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公开(公告)号：EP2681194B1
公开(公告)日：2015-04-15
申请号：EP12706049.9
申请日：2012-02-29
发明人： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn David , KARNACHI, Prabha Saba , KIM, Kyungjin , MARTIN, Rainer, E. , MATTEI, Patrizio , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie Lynn , RICHTER, Hans , ULLMER, Christoph
IPC分类号： C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107 , A61K31/4418 , A61K31/4433
CPC分类号： C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
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12.发明公开1,2- PYRIDAZINE, 1,6- PYRIDAZINE OR PYRIMIDINE - BENZAMIDE DERIVATIVES AS GPBAR1 MODULATORS 有权作为GPBAR1调节剂的1,2-哒嗪，1,6-哒嗪或嘧啶 - 苯甲酰胺衍生物
公开(公告)号：EP2834226A1
公开(公告)日：2015-02-11
申请号：EP13713197.5
申请日：2013-04-02
IPC分类号： C07D401/04 , A61K31/50 , A61K31/505 , C07D237/20 , C07D239/42 , A61P3/00 , A61P29/00
CPC分类号： C07D239/42 , C07D237/20 , C07D295/26 , C07D401/04
摘要： This invention relates to novel 1,2-pyridazines, 1,6-pyridazines or pyrimidines of the formula I wherein B
1 to B
3 and R
1 to R
7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.摘要翻译： 本发明涉及式I的新1,2-哒嗪，1,6-哒嗪或嘧啶，其中B 1至B 3和R 1至R 7如说明书和权利要求书中所定义，以及药学上可接受的 其盐。 这些化合物是GPBAR1激动剂，因此可用作治疗疾病例如II型糖尿病的药物。
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公开(公告)号：EP2593426A1
公开(公告)日：2013-05-22
申请号：EP11730660.5
申请日：2011-07-08
发明人： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , MATTEI, Patrizio , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
IPC分类号： C07C251/48 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12
CPC分类号： C07C251/48 , C07C2601/02 , C07C2601/14 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12 , C07D401/10 , C07D413/10 , C07D417/10
摘要： This invention relates to novel 1-hydroxyimino-3-phenyl-propanes of the formula (I) wherein R
1 to R
10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.-
14.发明授权NOVEL HETEROBICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF LIVER CARNITINE PALMITOYL TRANSFERASE 有权新杂衍生物肝脏肉碱棕榈酰TRANSFERASEHEMMER
公开(公告)号：EP1926711B1
公开(公告)日：2012-11-07
申请号：EP06793207.9
申请日：2006-09-05
发明人： ACKERMANN, Jean , BLEICHER, Konrad , CECCARELLI, Simona Maria , CHOMIENNE, Odile , MATTEI, Patrizio , SCHULZ-GASCH, Tanja
IPC分类号： C07D209/10 , C07D403/12 , C07D413/12 , C07D215/58 , C07D223/16
CPC分类号： C07D223/16 , C07D209/10 , C07D215/58 , C07D403/12 , C07D413/12
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15.发明授权
公开(公告)号：EP1638968B1
公开(公告)日：2009-07-29
申请号：EP04739825.0
申请日：2004-06-11
发明人： BOEHRINGER, Markus , KUHN, Bernd , LUEBBERS, Thomas , MATTEI, Patrizio , NARQUIZIAN, Robert , WESSEL, Hans, Peter
IPC分类号： C07D471/04 , A61K31/4745 , A61P5/50
CPC分类号： C07D471/04 , A61K31/4745
摘要： The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
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公开(公告)号：EP1996563A1
公开(公告)日：2008-12-03
申请号：EP07726290.5
申请日：2007-02-02
发明人： ACKERMANN, Jean , BLEICHER, Konrad , CECCARELLI, Simona, M. , CHOMIENNE, Odile , MATTEI, Patrizio , OBST SANDER, Ulrike
IPC分类号： C07D241/42 , C07D263/56 , C07D265/14 , C07D265/36 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04 , C07D498/04 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61P3/00
CPC分类号： C07D265/36 , C07D241/42 , C07D263/56 , C07D265/14 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04
摘要： The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPTl and can be used as medicaments.
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公开(公告)号：EP1480976B1
公开(公告)日：2007-09-19
申请号：EP03742945.3
申请日：2003-02-19
发明人： MATTEI, Patrizio , NEIDHART, Werner , NETTEKOVEN, Matthias, Heinrich , PFLIEGER, Philippe , TAYLOR, Sven
IPC分类号： C07D417/06 , C07D277/42 , C07D417/12 , C07D417/14 , A61K31/425
CPC分类号： C07D417/06 , C07D277/42
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, n, m and A have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
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公开(公告)号：EP1638968A1
公开(公告)日：2006-03-29
申请号：EP04739825.0
申请日：2004-06-11
发明人： BOEHRINGER, Markus , KUHN, Bernd , LUEBBERS, Thomas , MATTEI, Patrizio , NARQUIZIAN, Robert , WESSEL, Hans, Peter
IPC分类号： C07D471/04 , A61K31/4745 , A61P5/50
CPC分类号： C07D471/04 , A61K31/4745
摘要： The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
摘要翻译： 本发明涉及其中R 1如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与DPP-IV相关的疾病，例如糖尿病，特别是非胰岛素依赖性糖尿病和葡萄糖耐量降低。
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19.发明授权1,2-PYRIDAZINE, 1,6-PYRIDAZINE OR PYRIMIDINE-BENZAMIDE DERIVATIVES AS GPBAR1 MODULATORS 有权作为GPBAR1调节剂的1,2-哒嗪，1,6-哒嗪或嘧啶 - 苯甲酰胺衍生物
公开(公告)号：EP2834226B1
公开(公告)日：2016-05-25
申请号：EP13713197.5
申请日：2013-04-02
IPC分类号： C07D401/04 , A61K31/50 , A61K31/505 , C07D237/20 , C07D239/42 , A61P3/00 , A61P29/00
CPC分类号： C07D239/42 , C07D237/20 , C07D295/26 , C07D401/04
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20.发明授权1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS 有权1-吡啶基 - 羟基亚氨基-3-苯基 - 丙酸甲酯GPBAR1-AGONISTEN
公开(公告)号：EP2780330B1
公开(公告)日：2016-01-06
申请号：EP12784005.6
申请日：2012-11-12
发明人： DEHMLOW, Henrietta , MARTIN, Rainer E. , MATTEI, Patrizio , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D237/08 , A61K31/50 , A61P3/10
CPC分类号： C07D237/08 , C07D237/14 , C07D401/10
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