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11.发明公开DIFFERENTIALLY EXPRESSED GENES IN CARDIAC HYPERTROPHY AND THEIR USES IN TREATMENT AND DIAGNOSIS 审中-公开心肌肥厚差异表达的基因和它们使用的治疗和诊断
公开(公告)号：EP1030916A2
公开(公告)日：2000-08-30
申请号：EP98957774.7
申请日：1998-11-10
申请人： Curagen Corporation
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , A61K39/395 , G01N33/53 , C12Q1/68 , C12N15/62 , C12N15/11 , C07K16/18 , A01K67/027 , A61K48/00
CPC分类号： C12N9/0053 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/665 , C07K14/70585 , C07K14/78 , C07K2319/02 , C12N9/88 , C12N15/11 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is based upon the identification of genes which are differentially expressed in hypertrophic cardiac tissue as compared to normal cardiac tissue. Accordingly, the present invention provides nucleotide sequences of genes selected from the group consisting of CH-1, CH-2, CH-3, CH-4, CH-5, CH-6, CH-7, CH-8, and CH-9, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. The invention also provides therapeutic methods and pharmaceutical compositions which are based on the promotion or inhibition of the function of the differentially expressed genes. The invention further provides methods of diagnosis, prognosis and screening for a disposition for diseases or disorders associated with cardiac hypertrophy. Methods for screening for modulators of the protein products of the differentially expressed genes in cardiac hypertrophy tissue are additionally provided.
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12.发明公开METHODS FOR DIAGNOSING AND TREATMENT OF CONDITIONS THAT ALTER PHOSPHATE TRANSPORT IN MAMMALS 审中-公开方法进行诊断和治疗的痛苦在于磷酸根运输在哺乳动物CHANGE
公开(公告)号：EP1664075A2
公开(公告)日：2006-06-07
申请号：EP04781657.4
申请日：2004-08-20
申请人： Curagen Corporation
IPC分类号： C07H21/02 , C07H21/04 , C07K14/435 , C12Q1/68 , A61K38/17 , A61K39/395 , A61K48/00 , G01N33/53
CPC分类号： G01N33/6872 , A61K38/1825 , C12Q1/6883 , C12Q2600/156 , G01N33/74 , G01N2333/50 , G01N2800/04 , G01N2800/52
摘要： The present invention describes novel methods for diagnosis and treatment of conditions that alter phosphate transport in mammals. The fibroblast growth factor proteins and nucleotides that may be useful as a therapeutic or in the diagnosis of such conditions are also described.
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13.发明公开
公开(公告)号：EP1581618A2
公开(公告)日：2005-10-05
申请号：EP03747643.9
申请日：2003-05-02
申请人： Curagen Corporation
发明人： ALVAREZ, Enrique , ANDERSON, David, W. , BOLDOG, Ferenc, L. , CATTERTON, Elina , EDINGER, Shlomit, R. , FERNANDES, Elma, R. , GERLACH, Valerie, L. , GORMAN, Linda , GROSSE, William, M. , GUO, Xiaojia , JI, Weizhen , KEKUDA, Ramesh , LI, Li , MACDOUGALL, John, R. , PADIGARU, Muralidhara , PATTURAJAN, Meera , PETERSON, Jeffrey, D. , RASTELLI, Luca , SHIMKETS, Richard, A. , STONE, David, J. , VERNET, Corine, A.M. , VOSS, Edward Z. , ZHONG, Mei
IPC分类号： C12N1/00
CPC分类号： C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。 公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。 本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。
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14.发明公开
公开(公告)号：EP1432726A2
公开(公告)日：2004-06-30
申请号：EP02770481.6
申请日：2002-09-09
申请人： Curagen Corporation
发明人： ALSOBROOK, John, P., II , BURGESS, Catherine, E. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , LEPLEY, Denise, M. , PATTURAJAN, Meera , PENA, Carol, E., A. , RIEGER, Daniel, K. , SHIMKETS, Richard, A. , SPYTEK, Kimberly, A. , TAUPIER, Raymond, J., Jr. , ZHONG, Mei
IPC分类号： C07K1/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1366162A2
公开(公告)日：2003-12-03
申请号：EP01996122.6
申请日：2001-12-06
申请人： Curagen Corporation
发明人： GUO, Xiaojia , LI, Li , PATTURAJAN, Meera , SHIMKETS, Richard, A. , CASMAN, Stacie, J. , MALYANKAR, Uriel, M. , TCHERNEV, Velizar, T. , VERNET, Corinne, A.M. , SPYTEK, Kimberly A. , SHENOY, Suresh, G. , ALSOBROOK, John, P., II , EDINGER, Schlomit , PEYMAN, John, A. , STONE, David, J. , ELLERMAN, Karen , GANGOLLI, Esha, A. , BOLDOG, Ferenc, L. , COLMAN, Steven, D. , EISEN, Andrew, J. , LIU, Xiaohong , PADIGARU, Muralidhara , SPADERNA, Steven K. , ZERHUSEN, Bryan D.
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/53 , G01N33/50 , G01N33/68 , A61K38/17 , A61K48/00 , A61K39/395
摘要： Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
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16.发明公开NUCLEIC ACIDS CONTAINING SINGLE NUCLEOTIDE POLYMORPHISMS AND METHODS OF USE THEREOF 审中-公开单核苷酸和使用方法NUCLEIC
公开(公告)号：EP1282726A2
公开(公告)日：2003-02-12
申请号：EP00990358.4
申请日：2000-12-27
申请人： Curagen Corporation
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention provides nucleic acids containing single-nucleotide polymorphisms identified for transcribed human sequences, as well as methods of using the nucleic acids.
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公开(公告)号：EP1261712A2
公开(公告)日：2002-12-04
申请号：EP01920218.3
申请日：2001-03-05
申请人： Curagen Corporation
发明人： VERNET, Corine, A., M. , FERNANDES, Elma , SHIMKETS, Richard, A. , HERRMANN, John, L. , MAJUMDER, Kumud , MACDOUGALL, John , MISHRA, Vishnu , MEZES, Peter, S. , RASTELLI, Luca
IPC分类号： C12N15/12 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , G01N33/68 , C12Q1/68 , A61K38/17 , A61K31/70 , A61K39/395 , C12N1/21 , C12N5/10
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C07K14/54 , C07K14/70571 , Y02A50/423 , Y10T436/143333
摘要： Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1255835A2
公开(公告)日：2002-11-13
申请号：EP01912743.0
申请日：2001-02-15
申请人： Curagen Corporation
发明人： VERNET, Corine, A., M. , SHIMKETS, Richard, A. , RASTELLI, Luca , BURGESS, Catherine, E. , TAUPIER, Raymond, J., Jr.
IPC分类号： C12N15/12 , C12N15/54 , C07K14/47 , C07K14/705 , C12N9/10 , C12N15/70 , C12N1/21 , C07K16/18 , C07K16/42 , C12Q1/68 , G01N33/577 , G01N33/68 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , C12N9/1051
摘要： The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide, or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide, and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
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公开(公告)号：EP1240324A2
公开(公告)日：2002-09-18
申请号：EP00984377.2
申请日：2000-12-14
申请人： Curagen Corporation
发明人： SPADERNA, Steven, K. , QUINN, Kerry, E. , SHIMKETS, Richard, A. , PADRIGARU, Muralidhara , SPYTEK, Kimberley, A.
IPC分类号： C12N15/12 , C07K14/705 , C07K16/28 , G01N33/68 , C12Q1/68 , A61K38/17 , A61K48/00 , A61K39/395 , A61K31/713
摘要： The present invention provides novel isolated MEMX polynucleotides and polypeptides encoded by the MEMX polynucleotides. Also provided are the antibodies that immunospecifically bind to a MEMX polypeptide or any derivative, variant, mutant or fragment of the MEMX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the MEMX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
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20.发明公开NUCLEIC ACIDS CONTAINING SINGLE NUCLEOTIDE POLYMORPHISMS AND METHODS OF USE THEREOF 审中-公开NUCLEIC与EINFACHNUKLEOTID-多态性与它们的使用方法
公开(公告)号：EP1144682A3
公开(公告)日：2002-07-31
申请号：EP99965828.9
申请日：1999-11-17
申请人： Curagen Corporation
CPC分类号： C12Q1/6827 , A61K38/00 , A61K48/00 , C07K14/47 , C12Q1/6837 , C12Q1/6883 , C12Q2600/156
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