公开(公告)号：EP4431105A1

公开(公告)日：2024-09-18

申请号：EP22892849.5

申请日：2022-11-10

申请人： KJ Bio Co., Ltd. ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM

发明人： KUNO, Hitoshi ,  KANNO, Akiko ,  KOMATSU, Satoko ,  KAMETANI, Yoshie ,  OHSHIMA, Shino ,  OHNO, Yusuke

IPC分类号： A61K36/05 ,  A23K10/30 ,  A23L33/10 ,  A61K8/9722 ,  A61P37/04 ,  A61P43/00 ,  A61Q19/00 ,  C12N1/12

CPC分类号： A23K10/30 ,  A23L33/10 ,  A61K8/9722 ,  A61K36/05 ,  A61P37/04 ,  A61P43/00 ,  A61Q19/00 ,  C12N1/12

摘要： It is an object of the present invention to provide a means capable of appropriately regulating differentiation of T cells, in order to avoid overactivation of T cells after stimulation of the T cells with superantigens or the like and the subsequent decrease in the immune functions (exhaustion of the immune system). The present invention relates to a T cell differentiation-regulating agent, comprising, as an active ingredient, an algal body of microalgae belonging to the genus Coccomyxa, a dry powder thereof, or an extract thereof.

公开(公告)号：EP3269344B1

公开(公告)日：2022-08-10

申请号：EP16764474.9

申请日：2016-03-14

发明人： FUJIWARA, Toshiyuki ,  MASAKADO, Yoshihisa ,  USHIBA, Junichi

IPC分类号： A61H1/02 ,  A61N1/36 ,  A61N1/04

公开(公告)号：EP3647775A1

公开(公告)日：2020-05-06

申请号：EP18822823.3

申请日：2018-05-18

申请人： Tokai University Educational System

发明人： AZETSU, Akihiko ,  KITAJIMA, Ikkei ,  KURATSUJI, Kazaki ,  OCHIAI, Masayuki

IPC分类号： G01N21/85 ,  G01N21/27 ,  G01P13/00

摘要： According to the present invention, a measurement method for visualizing the flow of a fluid (23) has: a preparation step for dissolving, in the fluid (23), a photochromic compound of which the amount of light absorption changes when the photochromic compound is irradiated with a transformation-generating light (31); a transformation-generating light irradiating step for irradiating the fluid (23) with the transformation-generating light (31) that causes photochromism; and a post-transformation image capturing step for capturing an image of the fluid (23) irradiated with the transformation-generating light. In the post-transformation image capturing step, a first image (B) is generated by capturing the image of the fluid (23) using first light in a first wavelength range, wherein the amount of light absorption of the first light changes due to the irradiation of the transformation-generating light (31).

公开(公告)号：EP3578682A1

公开(公告)日：2019-12-11

申请号：EP18748656.8

申请日：2018-01-30

申请人： Tokai University Educational System ,  Shincron Co., Ltd.

发明人： MUROTANI, Hiroshi ,  HORIGUCHI, Yukio ,  SUGAWARA, Takuya

IPC分类号： C23C14/08 ,  C23C14/22

摘要： Provided is a film-formation method for a surface layer having high mechanical strength and a low refractive index. A step of film formation from a vapor deposition material by a vacuum vapor deposition method and a step of film formation by sputtering of a target constituent substance are repeated for the surfaces of substrates (S), thereby forming films with a lower refractive index than that of a film-forming material.

公开(公告)号：EP3527215A1

公开(公告)日：2019-08-21

申请号：EP19158239.4

申请日：2019-02-20

申请人： Tokai University Educational System ,  Nippon Zoki Pharmaceutical Co., Ltd.

发明人： Sakai, Daisuke ,  Nakai, Tomoko ,  Naiki, Mitsuru ,  Shibayama, Yoji

IPC分类号： A61K35/32 ,  C12Q1/02 ,  G01N33/50

摘要： An object of the present invention is to provide an agent for promoting expression of N-acetylgalactosaminyltransferase that contains an extract from inflamed tissues inoculated with vaccinia virus. The present invention demonstrated that the extract from inflamed tissues inoculated with vaccinia virus promotes the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells. Thus, the extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract is useful as an agent for promoting the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells.

公开(公告)号：EP3135315A1

公开(公告)日：2017-03-01

申请号：EP15783466.4

申请日：2015-04-20

申请人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  Toray Industries, Inc.

发明人： OKAMURA, Yosuke ,  NAGASE, Yu ,  KOMACHI, Takuya ,  HOCHI, Motonori ,  SEKIDO, Yuki ,  ARAKANE, Toru

IPC分类号： A61L31/00 ,  A61L15/16 ,  B32B27/30 ,  B32B27/36

CPC分类号： A61L31/00 ,  A61L15/16 ,  A61L15/24 ,  A61L15/26 ,  A61L15/28 ,  A61L15/64 ,  A61L31/042 ,  A61L31/048 ,  A61L31/06 ,  A61L31/148 ,  A61L2400/12 ,  B32B7/045 ,  B32B9/02 ,  B32B9/04 ,  B32B9/045 ,  B32B27/08 ,  B32B27/306 ,  B32B27/36 ,  B32B2250/05 ,  B32B2250/24 ,  B32B2250/44 ,  B32B2307/7163 ,  B32B2307/73 ,  B32B2535/00 ,  C08L67/04 ,  C08L5/04 ,  C08L29/04

摘要： The present invention provides a polymer laminate in which 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. By the present invention, a polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.

摘要翻译： 本发明提供一种聚合物层叠体，其中层叠2〜100层各自含有生物降解性树脂，厚度为10nm〜400nm的聚合物层叠体，至少一层最外层的厚度为10nm〜180nm， 最外层彼此连接。 通过本发明，可以获得生物相容性和机械强度优异且适用于医疗用途如伤口敷料和防粘附材料的聚合物层压体。

公开(公告)号：EP2735314A1

公开(公告)日：2014-05-28

申请号：EP12779704.1

申请日：2012-05-01

申请人： BioMedCore Inc. ,  Sapporo Medical University ,  Tokai University Educational System ,  Torigoe, Toshihiko ,  Sato, Noriyuki

发明人： KAJIWARA, Toshimitsu ,  NUMAZAKI, Maki ,  SHIMIZU, Yoshitaka ,  TAMURA, Yasuaki ,  KOJIMA, Naoya

IPC分类号： A61K39/39 ,  A61K9/127 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K47/36 ,  A61K48/00 ,  A61P35/00 ,  C07K14/705

CPC分类号： A61K31/7088 ,  A61K9/1271 ,  A61K39/0011 ,  A61K39/39 ,  A61K47/6911 ,  A61K2039/55555

摘要： [Problem] The purpose of the present invention is to provide a preparation which has an effect of further promoting cellular immunity when used in an adjuvant or in a method for removing an immunosuppression mechanism.
[Solution] Provided is a sugar-coated liposome (particularly a mannose-coated liposome) which can activate a CTL in an MHC-class II antigen-independent (CD4+T cell-independent) manner when administered together with an MHC class I antigen. Particularly provided is a sugar-coated liposome which has a particle diameter of 100-1100 nm and/or in which the molar ratio of a sugar-modified lipid to a lipid is 0.00075-0.075.

摘要翻译： 本发明的目的在于提供一种在佐剂中使用时具有进一步促进细胞免疫的作用的制剂，或者是除去免疫抑制机理的方法。 [解决方案]提供了当与MHC I类抗原一起施用时，可以激活MHC-II类抗原非依赖性（CD4 + T细胞非依赖性）方式的CTL的糖包衣脂质体（特别是甘露糖包被的脂质体） 。 特别提供的是具有100-1100nm粒径和/或其中糖改性脂质与脂质的摩尔比为0.00075-0.075的糖衣脂质体。

公开(公告)号：EP1240902B1

公开(公告)日：2013-02-13

申请号：EP00981764.4

申请日：2000-12-15

申请人： Kurokawa, Kiyoshi ,  Miyata, Toshio ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM

发明人： MIYATA, Toshio

IPC分类号： A61K38/51 ,  A61K45/00 ,  A61K38/46 ,  A61K38/06 ,  A61P43/00 ,  A61P7/08 ,  A61M1/16 ,  A61M1/28

CPC分类号： A61M1/287 ,  A61K38/51 ,  A61M1/3687 ,  A61K2300/00

公开(公告)号：EP2068379B1

公开(公告)日：2012-12-26

申请号：EP07807084.4

申请日：2007-09-11

申请人： Hiroshima University ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  NIPPON KAYAKU KABUSHIKI KAISHA

发明人： TAKIMIYA, Kazuo, c/o Graduate School of Engineering, Hiroshima University ,  KUNUGI, Yoshihito, c/o Tokai University

IPC分类号： H01L51/30 ,  C07D333/72 ,  C09K11/06 ,  H01L21/336 ,  H01L29/786 ,  H01L51/05 ,  H01L51/40 ,  H01L51/50

CPC分类号： C07D333/72 ,  H01L51/0051 ,  H01L51/0068

公开(公告)号：EP1860180A1

公开(公告)日：2007-11-28

申请号：EP06714935.1

申请日：2006-02-22

申请人： Foundation for Biomedical Research and Innovation ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM

发明人： ASAHARA, Takayuki,c/oDept.Reg.Med., Inst.Bio.Res. ,  MASUDA, Haruchika

IPC分类号： C12N5/00 ,  A61K35/12 ,  A61P9/10 ,  C12N5/06

CPC分类号： A61K35/44 ,  C12N5/0692 ,  C12N2500/90 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/15 ,  C12N2501/165 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2506/11

摘要： The present invention provides a method for expanding an endothelial progenitor cell in vitro. More particularly, the present invention provides a method for culturing a hemangioblast comprising incubating a hemangioblast in a serum-free culture medium containing one or more factors selected from the group consisting of stem cell growth factor, interleukin-6, FMS-like tyrosine kinase 3 and thrombopoietin, and a vascular endothelial cell produced by the method; and a serum-free culture medium containing one or more factors selected from the group consisting of stem cell growth factor, interleukin-6, FMS-like tyrosine kinase 3 and thrombopoietin, and a kit for the preparation of the serum-free culture medium and the like.

摘要翻译： 本发明提供了体外扩张内皮祖细胞的方法。 更具体地说，本发明提供培养成血成血管细胞的方法，包括在含有一种或多种选自干细胞生长因子，白细胞介素-6，FMS样酪氨酸激酶3的因素的无血清培养基中培养成血成血管细胞 和血小板生成素，以及通过该方法产生的血管内皮细胞; 和含有选自干细胞生长因子，白细胞介素-6，FMS样酪氨酸激酶3和血小板生成素的一种或多种因子的无血清培养基，以及用于制备无血清培养基的试剂盒和 类似。