公开(公告)号：EP0706319A4

公开(公告)日：1998-04-22

申请号：EP94909464

申请日：1994-01-17

申请人： BIOTRANSPLANT INC ,  GEN HOSPITAL CORP

发明人： LE GUERN CHRISTIAN A ,  SEED BRIAN ,  BANERJEE PAPIA T

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K35/12 ,  A61K35/76 ,  A61K38/00 ,  A61K48/00 ,  A61P37/06 ,  C07K14/74 ,  C12N5/10 ,  C12N7/01 ,  C12N15/79 ,  C12N15/867 ,  C12P21/02 ,  C12R1/91 ,  C12R1/92 ,  A01N63/00 ,  A01K49/00 ,  C12N5/00 ,  C12N5/16 ,  C12N5/22 ,  C12N15/00 ,  C12P21/06

CPC分类号： C12N15/86 ,  C07K14/70539 ,  C12N15/79 ,  C12N2740/13043 ,  C12N2800/108 ,  C12N2840/203 ,  C12N2840/206 ,  C12N2840/44 ,  C12N2840/85

摘要： This invention relates to retroviral vectors that express multiple polypeptide subunits of a eukaryotic protein from a single polycistronic mRNA and the proteins produced from these vectors. The expressed proteins are particularly useful for inducing transplantation tolerance and the vectors are useful as agents for mediating gene transfer into eukaryotic cells.

公开(公告)号：EP0959899B9

公开(公告)日：2009-10-21

申请号：EP96930529.1

申请日：1996-08-16

申请人： BIOTRANSPLANT, INC ,  Université Catholique de Louvain

发明人： BAZIN, Hervé ,  LATINNE, Dominique ,  KAPLAN, Ruth ,  KIEBER-EMMONS, Thomas ,  POSTEMA, Christina, E. ,  WHITE-SCHARF, Mary, E.

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/44 ,  C07K16/46 ,  C12P21/08

CPC分类号： C07K16/2806 ,  A61K38/00 ,  C07K2317/24

摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.

摘要翻译： 本发明涉及LO-CD2a抗体以及使用结合相同表位（或其一部分）的此类抗体或分子以预防和抑制人类患者中免疫应答的方法，优选地，其中免疫应答由 T细胞或自然杀伤细胞的活化和增殖。 向患者施用有效量的LO-CD2a抗体将预防或抑制移植排斥，移植物抗宿主病或自身免疫疾病。

公开(公告)号：EP1003552B1

公开(公告)日：2008-05-14

申请号：EP97936112.8

申请日：1997-07-18

申请人： BIOTRANSPLANT, INC ,  UNIVERSITE CATHOLIQUE DE LOUVAIN

发明人： BAZIN, Hervé ,  LATINNE, Dominique ,  KAPLAN, Ruth ,  KIEBER-EMMONS, Thomas ,  POSTEMA, Christina, E. ,  WHITE-SCHARF, Mary, E.

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2806 ,  A61K38/00 ,  C07K2317/24 ,  C07K2319/00

摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.

公开(公告)号：EP0755402B1

公开(公告)日：2008-05-14

申请号：EP95915459.2

申请日：1995-03-31

申请人： BIOTRANSPLANT, INC ,  THE GENERAL HOSPITAL CORPORATION ,  INSTITUTE OF CHILD HEALTH

发明人： BAETSCHER, Manfred, W. ,  SACHS, David, H. ,  GUSTAFSSON, Kenth, T.

IPC分类号： C12N15/54 ,  C12N15/19 ,  A61K31/70 ,  A61K35/16 ,  C12N15/00 ,  A01K67/027 ,  C12N15/52 ,  C12N9/10 ,  C12N9/00

CPC分类号： C12N15/113 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/108 ,  A01K2267/02 ,  A01K2267/025 ,  A61K2035/122 ,  C12N9/1051 ,  C12N15/1137 ,  C12N15/8509 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/315 ,  C12N2517/02 ,  C12N2830/52 ,  C12N2840/203 ,  C12Y204/01228

摘要： Transgenic swine in which the normal expression of alpha(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Galalpha1-3Galbeta1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.

公开(公告)号：EP1578897A2

公开(公告)日：2005-09-28

申请号：EP00967159.5

申请日：2000-09-29

申请人： BIOTRANSPLANT, INC

发明人： ANDERSSON, Goran, K.

IPC分类号： C12N1/00

CPC分类号： A61K48/00 ,  A61K39/001 ,  A61K2035/124 ,  A61K2039/5156

摘要： Methods of inducing functional tolerance for the expression products of transgenes in somatic cells are disclosed, which methods comprise the introduction into the recipient of stem cells, such as hematopoietic stem cells, transgenically modified so as to express one or more neoantigens, such procedure optionally preceded by a myeloreductive procedure. The purpose of the disclosed methods is to induce tolerance to these same antigens when later expressed by cells or vectors to be introduced as part of a gene therapy treatment.

公开(公告)号：EP1250594A1

公开(公告)日：2002-10-23

申请号：EP01903145.9

申请日：2001-01-19

申请人： BIOTRANSPLANT, INC

发明人： PATIENCE, Clive

IPC分类号： G01N33/00 ,  C12N15/85 ,  A61K35/00 ,  C12P19/34 ,  C12Q1/70

CPC分类号： A01K67/0271 ,  A01K67/027 ,  A61K35/12 ,  C12Q1/702

摘要： Miniature swine whose genomes contain sequences characteristic of pig endogenous retrovirus genes but which are non-infectious to humans are disclosed as sources of organs, tissues and cells for introduction into human recipients afflicted with diseases, or at risk of diseases, whose etiology involves the presence of inadequately functioning organs and for which xenotransplantation of such organs, tissues and cells would have a palliative effect. Methods of producing such animals and for screening animals for the desired properties are also disclosed.

公开(公告)号：EP1003552A1

公开(公告)日：2000-05-31

申请号：EP97936112.8

申请日：1997-07-18

申请人： BIOTRANSPLANT, INC ,  UNIVERSITE CATHOLIQUE DE LOUVAIN

发明人： BAZIN, Hervé ,  LATINNE, Dominique ,  KAPLAN, Ruth ,  KIEBER-EMMONS, Thomas ,  POSTEMA, Christina, E. ,  WHITE-SCHARF, Mary, E.

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2806 ,  A61K38/00 ,  C07K2317/24 ,  C07K2319/00

摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.

公开(公告)号：EP0669829A1

公开(公告)日：1995-09-06

申请号：EP93925071.0

申请日：1993-10-26

申请人： BIOTRANSPLANT, INC

发明人： PONATH, Paul, D. ,  ROSA, Margaret, D. ,  MONROY, Rodney, L. ,  SCHACTER, Bernice, Z. ,  HAWLEY, Robert, J.

IPC分类号： C12N15 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61P37 ,  C07H21 ,  C07K14 ,  C12N5 ,  C12P21 ,  C12R1

CPC分类号： A61K35/28 ,  A61K38/00 ,  A61K39/00 ,  A61K39/001 ,  C07K14/475 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K2319/00 ,  Y10S514/885

摘要： A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.

公开(公告)号：EP0959899B1

公开(公告)日：2009-05-27

申请号：EP96930529.1

申请日：1996-08-16

申请人： BIOTRANSPLANT, INC ,  University Catholique de Louvain

发明人： BAZIN, Hervé ,  LATINNE, Dominique ,  KAPLAN, Ruth ,  KIEBER-EMMONS, Thomas ,  POSTEMA, Christina, E. ,  WHITE-SCHARF, Mary, E.

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/44 ,  C07K16/46 ,  C12P21/08

CPC分类号： C07K16/2806 ,  A61K38/00 ,  C07K2317/24

摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.

公开(公告)号：EP0959899A4

公开(公告)日：2005-01-12

申请号：EP96930529

申请日：1996-08-16

申请人： BIOTRANSPLANT INC ,  UNIV LOUVAIN

发明人： BAZIN HERVE ,  LATINNE DOMINIQUE ,  KAPLAN RUTH ,  KIEBER-EMMONS THOMAS ,  POSTEMA CHRISTINA E ,  WHITE-SCHARF MARY E

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61P37/06 ,  A61P43/00 ,  C07K16/18 ,  C07K16/28 ,  C07K19/00 ,  C12P21/08 ,  A61K39/00 ,  A61K38/16 ,  C07K14/00 ,  C07K16/00 ,  C07K16/44 ,  C07K16/46

CPC分类号： C07K16/2806 ,  A61K38/00 ,  C07K2317/24