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    PHENOTHIAZINE DERIVATIVES AND METHODS FOR TREATING TUMORS
    24.
    发明公开
    PHENOTHIAZINE DERIVATIVES AND METHODS FOR TREATING TUMORS 有权
    菲尼克斯（VENFAHRENZEN ZER BEHANDLUNG VON TUMOREN）

    公开(公告)号：EP2998303A1

    公开(公告)日：2016-03-23

    申请号：EP15184718.3

    申请日：2015-09-10

    申请人： B & G Partners, LLC

    发明人： BARBEAU, Donald

    IPC分类号： C07D417/06 ,  A61K45/06 ,  A61P35/00

    CPC分类号： C07D417/06

    摘要： The present invention relates to pharmaceutical compositions and methods for controlling tumor growth in cancer patients. These compounds and pharmaceutical compositions modulate the P-glycoprotein multidrug transporter system and inhibit the activated PI3K/Akt/mTOR/p70S6K signaling pathway. The compounds and pharmaceutical compounds of the present invention are particularly useful for treating metastatic and drug-resistant tumors.

    摘要翻译： 本发明涉及用于控制癌症患者肿瘤生长的药物组合物和方法。 这些化合物和药物组合物调节P-糖蛋白多药转运系统并抑制活化的PI3K / Akt / mTOR / p70S6K信号通路。 本发明的化合物和药物化合物特别可用于治疗转移性和耐药性肿瘤。

    METHODS FOR DETECTING MOLECULES IN A SAMPLE
    25.
    发明公开
    METHODS FOR DETECTING MOLECULES IN A SAMPLE 审中-公开
    VERFAHREN ZUR DETEKTION VONMOLEKÜLENIN EINER PROBE

    公开(公告)号：EP2972357A1

    公开(公告)日：2016-01-20

    申请号：EP14710370.9

    申请日：2014-03-11

    申请人： Cancer Research Technology Ltd

    发明人： LARIJANI, Banafshe ,  PARKER, Peter ,  VEERIAH, Selvaraju

    IPC分类号： G01N33/543

    摘要： The present invention relates to a method for detecting molecules. The method employs: at least two primary antibodies, wherein the first primary antibody binds to a first site on a molecule and the second primary antibody binds to a second site on a molecule, wherein the second site is different from the first site and wherein the first and second primary antibodies are immunologically distinct; at least two secondary antibodies, wherein the first secondary antibody is labelled with a fluorescence resonance energy transfer (FRET) donor and binds to the first primary antibody; and the second secondary antibody is conjugated or fused to an enzyme and binds the second primary antibody, wherein the first secondary antibody does not bind the second primary antibody and the second secondary antibody does not bind the first primary antibody; a conjugate comprising a FRET acceptor and a substrate specific for the enzyme, wherein when the substrate reacts with the enzyme, an activated conjugate forms, which activated conjugate binds to electron rich moieties on a molecular surface adjacent to the enzyme; wherein the method comprises: contacting a sample with the at least two primary antibodies; contacting the sample with the at least two secondary antibodies; performing a wash step; contacting the sample with the conjugate; and detecting any FRET signal generated by the FRET acceptor.

    摘要翻译： 本发明涉及一种检测分子的方法。 该方法采用：至少两种一级抗体，其中第一种一级抗体结合分子上的第一位点，第二种一级抗体与分子上的第二位点结合，其中第二位点不同于第一位点，其中 第一和第二抗体具有免疫学差异; 至少两个二抗，其中所述第一二抗用荧光共振能量转移（FRET）供体标记并结合所述第一个一抗; 并且所述第二次抗体与酶缀合或融合并结合所述第二一抗，其中所述第一二抗不结合所述第二一抗，所述第二二抗不结合所述第一一抗; 包含FRET受体和对酶特异性的底物的缀合物，其中当底物与酶反应时，活化的缀合物形成，其活化的缀合物结合与邻近酶的分子表面上的富含电子部分; 其中所述方法包括：使样品与所述至少两种一抗接触; 使所述样品与所述至少两种第二抗体接触; 执行洗涤步骤; 使样品与缀合物接触; 并检测由FRET接收器产生的任何FRET信号。

    NANOWIRE FIELD-EFFECT TRANSISTOR BIOSENSOR WITH IMPROVED SENSITIVITY
    29.
    发明公开
    NANOWIRE FIELD-EFFECT TRANSISTOR BIOSENSOR WITH IMPROVED SENSITIVITY 审中-公开
    使用更高的灵敏度纳米线场效应晶体管生物传感器

    公开(公告)号：EP2646812A2

    公开(公告)日：2013-10-09

    申请号：EP11845848.8

    申请日：2011-12-02

    申请人： The Regents of the University of California

    发明人： CHUI, Chi On ,  SHIN, Kyeong-Sik

    IPC分类号： G01N27/414 ,  G01N33/483 ,  C12Q1/68

    CPC分类号： G01N33/50 ,  B82Y15/00 ,  G01N27/4146 ,  H01L29/78 ,  Y10T436/143333

    摘要： The present invention is directed to a multiwire nanowire field effect transistor (nwFET) device for the measurement. The device includes a sensing nanowire having a first end and a second end and a nanowire FET having a first end and a second end, wherein the first end of the sensing nanowire is connected to the nanowire FET to form a node. Additionally, the first end of the nanowire FET is connected to a source electrode, the second end of the nanowire FET is connected to a drain electrode, and the second end of the sensing nanowire is connected to a base electrode. The sensing nanowire is derivatized with a plurality of immobilized capture probes that are specific for a target(s) of interest. The device is used to detect biomolecules or to detect the change in the ionic environment of a sample. In a further embodiment, the sensing nanowire is derivatized with amino, carboxyl or hydroxyl groups. Upon a change in ionic environment, or binding of a molecule to the sensing nanowire, the sensing nanowire current (IB) fluctuates. This fluctuation is amplified and readout as the nanowire FET drain current (ID). Accordingly, the present invention provides for label-free detection of biomolecules and may find use as a point-of-care diagnostic device.