授权CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH 有权HIV蛋白酶抑制剂化合物及其化合物的膦酸盐类似物的细胞积累
公开(公告)号：EP1509537B9
公开(公告)日：2007-11-14
申请号：EP03747326.1
申请日：2003-04-25
发明人： ARIMILLI, Murty, N. , BECKER, Mark, W. , BRYANT, Clifford , CHEN, James, M. , CHEN, Xiaowu , DASTGAH, Azar , FARDIS, Maria , HE, Gong-Xin , JIN, Haolun , KIM, Choung, U. , LEE, William, A. , LEE, Christopher, P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard, L. , MITCHELL, Michael, L. , NELSON, Peter, H. , PYUN, Hyung-Jung , ROWE, Tanisha, D. , SWAMINATHAN, Sundaramoorthi , TARIO, James, D. , ZHANG, Lijun , SPARACINO, Mark , WANG, Jianying , WILLIAMS, Matthew, A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard, H. , ZHANG, Jiancun
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
摘要翻译： 公开了具有用作治疗剂和用于其他工业目的的HIV蛋白酶抑制性质的膦酸酯取代的化合物。 该组合物抑制HIV蛋白酶活性和/或可用于治疗AIDS和其他抗病毒感染以及用于检测HIV蛋白酶的分析。
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6.发明公开CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH 有权富集在单元格中膦酸酯类似物的HIV蛋白酶抑制剂化合物和接线SELF
公开(公告)号：EP1509537A2
公开(公告)日：2005-03-02
申请号：EP03747326.1
申请日：2003-04-25
发明人： ARIMILLI, Murty, N. , BECKER, Mark, M. , BRYANT, Clifford , CHEN, James, M. , CHEN, Xiaowu , DASTGAH, Azar , FARDIS, Maria , HE, Gong-Xin , JIN, Haolun , KIM, Choung, U. , LEE, William, A. , LEE, Christopher, P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard, L. , MITCHELL, Michael, L. , NELSON, Peter, H. , PYUN, Hyung-Jung , ROWE, Tanisha, D. , SWAMINATHAN, Sundaramoorthi , TARIO, James, D. , ZHANG, Lijun , SPARACINO, Mark , WANG, Jianying , WILLIAMS, Matthew, A , XU, Lianhong , YANG, Zheng-Yu , YU, Richard, H. , ZHANG, Jiancun
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
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7.发明授权BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION 有权苯并噻唑-6-基乙酸衍生物及其用于HIV感染的治疗
公开(公告)号：EP2788336B1
公开(公告)日：2016-03-02
申请号：EP13719355.3
申请日：2013-04-19
发明人： BABAOGLU, Kerim , BRIZGYS, Gediminas , CHA, Jake , CHEN, Xiaowu , GUO, Hongyan , HALCOMB, Randall, L. , HAN, Xiaochun , HUANG, Richard , LIU, Hongtao , MCFADDEN, Ryan , MITCHELL, Michael, L. , QI, Yingmei , ROETHLE, Paul, A. , XU, Lianhong , YANG, Hong
IPC分类号： C07D277/66 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K31/428 , A61P31/18 , A61K45/06 , A61K31/444
CPC分类号： C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
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8.发明授权CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH 有权富集在单元格中膦酸酯类似物的HIV蛋白酶抑制剂化合物和接线SELF
公开(公告)号：EP1509537B1
公开(公告)日：2007-07-18
申请号：EP03747326.1
申请日：2003-04-25
发明人： ARIMILLI, Murty, N. , BECKER, Mark, W. , BRYANT, Clifford , CHEN, James, M. , CHEN, Xiaowu , DASTGAH, Azar , FARDIS, Maria , HE, Gong-Xin , JIN, Haolun , KIM, Choung, U. , LEE, William, A. , LEE, Christopher, P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard, L. , MITCHELL, Michael, L. , NELSON, Peter, H. , PYUN, Hyung-Jung , ROWE, Tanisha, D. , SWAMINATHAN, Sundaramoorthi , TARIO, James, D. , ZHANG, Lijun , SPARACINO, Mark , WANG, Jianying , WILLIAMS, Matthew, A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard, H. , ZHANG, Jiancun
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
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9.发明公开
公开(公告)号：EP1620445A2
公开(公告)日：2006-02-01
申请号：EP03767521.2
申请日：2003-11-06
发明人： BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin J. , SWAMINATHAN, Sundaramoorthi
IPC分类号： C07F9/40 , C07F9/6561 , G01N33/04
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).
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10.发明公开POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE 有权多环CARBAMOYLPYRIDONVERBINDUNGEN和它们的药物用途
公开(公告)号：EP2822954A1
公开(公告)日：2015-01-14
申请号：EP13815937.1
申请日：2013-12-19
发明人： JIN, Haolun , LAZERWITH, Scott, E. , MARTIN, Teresa, Alejandra, Trejo , BACON, Elizabeth, M. , COTTELL, Jeromy, J. , CAI, Zhenhong, R. , PYUN, Hyung-Jung , MORGANELLI, Philip, Anthony , JI, Mingzhe , TAYLOR, James, G. , CHEN, Xiaowu , MISH, Michael, R. , DESAI, Manoj, C.
IPC分类号： C07D498/14 , C07D471/04 , C07D471/14 , C07D471/22 , C07D487/04
CPC分类号： C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , X, W, Y 1 , Y 2 , Z 1 and Z 4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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