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公开(公告)号：EP3262026B1
公开(公告)日：2020-03-18
申请号：EP16705540.9
申请日：2016-02-22
发明人： HORNSPERGER, Benoit , IACONE, Roberto , KUHN, Bernd , MAERKI, Hans P. , MOHR, Peter , REUTLINGER, Michael
IPC分类号： C07C255/54 , C07D333/68 , C07D241/12 , C07C237/22 , C07D295/145 , C07D213/56 , C07D307/85 , A61K31/165 , A61K31/4402 , A61K31/4406 , A61K31/4965 , C07D213/06
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公开(公告)号：EP2998289B1
公开(公告)日：2019-08-07
申请号：EP15181729.3
申请日：2012-06-08
发明人： Sridhar, C. Nagarajan , Karmali, Priya , Payne, Joseph E. , Hou, Zheng , Gaudette, John A. , Knopov, Victor , Witte, Richard P. , Ahmadian, Mohammad , Perelman, Loren A. , Tanaka, Yasunobu , Akopian, Violetta , Niitsu, Yoshiro
IPC分类号： C07C237/08 , A61K31/16 , A61P1/16 , C07C237/22 , C07C323/60 , C07C333/04 , A61K9/127
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公开(公告)号：EP3484859A1
公开(公告)日：2019-05-22
申请号：EP17736967.5
申请日：2017-07-12
IPC分类号： C07D295/13 , C07D213/65 , C07C237/22 , C07C255/54 , A61K31/44 , A61K31/5375 , A61K31/16 , A61K31/275 , A61P27/02
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公开(公告)号：EP3286174A1
公开(公告)日：2018-02-28
申请号：EP16719712
申请日：2016-04-22
发明人： BENDER JOHN A , LOPEZ OMAR D , NGUYEN VAN N , YANG ZHONG , WANG ALAN XIANGDONG , WANG GAN , MEANWELL NICHOLAS A , BENO BRETT R , FRIDELL ROBERT A , BELEMA MAKONEN , THANGATHIRUPATHY SRINIVASAN
IPC分类号： C07D317/66 , A61K31/17 , A61K31/18 , A61K31/4245 , A61P31/18 , C07C237/22 , C07C275/24 , C07C311/03 , C07D213/61 , C07D235/26 , C07D271/12 , C07D277/62 , C07D285/14 , C07D295/192
CPC分类号： C07D213/61 , C07C237/22 , C07C271/22 , C07C275/24 , C07C307/06 , C07C311/06 , C07C311/19 , C07C323/60 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D235/26 , C07D271/12 , C07D277/62 , C07D285/14 , C07D295/192 , C07D317/66 , C07K5/022
摘要： Compounds of Formulas I-VI, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth. Formula I is exemplified below: Formula (i)
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公开(公告)号：EP3122721A4
公开(公告)日：2018-01-10
申请号：EP15769739
申请日：2015-03-25
发明人： SHARMA RAJIV , SAHU BICHISMITA , MALI SUNIL VASANTRAO , SINGH DEEPAK , KUMAR PRAMOD BHASKAR , DAWANGE MAHESH , MISTRY HITESH
IPC分类号： C07C317/32 , A61K31/165 , A61K31/18 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/402 , A61K31/5375 , A61P19/02 , A61P35/00 , A61P37/00 , C07C237/22 , C07C311/08 , C07C311/37 , C07D207/27 , C07D265/36 , C07D311/22 , C07D335/06
CPC分类号： A61K31/165 , A61K31/18 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/402 , A61K31/5375 , C07C205/36 , C07C211/45 , C07C215/70 , C07C217/48 , C07C217/76 , C07C217/88 , C07C225/22 , C07C229/42 , C07C233/29 , C07C233/54 , C07C237/22 , C07C255/46 , C07C255/50 , C07C309/89 , C07C311/08 , C07C311/37 , C07C317/24 , C07C317/32 , C07C317/44 , C07C323/09 , C07C2601/02 , C07C2601/14 , C07D207/27 , C07D265/36 , C07D295/26 , C07D311/22 , C07D317/72 , C07D335/06 , C07F5/025 , C07F7/1852
摘要： The present invention relates to a compound of formula I, or an isotopic form, stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparation. The invention further relates to pharmaceutical compositions containing the compounds and their use in the treatment of diseases or disorders mediated by RORγ.
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公开(公告)号：EP3262026A1
公开(公告)日：2018-01-03
申请号：EP16705540.9
申请日：2016-02-22
发明人： HORNSPERGER, Benoit , IACONE, Roberto , KUHN, Bernd , MAERKI, Hans P. , MOHR, Peter , REUTLINGER, Michael
IPC分类号： C07C255/54 , C07D333/68 , C07D241/12 , C07C237/22 , C07D295/145 , C07D213/56 , C07D307/85
摘要： wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：EP3256218A1
公开(公告)日：2017-12-20
申请号：EP16749986.2
申请日：2016-02-12
发明人： RIENHOFF, Hugh, Young, Jr. , MCCALL, John, M. , CLARE, Michael , CELATKA, Cassandra , TAPPER, Amy, E.
IPC分类号： A61P35/02 , C07C237/22 , C07C211/35
CPC分类号： C07D249/06 , A61K9/0053 , A61K9/1623 , A61K9/4858 , A61K31/397 , A61K31/41 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/551 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C53/18 , C07C309/30 , C07D205/04 , C07D211/66 , C07D215/54 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/42 , C07D249/08 , C07D263/32 , C07D279/12 , C07D295/192 , C07D295/26 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , A61K2300/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：EP2315740B1
公开(公告)日：2017-10-25
申请号：EP09790168.0
申请日：2009-07-08
IPC分类号： C07C233/18 , C07C233/49 , C07C233/55 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/192 , C07C69/90 , C07C69/94 , C07C69/587 , A61K31/165 , A61K31/17 , A61K31/232 , A61K31/235
CPC分类号： A61K31/609 , A61K31/60 , C07C69/86 , C07C69/94 , C07C233/18 , C07C233/49 , C07C233/55 , C07C235/52 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/182 , C07D295/192
摘要： The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.
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19.发明公开BENZAMIDE AND NICOTINAMIDE COMPOUNDS AND METHODS OF USING SAME 审中-公开BENZAMID-UND NICOTINAMIDVERBINDUNGEN UND VERFAHREN ZUR VERWENDUNG DAVON
公开(公告)号：EP3087051A4
公开(公告)日：2017-07-12
申请号：EP14875542
申请日：2014-12-23
申请人： ONCOTARTIS INC
IPC分类号： C07C237/22 , A61K31/166 , A61K31/4155 , A61P35/00
CPC分类号： C07D471/04 , A61K31/4155 , A61K31/5355 , C07D231/12 , C07D233/61 , C07D233/64 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D451/06 , C07D487/08
摘要： The present disclosure provides benzamide and nicotinamide compounds and pharmaceutical uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia). The preferred compounds of the invention contain a phenylethynyl moiety as well as an amine-based heterocyclyl or heteroaryl moiety attached to the benzamide or nicotinamide compound.
摘要翻译： 本公开提供苯甲酰胺和烟酰胺化合物以及这些化合物的药物用途。 该化合物可用于治疗例如癌症如造血系统癌症（例如白血病）。 本发明优选的化合物含有苯乙炔基部分以及与苯甲酰胺或烟酰胺化合物连接的基于胺的杂环基或杂芳基部分。
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20.发明授权COMPOSITIONS INCLUDING 6-AMINOHEXANOIC ACID DERIVATIVES AS HDAC INHIBITORS 有权ZUSAMMENSETZUNGEN MIT 6-AMINOHEXANSAUREDERIVATEN ALS HDAC-HEMMER
公开(公告)号：EP2330894B8
公开(公告)日：2017-04-19
申请号：EP09812248.4
申请日：2009-09-03
IPC分类号： C07C235/16 , C07C237/22 , C07C255/57 , C07C311/16 , C07C311/19 , C07C317/44 , C07C323/62 , C07D209/48 , C07D213/30 , C07D231/56 , C07D277/56 , C07D295/14 , C07D307/84 , C07D409/12 , A01N37/18 , A61K31/00 , A61K31/16
CPC分类号： C07C233/80 , A61K31/00 , A61K31/16 , C07C235/16 , C07C237/22 , C07C255/57 , C07C311/16 , C07C311/19 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D209/48 , C07D213/30 , C07D213/81 , C07D217/24 , C07D231/12 , C07D231/56 , C07D237/24 , C07D241/24 , C07D241/44 , C07D271/12 , C07D277/56 , C07D295/14 , C07D295/15 , C07D307/84 , C07D307/85 , C07D333/38 , C07D409/12 , Y02A50/411
摘要： This invention relates to compounds of Formula (I) wherein Cy1, L1, Y, R1, L2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions.
摘要翻译： 本发明涉及式（I）化合物，其中Cy1，L1，Y，R1，L2和Ar2在本文中定义，用于治疗癌症，炎症性疾病和神经病症。
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